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Thecoma

MedGen UID:
21505
Concept ID:
C0039747
Neoplastic Process
Synonyms: Theca Cell Tumor; Theca Cell Tumors; Thecomas; Tumor, Theca Cell; Tumors, Theca Cell
 
Monarch Initiative: MONDO:0037252

Definition

An ovarian or testicular stromal tumor characterized by the presence of lipid-rich neoplastic spindle cells. In females, uterine bleeding is the most common symptom. A minority of post-menopausal women with thecoma have an associated endometrial adenocarcinoma or rarely a malignant mixed mullerian tumor or endometrial stromal sarcoma. Rare cases with nuclear atypia and mitotic activity may metastasize. In males, thecomas are rare and they usually present as slow growing, sometimes painful masses. Metastases have not been reported. [from NCI]

Professional guidelines

PubMed

Fang M, Dong J, Zhong Q, Fang X, Chen Y, Wang C, Yan H
Acta Radiol 2019 Nov;60(11):1532-1542. Epub 2019 Feb 18 doi: 10.1177/0284185119830280. PMID: 30776906
Buza N, Wong S, Hui P
Int J Gynecol Pathol 2018 Jul;37(4):305-315. doi: 10.1097/PGP.0000000000000426. PMID: 28700438
Burandt E, Young RH
Am J Surg Pathol 2014 Aug;38(8):1023-32. doi: 10.1097/PAS.0000000000000252. PMID: 25025365

Recent clinical studies

Etiology

Pat JJ, Rothnie KK, Kolomainen D, Sundaresan M, Zhang J, Liyanage SH
Br J Radiol 2022 Aug 1;95(1136):20210790. Epub 2022 Jul 12 doi: 10.1259/bjr.20210790. PMID: 35451310Free PMC Article
Javadi S, Ganeshan DM, Jensen CT, Iyer RB, Bhosale PR
Abdom Radiol (NY) 2021 Apr;46(4):1519-1529. Epub 2021 Mar 16 doi: 10.1007/s00261-021-02998-w. PMID: 33725145
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Blake EA, Carter CM, Kashani BN, Kodama M, Mabuchi S, Yoshino K, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:1-7. Epub 2013 Dec 25 doi: 10.1016/j.ejogrb.2013.12.025. PMID: 24439718
Roth LM, Czernobilsky B
Am J Surg Pathol 2011 Mar;35(3):e15-33. doi: 10.1097/PAS.0b013e31820acb89. PMID: 21317704

Diagnosis

Costeira FS, Félix A, Cunha TM
Br J Radiol 2022 Feb 1;95(1130):20210687. Epub 2021 Dec 20 doi: 10.1259/bjr.20210687. PMID: 34928171Free PMC Article
Schoolmeester JK, Erickson LA
Mayo Clin Proc 2019 Aug;94(8):1652-1653. doi: 10.1016/j.mayocp.2019.04.019. PMID: 31378246
Hanley KZ, Mosunjac MB
Surg Pathol Clin 2019 Jun;12(2):587-620. doi: 10.1016/j.path.2019.02.005. PMID: 31097116
Haghayeghi K, Hansen K, Quddus MR
Int J Surg Pathol 2019 Sep;27(6):654-655. Epub 2018 Dec 6 doi: 10.1177/1066896918817372. PMID: 30520326
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Therapy

Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537
Levavi H, Sabah G, Heifetz M, Feinmesser M
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Bridgewater JA, Rustin GJ
Oncology 1999;57(2):89-98. doi: 10.1159/000012014. PMID: 10461054
Freeman DA
Endocr Rev 1986 May;7(2):204-20. doi: 10.1210/edrv-7-2-204. PMID: 3013606
Dunaif A, Scully RE, Andersen RN, Chapin DS, Crowley WF Jr
J Clin Endocrinol Metab 1984 Sep;59(3):389-93. doi: 10.1210/jcem-59-3-389. PMID: 6086692

Prognosis

Javadi S, Ganeshan DM, Jensen CT, Iyer RB, Bhosale PR
Abdom Radiol (NY) 2021 Apr;46(4):1519-1529. Epub 2021 Mar 16 doi: 10.1007/s00261-021-02998-w. PMID: 33725145
Schoolmeester JK, Erickson LA
Mayo Clin Proc 2019 Aug;94(8):1652-1653. doi: 10.1016/j.mayocp.2019.04.019. PMID: 31378246
Hanley KZ, Mosunjac MB
Surg Pathol Clin 2019 Jun;12(2):587-620. doi: 10.1016/j.path.2019.02.005. PMID: 31097116
Werness BA
Arch Pathol Lab Med 1996 Mar;120(3):303-6. PMID: 8629912
Freeman DA
Endocr Rev 1986 May;7(2):204-20. doi: 10.1210/edrv-7-2-204. PMID: 3013606

Clinical prediction guides

Slimani O, Ben Temim R, Ajroudi M, Makhlouf T, Mathlouthi N, Attia L
Tunis Med 2017 Jan;95(1):29-36. PMID: 29327766
Blake EA, Carter CM, Kashani BN, Kodama M, Mabuchi S, Yoshino K, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:1-7. Epub 2013 Dec 25 doi: 10.1016/j.ejogrb.2013.12.025. PMID: 24439718
Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537
Parker RL, Dadmanesh F, Young RH, Clement PB
Am J Surg Pathol 2004 Mar;28(3):285-97. doi: 10.1097/00000478-200403000-00001. PMID: 15104291
Lee S, Mao L, Wang Y, D'Silva M, Yoo CH, Wolf P, Chung WS, Takahashi E, Chung DY, Gittes RF
Microsurgery 1995;16(4):191-8. doi: 10.1002/micr.1920160406. PMID: 7674907

Recent systematic reviews

Muratori L, Trevisi E, Delcuratolo MD, Sperone P, Di Maio M
Expert Rev Anticancer Ther 2021 Jan;21(1):23-32. Epub 2020 Oct 22 doi: 10.1080/14737140.2021.1837629. PMID: 33053314
Blake EA, Carter CM, Kashani BN, Kodama M, Mabuchi S, Yoshino K, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:1-7. Epub 2013 Dec 25 doi: 10.1016/j.ejogrb.2013.12.025. PMID: 24439718

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