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Fibromatosis, gingival, 2(HGF2; GINGF2)

MedGen UID:
344226
•Concept ID:
C1854181
•
Disease or Syndrome
Synonyms: GINGF2; Hereditary gingival fibromatosis, 2
 
Monarch Initiative: MONDO:0011563
OMIM®: 605544

Definition

Hereditary gingival fibromatosis is a benign disorder manifested by a slowly progressive enlargement of the oral gingival tissues (summary by Xiao et al., 2001). For general phenotypic information and a discussion of genetic heterogeneity of hereditary gingival fibromatosis, see GINGF (135300). [from OMIM]

Professional guidelines

PubMed

Anesthetic Management of a Juvenile Hyaline Fibromatosis Patient With Trismus and Cervical Movement Limitation.
Yasuda A, Miyazawa N, Inoue E, Imai T, Shionoya Y, Nakamura K
Anesth Prog 2021 Jun 1;68(2):117-118. doi: 10.2344/anpr-68-01-04. PMID: 34185859Free PMC Article
Hyaline fibromatosis syndrome: Clinical update and phenotype-genotype correlations.
Casas-Alba D, Martínez-Monseny A, Pino-Ramírez RM, Alsina L, Castejón E, Navarro-Vilarrubí S, Pérez-Dueñas B, Serrano M, Palau F, García-Alix A
Hum Mutat 2018 Dec;39(12):1752-1763. Epub 2018 Sep 17 doi: 10.1002/humu.23638. PMID: 30176098
Diagnosis and treatment of a hereditary gingival fibromatosis case.
Zhou M, Xu L, Meng HX
Chin J Dent Res 2011;14(2):155-8. PMID: 22319759

Recent clinical studies

Etiology

A 15-year Follow-Up of a Gingivectomy Procedure for Idiopathic Gingival Fibromatosis: A Case Report and Literature Review.
Seki K, Sato S
J Clin Pediatr Dent 2022 Mar 1;46(2):119-124. doi: 10.17796/1053-4625-46.2.5. PMID: 35533227
Fibroblasts from recurrent fibrotic overgrowths reveal high rate of proliferation in vitro - findings from the study of hereditary and idiopathic gingival fibromatosis.
Gawron K, Łazarz-Bartyzel K, Kowalska A, Bereta G, Nowakowska Z, Plakwicz P, Potempa J, Fertala A, Chomyszyn-Gajewska M
Connect Tissue Res 2019 Jan;60(1):29-39. Epub 2018 Sep 20 doi: 10.1080/03008207.2018.1517758. PMID: 30231645
Immunoexpression of α2-integrin and Hsp47 in hereditary gingival fibromatosis and gingival fibromatosis-associated dental abnormalities.
Vieira-Júnior JR, de Oliveira-Santos C, Della-Coletta R, Cristianismo-Costa D, Paranaíba LM, Martelli-Júnior H
Med Oral Patol Oral Cir Bucal 2013 Jan 1;18(1):e45-8. doi: 10.4317/medoral.17970. PMID: 23229240Free PMC Article
Infantile systemic hyalinosis.
Giri PP, Raushan R, Ghosh A, Pal P
Indian Pediatr 2012 Jan;49(1):62-4. PMID: 22318104
Diagnosis and treatment of a hereditary gingival fibromatosis case.
Zhou M, Xu L, Meng HX
Chin J Dent Res 2011;14(2):155-8. PMID: 22319759

Diagnosis

Juvenile hyaline fibromatosis in siblings.
Ravikumar VR, Veerappan Ramamoorthi RG, Manisankar S
Indian J Pathol Microbiol 2019 Apr-Jun;62(2):300-302. doi: 10.4103/IJPM.IJPM_76_17. PMID: 30971561
Epilepsy in KCNH1-related syndromes.
Mastrangelo M, Scheffer IE, Bramswig NC, Nair LD, Myers CT, Dentici ML, Korenke GC, Schoch K, Campeau PM, White SM, Shashi V, Kansagra S, Van Essen AJ, Leuzzi V
Epileptic Disord 2016 Jun 1;18(2):123-36. doi: 10.1684/epd.2016.0830. PMID: 27267311
Current concepts on gingival fibromatosis-related syndromes.
Poulopoulos A, Kittas D, Sarigelou A
J Investig Clin Dent 2011 Aug;2(3):156-61. Epub 2011 Mar 15 doi: 10.1111/j.2041-1626.2011.00054.x. PMID: 25426785
Diagnosis and treatment of a hereditary gingival fibromatosis case.
Zhou M, Xu L, Meng HX
Chin J Dent Res 2011;14(2):155-8. PMID: 22319759
Hereditary gingival fibromatosis--a review.
DeAngelo S, Murphy J, Claman L, Kalmar J, Leblebicioglu B
Compend Contin Educ Dent 2007 Mar;28(3):138-43; quiz 144, 152. PMID: 17385395

Therapy

Enamel Renal Gingival Syndrome in an Adolescent.
Koul R, Chengappa D, Mathur VP, Singh TA, Chopra SS
J Dent Child (Chic) 2024 Jan 15;91(1):38-42. PMID: 38671566
Epilepsy in KCNH1-related syndromes.
Mastrangelo M, Scheffer IE, Bramswig NC, Nair LD, Myers CT, Dentici ML, Korenke GC, Schoch K, Campeau PM, White SM, Shashi V, Kansagra S, Van Essen AJ, Leuzzi V
Epileptic Disord 2016 Jun 1;18(2):123-36. doi: 10.1684/epd.2016.0830. PMID: 27267311
An update on crown lengthening. Part 1: Gingival tissue excess.
Kalsi HJ, Hussain Z, Darbar U
Dent Update 2015 Mar;42(2):144-6, 149-50, 153. doi: 10.12968/denu.2015.42.2.144. PMID: 26058228
Drug-induced gingival enlargement: biofilm control and surgical therapy with gallium-aluminum-arsenide (GaAlAs) diode laser-A 2-year follow-up.
de Oliveira Guaré R, Costa SC, Baeder F, de Souza Merli LA, Dos Santos MT
Spec Care Dentist 2010 Mar-Apr;30(2):46-52. doi: 10.1111/j.1754-4505.2009.00126.x. PMID: 20415800
Collagen synthesis in idiopathic and dilantin-induced gingival fibromatosis.
Huang JS, Ho KY, Chen CC, Wu YM, Wang CC, Ho YP, Liu CS
Kaohsiung J Med Sci 1997 Mar;13(3):141-8. PMID: 9109300

Prognosis

Exosomes derived from idiopathic gingival fibroma fibroblasts regulate gingival fibroblast proliferation and apoptosis.
Yin S, Jia F, Ran L, Xie L, Wu Z, Zhan Y, Zhang Y, Zhang M
Oral Dis 2021 Oct;27(7):1789-1795. Epub 2020 Nov 19 doi: 10.1111/odi.13707. PMID: 33140502
Juvenile hyaline fibromatosis in siblings.
Ravikumar VR, Veerappan Ramamoorthi RG, Manisankar S
Indian J Pathol Microbiol 2019 Apr-Jun;62(2):300-302. doi: 10.4103/IJPM.IJPM_76_17. PMID: 30971561
Hyaline fibromatosis syndrome: Clinical update and phenotype-genotype correlations.
Casas-Alba D, Martínez-Monseny A, Pino-Ramírez RM, Alsina L, Castejón E, Navarro-Vilarrubí S, Pérez-Dueñas B, Serrano M, Palau F, García-Alix A
Hum Mutat 2018 Dec;39(12):1752-1763. Epub 2018 Sep 17 doi: 10.1002/humu.23638. PMID: 30176098
Infantile systemic hyalinosis.
Giri PP, Raushan R, Ghosh A, Pal P
Indian Pediatr 2012 Jan;49(1):62-4. PMID: 22318104
Current concepts on gingival fibromatosis-related syndromes.
Poulopoulos A, Kittas D, Sarigelou A
J Investig Clin Dent 2011 Aug;2(3):156-61. Epub 2011 Mar 15 doi: 10.1111/j.2041-1626.2011.00054.x. PMID: 25426785

Clinical prediction guides

Hub Genes, Possible Pathways and Predicted Drugs in Hereditary Gingival Fibromatosis by Bioinformatics Analysis.
Yang RX, Shi F, Du SN, Luo XY, Wang WQ, Yuan ZL, Chen D
Chin J Dent Res 2024 Mar 28;27(1):101-109. doi: 10.3290/j.cjdr.b5128671. PMID: 38546525
Clinics and genetic background of hereditary gingival fibromatosis.
Strzelec K, Dziedzic A, Łazarz-Bartyzel K, Grabiec AM, Gutmajster E, Kaczmarzyk T, Plakwicz P, Gawron K
Orphanet J Rare Dis 2021 Nov 24;16(1):492. doi: 10.1186/s13023-021-02104-9. PMID: 34819125Free PMC Article
Epilepsy in KCNH1-related syndromes.
Mastrangelo M, Scheffer IE, Bramswig NC, Nair LD, Myers CT, Dentici ML, Korenke GC, Schoch K, Campeau PM, White SM, Shashi V, Kansagra S, Van Essen AJ, Leuzzi V
Epileptic Disord 2016 Jun 1;18(2):123-36. doi: 10.1684/epd.2016.0830. PMID: 27267311
FAM20A mutations can cause enamel-renal syndrome (ERS).
Wang SK, Aref P, Hu Y, Milkovich RN, Simmer JP, El-Khateeb M, Daggag H, Baqain ZH, Hu JC
PLoS Genet 2013;9(2):e1003302. Epub 2013 Feb 28 doi: 10.1371/journal.pgen.1003302. PMID: 23468644Free PMC Article
Immunoexpression of α2-integrin and Hsp47 in hereditary gingival fibromatosis and gingival fibromatosis-associated dental abnormalities.
Vieira-Júnior JR, de Oliveira-Santos C, Della-Coletta R, Cristianismo-Costa D, Paranaíba LM, Martelli-Júnior H
Med Oral Patol Oral Cir Bucal 2013 Jan 1;18(1):e45-8. doi: 10.4317/medoral.17970. PMID: 23229240Free PMC Article

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