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Cervical Squamous Intraepithelial Neoplasia 2

MedGen UID:
87600
•Concept ID:
C0349459
•
Neoplastic Process
Synonyms: Cervical intraepithelial neoplasia grade 2; Cervical intraepithelial neoplasia grade II; CIN 2 - Cervical intraepithelial neoplasia 2; Moderate cervical dysplasia; Moderate dysplasia of cervix; Moderate Squamous Dysplasia of the Cervix
SNOMED CT: Cervical intraepithelial neoplasia grade 2 (285838002); Moderate cervical dysplasia (285838002); Cervical intraepithelial neoplasia grade II (285838002); CIN 2 - Cervical intraepithelial neoplasia 2 (285838002); Moderate dysplasia of cervix (285838002)

Definition

Cervical squamous intraepithelial neoplasia characterized by the presence of maturation in the upper half of the squamous epithelium and conspicuous nuclear atypia which is present in all epithelial layers. Mitotic figures are present in the basal two thirds of the epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Squamous Intraepithelial Neoplasia 2

Professional guidelines

PubMed

Diagnosis and Management of Cervical Squamous Intraepithelial Lesions in Pregnancy and Postpartum.
Larish A, Long ME
Obstet Gynecol 2024 Sep 1;144(3):328-338. Epub 2024 Mar 29 doi: 10.1097/AOG.0000000000005566. PMID: 38547493
The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Cervical Colposcopy: Indications and Risk Assessment.
Burness JV, Schroeder JM, Warren JB
Am Fam Physician 2020 Jul 1;102(1):39-48. PMID: 32603071

Recent clinical studies

Etiology

Diagnosis and Management of Cervical Squamous Intraepithelial Lesions in Pregnancy and Postpartum.
Larish A, Long ME
Obstet Gynecol 2024 Sep 1;144(3):328-338. Epub 2024 Mar 29 doi: 10.1097/AOG.0000000000005566. PMID: 38547493
The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Cervical laser vaporization for women with cervical intraepithelial neoplasia-3.
Shimada C, Todo Y, Yamazaki H, Minobe S, Kato H
Jpn J Clin Oncol 2019 May 1;49(5):447-451. doi: 10.1093/jjco/hyz001. PMID: 30796831
Does Differentiated Squamous Intraepithelial Neoplasia Occur in the Cervix?
Mai KT
Appl Immunohistochem Mol Morphol 2018 Apr;26(4):e52-e60. doi: 10.1097/PAI.0000000000000577. PMID: 28877072
Anal intraepithelial neoplasia and squamous cell carcinoma in HIV-infected adults.
Tong WW, Hillman RJ, Kelleher AD, Grulich AE, Carr A
HIV Med 2014 Feb;15(2):65-76. Epub 2013 Sep 6 doi: 10.1111/hiv.12080. PMID: 24007498

Diagnosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Classifying Anal Intraepithelial Neoplasia 2 Based on LAST Recommendations.
Liu Y, McCluggage WG, Darragh TM, Zheng W, Roberts JM, Park KJ, Hui P, Blakely M, Sigel K, Gaisa MM
Am J Clin Pathol 2021 May 18;155(6):845-852. doi: 10.1093/ajcp/aqaa188. PMID: 33210115Free PMC Article
Vulval squamous cell carcinoma and its precursors.
Singh N, Gilks CB
Histopathology 2020 Jan;76(1):128-138. doi: 10.1111/his.13989. PMID: 31846523
Laryngeal Squamous Intraepithelial Lesions: An Updated Review on Etiology, Classification, Molecular Changes, and Treatment.
Gale N, Gnepp DR, Poljak M, Strojan P, Cardesa A, Helliwell T, Šifrer R, Volavšek M, Sandison A, Zidar N
Adv Anat Pathol 2016 Mar;23(2):84-91. doi: 10.1097/PAP.0000000000000106. PMID: 26849814
Anal intraepithelial neoplasia and squamous cell carcinoma in HIV-infected adults.
Tong WW, Hillman RJ, Kelleher AD, Grulich AE, Carr A
HIV Med 2014 Feb;15(2):65-76. Epub 2013 Sep 6 doi: 10.1111/hiv.12080. PMID: 24007498

Therapy

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Oral contraceptives use and risk of cervical cancer-A systematic review & meta-analysis.
Asthana S, Busa V, Labani S
Eur J Obstet Gynecol Reprod Biol 2020 Apr;247:163-175. Epub 2020 Feb 21 doi: 10.1016/j.ejogrb.2020.02.014. PMID: 32114321
Anal intraepithelial neoplasia and squamous cell carcinoma in HIV-infected adults.
Tong WW, Hillman RJ, Kelleher AD, Grulich AE, Carr A
HIV Med 2014 Feb;15(2):65-76. Epub 2013 Sep 6 doi: 10.1111/hiv.12080. PMID: 24007498
Surgery for cervical intraepithelial neoplasia.
Martin-Hirsch PP, Paraskevaidis E, Bryant A, Dickinson HO
Cochrane Database Syst Rev 2013 Dec 4;2013(12):CD001318. doi: 10.1002/14651858.CD001318.pub3. PMID: 24302546Free PMC Article
Surgery for cervical intraepithelial neoplasia.
Martin-Hirsch PP, Paraskevaidis E, Bryant A, Dickinson HO, Keep SL
Cochrane Database Syst Rev 2010 Jun 16;(6):CD001318. doi: 10.1002/14651858.CD001318.pub2. PMID: 20556751Free PMC Article

Prognosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Vulval squamous cell carcinoma and its precursors.
Singh N, Gilks CB
Histopathology 2020 Jan;76(1):128-138. doi: 10.1111/his.13989. PMID: 31846523
Cervical laser vaporization for women with cervical intraepithelial neoplasia-3.
Shimada C, Todo Y, Yamazaki H, Minobe S, Kato H
Jpn J Clin Oncol 2019 May 1;49(5):447-451. doi: 10.1093/jjco/hyz001. PMID: 30796831
Does Differentiated Squamous Intraepithelial Neoplasia Occur in the Cervix?
Mai KT
Appl Immunohistochem Mol Morphol 2018 Apr;26(4):e52-e60. doi: 10.1097/PAI.0000000000000577. PMID: 28877072
Laryngeal Squamous Intraepithelial Lesions: An Updated Review on Etiology, Classification, Molecular Changes, and Treatment.
Gale N, Gnepp DR, Poljak M, Strojan P, Cardesa A, Helliwell T, Šifrer R, Volavšek M, Sandison A, Zidar N
Adv Anat Pathol 2016 Mar;23(2):84-91. doi: 10.1097/PAP.0000000000000106. PMID: 26849814

Clinical prediction guides

The role of differentiated dysplasia in the prediction of malignant transformation of oral leukoplakia.
Wils LJ, Poell JB, Peferoen LAN, Evren I, Brouns ER, de Visscher JGAM, van der Meij EH, Brakenhoff RH, Bloemena E
J Oral Pathol Med 2023 Nov;52(10):930-938. Epub 2023 Sep 25 doi: 10.1111/jop.13483. PMID: 37749621
The efficacy of human papillomavirus prophylactic vaccination after conization in preventing cervical intraepithelial neoplasia recurrence: A prospective observational study in China.
Chen M, Li C, Cui Q, Zhou C, Chen P, Yao S
Eur J Obstet Gynecol Reprod Biol 2023 Jul;286:10-15. Epub 2023 Apr 19 doi: 10.1016/j.ejogrb.2023.04.014. PMID: 37159990
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Cervical laser vaporization for women with cervical intraepithelial neoplasia-3.
Shimada C, Todo Y, Yamazaki H, Minobe S, Kato H
Jpn J Clin Oncol 2019 May 1;49(5):447-451. doi: 10.1093/jjco/hyz001. PMID: 30796831
Cervical cytology ASCUS patients with HPV detection and clinical value.
Cheng JX, Yao LL, Xiang H, Zhan YJ, Zhou P, Yuan M, Mei LP, Zhang Y
Clin Exp Obstet Gynecol 2016;43(4):592-596. PMID: 29734556

Recent systematic reviews

Oral contraceptives use and risk of cervical cancer-A systematic review & meta-analysis.
Asthana S, Busa V, Labani S
Eur J Obstet Gynecol Reprod Biol 2020 Apr;247:163-175. Epub 2020 Feb 21 doi: 10.1016/j.ejogrb.2020.02.014. PMID: 32114321
Guidelines for Cervical Cancer Screening in Immunosuppressed Women Without HIV Infection.
Moscicki AB, Flowers L, Huchko MJ, Long ME, MacLaughlin KL, Murphy J, Spiryda LB, Gold MA
J Low Genit Tract Dis 2019 Apr;23(2):87-101. doi: 10.1097/LGT.0000000000000468. PMID: 30907775
Surgery for cervical intraepithelial neoplasia.
Martin-Hirsch PP, Paraskevaidis E, Bryant A, Dickinson HO
Cochrane Database Syst Rev 2013 Dec 4;2013(12):CD001318. doi: 10.1002/14651858.CD001318.pub3. PMID: 24302546Free PMC Article
Association between bacterial vaginosis and cervical intraepithelial neoplasia: systematic review and meta-analysis.
Gillet E, Meys JF, Verstraelen H, Verhelst R, De Sutter P, Temmerman M, Vanden Broeck D
PLoS One 2012;7(10):e45201. Epub 2012 Oct 2 doi: 10.1371/journal.pone.0045201. PMID: 23056195Free PMC Article
Surgery for cervical intraepithelial neoplasia.
Martin-Hirsch PP, Paraskevaidis E, Bryant A, Dickinson HO, Keep SL
Cochrane Database Syst Rev 2010 Jun 16;(6):CD001318. doi: 10.1002/14651858.CD001318.pub2. PMID: 20556751Free PMC Article

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