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Fibromatosis, gingival, 3(HGF3; GINGF3)

MedGen UID:
351261
•Concept ID:
C1864960
•
Disease or Syndrome
Synonyms: GINGF3; Hereditary gingival fibromatosis, 3
 
Monarch Initiative: MONDO:0012378
OMIM®: 609955

Definition

Gingival fibromatosis-3 (GINGF3) is an autosomal dominant disorder characterized by the development of gingival overgrowth in early childhood, at the time of tooth eruption. Gingival fibromatosis develops slowly in affected individuals, and consists of firm and nodular fibrous tissue (Ye et al., 2005; Pampel et al., 2010). For phenotypic information and a discussion of genetic heterogeneity of hereditary gingival fibromatosis, see GINGF (135300). [from OMIM]

Professional guidelines

PubMed

Periodontology Part 3: Hereditary Gingival Fibromatosis (HGF): from diagnosis to treatment in the paediatric age.
Carli E, Lardani L, Fitzgibbon R, Fambrini E, Bagattoni S
Eur J Paediatr Dent 2022 Sep;23(3):249-250. doi: 10.23804/ejpd.2022.23.03.13. PMID: 36172902
Diagnosis and treatment of a hereditary gingival fibromatosis case.
Zhou M, Xu L, Meng HX
Chin J Dent Res 2011;14(2):155-8. PMID: 22319759

Recent clinical studies

Etiology

Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis.
Chen J, Xu X, Chen S, Lu T, Zheng Y, Gan Z, Shen Z, Ma S, Wang D, Su L, He F, Shang X, Xu H, Chen D, Zhang L, Xiong F
Int J Oral Sci 2023 Sep 26;15(1):46. doi: 10.1038/s41368-023-00244-1. PMID: 37752101Free PMC Article
Antifibrotic Potential of MiR-335-3p in Hereditary Gingival Fibromatosis.
Gao Q, Yang K, Chen D, Song Y, Qiao W, Sun X, Meng L, Bian Z
J Dent Res 2019 Sep;98(10):1140-1149. Epub 2019 Jul 19 doi: 10.1177/0022034519863300. PMID: 31323181
Modeling RASopathies with Genetically Modified Mouse Models.
Hernández-Porras I, Guerra C
Methods Mol Biol 2017;1487:379-408. doi: 10.1007/978-1-4939-6424-6_28. PMID: 27924582
Immunoexpression of α2-integrin and Hsp47 in hereditary gingival fibromatosis and gingival fibromatosis-associated dental abnormalities.
Vieira-Júnior JR, de Oliveira-Santos C, Della-Coletta R, Cristianismo-Costa D, Paranaíba LM, Martelli-Júnior H
Med Oral Patol Oral Cir Bucal 2013 Jan 1;18(1):e45-8. doi: 10.4317/medoral.17970. PMID: 23229240Free PMC Article
Diagnosis and treatment of a hereditary gingival fibromatosis case.
Zhou M, Xu L, Meng HX
Chin J Dent Res 2011;14(2):155-8. PMID: 22319759

Diagnosis

Periodontology Part 3: Hereditary Gingival Fibromatosis (HGF): from diagnosis to treatment in the paediatric age.
Carli E, Lardani L, Fitzgibbon R, Fambrini E, Bagattoni S
Eur J Paediatr Dent 2022 Sep;23(3):249-250. doi: 10.23804/ejpd.2022.23.03.13. PMID: 36172902
Hereditary gingival fibromatosis in children: a systematic review of the literature.
Boutiou E, Ziogas IA, Giannis D, Doufexi AE
Clin Oral Investig 2021 Jun;25(6):3599-3607. Epub 2020 Nov 13 doi: 10.1007/s00784-020-03682-x. PMID: 33188467
Current concepts on gingival fibromatosis-related syndromes.
Poulopoulos A, Kittas D, Sarigelou A
J Investig Clin Dent 2011 Aug;2(3):156-61. Epub 2011 Mar 15 doi: 10.1111/j.2041-1626.2011.00054.x. PMID: 25426785
Diagnosis and treatment of a hereditary gingival fibromatosis case.
Zhou M, Xu L, Meng HX
Chin J Dent Res 2011;14(2):155-8. PMID: 22319759
Hereditary gingival fibromatosis--a review.
DeAngelo S, Murphy J, Claman L, Kalmar J, Leblebicioglu B
Compend Contin Educ Dent 2007 Mar;28(3):138-43; quiz 144, 152. PMID: 17385395

Therapy

Laser-assisted gingivectomy in pediatric patients: a novel alternative treatment.
Gontiya G, Bhatnagar S, Mohandas U, Galgali SR
J Indian Soc Pedod Prev Dent 2011 Jul-Sep;29(3):264-9. doi: 10.4103/0970-4388.85839. PMID: 21985887
Apoptosis in gingival overgrowth tissues.
Kantarci A, Augustin P, Firatli E, Sheff MC, Hasturk H, Graves DT, Trackman PC
J Dent Res 2007 Sep;86(9):888-92. doi: 10.1177/154405910708600916. PMID: 17720861Free PMC Article
Gingival overgrowth in children: epidemiology, pathogenesis, and complications. A literature review.
Doufexi A, Mina M, Ioannidou E
J Periodontol 2005 Jan;76(1):3-10. doi: 10.1902/jop.2005.76.1.3. PMID: 15830631
Collagen synthesis in idiopathic and dilantin-induced gingival fibromatosis.
Huang JS, Ho KY, Chen CC, Wu YM, Wang CC, Ho YP, Liu CS
Kaohsiung J Med Sci 1997 Mar;13(3):141-8. PMID: 9109300
Enhanced cytokine production and collagen synthesis of gingival fibroblasts from patients with denture fibromatosis.
Nakao K, Yoneda K, Osaki T
J Dent Res 1995 Apr;74(4):1072-8. doi: 10.1177/00220345950740040701. PMID: 7782537

Prognosis

Hyaline fibromatosis syndrome: a rare, yet recognizable syndrome.
Daşar T, Gönen HN, Kösemehmetoğlu K, Tekşam Ö, Boduroğlu K, Utine GE, Şimşek Kiper PÖ
Turk J Pediatr 2024 May 23;66(2):205-214. doi: 10.24953/turkjpediatr.2024.4511. PMID: 38814306
New evidence of genetic heterogeneity causing hereditary gingival fibromatosis and ALK and CD36 as new candidate genes.
Machado RA, de Andrade RS, Pêgo SPB, Krepischi ACV, Coletta RD, Martelli-Júnior H
J Periodontol 2023 Jan;94(1):108-118. Epub 2022 Jul 1 doi: 10.1002/JPER.22-0219. PMID: 35665929
Antifibrotic Potential of MiR-335-3p in Hereditary Gingival Fibromatosis.
Gao Q, Yang K, Chen D, Song Y, Qiao W, Sun X, Meng L, Bian Z
J Dent Res 2019 Sep;98(10):1140-1149. Epub 2019 Jul 19 doi: 10.1177/0022034519863300. PMID: 31323181
Current concepts on gingival fibromatosis-related syndromes.
Poulopoulos A, Kittas D, Sarigelou A
J Investig Clin Dent 2011 Aug;2(3):156-61. Epub 2011 Mar 15 doi: 10.1111/j.2041-1626.2011.00054.x. PMID: 25426785
Diagnosis and treatment of a hereditary gingival fibromatosis case.
Zhou M, Xu L, Meng HX
Chin J Dent Res 2011;14(2):155-8. PMID: 22319759

Clinical prediction guides

New evidence of genetic heterogeneity causing hereditary gingival fibromatosis and ALK and CD36 as new candidate genes.
Machado RA, de Andrade RS, Pêgo SPB, Krepischi ACV, Coletta RD, Martelli-Júnior H
J Periodontol 2023 Jan;94(1):108-118. Epub 2022 Jul 1 doi: 10.1002/JPER.22-0219. PMID: 35665929
Antifibrotic Potential of MiR-335-3p in Hereditary Gingival Fibromatosis.
Gao Q, Yang K, Chen D, Song Y, Qiao W, Sun X, Meng L, Bian Z
J Dent Res 2019 Sep;98(10):1140-1149. Epub 2019 Jul 19 doi: 10.1177/0022034519863300. PMID: 31323181
REST Final-Exon-Truncating Mutations Cause Hereditary Gingival Fibromatosis.
Bayram Y, White JJ, Elcioglu N, Cho MT, Zadeh N, Gedikbasi A, Palanduz S, Ozturk S, Cefle K, Kasapcopur O, Coban Akdemir Z, Pehlivan D, Begtrup A, Carvalho CMB, Paine IS, Mentes A, Bektas-Kayhan K, Karaca E, Jhangiani SN, Muzny DM; Baylor-Hopkins Center for Mendelian Genomics, Gibbs RA, Lupski JR
Am J Hum Genet 2017 Jul 6;101(1):149-156. doi: 10.1016/j.ajhg.2017.06.006. PMID: 28686854Free PMC Article
The paradox of FGFR3 signaling in skeletal dysplasia: why chondrocytes growth arrest while other cells over proliferate.
Krejci P
Mutat Res Rev Mutat Res 2014 Jan-Mar;759:40-8. Epub 2013 Dec 1 doi: 10.1016/j.mrrev.2013.11.001. PMID: 24295726
Immunoexpression of α2-integrin and Hsp47 in hereditary gingival fibromatosis and gingival fibromatosis-associated dental abnormalities.
Vieira-Júnior JR, de Oliveira-Santos C, Della-Coletta R, Cristianismo-Costa D, Paranaíba LM, Martelli-Júnior H
Med Oral Patol Oral Cir Bucal 2013 Jan 1;18(1):e45-8. doi: 10.4317/medoral.17970. PMID: 23229240Free PMC Article

Recent systematic reviews

Hereditary gingival fibromatosis in children: a systematic review of the literature.
Boutiou E, Ziogas IA, Giannis D, Doufexi AE
Clin Oral Investig 2021 Jun;25(6):3599-3607. Epub 2020 Nov 13 doi: 10.1007/s00784-020-03682-x. PMID: 33188467

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