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Germinoma

MedGen UID:
64626
•Concept ID:
C0206660
•
Neoplastic Process
Synonym: Germinoma (disease)
SNOMED CT: Germinoma (28307001)
 
HPO: HP:0100620
Monarch Initiative: MONDO:0002598

Definition

A type of undifferentiated germ cell tumor that may be benign or malignant. [from HPO]

Professional guidelines

PubMed

Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management.
Kremenevski N, Buchfelder M, Hore N
Curr Oncol Rep 2023 Jul;25(7):765-775. Epub 2023 Apr 10 doi: 10.1007/s11912-023-01416-2. PMID: 37036624Free PMC Article
EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.
Frappaz D, Dhall G, Murray MJ, Goldman S, Faure Conter C, Allen J, Kortmann RD, Haas-Kogen D, Morana G, Finlay J, Nicholson JC, Bartels U, Souweidane M, Schönberger S, Vasiljevic A, Robertson P, Albanese A, Alapetite C, Czech T, Lau CC, Wen P, Schiff D, Shaw D, Calaminus G, Bouffet E
Neuro Oncol 2022 Apr 1;24(4):516-527. doi: 10.1093/neuonc/noab252. PMID: 34724065Free PMC Article
Diabetes insipidus--diagnosis and management.
Di Iorgi N, Napoli F, Allegri AE, Olivieri I, Bertelli E, Gallizia A, Rossi A, Maghnie M
Horm Res Paediatr 2012;77(2):69-84. Epub 2012 Mar 16 doi: 10.1159/000336333. PMID: 22433947

Recent clinical studies

Etiology

Differentiation between germinoma and other pineal region tumors using diffusion-and susceptibility-weighted MRI.
Phuttharak W, Wannasarnmetha M, Lueangingkasut P, Waraasawapati S, Mukherji SK
Eur J Radiol 2023 Feb;159:110663. Epub 2022 Dec 20 doi: 10.1016/j.ejrad.2022.110663. PMID: 36584565
Phase II trial of response-based radiation therapy for patients with localized germinoma: a Children's Oncology Group study.
Bartels U, Onar-Thomas A, Patel SK, Shaw D, Fangusaro J, Dhall G, Souweidane M, Bhatia A, Embry L, Trask CL, Murphy ES, MacDonald S, Wu S, Boyett JM, Leary S, Fouladi M, Gajjar A, Khatua S
Neuro Oncol 2022 Jun 1;24(6):974-983. doi: 10.1093/neuonc/noab270. PMID: 34850169Free PMC Article
EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.
Frappaz D, Dhall G, Murray MJ, Goldman S, Faure Conter C, Allen J, Kortmann RD, Haas-Kogen D, Morana G, Finlay J, Nicholson JC, Bartels U, Souweidane M, Schönberger S, Vasiljevic A, Robertson P, Albanese A, Alapetite C, Czech T, Lau CC, Wen P, Schiff D, Shaw D, Calaminus G, Bouffet E
Neuro Oncol 2022 Apr 1;24(4):516-527. doi: 10.1093/neuonc/noab252. PMID: 34724065Free PMC Article
Re-irradiation for Paediatric Tumours.
Tsang DS, Laperriere NJ
Clin Oncol (R Coll Radiol) 2019 Mar;31(3):191-198. Epub 2018 Oct 29 doi: 10.1016/j.clon.2018.10.003. PMID: 30385005
International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group.
J Clin Oncol 1997 Feb;15(2):594-603. doi: 10.1200/JCO.1997.15.2.594. PMID: 9053482

Diagnosis

Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management.
Kremenevski N, Buchfelder M, Hore N
Curr Oncol Rep 2023 Jul;25(7):765-775. Epub 2023 Apr 10 doi: 10.1007/s11912-023-01416-2. PMID: 37036624Free PMC Article
Differentiation between germinoma and other pineal region tumors using diffusion-and susceptibility-weighted MRI.
Phuttharak W, Wannasarnmetha M, Lueangingkasut P, Waraasawapati S, Mukherji SK
Eur J Radiol 2023 Feb;159:110663. Epub 2022 Dec 20 doi: 10.1016/j.ejrad.2022.110663. PMID: 36584565
Pineal germinoma.
Srinivasan N, Pakala A, Mukkamalla C, Oswal A
South Med J 2010 Oct;103(10):1031-7. doi: 10.1097/SMJ.0b013e3181ebeeff. PMID: 20818311
Primary midbrain germinoma.
Kalra SK, Vaid VK, Jaiswal AK, Behari S, Jain VK, Kumari N
J Clin Neurosci 2008 Nov;15(11):1282-4. Epub 2008 Sep 9 doi: 10.1016/j.jocn.2007.07.079. PMID: 18783953
Testicular cancer.
Brock D, Fox S, Gosling G, Haney L, Kneebone P, Nagy C, Qualitza B
Semin Oncol Nurs 1993 Nov;9(4):224-36. doi: 10.1016/s0749-2081(05)80051-8. PMID: 8290818

Therapy

Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management.
Kremenevski N, Buchfelder M, Hore N
Curr Oncol Rep 2023 Jul;25(7):765-775. Epub 2023 Apr 10 doi: 10.1007/s11912-023-01416-2. PMID: 37036624Free PMC Article
Phase II trial of response-based radiation therapy for patients with localized germinoma: a Children's Oncology Group study.
Bartels U, Onar-Thomas A, Patel SK, Shaw D, Fangusaro J, Dhall G, Souweidane M, Bhatia A, Embry L, Trask CL, Murphy ES, MacDonald S, Wu S, Boyett JM, Leary S, Fouladi M, Gajjar A, Khatua S
Neuro Oncol 2022 Jun 1;24(6):974-983. doi: 10.1093/neuonc/noab270. PMID: 34850169Free PMC Article
Combination of paclitaxel, ifosfamide, and cisplatin is an effective second-line therapy for patients with relapsed testicular germ cell tumors.
Kondagunta GV, Bacik J, Donadio A, Bajorin D, Marion S, Sheinfeld J, Bosl GJ, Motzer RJ
J Clin Oncol 2005 Sep 20;23(27):6549-55. doi: 10.1200/JCO.2005.19.638. PMID: 16170162
Randomized comparison of cisplatin and etoposide and either bleomycin or ifosfamide in treatment of advanced disseminated germ cell tumors: an Eastern Cooperative Oncology Group, Southwest Oncology Group, and Cancer and Leukemia Group B Study.
Nichols CR, Catalano PJ, Crawford ED, Vogelzang NJ, Einhorn LH, Loehrer PJ
J Clin Oncol 1998 Apr;16(4):1287-93. doi: 10.1200/JCO.1998.16.4.1287. PMID: 9552027
International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group.
J Clin Oncol 1997 Feb;15(2):594-603. doi: 10.1200/JCO.1997.15.2.594. PMID: 9053482

Prognosis

Time to dismiss boost? Outcomes of children with localized and metastatic germinoma.
Foo JC, Yaman Bajin I, Marushchak O, McKeown T, Bouffet E, Tsang DS, Laperriere N, Dirks P, Drake J, Ertl-Wagner B, Bartels U
J Neurooncol 2023 Apr;162(2):443-448. Epub 2023 Apr 11 doi: 10.1007/s11060-023-04307-5. PMID: 37039951
Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management.
Kremenevski N, Buchfelder M, Hore N
Curr Oncol Rep 2023 Jul;25(7):765-775. Epub 2023 Apr 10 doi: 10.1007/s11912-023-01416-2. PMID: 37036624Free PMC Article
Salvage craniospinal irradiation for recurrent intracranial germinoma: a single institution analysis.
Kanamori M, Shimoda Y, Umezawa R, Iizuka O, Mugikura S, Suzuki K, Ariga H, Jingu K, Saito R, Sonoda Y, Kumabe T, Tominaga T
J Radiat Res 2023 Mar 23;64(2):428-437. doi: 10.1093/jrr/rrac095. PMID: 36610798Free PMC Article
Optimization of Intracranial Germinoma Treatment: Radiotherapy Alone with Reduced Volume and Dose.
Byun HK, Yoon HI, Cho J, Shim KW, Han JW, Lyu CJ, Kim DS, Suh CO
Int J Radiat Oncol Biol Phys 2020 Nov 1;108(3):657-666. Epub 2020 May 17 doi: 10.1016/j.ijrobp.2020.05.019. PMID: 32434039
Treatment in germ cell tumours: state of the art.
Tjan-Heijnen VC, Oosterhof GO, de Wit R, De Mulder PH
Eur J Surg Oncol 1997 Apr;23(2):110-7. doi: 10.1016/s0748-7983(97)80002-9. PMID: 9158183

Clinical prediction guides

Differentiation between germinoma and other pineal region tumors using diffusion-and susceptibility-weighted MRI.
Phuttharak W, Wannasarnmetha M, Lueangingkasut P, Waraasawapati S, Mukherji SK
Eur J Radiol 2023 Feb;159:110663. Epub 2022 Dec 20 doi: 10.1016/j.ejrad.2022.110663. PMID: 36584565
Influence of growth hormone therapy on germinoma survivors.
Kinoshita Y, Yamasaki F, Taguchi A, Takayasu T, Yonezawa U, Tominaga A, Arita K, Okada S, Horie N, Sugiyama K
Pituitary 2022 Dec;25(6):854-860. Epub 2022 Aug 20 doi: 10.1007/s11102-022-01273-5. PMID: 35986827
Pituitary Stalk Thickening: Causes and Consequences. The Children's Memorial Health Institute Experience and Literature Review.
Moszczyńska E, Kunecka K, Baszyńska-Wilk M, Perek-Polnik M, Majak D, Grajkowska W
Front Endocrinol (Lausanne) 2022;13:868558. Epub 2022 May 20 doi: 10.3389/fendo.2022.868558. PMID: 35669693Free PMC Article
Phase II trial of response-based radiation therapy for patients with localized germinoma: a Children's Oncology Group study.
Bartels U, Onar-Thomas A, Patel SK, Shaw D, Fangusaro J, Dhall G, Souweidane M, Bhatia A, Embry L, Trask CL, Murphy ES, MacDonald S, Wu S, Boyett JM, Leary S, Fouladi M, Gajjar A, Khatua S
Neuro Oncol 2022 Jun 1;24(6):974-983. doi: 10.1093/neuonc/noab270. PMID: 34850169Free PMC Article
Suprasellar germinoma.
Takeuchi J, Handa H, Nagata I
J Neurosurg 1978 Jul;49(1):41-8. doi: 10.3171/jns.1978.49.1.0041. PMID: 660267

Recent systematic reviews

Venous thromboembolism in the setting of pediatric central diabetes insipidus: a systematic review of the literature and report of 2 cases.
Lambert WA, Paro M, Pinci E, Bookland MJ, Martin JE, Riba-Wolman R, McKay L, Hersh DS
J Neurosurg Pediatr 2022 May 1;29(5):580-589. Epub 2022 Feb 25 doi: 10.3171/2022.1.PEDS21469. PMID: 35213827
Proton Therapy in Children: A Systematic Review of Clinical Effectiveness in 15 Pediatric Cancers.
Leroy R, Benahmed N, Hulstaert F, Van Damme N, De Ruysscher D
Int J Radiat Oncol Biol Phys 2016 May 1;95(1):267-278. Epub 2015 Oct 17 doi: 10.1016/j.ijrobp.2015.10.025. PMID: 27084646
Paediatric brain tumours: A review of radiotherapy, state of the art and challenges for the future regarding protontherapy and carbontherapy.
Laprie A, Hu Y, Alapetite C, Carrie C, Habrand JL, Bolle S, Bondiau PY, Ducassou A, Huchet A, Bertozzi AI, Perel Y, Moyal É, Balosso J; radiotherapy committee of SFCE and France Hadron
Cancer Radiother 2015 Dec;19(8):775-89. Epub 2015 Nov 6 doi: 10.1016/j.canrad.2015.05.028. PMID: 26548600
A systematic review of lactate dehydrogenase isoenzyme 1 and germ cell tumors.
von Eyben FE
Clin Biochem 2001 Sep;34(6):441-54. doi: 10.1016/s0009-9120(01)00236-3. PMID: 11676973
Surveillance programs for early stage non-seminomatous testicular cancer: a practice guideline.
Segal R, Lukka H, Klotz LH, Eady A, Bestic N, Johnston M; Cancer Care Ontario Practice Guidelines Initiative Genitourinary Cancer Disease Site Group
Can J Urol 2001 Feb;8(1):1184-92. PMID: 11268306

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