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Pancreatic mucinous-cystic neoplasm

MedGen UID:
274120
•Concept ID:
C1518872
•
Neoplastic Process
Synonyms: mucinous cystic neoplasm; Pancreatic Mucinous Cystic Neoplasm; Pancreatic mucinous cystic neoplasm; Pancreatic Mucinous-Cystic Neoplasm; pancreatic mucinous-cystic neoplasm
 
Monarch Initiative: MONDO:0044879

Definition

A non-invasive or invasive cystic epithelial neoplasm that affects almost exclusively females. It is characterized by the presence of columnar mucin-producing epithelial cells and ovarian-type stroma formation. [from NCI]

Professional guidelines

PubMed

Validation of Sendai and Fukuoka consensus guidelines in predicting malignancy in patients with preoperatively diagnosed mucinous pancreatic cystic neoplasms.
Zhou W, Xu Y, Rong Y, Wu W, Kuang T, Xin B, Zhu H, Lou W, Wang D
J Surg Oncol 2018 Mar;117(3):409-416. Epub 2017 Oct 16 doi: 10.1002/jso.24882. PMID: 29044541
Nature and management of pancreatic mucinous cystic neoplasm (MCN): A systematic review of the literature.
Nilsson LN, Keane MG, Shamali A, Millastre Bocos J, Marijinissen van Zanten M, Antila A, Verdejo Gil C, Del Chiaro M, Laukkarinen J
Pancreatology 2016 Nov-Dec;16(6):1028-1036. Epub 2016 Sep 20 doi: 10.1016/j.pan.2016.09.011. PMID: 27681503
Management of mucinous cystic neoplasms of the pancreas.
Testini M, Gurrado A, Lissidini G, Venezia P, Greco L, Piccinni G
World J Gastroenterol 2010 Dec 7;16(45):5682-92. doi: 10.3748/wjg.v16.i45.5682. PMID: 21128317Free PMC Article

Recent clinical studies

Etiology

A nomogram for predicting pancreatic mucinous cystic neoplasm and serous cystic neoplasm.
Shao C, Feng X, Yu J, Meng Y, Liu F, Zhang H, Fang X, Li J, Wang L, Jiang H, Lu J, Bian Y
Abdom Radiol (NY) 2021 Aug;46(8):3963-3973. Epub 2021 Mar 22 doi: 10.1007/s00261-021-03038-3. PMID: 33748881
Preoperative differentiation of pancreatic mucinous cystic neoplasm from macrocystic serous cystic adenoma using radiomics: Preliminary findings and comparison with radiological model.
Xie H, Ma S, Guo X, Zhang X, Wang X
Eur J Radiol 2020 Jan;122:108747. Epub 2019 Nov 14 doi: 10.1016/j.ejrad.2019.108747. PMID: 31760275
An osteoclast-like giant cell tumor embedded in the mural nodule of a pancreatic mucinous cystic neoplasm: A case report and literature review.
Fan X, Wang W, Li C, Tang T, Han Y, An K
Medicine (Baltimore) 2019 Apr;98(16):e15246. doi: 10.1097/MD.0000000000015246. PMID: 31008959Free PMC Article
Immunohistochemical characteristics and malignant progression of hepatic cystic neoplasms in comparison with pancreatic counterparts.
Matsubara T, Sato Y, Sasaki M, Harada K, Nomoto K, Tsuneyama K, Nakamura K, Gabata T, Matsui O, Nakanuma Y
Hum Pathol 2012 Dec;43(12):2177-86. Epub 2012 Jun 15 doi: 10.1016/j.humpath.2012.03.007. PMID: 22705005
Pancreatic mucinous cystic neoplasm defined by ovarian stroma: demographics, clinical features, and prevalence of cancer.
Reddy RP, Smyrk TC, Zapiach M, Levy MJ, Pearson RK, Clain JE, Farnell MB, Sarr MG, Chari ST
Clin Gastroenterol Hepatol 2004 Nov;2(11):1026-31. doi: 10.1016/s1542-3565(04)00450-1. PMID: 15551256

Diagnosis

A nomogram for predicting pancreatic mucinous cystic neoplasm and serous cystic neoplasm.
Shao C, Feng X, Yu J, Meng Y, Liu F, Zhang H, Fang X, Li J, Wang L, Jiang H, Lu J, Bian Y
Abdom Radiol (NY) 2021 Aug;46(8):3963-3973. Epub 2021 Mar 22 doi: 10.1007/s00261-021-03038-3. PMID: 33748881
The diagnosis of pancreatic mucinous cystic neoplasm and associated adenocarcinoma in males: An eight-institution study of 349 patients over 15 years.
Ethun CG, Postlewait LM, McInnis MR, Merchant N, Parikh A, Idrees K, Isom CA, Hawkins W, Fields RC, Strand M, Weber SM, Cho CS, Salem A, Martin RCG, Scoggins CR, Bentrem D, Kim HJ, Carr J, Ahmad SA, Abbott DE, Wilson G, Kooby DA, Maithel SK
J Surg Oncol 2017 Jun;115(7):784-787. Epub 2017 Feb 17 doi: 10.1002/jso.24582. PMID: 28211072Free PMC Article
Nature and management of pancreatic mucinous cystic neoplasm (MCN): A systematic review of the literature.
Nilsson LN, Keane MG, Shamali A, Millastre Bocos J, Marijinissen van Zanten M, Antila A, Verdejo Gil C, Del Chiaro M, Laukkarinen J
Pancreatology 2016 Nov-Dec;16(6):1028-1036. Epub 2016 Sep 20 doi: 10.1016/j.pan.2016.09.011. PMID: 27681503
Management of mucinous cystic neoplasms of the pancreas.
Testini M, Gurrado A, Lissidini G, Venezia P, Greco L, Piccinni G
World J Gastroenterol 2010 Dec 7;16(45):5682-92. doi: 10.3748/wjg.v16.i45.5682. PMID: 21128317Free PMC Article
Pancreatic mucinous cystic neoplasm defined by ovarian stroma: demographics, clinical features, and prevalence of cancer.
Reddy RP, Smyrk TC, Zapiach M, Levy MJ, Pearson RK, Clain JE, Farnell MB, Sarr MG, Chari ST
Clin Gastroenterol Hepatol 2004 Nov;2(11):1026-31. doi: 10.1016/s1542-3565(04)00450-1. PMID: 15551256

Therapy

An indeterminate mucin-producing cystic neoplasm containing an undifferentiated carcinoma with osteoclast-like giant cells: a case report of a rare association of pancreatic tumors.
Chiarelli M, Guttadauro A, Gerosa M, Marando A, Gabrielli F, De Simone M, Cioffi U
BMC Gastroenterol 2015 Nov 18;15:161. doi: 10.1186/s12876-015-0391-2. PMID: 26581412Free PMC Article
Management of mucinous cystic neoplasms of the pancreas.
Testini M, Gurrado A, Lissidini G, Venezia P, Greco L, Piccinni G
World J Gastroenterol 2010 Dec 7;16(45):5682-92. doi: 10.3748/wjg.v16.i45.5682. PMID: 21128317Free PMC Article

Prognosis

RNF43 as a predictor of malignant transformation of pancreatic mucinous cystic neoplasm.
Sakihama K, Koga Y, Yamamoto T, Shimada Y, Yamada Y, Kawata J, Shindo K, Nakamura M, Oda Y
Virchows Arch 2022 Jun;480(6):1189-1199. Epub 2022 Jan 23 doi: 10.1007/s00428-022-03277-9. PMID: 35066614
A nomogram for predicting pancreatic mucinous cystic neoplasm and serous cystic neoplasm.
Shao C, Feng X, Yu J, Meng Y, Liu F, Zhang H, Fang X, Li J, Wang L, Jiang H, Lu J, Bian Y
Abdom Radiol (NY) 2021 Aug;46(8):3963-3973. Epub 2021 Mar 22 doi: 10.1007/s00261-021-03038-3. PMID: 33748881
Nature and management of pancreatic mucinous cystic neoplasm (MCN): A systematic review of the literature.
Nilsson LN, Keane MG, Shamali A, Millastre Bocos J, Marijinissen van Zanten M, Antila A, Verdejo Gil C, Del Chiaro M, Laukkarinen J
Pancreatology 2016 Nov-Dec;16(6):1028-1036. Epub 2016 Sep 20 doi: 10.1016/j.pan.2016.09.011. PMID: 27681503
Pancreatic mucinous cystic neoplasm in a transgender patient.
Foster D, Shaikh MF, Gleeson E, Babcock BD, Lin J, Ownbey RT, Hysell ME, Ringold D, Bowne WB
World J Surg Oncol 2015 Jun 24;13:205. doi: 10.1186/s12957-015-0620-8. PMID: 26104783Free PMC Article
Management of mucinous cystic neoplasms of the pancreas.
Testini M, Gurrado A, Lissidini G, Venezia P, Greco L, Piccinni G
World J Gastroenterol 2010 Dec 7;16(45):5682-92. doi: 10.3748/wjg.v16.i45.5682. PMID: 21128317Free PMC Article

Clinical prediction guides

Intralobular distribution of ovarian-like stroma in pancreatic mucinous cystic neoplasms: a discussion on its tumorigenesis.
Fukumura Y, Kinowaki Y, Matsuda Y, Takase M, Tonosaki M, Minagawa M, Saiura A, Tanabe M, Okano K, Suzuki Y, Kato K, Yao T
Sci Rep 2022 Feb 28;12(1):3326. doi: 10.1038/s41598-022-07416-9. PMID: 35228647Free PMC Article
RNF43 as a predictor of malignant transformation of pancreatic mucinous cystic neoplasm.
Sakihama K, Koga Y, Yamamoto T, Shimada Y, Yamada Y, Kawata J, Shindo K, Nakamura M, Oda Y
Virchows Arch 2022 Jun;480(6):1189-1199. Epub 2022 Jan 23 doi: 10.1007/s00428-022-03277-9. PMID: 35066614
A nomogram for predicting pancreatic mucinous cystic neoplasm and serous cystic neoplasm.
Shao C, Feng X, Yu J, Meng Y, Liu F, Zhang H, Fang X, Li J, Wang L, Jiang H, Lu J, Bian Y
Abdom Radiol (NY) 2021 Aug;46(8):3963-3973. Epub 2021 Mar 22 doi: 10.1007/s00261-021-03038-3. PMID: 33748881
Management of mucinous cystic neoplasms of the pancreas.
Testini M, Gurrado A, Lissidini G, Venezia P, Greco L, Piccinni G
World J Gastroenterol 2010 Dec 7;16(45):5682-92. doi: 10.3748/wjg.v16.i45.5682. PMID: 21128317Free PMC Article
Pancreatic mucinous cystic neoplasm defined by ovarian stroma: demographics, clinical features, and prevalence of cancer.
Reddy RP, Smyrk TC, Zapiach M, Levy MJ, Pearson RK, Clain JE, Farnell MB, Sarr MG, Chari ST
Clin Gastroenterol Hepatol 2004 Nov;2(11):1026-31. doi: 10.1016/s1542-3565(04)00450-1. PMID: 15551256

Recent systematic reviews

Nature and management of pancreatic mucinous cystic neoplasm (MCN): A systematic review of the literature.
Nilsson LN, Keane MG, Shamali A, Millastre Bocos J, Marijinissen van Zanten M, Antila A, Verdejo Gil C, Del Chiaro M, Laukkarinen J
Pancreatology 2016 Nov-Dec;16(6):1028-1036. Epub 2016 Sep 20 doi: 10.1016/j.pan.2016.09.011. PMID: 27681503
Management of mucinous cystic neoplasms of the pancreas.
Testini M, Gurrado A, Lissidini G, Venezia P, Greco L, Piccinni G
World J Gastroenterol 2010 Dec 7;16(45):5682-92. doi: 10.3748/wjg.v16.i45.5682. PMID: 21128317Free PMC Article

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