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Glandular cell neoplasm

MedGen UID:: 64458
•Concept ID:: C0205854
•: Neoplastic Process

Synonyms:	Cell Neoplasm, Glandular; Glandular Cell Neoplasm; Glandular Cell Neoplasms; Glandular Neoplasm; Glandular Neoplasms; Neoplasm, Glandular; Neoplasm, Glandular Cell; Neoplasms, Glandular

HPO:	HP:0031493
Monarch Initiative:	MONDO:0024276

Definition

A tumor that arises from a gland cell. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGlandular cell neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Epithelial neoplasm
        Glandular cell neoplasm
        Mucinous neoplasm
        Appendiceal mucinous neoplasm
        Appendix Mucinous Neoplasm
        High Grade Appendix Mucinous Neoplasm
        Low Grade Appendix Mucinous Neoplasm
        Fallopian tube mucinous tumor
        Borderline Fallopian Tube Mucinous Tumor
        Fallopian tube mucinous adenocarcinoma
        Mucinous adenocarcinoma
        Acinar prostate mucinous adenocarcinoma
        Ampulla of vater mucinous adenocarcinoma
        Anal mucinous adenocarcinoma
        Bladder colloid adenocarcinoma
        Breast mucinous carcinoma
        Broad Ligament Mucinous Adenocarcinoma
        Cervical mucinous adenocarcinoma
        Colloid carcinoma of the pancreas
        Colorectal Mucinous Adenocarcinoma
        Endometrial mucinous adenocarcinoma
        Extrahepatic bile duct mucinous adenocarcinoma
        Gallbladder mucinous adenocarcinoma
        Invasive Lung Mucinous Adenocarcinoma
        Lung colloid adenocarcinoma
        Mucinous adenocarcinoma of the appendix
        Mucinous cystadenocarcinoma
        Mucinous gastric adenocarcinoma
        Mucinous intrahepatic cholangiocarcinoma
        Ovarian mucinous adenocarcinoma
        Primary Cutaneous Mucinous Carcinoma
        Pseudomyxoma peritonei
        Salivary gland mucinous adenocarcinoma
        Sinonasal Adenocarcinoma, Intestinal-Type with Mucinous Pattern
        Small Intestinal Mucinous Adenocarcinoma
        Vaginal Mucinous Adenocarcinoma
        Vulvar Adenocarcinoma, Intestinal-Type
        Mucinous adenofibroma
        Borderline Ovarian Mucinous Adenofibroma
        Mucinous cystadenofibroma
        Ovarian mucinous adenofibroma
        Mucinous colorectal carcinoma
        Mucinous cystadenoma
        Appendix Mucinous Cystadenoma
        Lung Mucinous Cystadenoma
        Mucinous ovarian cystadenoma
        Papillary Mucinous Cystadenoma
        Mucinous cystic neoplasm of the pancreas
        Mucinous gastric carcinoma
        Ovarian mucinous tumor
        Benign ovarian mucinous tumor
        Borderline Ovarian Mucinous Tumor
        Borderline Ovarian Mucinous Tumor/Atypical Proliferative Ovarian Mucinous Tumor with Microinvasion
        Mucinous ovarian cancer
        Ovarian Mucinous Cystic Tumor Associated with Pseudomyxoma Peritonei
        Ovarian Mucinous Cystic Tumor with Mural Nodules
        Pancreatic mucinous-cystic neoplasm
        Non-Invasive Pancreatic Mucinous-Cystic Neoplasm
        Pancreatic mucinous-cystic neoplasm with an associated invasive carcinoma

Professional guidelines

PubMed

Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment.

Wood LD, Canto MI, Jaffee EM, Simeone DM
Gastroenterology 2022 Aug;163(2):386-402.e1. Epub 2022 Apr 7 doi: 10.1053/j.gastro.2022.03.056. PMID: 35398344 Free PMC Article

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma.

European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2018 Jul;69(1):182-236. Epub 2018 Apr 5 doi: 10.1016/j.jhep.2018.03.019. PMID: 29628281

Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline.

Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA; Endocrine Society
J Clin Endocrinol Metab 2011 Feb;96(2):273-88. doi: 10.1210/jc.2010-1692. PMID: 21296991

See all (39885)

Recent clinical studies

Etiology

Thymic Epithelial Neoplasms: Radiologic-Pathologic Correlation.

Lichtenberger JP 3rd, Carter BW, Fisher DA, Parker RF, Peterson PG
Radiol Clin North Am 2021 Mar;59(2):169-182. Epub 2021 Jan 9 doi: 10.1016/j.rcl.2020.11.005. PMID: 33551079

Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells.

Winterhoff BJ, Maile M, Mitra AK, Sebe A, Bazzaro M, Geller MA, Abrahante JE, Klein M, Hellweg R, Mullany SA, Beckman K, Daniel J, Starr TK
Gynecol Oncol 2017 Mar;144(3):598-606. Epub 2017 Jan 19 doi: 10.1016/j.ygyno.2017.01.015. PMID: 28111004 Free PMC Article

Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.

Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153

Epithelial ovarian cancer.

Ng JS, Low JJ, Ilancheran A
Best Pract Res Clin Obstet Gynaecol 2012 Jun;26(3):337-45. Epub 2012 Jan 24 doi: 10.1016/j.bpobgyn.2011.12.005. PMID: 22281513

Ovarian cancer.

Hennessy BT, Coleman RL, Markman M
Lancet 2009 Oct 17;374(9698):1371-82. Epub 2009 Sep 28 doi: 10.1016/S0140-6736(09)61338-6. PMID: 19793610

See all (266590)

Diagnosis

Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.

Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060

Immunohistochemical profiles in primary lung cancers and epithelial pulmonary metastases.

Vidarsdottir H, Tran L, Nodin B, Jirström K, Planck M, Jönsson P, Mattsson JSM, Botling J, Micke P, Brunnström H
Hum Pathol 2019 Feb;84:221-230. Epub 2018 Oct 31 doi: 10.1016/j.humpath.2018.10.009. PMID: 30389437

Ovarian cancer stem cells more questions than answers.

Ottevanger PB
Semin Cancer Biol 2017 Jun;44:67-71. Epub 2017 Apr 24 doi: 10.1016/j.semcancer.2017.04.009. PMID: 28450177

Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.

Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153

Ovarian cancer.

Hennessy BT, Coleman RL, Markman M
Lancet 2009 Oct 17;374(9698):1371-82. Epub 2009 Sep 28 doi: 10.1016/S0140-6736(09)61338-6. PMID: 19793610

See all (271617)

Therapy

Molecular and cellular mechanisms controlling integrin-mediated cell adhesion and tumor progression in ovarian cancer metastasis: a review.

Dhaliwal D, Shepherd TG
Clin Exp Metastasis 2022 Apr;39(2):291-301. Epub 2021 Nov 25 doi: 10.1007/s10585-021-10136-5. PMID: 34822024 Free PMC Article

Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer.

van Driel WJ, Koole SN, Sikorska K, Schagen van Leeuwen JH, Schreuder HWR, Hermans RHM, de Hingh IHJT, van der Velden J, Arts HJ, Massuger LFAG, Aalbers AGJ, Verwaal VJ, Kieffer JM, Van de Vijver KK, van Tinteren H, Aaronson NK, Sonke GS
N Engl J Med 2018 Jan 18;378(3):230-240. doi: 10.1056/NEJMoa1708618. PMID: 29342393

Treatment of recurrent ovarian cancer.

Pignata S, C Cecere S, Du Bois A, Harter P, Heitz F
Ann Oncol 2017 Nov 1;28(suppl_8):viii51-viii56. doi: 10.1093/annonc/mdx441. PMID: 29232464

Targeted Therapies for Ovarian Cancer.

Grunewald T, Ledermann JA
Best Pract Res Clin Obstet Gynaecol 2017 May;41:139-152. Epub 2016 Dec 8 doi: 10.1016/j.bpobgyn.2016.12.001. PMID: 28111228

Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer.

Konstantinopoulos PA, Ceccaldi R, Shapiro GI, D'Andrea AD
Cancer Discov 2015 Nov;5(11):1137-54. Epub 2015 Oct 13 doi: 10.1158/2159-8290.CD-15-0714. PMID: 26463832 Free PMC Article

See all (174850)

Prognosis

Prognostic immunologic signatures in epithelial ovarian cancer.

James NE, Woodman M, Ribeiro JR
Oncogene 2022 Mar;41(10):1389-1396. Epub 2022 Jan 14 doi: 10.1038/s41388-022-02181-5. PMID: 35031772

Diversity and intratumoral heterogeneity in human gallbladder cancer progression revealed by single-cell RNA sequencing.

Chen P, Wang Y, Li J, Bo X, Wang J, Nan L, Wang C, Ba Q, Liu H, Wang H
Clin Transl Med 2021 Jun;11(6):e462. doi: 10.1002/ctm2.462. PMID: 34185421 Free PMC Article

Mesenchymal Cell Plasticity and Perfidy in Epithelial Malignancy.

Puré E, Hingorani SR
Trends Cancer 2018 Apr;4(4):273-277. Epub 2018 Mar 11 doi: 10.1016/j.trecan.2018.02.007. PMID: 29606311

Epidemiology of epithelial ovarian cancer.

Webb PM, Jordan SJ
Best Pract Res Clin Obstet Gynaecol 2017 May;41:3-14. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.006. PMID: 27743768

Therapeutic strategies in epithelial ovarian cancer.

Kim A, Ueda Y, Naka T, Enomoto T
J Exp Clin Cancer Res 2012 Feb 13;31(1):14. doi: 10.1186/1756-9966-31-14. PMID: 22330607 Free PMC Article

See all (258550)

Clinical prediction guides

Prognostic immunologic signatures in epithelial ovarian cancer.

James NE, Woodman M, Ribeiro JR
Oncogene 2022 Mar;41(10):1389-1396. Epub 2022 Jan 14 doi: 10.1038/s41388-022-02181-5. PMID: 35031772

Spindle Cell Lesions of the Breast on Fine-Needle Aspiration Biopsy: A Miscellany of Masses.

Michelow P, Field AS
Acta Cytol 2019;63(4):328-339. Epub 2019 May 22 doi: 10.1159/000500703. PMID: 31117069

Spindle cell lesions of the breast - An approach to diagnosis.

Tay TKY, Tan PH
Semin Diagn Pathol 2017 Sep;34(5):400-409. Epub 2017 May 27 doi: 10.1053/j.semdp.2017.05.012. PMID: 28629810

Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.

Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153

Glandular epithelial abnormalities on thinprep® pap tests: Clinical and cytohistologic correlation.

Selvaggi SM
Diagn Cytopathol 2016 May;44(5):389-93. Epub 2016 Feb 16 doi: 10.1002/dc.23452. PMID: 26878832

See all (200907)

Recent systematic reviews

Evaluation of Clinical and Safety Outcomes of Neoadjuvant Immunotherapy Combined With Chemotherapy for Patients With Resectable Esophageal Cancer: A Systematic Review and Meta-analysis.

Ge F, Huo Z, Cai X, Hu Q, Chen W, Lin G, Zhong R, You Z, Wang R, Lu Y, Wang R, Huang Q, Zhang H, Song A, Li C, Wen Y, Jiang Y, Liang H, He J, Liang W, Liu J
JAMA Netw Open 2022 Nov 1;5(11):e2239778. doi: 10.1001/jamanetworkopen.2022.39778. PMID: 36322089 Free PMC Article

Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.

Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310

Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline.

Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238

2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer.

Bible KC, Kebebew E, Brierley J, Brito JP, Cabanillas ME, Clark TJ Jr, Di Cristofano A, Foote R, Giordano T, Kasperbauer J, Newbold K, Nikiforov YE, Randolph G, Rosenthal MS, Sawka AM, Shah M, Shaha A, Smallridge R, Wong-Clark CK
Thyroid 2021 Mar;31(3):337-386. doi: 10.1089/thy.2020.0944. PMID: 33728999 Free PMC Article

International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.

Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716 Free PMC Article

See all (5999)

MedGen

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Glandular cell neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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