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Pineal region immature teratoma

MedGen UID:
277516
•Concept ID:
C1335416
•
Neoplastic Process
Synonyms: Atypical Pineal Teratoma; atypical pineal teratoma; Immature Teratoma of Pineal Area; immature teratoma of pineal area; Immature Teratoma of Pineal Region; immature teratoma of pineal region; Immature Teratoma of the Pineal Area; immature teratoma of the pineal area; Immature Teratoma of the Pineal Region; immature teratoma of the pineal region; Pineal Area Immature Teratoma; pineal area immature teratoma; Pineal Region Immature Teratoma; pineal region immature teratoma
 
Monarch Initiative: MONDO:0004017

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPineal region immature teratoma

Professional guidelines

PubMed

Outcome of Children and Adolescents With Primary Intracranial Germinoma Treated With Chemotherapy and Reduced Dose-Field Irradiation: A Prospective Brazilian Experience.
Cappellano AM, Dassi N, Mançano B, Epelman S, Almeida DB, Cavalheiro S, Dastoli PA, Seixas MT, Nicacio JM, Costa MD, Silva FA, Aguiar SS, Almeida CR, Teixeira GR, Chen M, Figueiredo ML, Silva NS, Finlay JL
JCO Glob Oncol 2023 Apr;9:e2200257. doi: 10.1200/GO.22.00257. PMID: 37075267Free PMC Article
Recent advances in molecular biology and treatment strategies for intracranial germ cell tumors.
Huang X, Zhang R, Mao Y, Zhou LF, Zhang C
World J Pediatr 2016 Aug;12(3):275-282. Epub 2016 Jun 29 doi: 10.1007/s12519-016-0021-2. PMID: 27351562
Management of primary intracranial germ cell tumors.
Kyritsis AP
J Neurooncol 2010 Jan;96(2):143-9. Epub 2009 Jul 9 doi: 10.1007/s11060-009-9951-z. PMID: 19588227

Recent clinical studies

Etiology

Constitutional balanced translocations involving SMARCB1: A rare cause of rhabdoid tumor predisposition syndrome.
Blackburn PR, McGee RB, Mostafavi R, Carroll AJ, Mikhail FM, Armstrong GT, Furtado LV, Chiang J, Wheeler DA, Carey SS, Nichols KE, Upadhyaya SA
Genes Chromosomes Cancer 2024 Jan;63(1):e23195. Epub 2023 Aug 7 doi: 10.1002/gcc.23195. PMID: 37548271
Second-look surgery for pineal region tumors.
Ogiwara H
Childs Nerv Syst 2023 Sep;39(9):2349-2352. Epub 2022 Oct 1 doi: 10.1007/s00381-022-05676-4. PMID: 36181520
Pineal Atypical Teratoid Rhabdoid Tumor in a 5-Month-Old Child.
Gendle C, Karthigeyan M, Salunke P, Gupta K
Pediatr Neurosurg 2020;55(6):404-408. Epub 2020 Dec 10 doi: 10.1159/000511995. PMID: 33302285
Radiologic-pathologic conference of Children's Hospital Boston: pineal region mass in a neonate.
Robson CD, Price DL, Barnes PD, Taylor GA
Pediatr Radiol 1997 Oct;27(10):829-31. doi: 10.1007/s002470050247. PMID: 9323255
Surgical removal of pineal tumors (pinealomas and teratomas). Experience in a series of 19 cases.
Suzuki J, Iwabuchi T
J Neurosurg 1965 Dec;23(6):565-71. doi: 10.3171/jns.1965.23.6.0565. PMID: 5861139

Diagnosis

Constitutional balanced translocations involving SMARCB1: A rare cause of rhabdoid tumor predisposition syndrome.
Blackburn PR, McGee RB, Mostafavi R, Carroll AJ, Mikhail FM, Armstrong GT, Furtado LV, Chiang J, Wheeler DA, Carey SS, Nichols KE, Upadhyaya SA
Genes Chromosomes Cancer 2024 Jan;63(1):e23195. Epub 2023 Aug 7 doi: 10.1002/gcc.23195. PMID: 37548271
A case of desmoplastic myxoid tumor, SMARCB1 mutant, in the pineal region.
Wang YE, Chen JJ, Wang W, Zhang AL, Zhou W, Wu HB
Neuropathology 2021 Feb;41(1):37-41. Epub 2020 Sep 9 doi: 10.1111/neup.12695. PMID: 32901946
Atypical teratoid/rhabdoid tumors with multilayered rosettes in the pineal region.
Wang J, Liu Z, Fang J, Du J, Cui Y, Xu L, Li G
Brain Tumor Pathol 2016 Oct;33(4):261-266. Epub 2016 Jun 15 doi: 10.1007/s10014-016-0267-3. PMID: 27307151
Review of pineal anlage tumor with divergent histology.
Berns S, Pearl G
Arch Pathol Lab Med 2006 Aug;130(8):1233-5. doi: 10.5858/2006-130-1233-ROPATW. PMID: 16879032
Ruptured intracranial dermoid cysts.
El-Bahy K, Kotb A, Galal A, El-Hakim A
Acta Neurochir (Wien) 2006 Apr;148(4):457-62. Epub 2006 Jan 27 doi: 10.1007/s00701-005-0722-0. PMID: 16437187

Therapy

PD0332991 (palbociclib) for treatment of pediatric intracranial growing teratoma syndrome.
Schultz KA, Petronio J, Bendel A, Patterson R, Vaughn DJ
Pediatr Blood Cancer 2015 Jun;62(6):1072-4. Epub 2014 Nov 21 doi: 10.1002/pbc.25338. PMID: 25417786
Ruptured intracranial dermoid cysts.
El-Bahy K, Kotb A, Galal A, El-Hakim A
Acta Neurochir (Wien) 2006 Apr;148(4):457-62. Epub 2006 Jan 27 doi: 10.1007/s00701-005-0722-0. PMID: 16437187
Recurrent intracranial germinoma outside the initial radiation field with progressive malignant transformation.
Kon H, Kumabe T, Jokura H, Shirane R
Acta Neurochir (Wien) 2002 Jun;144(6):611-6. doi: 10.1007/s00701-002-0951-4. PMID: 12111494
Mixed germ cell tumour of the pineal region: a case report.
Tandon N, Chopra R, Ghoshal S, Singh P, Sharma BS
Neurol India 1999 Dec;47(4):321-3. PMID: 10625909
Treatment and long-term outcome of pineal nongerminomatous germ cell tumors.
Knappe UJ, Bentele K, Horstmann M, Herrmann HD
Pediatr Neurosurg 1998 May;28(5):241-5. doi: 10.1159/000028658. PMID: 9732256

Prognosis

Adult Atypical Teratoid/Rhabdoid Tumors.
Wu WW, Bi WL, Kang YJ, Ramkissoon SH, Prasad S, Shih HA, Reardon DA, Dunn IF
World Neurosurg 2016 Jan;85:197-204. Epub 2015 Sep 4 doi: 10.1016/j.wneu.2015.08.076. PMID: 26344637
Primary yolk sac tumor of the cerebellar vermis: a case report.
Shenoy AS, Desai HM, Tyagi DK, Savant HV, Kavishwar VS, Balasubramaniam M
Indian J Pathol Microbiol 2014 Apr-Jun;57(2):278-80. doi: 10.4103/0377-4929.134711. PMID: 24943765
Review of pineal anlage tumor with divergent histology.
Berns S, Pearl G
Arch Pathol Lab Med 2006 Aug;130(8):1233-5. doi: 10.5858/2006-130-1233-ROPATW. PMID: 16879032
Treatment and long-term outcome of pineal nongerminomatous germ cell tumors.
Knappe UJ, Bentele K, Horstmann M, Herrmann HD
Pediatr Neurosurg 1998 May;28(5):241-5. doi: 10.1159/000028658. PMID: 9732256
Neuropathology of pineal region tumors.
Scheithauer BW
Clin Neurosurg 1985;32:351-83. PMID: 3905145

Clinical prediction guides

Second-look surgery for pineal region tumors.
Ogiwara H
Childs Nerv Syst 2023 Sep;39(9):2349-2352. Epub 2022 Oct 1 doi: 10.1007/s00381-022-05676-4. PMID: 36181520
Coexistence of Intracranial Germ Cell Tumor with Growing Arteriovenous Fistula.
Ishida T, Endo H, Saito R, Kanamori M, Sato K, Matsumoto Y, Endo T, Fujimura M, Tominaga T
World Neurosurg 2019 Jul;127:126-130. Epub 2019 Apr 6 doi: 10.1016/j.wneu.2019.04.015. PMID: 30965172
Adult Atypical Teratoid/Rhabdoid Tumors.
Wu WW, Bi WL, Kang YJ, Ramkissoon SH, Prasad S, Shih HA, Reardon DA, Dunn IF
World Neurosurg 2016 Jan;85:197-204. Epub 2015 Sep 4 doi: 10.1016/j.wneu.2015.08.076. PMID: 26344637
Pathology of pineal region tumors.
Hirato J, Nakazato Y
J Neurooncol 2001 Sep;54(3):239-49. doi: 10.1023/a:1012721723387. PMID: 11767290
Suprasellar germinoma.
Takeuchi J, Handa H, Nagata I
J Neurosurg 1978 Jul;49(1):41-8. doi: 10.3171/jns.1978.49.1.0041. PMID: 660267

Recent systematic reviews

Radiological image features of the atypical teratoid/rhabdoid tumor in adults: a systematic review.
Kanoto M, Toyoguchi Y, Hosoya T, Kuchiki M, Sugai Y
Clin Neuroradiol 2015 Mar;25(1):55-60. Epub 2014 Jan 30 doi: 10.1007/s00062-013-0282-2. PMID: 24477665

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