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Rectal Adenoma with Severe Dysplasia

MedGen UID:
277573
•Concept ID:
C1335677
•
Neoplastic Process
Synonyms: Adenoma of Rectum with Marked Dysplasia; Adenoma of the Rectum with Marked Dysplasia; Rectal Adenoma with Marked Dysplasia

Definition

An adenoma that arises from the rectum. It is characterized by the presence of severe epithelial dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRectal Adenoma with Severe Dysplasia

Professional guidelines

PubMed

Endoscopic snare resection followed by laser ablation in the treatment of large, sessile rectal adenomas.
Nesbakken A, Kristinsson J, Svindland A, Lunde OC
Scand J Surg 2011;100(2):99-104. doi: 10.1177/145749691110000206. PMID: 21737385
Long-term treatment with sulindac in familial adenomatous polyposis: is there an actual efficacy in prevention of rectal cancer?
Tonelli F, Valanzano R, Messerini L, Ficari F
J Surg Oncol 2000 May;74(1):15-20. doi: 10.1002/1096-9098(200005)74:1<15::aid-jso4>3.0.co;2-z. PMID: 10861602
Colonoscopy in the diagnosis and management of colorectal neoplasia in a DGH.
Rainsbury RM, Lallemand RC
Ann R Coll Surg Engl 1988 Mar;70(2):80-4. PMID: 3408165Free PMC Article

Recent clinical studies

Etiology

Ileal reservoir-associated complications in ulcerative colitis versus familial adenomatous polyposis: Impact on patient quality of life.
Castaño Llano R, Molina Meneses SP, Puerta JD, Escobar RM, Salazar Ochoa S, Puerta JE, Barreiro-de Acosta M
Gastroenterol Hepatol 2023 Jan;46(1):39-47. Epub 2022 May 20 doi: 10.1016/j.gastrohep.2022.05.005. PMID: 35605822
Cumulative incidence and risk factors for pouch adenomas associated with familial adenomatous polyposis following restorative proctocolectomy.
Ryu HS, Yu CS, Kim YI, Lee JL, Kim CW, Yoon YS, Park IJ, Lim SB, Kim JC
World J Gastroenterol 2022 Aug 14;28(30):4152-4162. doi: 10.3748/wjg.v28.i30.4152. PMID: 36157110Free PMC Article
Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature.
Bains L, Lal P, Vindal A, Singh M
World J Surg Oncol 2019 Jun 25;17(1):109. doi: 10.1186/s12957-019-1650-4. PMID: 31238922Free PMC Article
McKittrick Wheelock Syndrome Treated by Transanal Minimally Invasive Surgery: A Single-Center Experience and Review of the Literature.
van der Pool AEM, de Graaf EJR, Vermaas M, Barendse RM, Doornebosch PG
J Laparoendosc Adv Surg Tech A 2018 Feb;28(2):204-208. Epub 2017 Jun 28 doi: 10.1089/lap.2017.0195. PMID: 28657837
Colorectal polyps and their relationship to cancer.
Kim EC, Lance P
Gastroenterol Clin North Am 1997 Mar;26(1):1-17. doi: 10.1016/s0889-8553(05)70280-6. PMID: 9119435

Diagnosis

Familial adenomatous polyposis: a case report.
Kindie EA, Beyera TD, Teferi ET, Ashebir DZ, Wodajeneh HB
J Med Case Rep 2024 Sep 8;18(1):415. doi: 10.1186/s13256-024-04724-8. PMID: 39244621Free PMC Article
McKittrick Wheelock Syndrome Treated by Transanal Minimally Invasive Surgery: A Single-Center Experience and Review of the Literature.
van der Pool AEM, de Graaf EJR, Vermaas M, Barendse RM, Doornebosch PG
J Laparoendosc Adv Surg Tech A 2018 Feb;28(2):204-208. Epub 2017 Jun 28 doi: 10.1089/lap.2017.0195. PMID: 28657837
Large size, villous content and distal location are associated with severe dysplasia in colorectal adenomas.
Giuliani A, Caporale A, Corona M, Ricciardulli T, Di Bari M, Demoro M, Scarpini M, Angelico F
Anticancer Res 2006 Sep-Oct;26(5B):3717-22. PMID: 17094390
Diagnostic problems and advances in inflammatory bowel disease.
Odze R
Mod Pathol 2003 Apr;16(4):347-58. doi: 10.1097/01.MP.0000064746.82024.D1. PMID: 12692200
Colorectal polyps and their relationship to cancer.
Kim EC, Lance P
Gastroenterol Clin North Am 1997 Mar;26(1):1-17. doi: 10.1016/s0889-8553(05)70280-6. PMID: 9119435

Therapy

Familial adenomatous polyposis: a case report.
Kindie EA, Beyera TD, Teferi ET, Ashebir DZ, Wodajeneh HB
J Med Case Rep 2024 Sep 8;18(1):415. doi: 10.1186/s13256-024-04724-8. PMID: 39244621Free PMC Article
Ileal reservoir-associated complications in ulcerative colitis versus familial adenomatous polyposis: Impact on patient quality of life.
Castaño Llano R, Molina Meneses SP, Puerta JD, Escobar RM, Salazar Ochoa S, Puerta JE, Barreiro-de Acosta M
Gastroenterol Hepatol 2023 Jan;46(1):39-47. Epub 2022 May 20 doi: 10.1016/j.gastrohep.2022.05.005. PMID: 35605822
Cumulative incidence and risk factors for pouch adenomas associated with familial adenomatous polyposis following restorative proctocolectomy.
Ryu HS, Yu CS, Kim YI, Lee JL, Kim CW, Yoon YS, Park IJ, Lim SB, Kim JC
World J Gastroenterol 2022 Aug 14;28(30):4152-4162. doi: 10.3748/wjg.v28.i30.4152. PMID: 36157110Free PMC Article
Transanal single-port microsurgery for rectal tumors: minimal invasive surgery under spinal anesthesia.
Lee TG, Lee SJ
Surg Endosc 2014 Jan;28(1):271-80. Epub 2013 Sep 6 doi: 10.1007/s00464-013-3184-0. PMID: 24061623
Increased risk of early colorectal neoplasms after hepatic transplant in patients with inflammatory bowel disease.
Bleday R, Lee E, Jessurun J, Heine J, Wong WD
Dis Colon Rectum 1993 Oct;36(10):908-12. doi: 10.1007/BF02050624. PMID: 8404380

Prognosis

Cumulative incidence and risk factors for pouch adenomas associated with familial adenomatous polyposis following restorative proctocolectomy.
Ryu HS, Yu CS, Kim YI, Lee JL, Kim CW, Yoon YS, Park IJ, Lim SB, Kim JC
World J Gastroenterol 2022 Aug 14;28(30):4152-4162. doi: 10.3748/wjg.v28.i30.4152. PMID: 36157110Free PMC Article
Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature.
Bains L, Lal P, Vindal A, Singh M
World J Surg Oncol 2019 Jun 25;17(1):109. doi: 10.1186/s12957-019-1650-4. PMID: 31238922Free PMC Article
Transanal single-port microsurgery for rectal tumors: minimal invasive surgery under spinal anesthesia.
Lee TG, Lee SJ
Surg Endosc 2014 Jan;28(1):271-80. Epub 2013 Sep 6 doi: 10.1007/s00464-013-3184-0. PMID: 24061623
Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors.
Li JQ, Wu F, Masaki T, Kubo A, Fujita J, Dixon DA, Beauchamp RD, Ishida T, Kuriyama S, Imaida K
Int J Oncol 2004 Jul;25(1):87-95. PMID: 15201993
The adenoma-carcinoma sequence.
Day DW
Scand J Gastroenterol Suppl 1984;104:99-107. PMID: 6597553

Clinical prediction guides

Ileal reservoir-associated complications in ulcerative colitis versus familial adenomatous polyposis: Impact on patient quality of life.
Castaño Llano R, Molina Meneses SP, Puerta JD, Escobar RM, Salazar Ochoa S, Puerta JE, Barreiro-de Acosta M
Gastroenterol Hepatol 2023 Jan;46(1):39-47. Epub 2022 May 20 doi: 10.1016/j.gastrohep.2022.05.005. PMID: 35605822
Cumulative incidence and risk factors for pouch adenomas associated with familial adenomatous polyposis following restorative proctocolectomy.
Ryu HS, Yu CS, Kim YI, Lee JL, Kim CW, Yoon YS, Park IJ, Lim SB, Kim JC
World J Gastroenterol 2022 Aug 14;28(30):4152-4162. doi: 10.3748/wjg.v28.i30.4152. PMID: 36157110Free PMC Article
Adenomas with severe dysplasia and early carcinoma of the colon-rectum: our experience of 27 patients.
Brini C, Bogliolo G, Pontone S, Ierfone N, Chessa A, Pontone P
G Chir 2001 Jan-Feb;22(1-2):26-8. PMID: 11272432
BCL2 and BAX expression in hyperplastic and dysplastic rectal polyps.
Giarnieri E, Nagar C, Valli C, Brunetti E, Palmieri MB, Vecchione A
Hepatogastroenterology 2000 Jan-Feb;47(31):159-62. PMID: 10690601
DNA content and the adenoma-carcinoma sequence in the colorectum.
Goh HS, Jass JR
J Clin Pathol 1986 Apr;39(4):387-92. doi: 10.1136/jcp.39.4.387. PMID: 3700672Free PMC Article

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