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Benign Adrenal Cortical Neoplasm

MedGen UID:
234576
•Concept ID:
C1368669
•
Neoplastic Process
Synonyms: Benign Adrenal Cortex Neoplasm; Benign Adrenal Cortex Tumor; Benign neoplasm of adrenal cortex
SNOMED CT: Benign neoplasm of adrenal cortex (91966003)

Definition

A neoplasm that arises from the adrenal cortex and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Presentation and management of patients with adrenal masses: a large tertiary centre experience.
Suntornlohanakul O, Mandal S, Saha P, Saygili ES, Asia M, Arlt W, Elhassan YS, Prete A, Ronchi CL
Eur J Endocrinol 2024 Oct 29;191(5):481-490. doi: 10.1093/ejendo/lvae131. PMID: 39425921
Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches.
Prete A, Bancos I
Nat Rev Endocrinol 2024 Aug;20(8):460-473. Epub 2024 Apr 22 doi: 10.1038/s41574-024-00984-y. PMID: 38649778
Recent Updates on the Management of Adrenal Incidentalomas.
Park SS, Kim JH
Endocrinol Metab (Seoul) 2023 Aug;38(4):373-380. Epub 2023 Aug 16 doi: 10.3803/EnM.2023.1779. PMID: 37583083Free PMC Article

Recent clinical studies

Etiology

Prevalence and Characteristics of Adrenal Tumors in an Unselected Screening Population : A Cross-Sectional Study.
Jing Y, Hu J, Luo R, Mao Y, Luo Z, Zhang M, Yang J, Song Y, Feng Z, Wang Z, Cheng Q, Ma L, Yang Y, Zhong L, Du Z, Wang Y, Luo T, He W, Sun Y, Lv F, Li Q, Yang S
Ann Intern Med 2022 Oct;175(10):1383-1391. Epub 2022 Sep 13 doi: 10.7326/M22-1619. PMID: 36095315
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Radiotherapy-induced skin reactions: assessment and management.
Glover D, Harmer V
Br J Nurs 2014 Feb 27-Mar 12;23(4):S28, S30-5. doi: 10.12968/bjon.2014.23.Sup2.S28. PMID: 24619051
Minimally invasive adrenalectomy in children.
Heloury Y, Muthucumaru M, Panabokke G, Cheng W, Kimber C, Leclair MD
J Pediatr Surg 2012 Feb;47(2):415-21. doi: 10.1016/j.jpedsurg.2011.08.003. PMID: 22325405
Adrenal incidentalomas.
Aron D, Terzolo M, Cawood TJ
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):69-82. doi: 10.1016/j.beem.2011.06.012. PMID: 22305453

Diagnosis

Recent Updates on the Management of Adrenal Incidentalomas.
Park SS, Kim JH
Endocrinol Metab (Seoul) 2023 Aug;38(4):373-380. Epub 2023 Aug 16 doi: 10.3803/EnM.2023.1779. PMID: 37583083Free PMC Article
Adrenal Neoplasms: Lessons from Adrenal Multidisciplinary Tumor Boards.
Chung R, Garratt J, Remer EM, Navin P, Blake MA, Taffel MT, Hackett CE, Sharbidre KG, Tu W, Low G, Bara M, Carney BW, Corwin MT, Campbell MJ, Lee JT, Lee CY, Dueber JC, Shehata MA, Caoili EM, Schieda N, Elsayes KM
Radiographics 2023 Jul;43(7):e220191. doi: 10.1148/rg.220191. PMID: 37347698
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Minimally invasive adrenal surgery: virtue or vice?
Winoker JS, Ahlborn DT, Omidele OO, Fernandez-Ranvier G, Derweesh IH, Mehrazin R
Future Oncol 2018 Feb;14(3):267-276. Epub 2018 Jan 18 doi: 10.2217/fon-2017-0420. PMID: 29345155
Orbital pseudotumor.
Mendenhall WM, Lessner AM
Am J Clin Oncol 2010 Jun;33(3):304-6. doi: 10.1097/COC.0b013e3181a07567. PMID: 19738455

Therapy

Epidermolytic hyperkeratosis of the vulva.
Dai C, Sokumbi O, Bruce A, Thielen JM, Sluzevich JC
Dermatol Online J 2021 Jan 15;27(1) PMID: 33560797
Minimally invasive adrenal surgery: virtue or vice?
Winoker JS, Ahlborn DT, Omidele OO, Fernandez-Ranvier G, Derweesh IH, Mehrazin R
Future Oncol 2018 Feb;14(3):267-276. Epub 2018 Jan 18 doi: 10.2217/fon-2017-0420. PMID: 29345155
Surgical management of adrenocortical carcinoma.
Ranvier GG, Inabnet WB 3rd
Endocrinol Metab Clin North Am 2015 Jun;44(2):435-52. Epub 2015 Mar 17 doi: 10.1016/j.ecl.2015.02.008. PMID: 26038210
Radiotherapy-induced skin reactions: assessment and management.
Glover D, Harmer V
Br J Nurs 2014 Feb 27-Mar 12;23(4):S28, S30-5. doi: 10.12968/bjon.2014.23.Sup2.S28. PMID: 24619051
Cushing's syndrome.
Howlett TA, Rees LH, Besser GM
Clin Endocrinol Metab 1985 Nov;14(4):911-45. doi: 10.1016/s0300-595x(85)80083-9. PMID: 3002679

Prognosis

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Adrenocortical carcinoma: Impact of surgical treatment.
Mirallié E, Blanchard C, Caillard C, Rodien P, Briet C, Mucci S, Drui D, Hamy A
Ann Endocrinol (Paris) 2019 Nov;80(5-6):308-313. Epub 2019 Oct 18 doi: 10.1016/j.ando.2019.09.001. PMID: 31722787
Unravelling Adrenal Oncocytic Neoplasm.
Virarkar M, Patnana M, Vikram R, Bhargava P, Birkenfeld E, Sagebiel T
Clin Genitourin Cancer 2019 Feb;17(1):e216-e220. Epub 2018 Oct 26 doi: 10.1016/j.clgc.2018.10.011. PMID: 30454970
Minimally invasive adrenal surgery: virtue or vice?
Winoker JS, Ahlborn DT, Omidele OO, Fernandez-Ranvier G, Derweesh IH, Mehrazin R
Future Oncol 2018 Feb;14(3):267-276. Epub 2018 Jan 18 doi: 10.2217/fon-2017-0420. PMID: 29345155
Cushing's syndrome.
Howlett TA, Rees LH, Besser GM
Clin Endocrinol Metab 1985 Nov;14(4):911-45. doi: 10.1016/s0300-595x(85)80083-9. PMID: 3002679

Clinical prediction guides

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Medical Management of Infantile Hemangiomas: An Update.
Colmant C, Powell J
Paediatr Drugs 2022 Jan;24(1):29-43. Epub 2021 Oct 22 doi: 10.1007/s40272-021-00477-9. PMID: 34677814
Current and emerging therapies for adrenocortical carcinoma--review.
Przytulska J, Rogala N, Bednarek-Tupikowska G
Adv Clin Exp Med 2015 Mar-Apr;24(2):185-93. doi: 10.17219/acem/30645. PMID: 25931348
Aberrant GPCR expression is a sufficient genetic event to trigger adrenocortical tumorigenesis.
Mazzuco TL, Chabre O, Feige JJ, Thomas M
Mol Cell Endocrinol 2007 Feb;265-266:23-8. Epub 2006 Dec 15 doi: 10.1016/j.mce.2006.12.034. PMID: 17250952
Adrenal incidentalomas.
Bertherat J, Mosnier-Pudar H, Bertagna X
Curr Opin Oncol 2002 Jan;14(1):58-63. doi: 10.1097/00001622-200201000-00011. PMID: 11790982

Recent systematic reviews

Discrepancies in the Recommended Management of Adrenal Incidentalomas by Various Guidelines.
Maas M, Nassiri N, Bhanvadia S, Carmichael JD, Duddalwar V, Daneshmand S
J Urol 2021 Jan;205(1):52-59. Epub 2020 Aug 28 doi: 10.1097/JU.0000000000001342. PMID: 32856984
Interventions for infantile haemangiomas of the skin.
Novoa M, Baselga E, Beltran S, Giraldo L, Shahbaz A, Pardo-Hernandez H, Arevalo-Rodriguez I
Cochrane Database Syst Rev 2018 Apr 18;4(4):CD006545. doi: 10.1002/14651858.CD006545.pub3. PMID: 29667726Free PMC Article
Propranolol versus corticosteroids: what should be the treatment of choice in infantile hemangiomas?
Theunissen CI, Smitt JH, van der Horst CM
Ann Plast Surg 2015 Feb;74(2):237-41. doi: 10.1097/SAP.0b013e318299cd4e. PMID: 24051459
Adrenal oncocytic neoplasm: a systematic review.
Mearini L, Del Sordo R, Costantini E, Nunzi E, Porena M
Urol Int 2013;91(2):125-33. Epub 2012 Nov 8 doi: 10.1159/000345141. PMID: 23147196
Minimally invasive adrenalectomy in children.
Heloury Y, Muthucumaru M, Panabokke G, Cheng W, Kimber C, Leclair MD
J Pediatr Surg 2012 Feb;47(2):415-21. doi: 10.1016/j.jpedsurg.2011.08.003. PMID: 22325405

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