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Malignant Conjunctival Neoplasm

MedGen UID:
56316
•Concept ID:
C0153628
•
Neoplastic Process
Synonyms: Malignant Conjunctiva Neoplasm; Malignant Conjunctiva Tumor; Malignant Conjunctival Tumor; Malignant Neoplasm of Conjunctiva; Malignant Neoplasm of the Conjunctiva; Malignant tumor of conjunctiva; Malignant Tumor of Conjunctiva; Malignant Tumor of the Conjunctiva
SNOMED CT: Malignant tumor of conjunctiva (363463000)

Definition

A primary or metastatic malignant neoplasm that affects the conjunctiva. [from NCI]

Professional guidelines

PubMed

Ocular surface squamous neoplasia: management and outcomes.
Hӧllhumer R, Williams S, Michelow P
Eye (Lond) 2021 Jun;35(6):1562-1573. Epub 2021 Feb 9 doi: 10.1038/s41433-021-01422-3. PMID: 33564137Free PMC Article
Clinical treatment options for early-stage and advanced conjunctival melanoma.
Zeng Y, Hu C, Shu L, Pan Y, Zhao L, Pu X, Wu F
Surv Ophthalmol 2021 May-Jun;66(3):461-470. Epub 2020 Sep 25 doi: 10.1016/j.survophthal.2020.09.004. PMID: 32980421
Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796

Recent clinical studies

Etiology

Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Conjunctival and uveal melanoma: Survival and risk factors following orbital exenteration.
Baum SH, Westekemper H, Bechrakis NE, Mohr C
Eur J Ophthalmol 2022 Jan;32(1):612-619. Epub 2021 Feb 11 doi: 10.1177/1120672121995131. PMID: 33573425
Tumors of the conjunctiva and cornea.
Shields CL, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1930-1948. doi: 10.4103/ijo.IJO_2040_19. PMID: 31755426Free PMC Article
Management of pigmented conjunctival lesions.
Oellers P, Karp CL
Ocul Surf 2012 Oct;10(4):251-63. Epub 2012 Aug 11 doi: 10.1016/j.jtos.2012.08.002. PMID: 23084146
Conjunctival melanoma.
Seregard S
Surv Ophthalmol 1998 Jan-Feb;42(4):321-50. doi: 10.1016/s0039-6257(97)00122-7. PMID: 9493274

Diagnosis

Conjunctival Lymphoma.
McGrath LA, Ryan DA, Warrier SK, Coupland SE, Glasson WJ
Eye (Lond) 2023 Apr;37(5):837-848. Epub 2022 Jul 26 doi: 10.1038/s41433-022-02176-2. PMID: 35882984Free PMC Article
Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Ocular surface squamous neoplasia: management and outcomes.
Hӧllhumer R, Williams S, Michelow P
Eye (Lond) 2021 Jun;35(6):1562-1573. Epub 2021 Feb 9 doi: 10.1038/s41433-021-01422-3. PMID: 33564137Free PMC Article
Tumors of the conjunctiva and cornea.
Shields CL, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1930-1948. doi: 10.4103/ijo.IJO_2040_19. PMID: 31755426Free PMC Article
Conjunctival lymphoma.
Li JJ, Chen W, Sadeghi N
BMJ Case Rep 2019 Jul 10;12(7) doi: 10.1136/bcr-2019-229599. PMID: 31296640Free PMC Article

Therapy

Conjunctival Lymphoma.
McGrath LA, Ryan DA, Warrier SK, Coupland SE, Glasson WJ
Eye (Lond) 2023 Apr;37(5):837-848. Epub 2022 Jul 26 doi: 10.1038/s41433-022-02176-2. PMID: 35882984Free PMC Article
Use of interferon alpha 2b to manage conjunctival primary acquired melanosis and conjunctival melanoma.
Cid-Bertomeu P, Huerva V
Surv Ophthalmol 2022 Sep-Oct;67(5):1391-1404. Epub 2022 Mar 9 doi: 10.1016/j.survophthal.2022.03.003. PMID: 35278438
Conjunctival Melanoma: Current Treatments and Future Options.
Grimes JM, Shah NV, Samie FH, Carvajal RD, Marr BP
Am J Clin Dermatol 2020 Jun;21(3):371-381. doi: 10.1007/s40257-019-00500-3. PMID: 31965542
Conjunctival lymphoma.
Li JJ, Chen W, Sadeghi N
BMJ Case Rep 2019 Jul 10;12(7) doi: 10.1136/bcr-2019-229599. PMID: 31296640Free PMC Article
Pharmacotherapy and Immunotherapy of Conjunctival Tumors.
Midena E, Frizziero L, Parrozzani R
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):121-131. doi: 10.22608/APO.201751. PMID: 28399343

Prognosis

Conjunctival Lymphoma.
McGrath LA, Ryan DA, Warrier SK, Coupland SE, Glasson WJ
Eye (Lond) 2023 Apr;37(5):837-848. Epub 2022 Jul 26 doi: 10.1038/s41433-022-02176-2. PMID: 35882984Free PMC Article
Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Clinical treatment options for early-stage and advanced conjunctival melanoma.
Zeng Y, Hu C, Shu L, Pan Y, Zhao L, Pu X, Wu F
Surv Ophthalmol 2021 May-Jun;66(3):461-470. Epub 2020 Sep 25 doi: 10.1016/j.survophthal.2020.09.004. PMID: 32980421
Conjunctival Melanoma - Epidemiological Trends and Features.
Kaštelan S, Gverović Antunica A, Beketić Orešković L, Salopek Rabatić J, Kasun B, Bakija I
Pathol Oncol Res 2018 Oct;24(4):787-796. Epub 2018 May 25 doi: 10.1007/s12253-018-0419-3. PMID: 29802540
Conjunctival melanoma.
Seregard S
Surv Ophthalmol 1998 Jan-Feb;42(4):321-50. doi: 10.1016/s0039-6257(97)00122-7. PMID: 9493274

Clinical prediction guides

Conjunctival Lymphoma.
McGrath LA, Ryan DA, Warrier SK, Coupland SE, Glasson WJ
Eye (Lond) 2023 Apr;37(5):837-848. Epub 2022 Jul 26 doi: 10.1038/s41433-022-02176-2. PMID: 35882984Free PMC Article
Conjunctival and uveal melanoma: Survival and risk factors following orbital exenteration.
Baum SH, Westekemper H, Bechrakis NE, Mohr C
Eur J Ophthalmol 2022 Jan;32(1):612-619. Epub 2021 Feb 11 doi: 10.1177/1120672121995131. PMID: 33573425
Actinic Granuloma of the Conjunctiva: Case Series and Review of the Literature.
Magan T, Rapuano CJ, Ayres BD, Skeens HM, Goyal V, Heersink S, Meghpara BB, Syed ZA, Eagle RC Jr, Milman T
Am J Ophthalmol 2021 Sep;229:120-126. Epub 2021 Apr 22 doi: 10.1016/j.ajo.2021.04.006. PMID: 33895150
Cancers of the eye.
Maheshwari A, Finger PT
Cancer Metastasis Rev 2018 Dec;37(4):677-690. doi: 10.1007/s10555-018-9762-9. PMID: 30203109
Conjunctival Melanoma - Epidemiological Trends and Features.
Kaštelan S, Gverović Antunica A, Beketić Orešković L, Salopek Rabatić J, Kasun B, Bakija I
Pathol Oncol Res 2018 Oct;24(4):787-796. Epub 2018 May 25 doi: 10.1007/s12253-018-0419-3. PMID: 29802540

Recent systematic reviews

Holding back the tears: is there a role for marsupialisation?
Chiu SJ, Currie ZI, Tan JH
BMJ Open Ophthalmol 2022 Aug;7(1) doi: 10.1136/bmjophth-2022-000985. PMID: 36161857Free PMC Article
Mutational Characteristics of Primary Mucosal Melanoma: A Systematic Review.
Beaudoux O, Oudart JB, Riffaud L, Visseaux L, Marchal A, Lebre AS, Grange F
Mol Diagn Ther 2022 Mar;26(2):189-202. Epub 2022 Feb 23 doi: 10.1007/s40291-021-00572-0. PMID: 35195858
Conjunctival myxoma: A systematic review of a rare tumor.
Alvarado-Villacorta R, Torres Zavala NM, Marroquín Loayza L, Rodríguez-Reyes AA
Surv Ophthalmol 2022 May-Jun;67(3):729-740. Epub 2021 Aug 27 doi: 10.1016/j.survophthal.2021.08.007. PMID: 34461119
Epidemiology of ocular surface squamous neoplasia in Africa.
Gichuhi S, Sagoo MS, Weiss HA, Burton MJ
Trop Med Int Health 2013 Dec;18(12):1424-43. Epub 2013 Oct 30 doi: 10.1111/tmi.12203. PMID: 24237784Free PMC Article
Interventions for squamous cell carcinoma of the conjunctiva in HIV-infected individuals.
Gichuhi S, Irlam JH
Cochrane Database Syst Rev 2013 Feb 28;2013(2):CD005643. doi: 10.1002/14651858.CD005643.pub3. PMID: 23450564Free PMC Article

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