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Colorectal Filiform Serrated Adenoma

MedGen UID:
474428
•Concept ID:
C3272795
•
Neoplastic Process
Synonym: Colorectal FSA

Definition

A traditional serrated adenoma that arises from the colon or rectum. It is characterized by the presence of prominent villous projections of the neoplastic epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Filiform Serrated Adenoma

Recent clinical studies

Etiology

Selective expression of gastric mucin MUC6 in colonic sessile serrated adenoma but not in hyperplastic polyp aids in morphological diagnosis of serrated polyps.
Owens SR, Chiosea SI, Kuan SF
Mod Pathol 2008 Jun;21(6):660-9. doi: 10.1038/modpathol.2008.55. PMID: 18360351
Filiform serrated adenomas: a clinicopathologic and immunophenotypic study of 18 cases.
Yantiss RK, Oh KY, Chen YT, Redston M, Odze RD
Am J Surg Pathol 2007 Aug;31(8):1238-45. doi: 10.1097/PAS.0b013e31802d74c0. PMID: 17667549

Diagnosis

Traditional serrated adenoma (TSA): morphological questions, queries and quandaries.
Chetty R
J Clin Pathol 2016 Jan;69(1):6-11. Epub 2015 Nov 9 doi: 10.1136/jclinpath-2015-203452. PMID: 26553935
Selective expression of gastric mucin MUC6 in colonic sessile serrated adenoma but not in hyperplastic polyp aids in morphological diagnosis of serrated polyps.
Owens SR, Chiosea SI, Kuan SF
Mod Pathol 2008 Jun;21(6):660-9. doi: 10.1038/modpathol.2008.55. PMID: 18360351

Prognosis

Traditional serrated adenoma (TSA): morphological questions, queries and quandaries.
Chetty R
J Clin Pathol 2016 Jan;69(1):6-11. Epub 2015 Nov 9 doi: 10.1136/jclinpath-2015-203452. PMID: 26553935

Clinical prediction guides

Traditional serrated adenoma (TSA): morphological questions, queries and quandaries.
Chetty R
J Clin Pathol 2016 Jan;69(1):6-11. Epub 2015 Nov 9 doi: 10.1136/jclinpath-2015-203452. PMID: 26553935
Filiform serrated adenomatous polyposis arising in a diverted rectum of an inflammatory bowel disease patient.
Klarskov L, Mogensen AM, Jespersen N, Ingeholm P, Holck S
APMIS 2011 Jun;119(6):393-8. Epub 2011 Feb 11 doi: 10.1111/j.1600-0463.2011.02717.x. PMID: 21569098
Selective expression of gastric mucin MUC6 in colonic sessile serrated adenoma but not in hyperplastic polyp aids in morphological diagnosis of serrated polyps.
Owens SR, Chiosea SI, Kuan SF
Mod Pathol 2008 Jun;21(6):660-9. doi: 10.1038/modpathol.2008.55. PMID: 18360351

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