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Mucinous cystadenocarcinoma

MedGen UID:
60211
•Concept ID:
C0206699
•
Neoplastic Process
Synonyms: Cystadenocarcinoma, Mucinous; Cystadenocarcinomas, Mucinous; Mucinous Cystadenocarcinoma; Mucinous Cystadenocarcinomas
SNOMED CT: Mucinous cystadenocarcinoma (79143006); Pseudomucinous adenocarcinoma (79143006); Pseudomucinous cystadenocarcinoma (79143006)
 
Monarch Initiative: MONDO:0005858

Definition

An invasive adenocarcinoma characterized by cystic changes and the presence of malignant glandular cells which contain intracytoplasmic mucin. It may arise from the ovary, pancreas, appendix, and lung. [from NCI]

Professional guidelines

PubMed

Ovarian needle aspiration in the diagnosis and management of ovarian masses.
Nagamine K, Kondo J, Kaneshiro R, Tauchi-Nishi P, Terada K
J Gynecol Oncol 2017 Jul;28(4):e40. doi: 10.3802/jgo.2017.28.e40. PMID: 28541632Free PMC Article
Intraductal papillary mucinous tumors of the pancreas: biology, diagnosis, and treatment.
Grützmann R, Niedergethmann M, Pilarsky C, Klöppel G, Saeger HD
Oncologist 2010;15(12):1294-309. Epub 2010 Dec 8 doi: 10.1634/theoncologist.2010-0151. PMID: 21147870Free PMC Article
Cyst fluid analysis in the differential diagnosis of pancreatic cystic lesions: a pooled analysis.
van der Waaij LA, van Dullemen HM, Porte RJ
Gastrointest Endosc 2005 Sep;62(3):383-9. doi: 10.1016/s0016-5107(05)01581-6. PMID: 16111956

Recent clinical studies

Etiology

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Mesenteric and Retroperitoneal Mucinous Cystic Neoplasms: A Case Series.
Van Treeck BJ, Horton RK, Lee HE, Rosty C, Pai RK, Graham RP
Int J Surg Pathol 2021 Sep;29(6):606-614. Epub 2021 Mar 18 doi: 10.1177/1066896921993536. PMID: 33736504
Pancreatic mucinous cystadenocarcinoma: Epidemiology and outcomes.
Doulamis IP, Mylonas KS, Kalfountzos CE, Mou D, Haj-Ibrahim H, Nasioudis D
Int J Surg 2016 Nov;35:76-82. Epub 2016 Sep 13 doi: 10.1016/j.ijsu.2016.09.017. PMID: 27638187
Approach to cystic lesions of the pancreas.
Schmid RM, Siveke JT
Wien Med Wochenschr 2014 Feb;164(3-4):44-50. Epub 2013 Nov 20 doi: 10.1007/s10354-013-0244-y. PMID: 24254128
Observations on the etiology and pathogenesis of intraductal papillary-mucinous neoplasms of the pancreas.
Longnecker DS
Hepatogastroenterology 1998 Nov-Dec;45(24):1973-80. PMID: 9951850

Diagnosis

The Spectrum of Mucinous Lesions of the Breast.
Joneja U, Palazzo J
Arch Pathol Lab Med 2023 Jan 1;147(1):19-29. doi: 10.5858/arpa.2022-0054-RA. PMID: 36577093
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
Pancreatic mucinous cystadenocarcinoma: Epidemiology and outcomes.
Doulamis IP, Mylonas KS, Kalfountzos CE, Mou D, Haj-Ibrahim H, Nasioudis D
Int J Surg 2016 Nov;35:76-82. Epub 2016 Sep 13 doi: 10.1016/j.ijsu.2016.09.017. PMID: 27638187
Pancreatic Cystic Neoplasms: An Update.
Ketwaroo GA, Mortele KJ, Sawhney MS
Gastroenterol Clin North Am 2016 Mar;45(1):67-81. Epub 2016 Jan 13 doi: 10.1016/j.gtc.2015.10.006. PMID: 26895681

Therapy

CT classification model of pancreatic serous cystic neoplasms and mucinous cystic neoplasms based on a deep neural network.
Yang R, Chen Y, Sa G, Li K, Hu H, Zhou J, Guan Q, Chen F
Abdom Radiol (NY) 2022 Jan;47(1):232-241. Epub 2021 Oct 12 doi: 10.1007/s00261-021-03230-5. PMID: 34636931Free PMC Article
Molecular abnormalities in ovarian carcinoma: clinical, morphological and therapeutic correlates.
Gurung A, Hung T, Morin J, Gilks CB
Histopathology 2013 Jan;62(1):59-70. doi: 10.1111/his.12033. PMID: 23240670
Appendiceal mucinous cystadenocarcinoma with implantation metastasis to the incision scar and cutaneous fistula.
Mishin I, Ghidirim G, Vozian M
J Gastrointest Cancer 2012 Jun;43(2):349-53. doi: 10.1007/s12029-010-9181-9. PMID: 20585997
Primary retroperitoneal mucinous cystadenocarcinoma: a case report and review of the literature.
Dierickx I, Jacomen G, Schelfhout V, Moerman P, Corveleyn P, Spiessens T, Amant F, Berteloot P
Gynecol Obstet Invest 2010;70(3):186-91. Epub 2010 Jun 16 doi: 10.1159/000316268. PMID: 20558993
Does smoking increase risk of ovarian cancer? A systematic review.
Jordan SJ, Whiteman DC, Purdie DM, Green AC, Webb PM
Gynecol Oncol 2006 Dec;103(3):1122-9. Epub 2006 Sep 26 doi: 10.1016/j.ygyno.2006.08.012. PMID: 17005245

Prognosis

The Spectrum of Mucinous Lesions of the Breast.
Joneja U, Palazzo J
Arch Pathol Lab Med 2023 Jan 1;147(1):19-29. doi: 10.5858/arpa.2022-0054-RA. PMID: 36577093
Mucinous Cystadenoma of the Urachus and Review of Current Classification of Urachal Mucinous Cystic Neoplasms.
Wang D, Sule N
Arch Pathol Lab Med 2019 Feb;143(2):258-263. Epub 2018 Nov 6 doi: 10.5858/arpa.2017-0319-RS. PMID: 30398914
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
Pancreatic mucinous cystadenocarcinoma: Epidemiology and outcomes.
Doulamis IP, Mylonas KS, Kalfountzos CE, Mou D, Haj-Ibrahim H, Nasioudis D
Int J Surg 2016 Nov;35:76-82. Epub 2016 Sep 13 doi: 10.1016/j.ijsu.2016.09.017. PMID: 27638187
Primary retroperitoneal mucinous cystadenocarcinoma (PRMCa): a systematic review of the literature and meta-analysis.
Myriokefalitaki E, Luqman I, Potdar N, Brown L, Steward W, Moss EL
Arch Gynecol Obstet 2016 Apr;293(4):709-20. Epub 2015 Dec 17 doi: 10.1007/s00404-015-3975-8. PMID: 26681306

Clinical prediction guides

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Pancreatic mucinous cystadenocarcinoma: Epidemiology and outcomes.
Doulamis IP, Mylonas KS, Kalfountzos CE, Mou D, Haj-Ibrahim H, Nasioudis D
Int J Surg 2016 Nov;35:76-82. Epub 2016 Sep 13 doi: 10.1016/j.ijsu.2016.09.017. PMID: 27638187
Therapeutic Approach to Cystic Neoplasms of the Pancreas.
Al Efishat M, Allen PJ
Surg Oncol Clin N Am 2016 Apr;25(2):351-61. doi: 10.1016/j.soc.2015.11.006. PMID: 27013369Free PMC Article
Updates in the Pathologic Diagnosis and Classification of Epithelial Neoplasms of Urachal Origin.
Paner GP, Lopez-Beltran A, Sirohi D, Amin MB
Adv Anat Pathol 2016 Mar;23(2):71-83. doi: 10.1097/PAP.0000000000000110. PMID: 26849813
Observations on the etiology and pathogenesis of intraductal papillary-mucinous neoplasms of the pancreas.
Longnecker DS
Hepatogastroenterology 1998 Nov-Dec;45(24):1973-80. PMID: 9951850

Recent systematic reviews

Pregnancy-associated mucinous cystic neoplasms of the pancreas - A systematic review.
Dhamor D, Irrinki S, Naik A, Kurdia KC, Rastogi P, Gupta P, Kapoor VK
Am J Surg 2023 Apr;225(4):630-638. Epub 2022 Nov 17 doi: 10.1016/j.amjsurg.2022.11.002. PMID: 36424200
Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.
Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358
Primary retroperitoneal mucinous cystadenocarcinoma (PRMCa): a systematic review of the literature and meta-analysis.
Myriokefalitaki E, Luqman I, Potdar N, Brown L, Steward W, Moss EL
Arch Gynecol Obstet 2016 Apr;293(4):709-20. Epub 2015 Dec 17 doi: 10.1007/s00404-015-3975-8. PMID: 26681306
Does smoking increase risk of ovarian cancer? A systematic review.
Jordan SJ, Whiteman DC, Purdie DM, Green AC, Webb PM
Gynecol Oncol 2006 Dec;103(3):1122-9. Epub 2006 Sep 26 doi: 10.1016/j.ygyno.2006.08.012. PMID: 17005245

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