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Gingival fibroepithelial polyp

MedGen UID:
98314
•Concept ID:
C0399441
•
Neoplastic Process
Synonyms: FEP (fibroepithelial polyp) of gingiva; Fibroepithelial Polyp of Gingiva; fibroepithelial polyp of gingiva; Fibroepithelial Polyp of Gum; fibroepithelial polyp of gum; Fibroepithelial Polyp of the Gingiva; fibroepithelial polyp of the gingiva; Fibroepithelial Polyp of the Gum; fibroepithelial polyp of the gum; Fibrous epulis; Gingival Fibroepithelial Polyp; gingival fibroepithelial polyp; Gum Fibroepithelial Polyp; gum fibroepithelial polyp
SNOMED CT: Gingival fibroepithelial polyp (235001002); Fibrous epulis (235001002); FEP (fibroepithelial polyp) of gingiva (235001002)
 
Monarch Initiative: MONDO:0060768

Definition

A non-neoplastic nodular lesion that arises from the gingiva. It is composed of epithelial cells lining connective tissue stroma. [from NCI]

Recent clinical studies

Etiology

RT-PCR investigation of fibronectin mRNA isoforms in malignant, normal and reactive oral mucosa.
Mighell AJ, Thompson J, Hume WJ, Markham AF, Robinson PA
Oral Oncol 1997 May;33(3):155-62. doi: 10.1016/s0964-1955(96)00074-7. PMID: 9307723
Histochemical and immunohistochemical localisation of elastic system fibres in focal reactive overgrowths of oral mucosa.
Mighell AJ, Robinson PA, Hume WJ
J Oral Pathol Med 1997 Apr;26(4):153-8. doi: 10.1111/j.1600-0714.1997.tb00450.x. PMID: 9176788
Immunolocalisation of tenascin-C in focal reactive overgrowths of oral mucosa.
Mighell AJ, Robinson PA, Hume WJ
J Oral Pathol Med 1996 Apr;25(4):163-9. doi: 10.1111/j.1600-0714.1996.tb00214.x. PMID: 8809684

Diagnosis

Oral fibroepithelial polyps ("chewing granulomas") in 21 dogs: Histomorphology, immunohistochemical characterization, and clinical outcome.
Nordio L, Stefanello C, Gasparini S
Vet Pathol 2023 Mar;60(2):172-177. Epub 2022 Dec 24 doi: 10.1177/03009858221144708. PMID: 36565269
Three cases of palatal polyps in infants.
Tomizawa M, Kohno M, Noda T, Suzuki M
Int J Paediatr Dent 1999 Sep;9(3):213-7. doi: 10.1046/j.1365-263x.1999.00107.x. PMID: 10815579
Histochemical and immunohistochemical localisation of elastic system fibres in focal reactive overgrowths of oral mucosa.
Mighell AJ, Robinson PA, Hume WJ
J Oral Pathol Med 1997 Apr;26(4):153-8. doi: 10.1111/j.1600-0714.1997.tb00450.x. PMID: 9176788
The fibroepithelial polyp - management of a case.
Kryshtalskyj B, Holmes HI, Moncarz V
Ont Dent 1983 Nov;60(11):14-5, 17-8. PMID: 6581446
The fibrous epulis and related lesions. Granuloma pyogenicum, 'Pregnancy tumour', fibro-epithelial polyp and calcifying fibroblastic granuloma. A clinico-pathological study.
Lee KW
Periodontics 1968 Dec;6(6):277-92. PMID: 5248843

Therapy

Immunolocalisation of tenascin-C in focal reactive overgrowths of oral mucosa.
Mighell AJ, Robinson PA, Hume WJ
J Oral Pathol Med 1996 Apr;25(4):163-9. doi: 10.1111/j.1600-0714.1996.tb00214.x. PMID: 8809684

Clinical prediction guides

Oral fibroepithelial polyps ("chewing granulomas") in 21 dogs: Histomorphology, immunohistochemical characterization, and clinical outcome.
Nordio L, Stefanello C, Gasparini S
Vet Pathol 2023 Mar;60(2):172-177. Epub 2022 Dec 24 doi: 10.1177/03009858221144708. PMID: 36565269
Immunohistochemical Characterization of Gingival Fibromas.
Darling M, Li K, Burnside K, Smith N, Jackson-Boeters L, Hamilton D
Head Neck Pathol 2023 Jun;17(2):355-363. Epub 2022 Dec 6 doi: 10.1007/s12105-022-01493-y. PMID: 36472794Free PMC Article
RT-PCR investigation of fibronectin mRNA isoforms in malignant, normal and reactive oral mucosa.
Mighell AJ, Thompson J, Hume WJ, Markham AF, Robinson PA
Oral Oncol 1997 May;33(3):155-62. doi: 10.1016/s0964-1955(96)00074-7. PMID: 9307723
Immunolocalisation of tenascin-C in focal reactive overgrowths of oral mucosa.
Mighell AJ, Robinson PA, Hume WJ
J Oral Pathol Med 1996 Apr;25(4):163-9. doi: 10.1111/j.1600-0714.1996.tb00214.x. PMID: 8809684

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