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Childhood central nervous system immature teratoma

MedGen UID:
232344
•Concept ID:
C1332954
•
Neoplastic Process
Synonyms: central nervous system immature teratoma of childhood; Childhood Central Nervous System Immature Teratoma; childhood central nervous system immature teratoma; paediatric central nervous system immature teratoma; pediatric central nervous system immature teratoma
 
Monarch Initiative: MONDO:0003958

Definition

An immature teratoma that arises from the central nervous system and occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood central nervous system immature teratoma

Professional guidelines

PubMed

Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors.
Theruvath J, Sotillo E, Mount CW, Graef CM, Delaidelli A, Heitzeneder S, Labanieh L, Dhingra S, Leruste A, Majzner RG, Xu P, Mueller S, Yecies DW, Finetti MA, Williamson D, Johann PD, Kool M, Pfister S, Hasselblatt M, Frühwald MC, Delattre O, Surdez D, Bourdeaut F, Puget S, Zaidi S, Mitra SS, Cheshier S, Sorensen PH, Monje M, Mackall CL
Nat Med 2020 May;26(5):712-719. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0821-8. PMID: 32341579Free PMC Article
Diagnosis and management of brain and spinal cord tumors in the neonate.
Hwang SW, Su JM, Jea A
Semin Fetal Neonatal Med 2012 Aug;17(4):202-206. Epub 2012 Mar 30 doi: 10.1016/j.siny.2012.03.001. PMID: 22465555
Atypical teratoid/rhabdoid tumors of the central nervous system: management and outcomes.
Chen ML, McComb JG, Krieger MD
Neurosurg Focus 2005 Jun 15;18(6A):E8. PMID: 16048294

Recent clinical studies

Etiology

Pineal Atypical Teratoid Rhabdoid Tumor in a 5-Month-Old Child.
Gendle C, Karthigeyan M, Salunke P, Gupta K
Pediatr Neurosurg 2020;55(6):404-408. Epub 2020 Dec 10 doi: 10.1159/000511995. PMID: 33302285
Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation.
Erkek S, Johann PD, Finetti MA, Drosos Y, Chou HC, Zapatka M, Sturm D, Jones DTW, Korshunov A, Rhyzova M, Wolf S, Mallm JP, Beck K, Witt O, Kulozik AE, Frühwald MC, Northcott PA, Korbel JO, Lichter P, Eils R, Gajjar A, Roberts CWM, Williamson D, Hasselblatt M, Chavez L, Pfister SM, Kool M
Cancer Cell 2019 Jan 14;35(1):95-110.e8. Epub 2018 Dec 27 doi: 10.1016/j.ccell.2018.11.014. PMID: 30595504Free PMC Article
Clinical and pathological features of paediatric malignant rhabdoid tumours.
Morgenstern DA, Gibson S, Brown T, Sebire NJ, Anderson J
Pediatr Blood Cancer 2010 Jan;54(1):29-34. doi: 10.1002/pbc.22231. PMID: 19653294
Atypical teratoid/rhabdoid tumor in a patient with Beckwith-Wiedemann syndrome.
Jackson EM, Shaikh TH, Zhang F, Wainwright LM, Storm PB, Hakonarson H, Zackai EH, Biegel JA
Am J Med Genet A 2007 Aug 1;143A(15):1767-70. doi: 10.1002/ajmg.a.31843. PMID: 17603804
A second brain tumour and irradiation.
Robinson RG
J Neurol Neurosurg Psychiatry 1978 Nov;41(11):1005-12. doi: 10.1136/jnnp.41.11.1005. PMID: 213536Free PMC Article

Diagnosis

Pediatric Brain Tumors.
Udaka YT, Packer RJ
Neurol Clin 2018 Aug;36(3):533-556. doi: 10.1016/j.ncl.2018.04.009. PMID: 30072070
Atypical teratoid/rhabdoid tumor with retained INI1 (SMARCB1) expression and loss of BRG1 (SMARCA4).
Bookhout C, Bouldin TW, Ellison DW
Neuropathology 2018 Jun;38(3):305-308. Epub 2017 Dec 21 doi: 10.1111/neup.12452. PMID: 29271065
Surgical treatment of a clival-C2 atypical teratoid/rhabdoid tumor.
Heuer GG, Kiefer H, Judkins AR, Belasco J, Biegel JA, Jackson EM, Cohen M, O'Malley BW Jr, Storm PB
J Neurosurg Pediatr 2010 Jan;5(1):75-9. doi: 10.3171/2009.8.PEDS08421. PMID: 20043739Free PMC Article
Intradural dermoid masquerading as pyogenic meningitis: case report.
Kaushik JS, Gomber S, Dewan P
Ann Trop Paediatr 2009 Dec;29(4):305-8. doi: 10.1179/027249309X12547917869122. PMID: 19941754
Congenital immature teratoma of the fetal brain.
Rickert CH, Probst-Cousin S, Louwen F, Feldt B, Gullotta F
Childs Nerv Syst 1997 Oct;13(10):556-9. doi: 10.1007/s003810050137. PMID: 9403206

Therapy

Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors.
Theruvath J, Sotillo E, Mount CW, Graef CM, Delaidelli A, Heitzeneder S, Labanieh L, Dhingra S, Leruste A, Majzner RG, Xu P, Mueller S, Yecies DW, Finetti MA, Williamson D, Johann PD, Kool M, Pfister S, Hasselblatt M, Frühwald MC, Delattre O, Surdez D, Bourdeaut F, Puget S, Zaidi S, Mitra SS, Cheshier S, Sorensen PH, Monje M, Mackall CL
Nat Med 2020 May;26(5):712-719. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0821-8. PMID: 32341579Free PMC Article
Clinical and pathological features of paediatric malignant rhabdoid tumours.
Morgenstern DA, Gibson S, Brown T, Sebire NJ, Anderson J
Pediatr Blood Cancer 2010 Jan;54(1):29-34. doi: 10.1002/pbc.22231. PMID: 19653294
Childhood atypical teratoid rhabdoid tumor of the central nervous system: a meta-analysis of observational studies.
Athale UH, Duckworth J, Odame I, Barr R
J Pediatr Hematol Oncol 2009 Sep;31(9):651-63. doi: 10.1097/MPH.0b013e3181b258a9. PMID: 19707161
Continuous remission of newly diagnosed and relapsed central nervous system atypical teratoid/rhabdoid tumor.
Zimmerman MA, Goumnerova LC, Proctor M, Scott RM, Marcus K, Pomeroy SL, Turner CD, Chi SN, Chordas C, Kieran MW
J Neurooncol 2005 Mar;72(1):77-84. doi: 10.1007/s11060-004-3115-y. PMID: 15803379
Pineal region tumors of childhood.
Packer RJ, Sutton LN, Rosenstock JG, Rorke LB, Bilaniuk LT, Zimmerman RA, Littman PA, Bruce DA, Schut L
Pediatrics 1984 Jul;74(1):97-102. PMID: 6739222

Prognosis

DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma.
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Atypical teratoid/rhabdoid tumor in an infant conceived by in vitro fertilization.
Cecen E, Gunes D, Uysal KM, Yuceer N, Ozer E
Childs Nerv Syst 2010 Feb;26(2):263-6. Epub 2009 Nov 24 doi: 10.1007/s00381-009-1005-5. PMID: 19937253
Clinical and pathological features of paediatric malignant rhabdoid tumours.
Morgenstern DA, Gibson S, Brown T, Sebire NJ, Anderson J
Pediatr Blood Cancer 2010 Jan;54(1):29-34. doi: 10.1002/pbc.22231. PMID: 19653294
Transcortical approach to a huge pineal mature teratoma.
Berhouma M, Jemel H, Ksira I, Khaldi M
Pediatr Neurosurg 2008;44(1):52-4. Epub 2007 Dec 14 doi: 10.1159/000110663. PMID: 18097192
Geographical neurosurgery.
Ohaegbulam SC
Neurol Res 1999 Mar;21(2):161-70. doi: 10.1080/01616412.1999.11740912. PMID: 10100202

Clinical prediction guides

Transcortical approach to a huge pineal mature teratoma.
Berhouma M, Jemel H, Ksira I, Khaldi M
Pediatr Neurosurg 2008;44(1):52-4. Epub 2007 Dec 14 doi: 10.1159/000110663. PMID: 18097192
Intradural dermoid tumor of the posterior fossa in a child with diastematobulbia.
Ciurea AV, Coman T, Tascu A, Ionescu V
Surg Neurol 2005 Jun;63(6):571-5; discussion 575. doi: 10.1016/j.surneu.2004.06.024. PMID: 15936393
Radiologic features of pediatric thalamic and hypothalamic tumors.
Lefton DR, Pinto RS, Silvera VM, DeLara FA, Schwartz JB, Haller JO
Crit Rev Diagn Imaging 2000 Aug;41(4):237-78. PMID: 10999238
Geographical neurosurgery.
Ohaegbulam SC
Neurol Res 1999 Mar;21(2):161-70. doi: 10.1080/01616412.1999.11740912. PMID: 10100202
The role of CT in the diagnosis and management of childhood pineal region tumours.
De Campo MP, Davis MD
Australas Radiol 1991 Nov;35(4):336-9. doi: 10.1111/j.1440-1673.1991.tb03042.x. PMID: 1812825

Recent systematic reviews

Atypical teratoid/rhabdoid tumor in adults: a systematic review of the literature with meta-analysis and additional reports of 4 cases.
Broggi G, Gianno F, Shemy DT, Massimino M, Milanaccio C, Mastronuzzi A, Rossi S, Arcella A, Giangaspero F, Antonelli M
J Neurooncol 2022 Mar;157(1):1-14. Epub 2022 Feb 25 doi: 10.1007/s11060-022-03959-z. PMID: 35217948

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