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High Grade Cervical Squamous Intraepithelial Neoplasia

MedGen UID:
268190
Concept ID:
C1512433
Neoplastic Process
Synonyms: High Grade Cervical Squamous Intraepithelial Lesion; High-Grade Cervical SIL; High-Grade Cervical Squamous Intraepithelial Lesion; High-Grade CIN; HSIL of Cervix

Definition

A precancerous neoplastic process that affects the cervical squamous epithelium. It is usually associated with human papillomavirus infection. It is classified as cervical squamous intraepithelial neoplasia 2 when there is nuclear atypia in both the upper and lower epithelial layers, mitotic figures are confined to the basal two-thirds of the epithelium, and maturation is present in the upper half of the epithelium. It is classified as cervical squamous intraepithelial neoplasia 3 when there is nuclear atypia and mitotic figures throughout the entire thickness of the epithelium, and maturation is absent or confined to the upper third of the epithelium. [from NCI]

Recent clinical studies

Etiology

Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Kir G, Gunel H, Olgun ZC, McCluggage WG
J Clin Pathol 2023 Jan;76(1):40-46. Epub 2021 Aug 10 doi: 10.1136/jclinpath-2021-207657. PMID: 34376567
Janke MJ, DeBlanc J, Kobernik EK, Skala SL, Hiles GL, Kelly R, Welch KC
J Low Genit Tract Dis 2022 Oct 1;26(4):319-322. Epub 2022 Aug 15 doi: 10.1097/LGT.0000000000000690. PMID: 35972920
Kietpeerakool C, Kleebkaow P, Srisomboon J
Asian Pac J Cancer Prev 2015;16(13):5153-8. doi: 10.7314/apjcp.2015.16.13.5153. PMID: 26225645
Noël JC, Bucella D, Fayt I, Simonart T, Buxant F, Anaf V, Simon P
Int J Gynecol Pathol 2008 Jul;27(3):437-41. doi: 10.1097/PGP.0b013e318160c599. PMID: 18580324

Diagnosis

Kir G, Gunel H, Olgun ZC, McCluggage WG
J Clin Pathol 2023 Jan;76(1):40-46. Epub 2021 Aug 10 doi: 10.1136/jclinpath-2021-207657. PMID: 34376567
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Jakovac H, Stašić N, Krašević M, Jonjić N, Radošević-Stašić B
Virchows Arch 2021 Apr;478(4):735-746. Epub 2020 Oct 21 doi: 10.1007/s00428-020-02947-w. PMID: 33084977Free PMC Article
Cytryn A, Russomano FB, Camargo MJ, Zardo LM, Horta NM, Fonseca Rde C, Tristão MA, Monteiro AC
Sao Paulo Med J 2009 Sep;127(5):283-7. doi: 10.1590/s1516-31802009000500007. PMID: 20169277
Hatem F, Wilbur DC
Diagn Cytopathol 1995 Mar;12(2):135-41. doi: 10.1002/dc.2840120209. PMID: 7774493

Therapy

Wang L, Liu X, Zhang J, Song M, Liu H, Xu Y, Meng L, Zhang Y, Jia L
Photodiagnosis Photodyn Ther 2024 Apr;46:104044. Epub 2024 Mar 11 doi: 10.1016/j.pdpdt.2024.104044. PMID: 38467338
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Arbyn M, Ronco G, Anttila A, Meijer CJ, Poljak M, Ogilvie G, Koliopoulos G, Naucler P, Sankaranarayanan R, Peto J
Vaccine 2012 Nov 20;30 Suppl 5:F88-99. doi: 10.1016/j.vaccine.2012.06.095. PMID: 23199969
Lörincz AT
Salud Publica Mex 2003;45 Suppl 3:S376-87. doi: 10.1590/s0036-36342003000900012. PMID: 14746031
Crum CP, McLachlin CM
J Cell Biochem Suppl 1995;23:71-9. doi: 10.1002/jcb.240590910. PMID: 8747380

Prognosis

Kir G, Gunel H, Olgun ZC, McCluggage WG
J Clin Pathol 2023 Jan;76(1):40-46. Epub 2021 Aug 10 doi: 10.1136/jclinpath-2021-207657. PMID: 34376567
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Fachetti-Machado G, Figueiredo-Alves RR, Moreira MAR
Rev Bras Ginecol Obstet 2018 Jul;40(7):410-416. Epub 2018 Jul 11 doi: 10.1055/s-0038-1666995. PMID: 29996168
Kietpeerakool C, Kleebkaow P, Srisomboon J
Asian Pac J Cancer Prev 2015;16(13):5153-8. doi: 10.7314/apjcp.2015.16.13.5153. PMID: 26225645
Moore MA, Tajima K
Asian Pac J Cancer Prev 2004 Oct-Dec;5(4):349-61. PMID: 15546236

Clinical prediction guides

Kir G, Gunel H, Olgun ZC, McCluggage WG
J Clin Pathol 2023 Jan;76(1):40-46. Epub 2021 Aug 10 doi: 10.1136/jclinpath-2021-207657. PMID: 34376567
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Salvadó A, Miralpeix E, Solé-Sedeno JM, Kanjou N, Lloveras B, Duran X, Mancebo G
Gynecol Oncol 2021 Sep;162(3):569-574. Epub 2021 Jul 2 doi: 10.1016/j.ygyno.2021.06.019. PMID: 34226019
Fachetti-Machado G, Figueiredo-Alves RR, Moreira MAR
Rev Bras Ginecol Obstet 2018 Jul;40(7):410-416. Epub 2018 Jul 11 doi: 10.1055/s-0038-1666995. PMID: 29996168
Noël JC, Bucella D, Fayt I, Simonart T, Buxant F, Anaf V, Simon P
Int J Gynecol Pathol 2008 Jul;27(3):437-41. doi: 10.1097/PGP.0b013e318160c599. PMID: 18580324

Recent systematic reviews

van de Sande AJM, Kengsakul M, Koeneman MM, Jozwiak M, Gerestein CG, Kruse AJ, van Esch EMG, de Vos van Steenwijk PJ, Muntinga CLP, Bramer WM, van Doorn HC, van Kemenade FJ, van Beekhuizen HJ
Int J Gynaecol Obstet 2024 Jan;164(1):66-74. Epub 2023 Jun 23 doi: 10.1002/ijgo.14953. PMID: 37350560
Kelly H, Benavente Y, Pavon MA, De Sanjose S, Mayaud P, Lorincz AT
Br J Cancer 2019 Nov;121(11):954-965. Epub 2019 Oct 16 doi: 10.1038/s41416-019-0593-4. PMID: 31616037Free PMC Article
Moscicki AB, Flowers L, Huchko MJ, Long ME, MacLaughlin KL, Murphy J, Spiryda LB, Gold MA
J Low Genit Tract Dis 2019 Apr;23(2):87-101. doi: 10.1097/LGT.0000000000000468. PMID: 30907775
Arbyn M, Xu L, Verdoodt F, Cuzick J, Szarewski A, Belinson JL, Wentzensen N, Gage JC, Khan MJ
Ann Intern Med 2017 Jan 17;166(2):118-127. Epub 2016 Nov 15 doi: 10.7326/M15-2735. PMID: 27842420
Arbyn M, Roelens J, Simoens C, Buntinx F, Paraskevaidis E, Martin-Hirsch PP, Prendiville WJ
Cochrane Database Syst Rev 2013 Mar 28;2013(3):CD008054. doi: 10.1002/14651858.CD008054.pub2. PMID: 23543559Free PMC Article

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