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Rectal Serrated Lesions and Polyps

MedGen UID:
474425
Concept ID:
C3272792
Neoplastic Process
Synonyms: Rectal Sessile Serrated Adenoma; Rectal Sessile Serrated Adenoma/Polyp; Rectal Sessile Serrated Polyp; Rectal SSA; Rectal SSA/P; Rectal SSP

Definition

Polyps that arises from the rectum. They are characterized by the presence of serrated glands and the absence of generalized dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRectal Serrated Lesions and Polyps

Professional guidelines

PubMed

East JE, Atkin WS, Bateman AC, Clark SK, Dolwani S, Ket SN, Leedham SJ, Phull PS, Rutter MD, Shepherd NA, Tomlinson I, Rees CJ
Gut 2017 Jul;66(7):1181-1196. Epub 2017 Apr 27 doi: 10.1136/gutjnl-2017-314005. PMID: 28450390Free PMC Article

Recent clinical studies

Etiology

Sung LB, Coleman HG, Shivappa N, Hébert JR, Murff HJ, Milne GL, Ness RM, Smalley WE, Zheng W, Shrubsole MJ
Nutr Cancer 2023;75(10):1900-1910. Epub 2023 Nov 30 doi: 10.1080/01635581.2023.2261651. PMID: 37791878Free PMC Article
Ashktorab H, Sherif Z, Tarjoman T, Azam S, Lee E, Shokrani B, Okereke I, Soleimani A, Carethers JM, Laiyemo AO, Aduli F, Nouraie M, Habtezion A, Brim H
Dig Dis Sci 2020 Sep;65(9):2686-2690. Epub 2019 Dec 12 doi: 10.1007/s10620-019-05991-y. PMID: 31832971Free PMC Article
East JE, Atkin WS, Bateman AC, Clark SK, Dolwani S, Ket SN, Leedham SJ, Phull PS, Rutter MD, Shepherd NA, Tomlinson I, Rees CJ
Gut 2017 Jul;66(7):1181-1196. Epub 2017 Apr 27 doi: 10.1136/gutjnl-2017-314005. PMID: 28450390Free PMC Article
Lochhead P, Chan AT, Giovannucci E, Fuchs CS, Wu K, Nishihara R, O'Brien M, Ogino S
Am J Gastroenterol 2014 Aug;109(8):1205-14. Epub 2014 Jun 17 doi: 10.1038/ajg.2014.153. PMID: 24935274Free PMC Article
Leonard DF, Dozois EJ, Smyrk TC, Suwanthanma W, Baron TH Sr, Cima RR, Larson DW
Br J Surg 2011 Dec;98(12):1685-94. Epub 2011 Aug 30 doi: 10.1002/bjs.7654. PMID: 22034178

Diagnosis

Sung LB, Coleman HG, Shivappa N, Hébert JR, Murff HJ, Milne GL, Ness RM, Smalley WE, Zheng W, Shrubsole MJ
Nutr Cancer 2023;75(10):1900-1910. Epub 2023 Nov 30 doi: 10.1080/01635581.2023.2261651. PMID: 37791878Free PMC Article
Joh HK, Lee DH, Hur J, Nimptsch K, Chang Y, Joung H, Zhang X, Rezende LFM, Lee JE, Ng K, Yuan C, Tabung FK, Meyerhardt JA, Chan AT, Pischon T, Song M, Fuchs CS, Willett WC, Cao Y, Ogino S, Giovannucci E, Wu K
Gastroenterology 2021 Jul;161(1):128-142.e20. Epub 2021 Mar 19 doi: 10.1053/j.gastro.2021.03.028. PMID: 33753105Free PMC Article
Ashktorab H, Sherif Z, Tarjoman T, Azam S, Lee E, Shokrani B, Okereke I, Soleimani A, Carethers JM, Laiyemo AO, Aduli F, Nouraie M, Habtezion A, Brim H
Dig Dis Sci 2020 Sep;65(9):2686-2690. Epub 2019 Dec 12 doi: 10.1007/s10620-019-05991-y. PMID: 31832971Free PMC Article
East JE, Atkin WS, Bateman AC, Clark SK, Dolwani S, Ket SN, Leedham SJ, Phull PS, Rutter MD, Shepherd NA, Tomlinson I, Rees CJ
Gut 2017 Jul;66(7):1181-1196. Epub 2017 Apr 27 doi: 10.1136/gutjnl-2017-314005. PMID: 28450390Free PMC Article
Wiland HO 4th, Shadrach B, Allende D, Carver P, Goldblum JR, Liu X, Patil DT, Rybicki LA, Pai RK
Am J Surg Pathol 2014 Sep;38(9):1290-7. doi: 10.1097/PAS.0000000000000253. PMID: 25127095

Therapy

Sung LB, Coleman HG, Shivappa N, Hébert JR, Murff HJ, Milne GL, Ness RM, Smalley WE, Zheng W, Shrubsole MJ
Nutr Cancer 2023;75(10):1900-1910. Epub 2023 Nov 30 doi: 10.1080/01635581.2023.2261651. PMID: 37791878Free PMC Article
Joh HK, Lee DH, Hur J, Nimptsch K, Chang Y, Joung H, Zhang X, Rezende LFM, Lee JE, Ng K, Yuan C, Tabung FK, Meyerhardt JA, Chan AT, Pischon T, Song M, Fuchs CS, Willett WC, Cao Y, Ogino S, Giovannucci E, Wu K
Gastroenterology 2021 Jul;161(1):128-142.e20. Epub 2021 Mar 19 doi: 10.1053/j.gastro.2021.03.028. PMID: 33753105Free PMC Article
Ashktorab H, Sherif Z, Tarjoman T, Azam S, Lee E, Shokrani B, Okereke I, Soleimani A, Carethers JM, Laiyemo AO, Aduli F, Nouraie M, Habtezion A, Brim H
Dig Dis Sci 2020 Sep;65(9):2686-2690. Epub 2019 Dec 12 doi: 10.1007/s10620-019-05991-y. PMID: 31832971Free PMC Article
East JE, Atkin WS, Bateman AC, Clark SK, Dolwani S, Ket SN, Leedham SJ, Phull PS, Rutter MD, Shepherd NA, Tomlinson I, Rees CJ
Gut 2017 Jul;66(7):1181-1196. Epub 2017 Apr 27 doi: 10.1136/gutjnl-2017-314005. PMID: 28450390Free PMC Article
Church J, Kravochuck S
Dis Colon Rectum 2016 Jun;59(6):565-9. doi: 10.1097/DCR.0000000000000575. PMID: 27145315

Prognosis

Bae JH, Lee C, Kang HY, Kwak MS, Doo EY, Seo JY, Song JH, Yang SY, Yang JI, Lim SH, Yim JY, Lim JH, Chung GE, Chung SJ, Jin EH, Park B, Kim JS
Clin Gastroenterol Hepatol 2019 Nov;17(12):2479-2488.e4. Epub 2019 Feb 14 doi: 10.1016/j.cgh.2019.02.019. PMID: 30772588
Vleugels JLA, Dijkgraaf MGW, Hazewinkel Y, Wanders LK, Fockens P, Dekker E; DISCOUNT study group
Gastroenterology 2018 May;154(6):1682-1693.e1. Epub 2018 Feb 6 doi: 10.1053/j.gastro.2018.01.063. PMID: 29425923
Church J, Kravochuck S
Dis Colon Rectum 2016 Jun;59(6):565-9. doi: 10.1097/DCR.0000000000000575. PMID: 27145315
Erichsen R, Baron JA, Hamilton-Dutoit SJ, Snover DC, Torlakovic EE, Pedersen L, Frøslev T, Vyberg M, Hamilton SR, Sørensen HT
Gastroenterology 2016 Apr;150(4):895-902.e5. Epub 2015 Dec 8 doi: 10.1053/j.gastro.2015.11.046. PMID: 26677986
Wiland HO 4th, Shadrach B, Allende D, Carver P, Goldblum JR, Liu X, Patil DT, Rybicki LA, Pai RK
Am J Surg Pathol 2014 Sep;38(9):1290-7. doi: 10.1097/PAS.0000000000000253. PMID: 25127095

Clinical prediction guides

Sung LB, Coleman HG, Shivappa N, Hébert JR, Murff HJ, Milne GL, Ness RM, Smalley WE, Zheng W, Shrubsole MJ
Nutr Cancer 2023;75(10):1900-1910. Epub 2023 Nov 30 doi: 10.1080/01635581.2023.2261651. PMID: 37791878Free PMC Article
Ashktorab H, Sherif Z, Tarjoman T, Azam S, Lee E, Shokrani B, Okereke I, Soleimani A, Carethers JM, Laiyemo AO, Aduli F, Nouraie M, Habtezion A, Brim H
Dig Dis Sci 2020 Sep;65(9):2686-2690. Epub 2019 Dec 12 doi: 10.1007/s10620-019-05991-y. PMID: 31832971Free PMC Article
Bae JH, Lee C, Kang HY, Kwak MS, Doo EY, Seo JY, Song JH, Yang SY, Yang JI, Lim SH, Yim JY, Lim JH, Chung GE, Chung SJ, Jin EH, Park B, Kim JS
Clin Gastroenterol Hepatol 2019 Nov;17(12):2479-2488.e4. Epub 2019 Feb 14 doi: 10.1016/j.cgh.2019.02.019. PMID: 30772588
Erichsen R, Baron JA, Hamilton-Dutoit SJ, Snover DC, Torlakovic EE, Pedersen L, Frøslev T, Vyberg M, Hamilton SR, Sørensen HT
Gastroenterology 2016 Apr;150(4):895-902.e5. Epub 2015 Dec 8 doi: 10.1053/j.gastro.2015.11.046. PMID: 26677986
Kim KM, Lee EJ, Ha S, Kang SY, Jang KT, Park CK, Kim JY, Kim YH, Chang DK, Odze RD
Am J Surg Pathol 2011 Sep;35(9):1274-86. doi: 10.1097/PAS.0b013e318224cd2e. PMID: 21836485

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