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Congenital epulis

MedGen UID:
83962
Concept ID:
C0376319
Congenital Abnormality
Synonyms: Congenital Epulides; Congenital Epulis; Epulides, Congenital; Epulis, Congenital
SNOMED CT: Congenital myoblastoma (360525006); Congenital gingival granular cell tumor (360525006)
 
Monarch Initiative: MONDO:0015528
Orphanet: ORPHA157826

Definition

A rare soft tissue tumor characterized by a benign space occupying lesion in neonates, most typically located on the gingival mucosa overlying the anterior alveolar ridge of the maxilla near the canine, although the mandibular region may also be involved. Females are much more frequently affected than males. The tumor mostly presents as a single lesion, potentially interfering with feeding and respiration. Metastasis, malignant transformation, or recurrence after excision have not been reported. [from ORDO]

Professional guidelines

PubMed

Lim KH, Toner MB, Millar D, Jackson C
Ulster Med J 2023 Jan;92(1):16-18. Epub 2023 Jan 6 PMID: 36762132Free PMC Article
Laje P, Howell LJ, Johnson MP, Hedrick HL, Flake AW, Adzick NS
J Pediatr Surg 2013 Oct;48(10):2005-10. doi: 10.1016/j.jpedsurg.2013.02.031. PMID: 24094948

Recent clinical studies

Etiology

De Stefano S, Nadal López E, Sabas M
J Craniofac Surg 2023 Sep 1;34(6):1741-1743. Epub 2023 Aug 4 doi: 10.1097/SCS.0000000000009558. PMID: 37539953
Zheng W, Gai S, Qin J, Qiu F, Li B, Zou Y
Sci Rep 2021 Jan 14;11(1):1385. doi: 10.1038/s41598-021-80976-4. PMID: 33446872Free PMC Article
Laje P, Howell LJ, Johnson MP, Hedrick HL, Flake AW, Adzick NS
J Pediatr Surg 2013 Oct;48(10):2005-10. doi: 10.1016/j.jpedsurg.2013.02.031. PMID: 24094948
Childers EL, Fanburg-Smith JC
Ann Diagn Pathol 2011 Jun;15(3):157-61. Epub 2011 Mar 10 doi: 10.1016/j.anndiagpath.2010.10.003. PMID: 21393037
Guven S, Kaymakci A, Bugday MS, Yilmaz M
J Craniofac Surg 2009 May;20(3):976-7. doi: 10.1097/SCS.0b013e3181a2e1e5. PMID: 19461349

Diagnosis

Regaieg C, Triki M, Charfi M, Charfi S, Karray F, Abdelmoula M, Boudawara T, Hamed AB, Hmida N
Fetal Pediatr Pathol 2023 Aug;42(4):675-678. Epub 2023 Feb 10 doi: 10.1080/15513815.2023.2176728. PMID: 36762726
Lim KH, Toner MB, Millar D, Jackson C
Ulster Med J 2023 Jan;92(1):16-18. Epub 2023 Jan 6 PMID: 36762132Free PMC Article
Kokubun K, Matsuzaka K, Akashi Y, Sumi M, Nakajima K, Murakami S, Narita M, Shibahara T, Inoue T
Bull Tokyo Dent Coll 2018;59(2):127-132. doi: 10.2209/tdcpublication.2017-0028. PMID: 29962420
Merglová V, Mukensnabl P, Andrle P
BMJ Case Rep 2012 Jul 9;2012 doi: 10.1136/bcr.01.2012.5483. PMID: 22778448Free PMC Article
Rehman MU, Khanani MF, Bekdache G, Rehman Durrani NU, Jamil A, Rahmani A, Chedid F
J Coll Physicians Surg Pak 2012 Jan;22(1):56-7. PMID: 22237195

Therapy

Zheng W, Gai S, Qin J, Qiu F, Li B, Zou Y
Sci Rep 2021 Jan 14;11(1):1385. doi: 10.1038/s41598-021-80976-4. PMID: 33446872Free PMC Article
Cheong SP, Fahy CJ, Craigie MJ
Anaesth Intensive Care 2008 Jan;36(1):116-8. doi: 10.1177/0310057X0803600122. PMID: 18326145

Prognosis

Zheng W, Gai S, Qin J, Qiu F, Li B, Zou Y
Sci Rep 2021 Jan 14;11(1):1385. doi: 10.1038/s41598-021-80976-4. PMID: 33446872Free PMC Article
Eghbalian F, Monsef A
J Pediatr Hematol Oncol 2009 Mar;31(3):198-9. doi: 10.1097/MPH.0b013e31818ab2f7. PMID: 19262247
Kumar B, Sharma SB
J Pediatr Surg 2008 Sep;43(9):e9-11. doi: 10.1016/j.jpedsurg.2008.03.055. PMID: 18778989
Lapid O, Shaco-Levy R, Krieger Y, Kachko L, Sagi A
Pediatrics 2001 Feb;107(2):E22. doi: 10.1542/peds.107.2.e22. PMID: 11158496
Subramaniam R, Shah R, Kapur V
J Postgrad Med 1993 Jan-Mar;39(1):36. PMID: 8295145

Clinical prediction guides

Zheng W, Gai S, Qin J, Qiu F, Li B, Zou Y
Sci Rep 2021 Jan 14;11(1):1385. doi: 10.1038/s41598-021-80976-4. PMID: 33446872Free PMC Article
Souto GR, Caldeira PC, Johann AC, Andrade Marigo H, Souza SC, Mesquita RA
J Oral Pathol Med 2013 Jul;42(6):450-3. Epub 2013 Jan 22 doi: 10.1111/jop.12035. PMID: 23336292
Childers EL, Fanburg-Smith JC
Ann Diagn Pathol 2011 Jun;15(3):157-61. Epub 2011 Mar 10 doi: 10.1016/j.anndiagpath.2010.10.003. PMID: 21393037
Junquera LM, de Vicente JC, Vega JA, Losa JL, Albertos JM, López-Arranz JS
Br J Oral Maxillofac Surg 1997 Jun;35(3):180-4. doi: 10.1016/s0266-4356(97)90560-x. PMID: 9212295
Kameyama Y, Mizohata M, Takehana S, Murata H, Manabe H, Mukai Y
Virchows Arch A Pathol Anat Histopathol 1983;401(3):251-60. doi: 10.1007/BF00734843. PMID: 6415906

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