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Low Grade Squamous Intraepithelial Neoplasia

MedGen UID:
266268
•Concept ID:
C1302773
•
Neoplastic Process
Synonyms: Low Grade Squamous Intraepithelial Lesion; Low Grade Squamous Intraepithelial Lesions; Low-Grade Squamous Intraepithelial Lesion; Low-Grade Squamous Intraepithelial Lesions; LSIL, Low Grade Squamous Intraepithelial Lesion; LSIL, Low Grade Squamous Intraepithelial Lesions; LSIL, Low-Grade Squamous Intraepithelial Lesion; LSIL, Low-Grade Squamous Intraepithelial Lesions
SNOMED CT: Squamous intraepithelial neoplasia grade 1 (400002005); Low-grade squamous intraepithelial lesion (112662005); Squamous intraepithelial neoplasia, low grade (450595003); Squamous intraepithelial neoplasia, grade I (400002005); Low grade SIL (squamous intraepithelial lesion) (112662005); LSIL - low-grade squamous intraepithelial lesion (112662005)

Definition

A precancerous neoplastic process characterized by the presence of mild dysplastic cytological changes which are usually present in the lower part of the squamous epithelium. Representative examples include the low grade esophageal squamous intraepithelial neoplasia, low grade cervical squamous intraepithelial neoplasia, low grade vaginal intraepithelial neoplasia, and low grade vulvar intraepithelial neoplasia. [from NCI]

Professional guidelines

PubMed

Human papillomavirus genotype distribution by cytological status and associated risk factors in the general population of Congolese women living in urban and rural areas: Implications for cervical cancer prevention.
Tsimba Lemba PC, Boumba LMA, Péré H, Nganga PC, Veyer D, Puech J, Mboumba Bouassa RS, Malanda-Kiminou P, Moukassa D, Bélec L
Infect Dis Now 2023 Oct;53(8):104762. Epub 2023 Jul 14 doi: 10.1016/j.idnow.2023.104762. PMID: 37454761
Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in Beijing, China: analysis of results from China's top 3 hospital, 2009-2019.
Liu Y, Ang Q, Wu H, Xu J, Chen D, Zhao H, Liu H, Guo X, Gu Y, Qiu H
Virol J 2020 Jul 13;17(1):104. doi: 10.1186/s12985-020-01383-1. PMID: 32660490Free PMC Article
Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in the Republic of Korea, 2014-2016.
Ouh YT, Min KJ, Cho HW, Ki M, Oh JK, Shin SY, Hong JH, Lee JK
J Gynecol Oncol 2018 Jan;29(1):e14. doi: 10.3802/jgo.2018.29.e14. PMID: 29185272Free PMC Article

Recent clinical studies

Etiology

Evaluation of 5-aminolevulinic acid-mediated photodynamic therapy on cervical low-grade squamous intraepithelial lesions with high-risk HPV infection.
Wang X, You L, Zhang W, Ma Y, Tang Y, Xu W
Photodiagnosis Photodyn Ther 2022 Jun;38:102807. Epub 2022 Mar 11 doi: 10.1016/j.pdpdt.2022.102807. PMID: 35288319
Combined detection of Twist1, Snail1 and squamous cell carcinoma antigen for the prognostic evaluation of invasion and metastasis in cervical squamous cell carcinoma.
Yang H, Hu H, Gou Y, Hu Y, Li H, Zhao H, Wang B, Li P, Zhang Z
Int J Clin Oncol 2018 Apr;23(2):321-328. Epub 2017 Nov 3 doi: 10.1007/s10147-017-1210-2. PMID: 29101499
Histopathologic outcomes and clinical correlations for high-risk patients screened with anal cytology.
Zhao C, Domfeh AB, Austin RM
Acta Cytol 2012;56(1):62-7. Epub 2012 Jan 4 doi: 10.1159/000331431. PMID: 22236747
Chemopreventive potential and safety profile of a Curcuma longa extract in women with cervical low-grade squamous intraepithelial neoplasia.
Joshi JV, Paradkar PH, Jagtap SS, Agashe SV, Soman G, Vaidya AB
Asian Pac J Cancer Prev 2011;12(12):3305-11. PMID: 22471471
Management of atypical squamous cells of undetermined significance and low-grade squamous intra-epithelial lesion by human papillomavirus testing.
Cox JT
Best Pract Res Clin Obstet Gynaecol 2001 Oct;15(5):715-41. doi: 10.1053/beog.2001.0216. PMID: 11563869

Diagnosis

Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in Beijing, China: analysis of results from China's top 3 hospital, 2009-2019.
Liu Y, Ang Q, Wu H, Xu J, Chen D, Zhao H, Liu H, Guo X, Gu Y, Qiu H
Virol J 2020 Jul 13;17(1):104. doi: 10.1186/s12985-020-01383-1. PMID: 32660490Free PMC Article
Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in the Republic of Korea, 2014-2016.
Ouh YT, Min KJ, Cho HW, Ki M, Oh JK, Shin SY, Hong JH, Lee JK
J Gynecol Oncol 2018 Jan;29(1):e14. doi: 10.3802/jgo.2018.29.e14. PMID: 29185272Free PMC Article
Repeat cytology and human papillomavirus screening strategies in detecting preinvasive cervical lesions.
Li K, Yin R
Medicine (Baltimore) 2015 Feb;94(5):e435. doi: 10.1097/MD.0000000000000435. PMID: 25654377Free PMC Article
Risk factors for human papillomavirus infection in Shanghai suburbs: a population-based study with 10,000 women.
Zhang R, Shi TY, Ren Y, Lu H, Wei ZH, Hou WJ, Zhang M, Xu C
J Clin Virol 2013 Sep;58(1):144-8. Epub 2013 Jul 9 doi: 10.1016/j.jcv.2013.06.012. PMID: 23849649
Histopathologic outcomes and clinical correlations for high-risk patients screened with anal cytology.
Zhao C, Domfeh AB, Austin RM
Acta Cytol 2012;56(1):62-7. Epub 2012 Jan 4 doi: 10.1159/000331431. PMID: 22236747

Therapy

Comparative analysis of Paiteling a traditional Chinese medicine (TCM) and CO2 laser therapy for high-risk HPV-associated with LSIL (CIN1) lesions.
Cobbinah P, Zheng Zheng S, Oklah F, Yuyang Z
Eur J Obstet Gynecol Reprod Biol 2024 Nov;302:81-86. Epub 2024 Aug 30 doi: 10.1016/j.ejogrb.2024.08.042. PMID: 39236645
Evaluation of 5-aminolevulinic acid-mediated photodynamic therapy on cervical low-grade squamous intraepithelial lesions with high-risk HPV infection.
Wang X, You L, Zhang W, Ma Y, Tang Y, Xu W
Photodiagnosis Photodyn Ther 2022 Jun;38:102807. Epub 2022 Mar 11 doi: 10.1016/j.pdpdt.2022.102807. PMID: 35288319
Efficacy of the AS04-Adjuvanted HPV16/18 Vaccine: Pooled Analysis of the Costa Rica Vaccine and PATRICIA Randomized Controlled Trials.
Tota JE, Struyf F, Sampson JN, Gonzalez P, Ryser M, Herrero R, Schussler J, Karkada N, Rodriguez AC, Folschweiller N, Porras C, Schiffman M, Schiller JT, Quint W, Kreimer AR, Wheeler CM, Hildesheim A; Costa Rica Vaccine Trial and PATRICIA Study
J Natl Cancer Inst 2020 Aug 1;112(8):818-828. doi: 10.1093/jnci/djz222. PMID: 31697384Free PMC Article
Chemopreventive potential and safety profile of a Curcuma longa extract in women with cervical low-grade squamous intraepithelial neoplasia.
Joshi JV, Paradkar PH, Jagtap SS, Agashe SV, Soman G, Vaidya AB
Asian Pac J Cancer Prev 2011;12(12):3305-11. PMID: 22471471

Prognosis

Combined detection of Twist1, Snail1 and squamous cell carcinoma antigen for the prognostic evaluation of invasion and metastasis in cervical squamous cell carcinoma.
Yang H, Hu H, Gou Y, Hu Y, Li H, Zhao H, Wang B, Li P, Zhang Z
Int J Clin Oncol 2018 Apr;23(2):321-328. Epub 2017 Nov 3 doi: 10.1007/s10147-017-1210-2. PMID: 29101499
Pooled analysis of the performance of liquid-based cytology in population-based cervical cancer screening studies in China.
Pan QJ, Hu SY, Zhang X, Ci PW, Zhang WH, Guo HQ, Cao J, Zhao FH, Lytwyn A, Qiao YL
Cancer Cytopathol 2013 Sep;121(9):473-82. Epub 2013 Apr 23 doi: 10.1002/cncy.21297. PMID: 23907807Free PMC Article
Chemopreventive potential and safety profile of a Curcuma longa extract in women with cervical low-grade squamous intraepithelial neoplasia.
Joshi JV, Paradkar PH, Jagtap SS, Agashe SV, Soman G, Vaidya AB
Asian Pac J Cancer Prev 2011;12(12):3305-11. PMID: 22471471
Disease persistence in patients with cervical intraepithelial neoplasia undergoing electrosurgical conization.
Costa S, De Nuzzo M, Infante FE, Bonavita B, Marinelli M, Rubino A, Rambelli V, Santini D, Cristiani P, Bucchi L
Gynecol Oncol 2002 Apr;85(1):119-24. doi: 10.1006/gyno.2001.6579. PMID: 11925130
Cytologic observations preceding high grade squamous intraepithelial lesions.
Troncone G, Gupta PK
Acta Cytol 1995 Jul-Aug;39(4):659-62. PMID: 7631539

Clinical prediction guides

Efficacy of the AS04-Adjuvanted HPV16/18 Vaccine: Pooled Analysis of the Costa Rica Vaccine and PATRICIA Randomized Controlled Trials.
Tota JE, Struyf F, Sampson JN, Gonzalez P, Ryser M, Herrero R, Schussler J, Karkada N, Rodriguez AC, Folschweiller N, Porras C, Schiffman M, Schiller JT, Quint W, Kreimer AR, Wheeler CM, Hildesheim A; Costa Rica Vaccine Trial and PATRICIA Study
J Natl Cancer Inst 2020 Aug 1;112(8):818-828. doi: 10.1093/jnci/djz222. PMID: 31697384Free PMC Article
Pooled analysis of the performance of liquid-based cytology in population-based cervical cancer screening studies in China.
Pan QJ, Hu SY, Zhang X, Ci PW, Zhang WH, Guo HQ, Cao J, Zhao FH, Lytwyn A, Qiao YL
Cancer Cytopathol 2013 Sep;121(9):473-82. Epub 2013 Apr 23 doi: 10.1002/cncy.21297. PMID: 23907807Free PMC Article
Cervicovaginal involvement in pemphigus vulgaris: a clinical study of 77 cases.
Akhyani M, Chams-Davatchi C, Naraghi Z, Daneshpazhooh M, Toosi S, Asgari M, Malekhami F
Br J Dermatol 2008 Mar;158(3):478-82. Epub 2007 Dec 6 doi: 10.1111/j.1365-2133.2007.08356.x. PMID: 18070212
Disease persistence in patients with cervical intraepithelial neoplasia undergoing electrosurgical conization.
Costa S, De Nuzzo M, Infante FE, Bonavita B, Marinelli M, Rubino A, Rambelli V, Santini D, Cristiani P, Bucchi L
Gynecol Oncol 2002 Apr;85(1):119-24. doi: 10.1006/gyno.2001.6579. PMID: 11925130
Cytologic observations preceding high grade squamous intraepithelial lesions.
Troncone G, Gupta PK
Acta Cytol 1995 Jul-Aug;39(4):659-62. PMID: 7631539

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