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Colorectal Adenoma with Severe Dysplasia

MedGen UID:
234164
•Concept ID:
C1333108
•
Neoplastic Process
Synonym: Colorectal Adenoma with Marked Dysplasia

Definition

An adenoma that arises from the colon or rectum. It is characterized by the presence of severe epithelial dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Adenoma with Severe Dysplasia

Professional guidelines

PubMed

Clinicopathological risk factors of early carcinoma in colorectal neoplasias according to Japanese and Western criteria.
Cha JM, Lee JI, Joo KR, Shin HP, Park JJ, Jeun JW, Lim JU
Hepatogastroenterology 2015 Jan-Feb;62(137):25-9. PMID: 25911861
Diagnosis and management of dysplasia in patients with inflammatory bowel diseases.
Itzkowitz SH, Harpaz N
Gastroenterology 2004 May;126(6):1634-48. doi: 10.1053/j.gastro.2004.03.025. PMID: 15168373
Colonoscopy in the diagnosis and management of colorectal neoplasia in a DGH.
Rainsbury RM, Lallemand RC
Ann R Coll Surg Engl 1988 Mar;70(2):80-4. PMID: 3408165Free PMC Article

Recent clinical studies

Etiology

Clinicopathological characterization of colonic polyps.
Qari YA
Niger J Clin Pract 2020 Aug;23(8):1048-1053. doi: 10.4103/njcp.njcp_490_19. PMID: 32788480
DCLK1 Expression in Colorectal Polyps Increases with the Severity of Dysplasia.
Takiyama A, Tanaka T, Kazama S, Nagata H, Kawai K, Hata K, Otani K, Nishikawa T, Sasaki K, Kaneko M, Emoto S, Murono K, Takiyama H, Nozawa H
In Vivo 2018 Mar-Apr;32(2):365-371. doi: 10.21873/invivo.11247. PMID: 29475922Free PMC Article
Surveillance of Duodenal Polyposis in Familial Adenomatous Polyposis: Should the Spigelman Score Be Modified?
Sourrouille I, Lefèvre JH, Shields C, Colas C, Bellanger J, Desaint B, Paye F, Tiret E, Parc Y
Dis Colon Rectum 2017 Nov;60(11):1137-1146. doi: 10.1097/DCR.0000000000000903. PMID: 28991077
Diagnosis and management of dysplasia in patients with inflammatory bowel diseases.
Itzkowitz SH, Harpaz N
Gastroenterology 2004 May;126(6):1634-48. doi: 10.1053/j.gastro.2004.03.025. PMID: 15168373
Colorectal polyps and their relationship to cancer.
Kim EC, Lance P
Gastroenterol Clin North Am 1997 Mar;26(1):1-17. doi: 10.1016/s0889-8553(05)70280-6. PMID: 9119435

Diagnosis

DCLK1 Expression in Colorectal Polyps Increases with the Severity of Dysplasia.
Takiyama A, Tanaka T, Kazama S, Nagata H, Kawai K, Hata K, Otani K, Nishikawa T, Sasaki K, Kaneko M, Emoto S, Murono K, Takiyama H, Nozawa H
In Vivo 2018 Mar-Apr;32(2):365-371. doi: 10.21873/invivo.11247. PMID: 29475922Free PMC Article
Surveillance of Duodenal Polyposis in Familial Adenomatous Polyposis: Should the Spigelman Score Be Modified?
Sourrouille I, Lefèvre JH, Shields C, Colas C, Bellanger J, Desaint B, Paye F, Tiret E, Parc Y
Dis Colon Rectum 2017 Nov;60(11):1137-1146. doi: 10.1097/DCR.0000000000000903. PMID: 28991077
Diagnosis and management of dysplasia in patients with inflammatory bowel diseases.
Itzkowitz SH, Harpaz N
Gastroenterology 2004 May;126(6):1634-48. doi: 10.1053/j.gastro.2004.03.025. PMID: 15168373
The Vienna classification of gastrointestinal epithelial neoplasia.
Schlemper RJ, Riddell RH, Kato Y, Borchard F, Cooper HS, Dawsey SM, Dixon MF, Fenoglio-Preiser CM, Fléjou JF, Geboes K, Hattori T, Hirota T, Itabashi M, Iwafuchi M, Iwashita A, Kim YI, Kirchner T, Klimpfinger M, Koike M, Lauwers GY, Lewin KJ, Oberhuber G, Offner F, Price AB, Rubio CA, Shimizu M, Shimoda T, Sipponen P, Solcia E, Stolte M, Watanabe H, Yamabe H
Gut 2000 Aug;47(2):251-5. doi: 10.1136/gut.47.2.251. PMID: 10896917Free PMC Article
Colorectal polyps and their relationship to cancer.
Kim EC, Lance P
Gastroenterol Clin North Am 1997 Mar;26(1):1-17. doi: 10.1016/s0889-8553(05)70280-6. PMID: 9119435

Therapy

Familial adenomatous polyposis: a case report.
Kindie EA, Beyera TD, Teferi ET, Ashebir DZ, Wodajeneh HB
J Med Case Rep 2024 Sep 8;18(1):415. doi: 10.1186/s13256-024-04724-8. PMID: 39244621Free PMC Article
Feasibility and Safety of Endoscopic Control for Patients with Serrated Polyposis Syndrome.
Nakaoka M, Chiba H, Kobayashi M, Okada N, Arimoto J, Tachikawa J, Ashikari K, Kuwabara H
Dig Dis 2024;42(1):31-40. Epub 2023 Nov 15 doi: 10.1159/000534968. PMID: 37967542Free PMC Article
Cumulative incidence and risk factors for pouch adenomas associated with familial adenomatous polyposis following restorative proctocolectomy.
Ryu HS, Yu CS, Kim YI, Lee JL, Kim CW, Yoon YS, Park IJ, Lim SB, Kim JC
World J Gastroenterol 2022 Aug 14;28(30):4152-4162. doi: 10.3748/wjg.v28.i30.4152. PMID: 36157110Free PMC Article
Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms.
Lv C, Zhao X, Gu H, Huang L, Zhou S, Zhi F
Med Sci Monit 2016 Dec 7;22:4794-4802. doi: 10.12659/msm.902274. PMID: 27926694Free PMC Article
Diagnosis and management of dysplasia in patients with inflammatory bowel diseases.
Itzkowitz SH, Harpaz N
Gastroenterology 2004 May;126(6):1634-48. doi: 10.1053/j.gastro.2004.03.025. PMID: 15168373

Prognosis

Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature.
Bains L, Lal P, Vindal A, Singh M
World J Surg Oncol 2019 Jun 25;17(1):109. doi: 10.1186/s12957-019-1650-4. PMID: 31238922Free PMC Article
Difference in the clinical characteristic and prognosis of colitis-associated cancer and sporadic neoplasia in ulcerative colitis patients.
Mutaguchi M, Naganuma M, Sugimoto S, Fukuda T, Nanki K, Mizuno S, Hosoe N, Shimoda M, Ogata H, Iwao Y, Kanai T
Dig Liver Dis 2019 Sep;51(9):1257-1264. doi: 10.1016/j.dld.2019.05.003. PMID: 31151895
Surveillance of Duodenal Polyposis in Familial Adenomatous Polyposis: Should the Spigelman Score Be Modified?
Sourrouille I, Lefèvre JH, Shields C, Colas C, Bellanger J, Desaint B, Paye F, Tiret E, Parc Y
Dis Colon Rectum 2017 Nov;60(11):1137-1146. doi: 10.1097/DCR.0000000000000903. PMID: 28991077
Colorectal cancer in patients with inflammatory bowel disease: the true impact of the risk.
Herszényi L, Barabás L, Miheller P, Tulassay Z
Dig Dis 2015;33(1):52-7. Epub 2014 Dec 17 doi: 10.1159/000368447. PMID: 25531497
The adenoma-carcinoma sequence.
Day DW
Scand J Gastroenterol Suppl 1984;104:99-107. PMID: 6597553

Clinical prediction guides

Cumulative incidence and risk factors for pouch adenomas associated with familial adenomatous polyposis following restorative proctocolectomy.
Ryu HS, Yu CS, Kim YI, Lee JL, Kim CW, Yoon YS, Park IJ, Lim SB, Kim JC
World J Gastroenterol 2022 Aug 14;28(30):4152-4162. doi: 10.3748/wjg.v28.i30.4152. PMID: 36157110Free PMC Article
DCLK1 Expression in Colorectal Polyps Increases with the Severity of Dysplasia.
Takiyama A, Tanaka T, Kazama S, Nagata H, Kawai K, Hata K, Otani K, Nishikawa T, Sasaki K, Kaneko M, Emoto S, Murono K, Takiyama H, Nozawa H
In Vivo 2018 Mar-Apr;32(2):365-371. doi: 10.21873/invivo.11247. PMID: 29475922Free PMC Article
Surveillance of Duodenal Polyposis in Familial Adenomatous Polyposis: Should the Spigelman Score Be Modified?
Sourrouille I, Lefèvre JH, Shields C, Colas C, Bellanger J, Desaint B, Paye F, Tiret E, Parc Y
Dis Colon Rectum 2017 Nov;60(11):1137-1146. doi: 10.1097/DCR.0000000000000903. PMID: 28991077
Characteristics and Clinical Outcomes of Duodenal Neoplasia in Japanese Patients With Familial Adenomatous Polyposis.
Yachida T, Nakajima T, Nonaka S, Nakamura K, Suzuki H, Yoshinaga S, Oda I, Moriya Y, Masaki T, Saito Y
J Clin Gastroenterol 2017 May/Jun;51(5):407-411. doi: 10.1097/MCG.0000000000000555. PMID: 27306941
Expression of RUNX3 and β-catenin in the carcinogenesis of sporadic colorectal tubular adenoma.
Wang L, Li D, Liu Y, Wang Y, Cui J, Cui A, Wu W
Tumour Biol 2014 Jun;35(6):6039-46. Epub 2014 Mar 14 doi: 10.1007/s13277-014-1800-9. PMID: 24622886

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