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Conjunctival Neoplasm

MedGen UID:
3208
•Concept ID:
C0009761
•
Neoplastic Process
Synonyms: Conjunctival Neoplasms; Neoplasm, Conjunctival; Neoplasms, Conjunctival
SNOMED CT: Neoplasm of conjunctiva (126996004); Tumor of conjunctiva (126996004)

Definition

A benign or malignant neoplasm that affects the conjunctiva. Representative examples include papilloma, squamous cell carcinoma, and melanoma. [from NCI]

Professional guidelines

PubMed

Ocular surface squamous neoplasia: management and outcomes.
Hӧllhumer R, Williams S, Michelow P
Eye (Lond) 2021 Jun;35(6):1562-1573. Epub 2021 Feb 9 doi: 10.1038/s41433-021-01422-3. PMID: 33564137Free PMC Article
Clinical treatment options for early-stage and advanced conjunctival melanoma.
Zeng Y, Hu C, Shu L, Pan Y, Zhao L, Pu X, Wu F
Surv Ophthalmol 2021 May-Jun;66(3):461-470. Epub 2020 Sep 25 doi: 10.1016/j.survophthal.2020.09.004. PMID: 32980421
Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796

Recent clinical studies

Etiology

Conjunctival metastasis as the presenting sign for stage IV lung cancer.
Chew R, Potter J, DiMattina A
Optom Vis Sci 2014 Feb;91(2):e38-42. doi: 10.1097/OPX.0000000000000131. PMID: 24270639

Diagnosis

Bilateral synchronous conjunctival myxoma and review of the literature.
Lin TPH, Wan KH, Cheuk W, Leung E, Yuen HKL, Lam DSC
Eur J Ophthalmol 2023 Sep;33(5):NP130-NP136. Epub 2022 Sep 9 doi: 10.1177/11206721221124665. PMID: 36083167
Conjunctival Melanoma Metastasis to the Contralateral Orbit.
He F, Wang Y, Jia R
J Craniofac Surg 2018 Nov;29(8):2128-2130. doi: 10.1097/SCS.0000000000004673. PMID: 29894459
Conjunctival metastasis as the presenting sign for stage IV lung cancer.
Chew R, Potter J, DiMattina A
Optom Vis Sci 2014 Feb;91(2):e38-42. doi: 10.1097/OPX.0000000000000131. PMID: 24270639
Foreign body after pterygium surgery simulating an epibulbar tumor.
Marback PM, Marback EF, Marback RL
Ophthalmic Plast Reconstr Surg 2009 Mar-Apr;25(2):150-2. doi: 10.1097/IOP.0b013e31819ac6c5. PMID: 19300168
Localized infection by Serratia marcescens simulating a conjunctival neoplasm.
Shields JA, Shields CL, Eagle RC Jr, Moster M
Am J Ophthalmol 2000 Feb;129(2):247-8. doi: 10.1016/s0002-9394(99)00422-5. PMID: 10682980

Therapy

Foreign body after pterygium surgery simulating an epibulbar tumor.
Marback PM, Marback EF, Marback RL
Ophthalmic Plast Reconstr Surg 2009 Mar-Apr;25(2):150-2. doi: 10.1097/IOP.0b013e31819ac6c5. PMID: 19300168
Localized infection by Serratia marcescens simulating a conjunctival neoplasm.
Shields JA, Shields CL, Eagle RC Jr, Moster M
Am J Ophthalmol 2000 Feb;129(2):247-8. doi: 10.1016/s0002-9394(99)00422-5. PMID: 10682980

Prognosis

Expression of vascular endothelial growth factor in human ocular adnexal lymphoma.
Kinoshita S, Kase S, Ando R, Dong Z, Fukuhara J, Dong Y, Inafuku S, Noda K, Noda M, Kanda A, Ishida S
Invest Ophthalmol Vis Sci 2014 May 13;55(6):3461-7. doi: 10.1167/iovs.13-13510. PMID: 24825110
Conjunctival metastasis as the presenting sign for stage IV lung cancer.
Chew R, Potter J, DiMattina A
Optom Vis Sci 2014 Feb;91(2):e38-42. doi: 10.1097/OPX.0000000000000131. PMID: 24270639

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