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Cystadenocarcinoma

MedGen UID:
41385
•Concept ID:
C0010631
•
Neoplastic Process
Synonym: Cystadenocarcinomas
SNOMED CT: Cystadenocarcinoma (21008007)
 
Monarch Initiative: MONDO:0005596

Definition

A malignant cystic epithelial neoplasm arising from the glandular epithelium. The malignant epithelial cells invade the stroma. The cystic spaces contain serous or mucinous fluid. Representative examples include ovarian and pancreatic cystadenocarcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCystadenocarcinoma

Professional guidelines

PubMed

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Hepatic Cysts: Reappraisal of the Classification, Terminology, Differential Diagnosis, and Clinicopathologic Characteristics in 258 Cases.
Armutlu A, Quigley B, Choi H, Basturk O, Akkas G, Pehlivanoglu B, Memis B, Jang KT, Erkan M, Erkan B, Balci S, Saka B, Bagci P, Farris AB, Kooby DA, Martin D, Kalb B, Maithel SK, Sarmiento J, Reid MD, Adsay NV
Am J Surg Pathol 2022 Sep 1;46(9):1219-1233. Epub 2022 Jul 4 doi: 10.1097/PAS.0000000000001930. PMID: 35778790
Ovarian needle aspiration in the diagnosis and management of ovarian masses.
Nagamine K, Kondo J, Kaneshiro R, Tauchi-Nishi P, Terada K
J Gynecol Oncol 2017 Jul;28(4):e40. doi: 10.3802/jgo.2017.28.e40. PMID: 28541632Free PMC Article

Recent clinical studies

Etiology

Bevacizumab Treatment for Low-Grade Serous Ovarian Cancer: A Systematic Review.
Lazurko C, Linder R, Pulman K, Lennox G, Feigenberg T, Fazelzad R, May T, Zigras T
Curr Oncol 2023 Sep 3;30(9):8159-8171. doi: 10.3390/curroncol30090592. PMID: 37754507Free PMC Article
Six cases of central cystadenocarcinoma and review of relevant papers.
Sun R, Zhang HW, Zhang WB, Yu Y, Yu GY, Peng X
Br J Oral Maxillofac Surg 2020 Nov;58(9):e86-e92. Epub 2020 Jul 13 doi: 10.1016/j.bjoms.2020.06.040. PMID: 32674915
Low-grade serous ovarian cancer: State of the science.
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252
High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints.
Lisio MA, Fu L, Goyeneche A, Gao ZH, Telleria C
Int J Mol Sci 2019 Feb 22;20(4) doi: 10.3390/ijms20040952. PMID: 30813239Free PMC Article
Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.
Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358

Diagnosis

Six cases of central cystadenocarcinoma and review of relevant papers.
Sun R, Zhang HW, Zhang WB, Yu Y, Yu GY, Peng X
Br J Oral Maxillofac Surg 2020 Nov;58(9):e86-e92. Epub 2020 Jul 13 doi: 10.1016/j.bjoms.2020.06.040. PMID: 32674915
Cystadenocarcinoma of the mandible.
Madathil J, Kumar NR, Shiny P
Indian J Dent Res 2018 May-Jun;29(3):396-399. doi: 10.4103/ijdr.IJDR_768_16. PMID: 29900928
Serous ovarian cancer signaling pathways.
Kotsopoulos IC, Papanikolaou A, Lambropoulos AF, Papazisis KT, Tsolakidis D, Touplikioti P, Tarlatzis BC
Int J Gynecol Cancer 2014 Mar;24(3):410-7. doi: 10.1097/IGC.0000000000000079. PMID: 24476895
Pancreatic cystic neoplasm.
Roggin KK, Chennat J, Oto A, Noffsinger A, Briggs A, Matthews JB
Curr Probl Surg 2010 Jun;47(6):459-510. doi: 10.1067/j.cpsurg.2010.02.002. PMID: 20451023
Multilocular cystadenoma and cystadenocarcinoma of the prostate.
Tuziak T, Spiess PE, Abrahams NA, Wrona A, Tu SM, Czerniak B
Urol Oncol 2007 Jan-Feb;25(1):19-25. doi: 10.1016/j.urolonc.2006.01.011. PMID: 17208134

Therapy

Uterine serous carcinoma.
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Enomoto T, Takehara K, Denys H, Nout RA, Lorusso D, Vaughan MM, Bini M, Takano M, Provencher D, Indini A, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Candido Dos Reis FJ, Lopez S, Mariani A, Leitao MM Jr, Raspagliesi F, Panici PB, Di Donato V, Muzii L, Colombo N, Scambia G, Pignata S, Monk BJ
Gynecol Oncol 2021 Jul;162(1):226-234. Epub 2021 Apr 30 doi: 10.1016/j.ygyno.2021.04.029. PMID: 33934848Free PMC Article
Randomized Phase II Trial of Carboplatin-Paclitaxel Compared with Carboplatin-Paclitaxel-Trastuzumab in Advanced (Stage III-IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis.
Fader AN, Roque DM, Siegel E, Buza N, Hui P, Abdelghany O, Chambers S, Secord AA, Havrilesky L, O'Malley DM, Backes FJ, Nevadunsky N, Edraki B, Pikaart D, Lowery W, ElSahwi K, Celano P, Bellone S, Azodi M, Litkouhi B, Ratner E, Silasi DA, Schwartz PE, Santin AD
Clin Cancer Res 2020 Aug 1;26(15):3928-3935. Epub 2020 Jun 29 doi: 10.1158/1078-0432.CCR-20-0953. PMID: 32601075Free PMC Article
Low-grade serous ovarian cancer: State of the science.
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252
Veliparib with First-Line Chemotherapy and as Maintenance Therapy in Ovarian Cancer.
Coleman RL, Fleming GF, Brady MF, Swisher EM, Steffensen KD, Friedlander M, Okamoto A, Moore KN, Efrat Ben-Baruch N, Werner TL, Cloven NG, Oaknin A, DiSilvestro PA, Morgan MA, Nam JH, Leath CA 3rd, Nicum S, Hagemann AR, Littell RD, Cella D, Baron-Hay S, Garcia-Donas J, Mizuno M, Bell-McGuinn K, Sullivan DM, Bach BA, Bhattacharya S, Ratajczak CK, Ansell PJ, Dinh MH, Aghajanian C, Bookman MA
N Engl J Med 2019 Dec 19;381(25):2403-2415. Epub 2019 Sep 28 doi: 10.1056/NEJMoa1909707. PMID: 31562800Free PMC Article
Randomized Phase II Trial of Carboplatin-Paclitaxel Versus Carboplatin-Paclitaxel-Trastuzumab in Uterine Serous Carcinomas That Overexpress Human Epidermal Growth Factor Receptor 2/neu.
Fader AN, Roque DM, Siegel E, Buza N, Hui P, Abdelghany O, Chambers SK, Secord AA, Havrilesky L, O'Malley DM, Backes F, Nevadunsky N, Edraki B, Pikaart D, Lowery W, ElSahwi KS, Celano P, Bellone S, Azodi M, Litkouhi B, Ratner E, Silasi DA, Schwartz PE, Santin AD
J Clin Oncol 2018 Jul 10;36(20):2044-2051. Epub 2018 Mar 27 doi: 10.1200/JCO.2017.76.5966. PMID: 29584549

Prognosis

Maintenance olaparib for patients with newly diagnosed advanced ovarian cancer and a BRCA mutation (SOLO1/GOG 3004): 5-year follow-up of a randomised, double-blind, placebo-controlled, phase 3 trial.
Banerjee S, Moore KN, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Oza A, González-Martín A, Aghajanian C, Bradley WH, Holmes E, Lowe ES, DiSilvestro P
Lancet Oncol 2021 Dec;22(12):1721-1731. Epub 2021 Oct 26 doi: 10.1016/S1470-2045(21)00531-3. PMID: 34715071
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage.
Peres LC, Cushing-Haugen KL, Köbel M, Harris HR, Berchuck A, Rossing MA, Schildkraut JM, Doherty JA
J Natl Cancer Inst 2019 Jan 1;111(1):60-68. doi: 10.1093/jnci/djy071. PMID: 29718305Free PMC Article
Cystadenocarcinoma of the mandible.
Madathil J, Kumar NR, Shiny P
Indian J Dent Res 2018 May-Jun;29(3):396-399. doi: 10.4103/ijdr.IJDR_768_16. PMID: 29900928
Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer.
Bowtell DD, Böhm S, Ahmed AA, Aspuria PJ, Bast RC Jr, Beral V, Berek JS, Birrer MJ, Blagden S, Bookman MA, Brenton JD, Chiappinelli KB, Martins FC, Coukos G, Drapkin R, Edmondson R, Fotopoulou C, Gabra H, Galon J, Gourley C, Heong V, Huntsman DG, Iwanicki M, Karlan BY, Kaye A, Lengyel E, Levine DA, Lu KH, McNeish IA, Menon U, Narod SA, Nelson BH, Nephew KP, Pharoah P, Powell DJ Jr, Ramos P, Romero IL, Scott CL, Sood AK, Stronach EA, Balkwill FR
Nat Rev Cancer 2015 Nov;15(11):668-79. doi: 10.1038/nrc4019. PMID: 26493647Free PMC Article

Clinical prediction guides

HER2 in uterine serous carcinoma: Current state and clinical perspectives.
Navarro Sanchez JM, Finkelman BS, Turner BM, Katerji H, Wang X, Varghese S, Wang T, Peng Y, Hicks DG, Zhang H
Am J Clin Pathol 2023 Oct 3;160(4):341-351. doi: 10.1093/ajcp/aqad056. PMID: 37267036
Prognostic relevance of HRDness gene expression signature in ovarian high-grade serous carcinoma; JGOG3025-TR2 study.
Takamatsu S, Yoshihara K, Baba T, Shimada M, Yoshida H, Kajiyama H, Oda K, Mandai M, Okamoto A, Enomoto T, Matsumura N
Br J Cancer 2023 Apr;128(6):1095-1104. Epub 2023 Jan 2 doi: 10.1038/s41416-022-02122-9. PMID: 36593360Free PMC Article
p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies.
Singh N, Piskorz AM, Bosse T, Jimenez-Linan M, Rous B, Brenton JD, Gilks CB, Köbel M
J Pathol 2020 Mar;250(3):336-345. Epub 2020 Jan 29 doi: 10.1002/path.5375. PMID: 31829441
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Chemotherapy Response Score: Development and Validation of a System to Quantify Histopathologic Response to Neoadjuvant Chemotherapy in Tubo-Ovarian High-Grade Serous Carcinoma.
Böhm S, Faruqi A, Said I, Lockley M, Brockbank E, Jeyarajah A, Fitzpatrick A, Ennis D, Dowe T, Santos JL, Cook LS, Tinker AV, Le ND, Gilks CB, Singh N
J Clin Oncol 2015 Aug 1;33(22):2457-63. Epub 2015 Jun 29 doi: 10.1200/JCO.2014.60.5212. PMID: 26124480

Recent systematic reviews

Bevacizumab Treatment for Low-Grade Serous Ovarian Cancer: A Systematic Review.
Lazurko C, Linder R, Pulman K, Lennox G, Feigenberg T, Fazelzad R, May T, Zigras T
Curr Oncol 2023 Sep 3;30(9):8159-8171. doi: 10.3390/curroncol30090592. PMID: 37754507Free PMC Article
Uptake and Outcomes of Neoadjuvant Chemotherapy Among US Patients With Less Common Epithelial Ovarian Carcinomas.
Matsuo K, Matsuzaki S, Maeda M, Rau AR, Yoshihara K, Tamura R, Shimada M, Machida H, Mikami M, Klar M, Roman LD, Wright JD, Sood AK, Gershenson DM
JAMA Netw Open 2023 Jun 1;6(6):e2318602. doi: 10.1001/jamanetworkopen.2023.18602. PMID: 37326992Free PMC Article
Recommendations for diagnosing STIC: a systematic review and meta-analysis.
Bogaerts JMA, Steenbeek MP, van Bommel MHD, Bulten J, van der Laak JAWM, de Hullu JA, Simons M
Virchows Arch 2022 Apr;480(4):725-737. Epub 2021 Dec 1 doi: 10.1007/s00428-021-03244-w. PMID: 34850262Free PMC Article
Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.
Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358
Primary retroperitoneal mucinous cystadenocarcinoma (PRMCa): a systematic review of the literature and meta-analysis.
Myriokefalitaki E, Luqman I, Potdar N, Brown L, Steward W, Moss EL
Arch Gynecol Obstet 2016 Apr;293(4):709-20. Epub 2015 Dec 17 doi: 10.1007/s00404-015-3975-8. PMID: 26681306

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