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Colorectal sessile serrated adenoma/polyp

MedGen UID:
415420
•Concept ID:
C2826783
•
Neoplastic Process
Synonyms: Colorectal Mixed Hyperplastic Adenomatous Polyp; colorectal mixed hyperplastic adenomatous polyp; Colorectal Mixed Hyperplastic Adenomatous Polyp/Serrated Adenoma; colorectal mixed hyperplastic adenomatous polyp/serrated adenoma; Colorectal Serrated Lesions and Polyps; Colorectal Sessile Serrated Adenoma; colorectal sessile serrated adenoma; Colorectal Sessile Serrated Adenoma/Polyp; colorectal sessile serrated adenoma/polyp; Colorectal Sessile Serrated Polyp; colorectal sessile serrated polyp; Colorectal SSA; colorectal SSA; Colorectal SSA/P; colorectal SSA/P; Colorectal SSP; colorectal SSP
 
Monarch Initiative: MONDO:0006164

Definition

Polyps that arises from the colon or rectum. They are characterized by the presence of serrated glands and the absence of generalized dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal sessile serrated adenoma/polyp

Professional guidelines

PubMed

Clinical and endoscopic characteristics and management of 220 cases with serrated polyps.
Lu Q, Peng QZ, Wang LS, Yao J, Li DF
Asian J Surg 2024 Jan;47(1):195-200. Epub 2023 Aug 2 doi: 10.1016/j.asjsur.2023.07.027. PMID: 37541874
Sessile serrated lesions: Clinicopathological characteristics, endoscopic diagnosis, and management.
Murakami T, Kurosawa T, Fukushima H, Shibuya T, Yao T, Nagahara A
Dig Endosc 2022 Sep;34(6):1096-1109. Epub 2022 Mar 29 doi: 10.1111/den.14273. PMID: 35352394
Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302

Recent clinical studies

Etiology

Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Serrated Polyps of Colon and Rectum: a Clinicopathologic Review.
Geramizadeh B, Robertson S
J Gastrointest Cancer 2017 Dec;48(4):291-298. doi: 10.1007/s12029-017-9977-y. PMID: 28639142
Sessile Serrated Polyps and Colon Cancer Prevention.
Rashtak S, Rego R, Sweetser SR, Sinicrope FA
Cancer Prev Res (Phila) 2017 May;10(5):270-278. Epub 2017 Mar 21 doi: 10.1158/1940-6207.CAPR-16-0264. PMID: 28325827
Serrated and non-serrated precursor lesions of colorectal cancer.
Langner C
Dig Dis 2015;33(1):28-37. Epub 2014 Dec 17 doi: 10.1159/000366032. PMID: 25531494
Colorectal serrated pathway cancers and precursors.
O'Brien MJ, Zhao Q, Yang S
Histopathology 2015 Jan;66(1):49-65. Epub 2014 Dec 1 doi: 10.1111/his.12564. PMID: 25263173

Diagnosis

Sessile serrated lesions: Clinicopathological characteristics, endoscopic diagnosis, and management.
Murakami T, Kurosawa T, Fukushima H, Shibuya T, Yao T, Nagahara A
Dig Endosc 2022 Sep;34(6):1096-1109. Epub 2022 Mar 29 doi: 10.1111/den.14273. PMID: 35352394
Serrated polyps of the colon and rectum: Remove or not?
Sano W, Hirata D, Teramoto A, Iwatate M, Hattori S, Fujita M, Sano Y
World J Gastroenterol 2020 May 21;26(19):2276-2285. doi: 10.3748/wjg.v26.i19.2276. PMID: 32476792Free PMC Article
Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Endoscopic diagnosis of sessile serrated adenoma/polyp with and without dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
World J Gastroenterol 2018 Aug 7;24(29):3250-3259. doi: 10.3748/wjg.v24.i29.3250. PMID: 30090005Free PMC Article
Sessile serrated adenoma/polyps: Where are we at in 2016?
Singh R, Zorrón Cheng Tao Pu L, Koay D, Burt A
World J Gastroenterol 2016 Sep 14;22(34):7754-9. doi: 10.3748/wjg.v22.i34.7754. PMID: 27678358Free PMC Article

Therapy

Validation of serrated polyps (SPs) in Swedish pathology registers.
Bozorg SR, Song M, Emilsson L, Ludvigsson JF
BMC Gastroenterol 2019 Dec 31;20(1):3. doi: 10.1186/s12876-019-1134-6. PMID: 31892305Free PMC Article
Folic acid supplementation and risk of colorectal neoplasia during long-term follow-up of a randomized clinical trial.
Passarelli MN, Barry EL, Rees JR, Mott LA, Zhang D, Ahnen DJ, Bresalier RS, Haile RW, McKeown-Eyssen G, Snover DC, Cole BF, Baron JA
Am J Clin Nutr 2019 Oct 1;110(4):903-911. doi: 10.1093/ajcn/nqz160. PMID: 31401653Free PMC Article
Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Impact of an Endoscopic Quality Improvement Program Focused on Adenoma Detection on Sessile Serrated Adenoma/Polyp Detection.
Racho RG, Krishna M, Coe SG, Thomas CS, Crook JE, Diehl NN, Wallace MB
Dig Dis Sci 2017 Jun;62(6):1464-1471. Epub 2017 Apr 25 doi: 10.1007/s10620-017-4582-2. PMID: 28444509
Efficiency of endocytoscopy in differentiating types of serrated polyps.
Kutsukawa M, Kudo SE, Ikehara N, Ogawa Y, Wakamura K, Mori Y, Ichimasa K, Misawa M, Kudo T, Wada Y, Hayashi T, Miyachi H, Inoue H, Hamatani S
Gastrointest Endosc 2014 Apr;79(4):648-56. Epub 2013 Oct 8 doi: 10.1016/j.gie.2013.08.029. PMID: 24119508

Prognosis

Validation of serrated polyps (SPs) in Swedish pathology registers.
Bozorg SR, Song M, Emilsson L, Ludvigsson JF
BMC Gastroenterol 2019 Dec 31;20(1):3. doi: 10.1186/s12876-019-1134-6. PMID: 31892305Free PMC Article
Clinical and endoscopic evaluations of sessile serrated adenoma/polyps with cytological dysplasia.
Sano W, Fujimori T, Ichikawa K, Sunakawa H, Utsumi T, Iwatate M, Hasuike N, Hattori S, Kosaka H, Sano Y
J Gastroenterol Hepatol 2018 Aug;33(8):1454-1460. Epub 2018 Mar 25 doi: 10.1111/jgh.14099. PMID: 29377243
Prevalence of sessile serrated adenoma/polyp in hyperplastic-appearing diminutive rectosigmoid polyps.
Ponugoti P, Lin J, Odze R, Snover D, Kahi C, Rex DK
Gastrointest Endosc 2017 Mar;85(3):622-627. Epub 2016 Oct 19 doi: 10.1016/j.gie.2016.10.022. PMID: 27771216
Endoscopic diagnosis of colorectal serrated lesions: Current status and future perspectives based on the results of a questionnaire survey.
Matsuda T, Oka S, Ikematsu H, Matsushita HO, Mori Y, Takeuchi Y, Tamai N, Kawamura T, Chino A, Keum B, Khomvilai S, Uraoka T
Dig Endosc 2016 Apr;28 Suppl 1:35-42. doi: 10.1111/den.12632. PMID: 26864882
Advantages of magnifying narrow-band imaging for diagnosing colorectal cancer coexisting with sessile serrated adenoma/polyp.
Chino A, Osumi H, Kishihara T, Morishige K, Ishikawa H, Tamegai Y, Igarashi M
Dig Endosc 2016 Apr;28 Suppl 1:53-9. doi: 10.1111/den.12631. PMID: 26864801

Clinical prediction guides

Clinical and endoscopic evaluations of sessile serrated adenoma/polyps with cytological dysplasia.
Sano W, Fujimori T, Ichikawa K, Sunakawa H, Utsumi T, Iwatate M, Hasuike N, Hattori S, Kosaka H, Sano Y
J Gastroenterol Hepatol 2018 Aug;33(8):1454-1460. Epub 2018 Mar 25 doi: 10.1111/jgh.14099. PMID: 29377243
Sessile Serrated Polyps and Colon Cancer Prevention.
Rashtak S, Rego R, Sweetser SR, Sinicrope FA
Cancer Prev Res (Phila) 2017 May;10(5):270-278. Epub 2017 Mar 21 doi: 10.1158/1940-6207.CAPR-16-0264. PMID: 28325827
Prevalence of sessile serrated adenoma/polyp in hyperplastic-appearing diminutive rectosigmoid polyps.
Ponugoti P, Lin J, Odze R, Snover D, Kahi C, Rex DK
Gastrointest Endosc 2017 Mar;85(3):622-627. Epub 2016 Oct 19 doi: 10.1016/j.gie.2016.10.022. PMID: 27771216
Qualities of sessile serrated adenoma/polyp/lesion and its borderline variant in the context of synchronous colorectal carcinoma.
Mohammadi M, Kristensen MH, Nielsen HJ, Bonde JH, Holck S
J Clin Pathol 2012 Oct;65(10):924-7. Epub 2012 Jul 10 doi: 10.1136/jclinpath-2012-200803. PMID: 22782936
Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from Korea.
Kim KM, Lee EJ, Ha S, Kang SY, Jang KT, Park CK, Kim JY, Kim YH, Chang DK, Odze RD
Am J Surg Pathol 2011 Sep;35(9):1274-86. doi: 10.1097/PAS.0b013e318224cd2e. PMID: 21836485

Recent systematic reviews

Clinical and endoscopic characteristics of colorectal sessile serrated lesions with or without dysplasia/carcinoma: A systematic review and meta-analysis.
Zhang QQ, Wu JD, Li XY, Fang FF, Li GP, Bai T, Song J
J Dig Dis 2024 Jul;25(7):424-435. Epub 2024 Aug 5 doi: 10.1111/1751-2980.13302. PMID: 39104049

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