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Rectal traditional serrated adenoma

MedGen UID:
474423
•Concept ID:
C3272790
•
Neoplastic Process
Synonyms: Rectal Serrated Adenoma; rectal serrated adenoma; Rectal Serrated Adenoma Type II; rectal serrated adenoma type II; Rectal Traditional Serrated Adenoma; rectal traditional serrated adenoma; Rectal TSA; rectal TSA
 
Monarch Initiative: MONDO:0006393

Definition

An adenoma that arises from the rectum. It is characterized by prominent serration of the glands. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRectal traditional serrated adenoma

Professional guidelines

PubMed

British Society of Gastroenterology position statement on serrated polyps in the colon and rectum.
East JE, Atkin WS, Bateman AC, Clark SK, Dolwani S, Ket SN, Leedham SJ, Phull PS, Rutter MD, Shepherd NA, Tomlinson I, Rees CJ
Gut 2017 Jul;66(7):1181-1196. Epub 2017 Apr 27 doi: 10.1136/gutjnl-2017-314005. PMID: 28450390Free PMC Article

Recent clinical studies

Etiology

Validation of serrated polyps (SPs) in Swedish pathology registers.
Bozorg SR, Song M, Emilsson L, Ludvigsson JF
BMC Gastroenterol 2019 Dec 31;20(1):3. doi: 10.1186/s12876-019-1134-6. PMID: 31892305Free PMC Article
Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer.
Mouchli MA, Ouk L, Scheitel MR, Chaudhry AP, Felmlee-Devine D, Grill DE, Rashtak S, Wang P, Wang J, Chaudhry R, Smyrk TC, Oberg AL, Druliner BR, Boardman LA
World J Gastroenterol 2018 Feb 28;24(8):905-916. doi: 10.3748/wjg.v24.i8.905. PMID: 29491684Free PMC Article
British Society of Gastroenterology position statement on serrated polyps in the colon and rectum.
East JE, Atkin WS, Bateman AC, Clark SK, Dolwani S, Ket SN, Leedham SJ, Phull PS, Rutter MD, Shepherd NA, Tomlinson I, Rees CJ
Gut 2017 Jul;66(7):1181-1196. Epub 2017 Apr 27 doi: 10.1136/gutjnl-2017-314005. PMID: 28450390Free PMC Article
Increased Risk of Colorectal Cancer Development Among Patients With Serrated Polyps.
Erichsen R, Baron JA, Hamilton-Dutoit SJ, Snover DC, Torlakovic EE, Pedersen L, Frøslev T, Vyberg M, Hamilton SR, Sørensen HT
Gastroenterology 2016 Apr;150(4):895-902.e5. Epub 2015 Dec 8 doi: 10.1053/j.gastro.2015.11.046. PMID: 26677986
Progress and opportunities in molecular pathological epidemiology of colorectal premalignant lesions.
Lochhead P, Chan AT, Giovannucci E, Fuchs CS, Wu K, Nishihara R, O'Brien M, Ogino S
Am J Gastroenterol 2014 Aug;109(8):1205-14. Epub 2014 Jun 17 doi: 10.1038/ajg.2014.153. PMID: 24935274Free PMC Article

Diagnosis

Validation of serrated polyps (SPs) in Swedish pathology registers.
Bozorg SR, Song M, Emilsson L, Ludvigsson JF
BMC Gastroenterol 2019 Dec 31;20(1):3. doi: 10.1186/s12876-019-1134-6. PMID: 31892305Free PMC Article
British Society of Gastroenterology position statement on serrated polyps in the colon and rectum.
East JE, Atkin WS, Bateman AC, Clark SK, Dolwani S, Ket SN, Leedham SJ, Phull PS, Rutter MD, Shepherd NA, Tomlinson I, Rees CJ
Gut 2017 Jul;66(7):1181-1196. Epub 2017 Apr 27 doi: 10.1136/gutjnl-2017-314005. PMID: 28450390Free PMC Article
Increased Risk of Colorectal Cancer Development Among Patients With Serrated Polyps.
Erichsen R, Baron JA, Hamilton-Dutoit SJ, Snover DC, Torlakovic EE, Pedersen L, Frøslev T, Vyberg M, Hamilton SR, Sørensen HT
Gastroenterology 2016 Apr;150(4):895-902.e5. Epub 2015 Dec 8 doi: 10.1053/j.gastro.2015.11.046. PMID: 26677986
Morphologic and molecular characterization of traditional serrated adenomas of the distal colon and rectum.
Wiland HO 4th, Shadrach B, Allende D, Carver P, Goldblum JR, Liu X, Patil DT, Rybicki LA, Pai RK
Am J Surg Pathol 2014 Sep;38(9):1290-7. doi: 10.1097/PAS.0000000000000253. PMID: 25127095
The association of lifestyle and dietary factors with the risk for serrated polyps of the colorectum.
Wallace K, Grau MV, Ahnen D, Snover DC, Robertson DJ, Mahnke D, Gui J, Barry EL, Summers RW, McKeown-Eyssen G, Haile RW, Baron JA
Cancer Epidemiol Biomarkers Prev 2009 Aug;18(8):2310-7. doi: 10.1158/1055-9965.EPI-09-0211. PMID: 19661090Free PMC Article

Therapy

Validation of serrated polyps (SPs) in Swedish pathology registers.
Bozorg SR, Song M, Emilsson L, Ludvigsson JF
BMC Gastroenterol 2019 Dec 31;20(1):3. doi: 10.1186/s12876-019-1134-6. PMID: 31892305Free PMC Article
British Society of Gastroenterology position statement on serrated polyps in the colon and rectum.
East JE, Atkin WS, Bateman AC, Clark SK, Dolwani S, Ket SN, Leedham SJ, Phull PS, Rutter MD, Shepherd NA, Tomlinson I, Rees CJ
Gut 2017 Jul;66(7):1181-1196. Epub 2017 Apr 27 doi: 10.1136/gutjnl-2017-314005. PMID: 28450390Free PMC Article
Lifetime alcohol intake is associated with an increased risk of KRAS+ and BRAF-/KRAS- but not BRAF+ colorectal cancer.
Jayasekara H, MacInnis RJ, Williamson EJ, Hodge AM, Clendenning M, Rosty C, Walters R, Room R, Southey MC, Jenkins MA, Milne RL, Hopper JL, Giles GG, Buchanan DD, English DR
Int J Cancer 2017 Apr 1;140(7):1485-1493. Epub 2016 Dec 26 doi: 10.1002/ijc.30568. PMID: 27943267
The association of lifestyle and dietary factors with the risk for serrated polyps of the colorectum.
Wallace K, Grau MV, Ahnen D, Snover DC, Robertson DJ, Mahnke D, Gui J, Barry EL, Summers RW, McKeown-Eyssen G, Haile RW, Baron JA
Cancer Epidemiol Biomarkers Prev 2009 Aug;18(8):2310-7. doi: 10.1158/1055-9965.EPI-09-0211. PMID: 19661090Free PMC Article

Prognosis

Validation of serrated polyps (SPs) in Swedish pathology registers.
Bozorg SR, Song M, Emilsson L, Ludvigsson JF
BMC Gastroenterol 2019 Dec 31;20(1):3. doi: 10.1186/s12876-019-1134-6. PMID: 31892305Free PMC Article
Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer.
Mouchli MA, Ouk L, Scheitel MR, Chaudhry AP, Felmlee-Devine D, Grill DE, Rashtak S, Wang P, Wang J, Chaudhry R, Smyrk TC, Oberg AL, Druliner BR, Boardman LA
World J Gastroenterol 2018 Feb 28;24(8):905-916. doi: 10.3748/wjg.v24.i8.905. PMID: 29491684Free PMC Article
Increased Risk of Colorectal Cancer Development Among Patients With Serrated Polyps.
Erichsen R, Baron JA, Hamilton-Dutoit SJ, Snover DC, Torlakovic EE, Pedersen L, Frøslev T, Vyberg M, Hamilton SR, Sørensen HT
Gastroenterology 2016 Apr;150(4):895-902.e5. Epub 2015 Dec 8 doi: 10.1053/j.gastro.2015.11.046. PMID: 26677986
Morphologic and molecular characterization of traditional serrated adenomas of the distal colon and rectum.
Wiland HO 4th, Shadrach B, Allende D, Carver P, Goldblum JR, Liu X, Patil DT, Rybicki LA, Pai RK
Am J Surg Pathol 2014 Sep;38(9):1290-7. doi: 10.1097/PAS.0000000000000253. PMID: 25127095
Underwater endoscopic mucosal resection of colorectal neoplasia is easily learned, efficacious, and safe.
Wang AY, Flynn MM, Patrie JT, Cox DG, Bleibel W, Mann JA, Sauer BG, Shami VM
Surg Endosc 2014 Apr;28(4):1348-54. doi: 10.1007/s00464-013-3297-5. PMID: 24232051

Clinical prediction guides

Serrated adenomas with a BRAF mutation in a young patient with familial adenomatous polyposis.
Moriichi K, Tanabe H, Ono Y, Kobayashi Y, Murakami Y, Iwama T, Kunogi T, Sasaki T, Takahashi K, Ando K, Ueno N, Kashima S, Takei H, Mizukami Y, Fujiya M, Okumura T
Int J Colorectal Dis 2020 Oct;35(10):1967-1972. Epub 2020 Jun 5 doi: 10.1007/s00384-020-03657-0. PMID: 32504335
Validation of serrated polyps (SPs) in Swedish pathology registers.
Bozorg SR, Song M, Emilsson L, Ludvigsson JF
BMC Gastroenterol 2019 Dec 31;20(1):3. doi: 10.1186/s12876-019-1134-6. PMID: 31892305Free PMC Article
Lifetime alcohol intake is associated with an increased risk of KRAS+ and BRAF-/KRAS- but not BRAF+ colorectal cancer.
Jayasekara H, MacInnis RJ, Williamson EJ, Hodge AM, Clendenning M, Rosty C, Walters R, Room R, Southey MC, Jenkins MA, Milne RL, Hopper JL, Giles GG, Buchanan DD, English DR
Int J Cancer 2017 Apr 1;140(7):1485-1493. Epub 2016 Dec 26 doi: 10.1002/ijc.30568. PMID: 27943267
Increased Risk of Colorectal Cancer Development Among Patients With Serrated Polyps.
Erichsen R, Baron JA, Hamilton-Dutoit SJ, Snover DC, Torlakovic EE, Pedersen L, Frøslev T, Vyberg M, Hamilton SR, Sørensen HT
Gastroenterology 2016 Apr;150(4):895-902.e5. Epub 2015 Dec 8 doi: 10.1053/j.gastro.2015.11.046. PMID: 26677986
Underwater endoscopic mucosal resection of colorectal neoplasia is easily learned, efficacious, and safe.
Wang AY, Flynn MM, Patrie JT, Cox DG, Bleibel W, Mann JA, Sauer BG, Shami VM
Surg Endosc 2014 Apr;28(4):1348-54. doi: 10.1007/s00464-013-3297-5. PMID: 24232051

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