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Physiological sexual disorder

MedGen UID:
66756
•Concept ID:
C0237873
•
Pathologic Function
Synonyms: Physiological Sexual Disorder; Physiological Sexual Disorders; Physiological Sexual Dysfunction; Physiological Sexual Dysfunctions; Sex Disorders; Sexual Disorder, Physiological; Sexual Disorders, Physiological; Sexual Dysfunction, Physiological; Sexual Dysfunctions, Physiological
 
Monarch Initiative: MONDO:0002134

Definition

Physiological disturbances in normal sexual performance in either the male or the female. [from MONDO]

Professional guidelines

PubMed

Medical Treatment of Female Sexual Dysfunction.
Nappi RE, Tiranini L, Martini E, Bosoni D, Righi A, Cucinella L
Urol Clin North Am 2022 May;49(2):299-307. doi: 10.1016/j.ucl.2022.02.001. PMID: 35428435
Global Consensus Position Statement on the Use of Testosterone Therapy for Women.
Davis SR, Baber R, Panay N, Bitzer J, Perez SC, Islam RM, Kaunitz AM, Kingsberg SA, Lambrinoudaki I, Liu J, Parish SJ, Pinkerton J, Rymer J, Simon JA, Vignozzi L, Wierman ME
J Clin Endocrinol Metab 2019 Oct 1;104(10):4660-4666. doi: 10.1210/jc.2019-01603. PMID: 31498871Free PMC Article
Management of the Perimenopause.
Delamater L, Santoro N
Clin Obstet Gynecol 2018 Sep;61(3):419-432. doi: 10.1097/GRF.0000000000000389. PMID: 29952797Free PMC Article

Recent clinical studies

Etiology

A clinical review of antidepressants, their sexual side-effects, post-SSRI sexual dysfunction, and serotonin syndrome.
Marks S
Br J Nurs 2023 Jul 27;32(14):678-682. doi: 10.12968/bjon.2023.32.14.678. PMID: 37495413
Post-SSRI Sexual Dysfunction (PSSD): Biological Plausibility, Symptoms, Diagnosis, and Presumed Risk Factors.
Peleg LC, Rabinovitch D, Lavie Y, Rabbie DM, Horowitz I, Fruchter E, Gruenwald I
Sex Med Rev 2022 Jan;10(1):91-98. Epub 2021 Oct 7 doi: 10.1016/j.sxmr.2021.07.001. PMID: 34627736
Antidepressant-induced sexual dysfunction.
Rothmore J
Med J Aust 2020 Apr;212(7):329-334. Epub 2020 Mar 15 doi: 10.5694/mja2.50522. PMID: 32172535
Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention.
Chen L, Shi GR, Huang DD, Li Y, Ma CC, Shi M, Su BX, Shi GJ
Biomed Pharmacother 2019 Apr;112:108585. Epub 2019 Feb 21 doi: 10.1016/j.biopha.2019.01.046. PMID: 30798136
Recent studies on aphrodisiac herbs for the management of male sexual dysfunction--a review.
Malviya N, Jain S, Gupta VB, Vyas S
Acta Pol Pharm 2011 Jan-Feb;68(1):3-8. PMID: 21485695

Diagnosis

Female Sexual Dysfunction.
Reed MA
Clin Plast Surg 2022 Oct;49(4):495-504. Epub 2022 Aug 17 doi: 10.1016/j.cps.2022.06.009. PMID: 36162944
Medical Treatment of Female Sexual Dysfunction.
Nappi RE, Tiranini L, Martini E, Bosoni D, Righi A, Cucinella L
Urol Clin North Am 2022 May;49(2):299-307. doi: 10.1016/j.ucl.2022.02.001. PMID: 35428435
Post-SSRI Sexual Dysfunction (PSSD): Biological Plausibility, Symptoms, Diagnosis, and Presumed Risk Factors.
Peleg LC, Rabinovitch D, Lavie Y, Rabbie DM, Horowitz I, Fruchter E, Gruenwald I
Sex Med Rev 2022 Jan;10(1):91-98. Epub 2021 Oct 7 doi: 10.1016/j.sxmr.2021.07.001. PMID: 34627736
Female Sexual Dysfunction.
Clayton AH, Valladares Juarez EM
Med Clin North Am 2019 Jul;103(4):681-698. doi: 10.1016/j.mcna.2019.02.008. PMID: 31078200
Use of bupropion in combination with serotonin reuptake inhibitors.
Zisook S, Rush AJ, Haight BR, Clines DC, Rockett CB
Biol Psychiatry 2006 Feb 1;59(3):203-10. Epub 2005 Sep 13 doi: 10.1016/j.biopsych.2005.06.027. PMID: 16165100

Therapy

Antidepressant-induced sexual dysfunction.
Rothmore J
Med J Aust 2020 Apr;212(7):329-334. Epub 2020 Mar 15 doi: 10.5694/mja2.50522. PMID: 32172535
Post-finasteride syndrome: a surmountable challenge for clinicians.
Traish AM
Fertil Steril 2020 Jan;113(1):21-50. doi: 10.1016/j.fertnstert.2019.11.030. PMID: 32033719
Sexual Health in Menopause.
Scavello I, Maseroli E, Di Stasi V, Vignozzi L
Medicina (Kaunas) 2019 Sep 2;55(9) doi: 10.3390/medicina55090559. PMID: 31480774Free PMC Article
Post-SSRI Sexual Dysfunction: A Literature Review.
Bala A, Nguyen HMT, Hellstrom WJG
Sex Med Rev 2018 Jan;6(1):29-34. Epub 2017 Aug 1 doi: 10.1016/j.sxmr.2017.07.002. PMID: 28778697
Use of bupropion in combination with serotonin reuptake inhibitors.
Zisook S, Rush AJ, Haight BR, Clines DC, Rockett CB
Biol Psychiatry 2006 Feb 1;59(3):203-10. Epub 2005 Sep 13 doi: 10.1016/j.biopsych.2005.06.027. PMID: 16165100

Prognosis

Final 5-Year Outcomes of the Multicenter Randomized Sham-Controlled Trial of a Water Vapor Thermal Therapy for Treatment of Moderate to Severe Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia.
McVary KT, Gittelman MC, Goldberg KA, Patel K, Shore ND, Levin RM, Pliskin M, Beahrs JR, Prall D, Kaminetsky J, Cowan BE, Cantrill CH, Mynderse LA, Ulchaker JC, Tadros NN, Gange SN, Roehrborn CG
J Urol 2021 Sep;206(3):715-724. Epub 2021 Apr 19 doi: 10.1097/JU.0000000000001778. PMID: 33872051
Let's talk about sex.
Goodwach R
Aust Fam Physician 2017 Jan/Feb;46(1):14-18. PMID: 28189125
Cancer, Benign Gynecology, and Sexual Function--Issues and Answers.
Bennett N, Incrocci L, Baldwin D, Hackett G, El-Zawahry A, Graziottin A, Lukasiewicz M, McVary K, Sato Y, Krychman M
J Sex Med 2016 Apr;13(4):519-37. Epub 2016 Mar 25 doi: 10.1016/j.jsxm.2016.01.018. PMID: 27045256
Depression and sexuality.
Reynaert C, Zdanowicz N, Janne P, Jacques D
Psychiatr Danub 2010 Nov;22 Suppl 1:S111-3. PMID: 21057415
Retarded ejaculation.
Perelman MA, Rowland DL
World J Urol 2006 Dec;24(6):645-52. doi: 10.1007/s00345-006-0127-6. PMID: 17082938

Clinical prediction guides

Sexual Dysfunction in Schizophrenia: A Systematic Review and Meta-Analysis.
Korchia T, Achour V, Faugere M, Albeash A, Yon DK, Boyer L, Fond G
JAMA Psychiatry 2023 Nov 1;80(11):1110-1120. doi: 10.1001/jamapsychiatry.2023.2696. PMID: 37703012Free PMC Article
The Sexual Incentive Motivation Model and Its Clinical Applications.
Ågmo A, Laan E
J Sex Res 2023 Sep;60(7):969-988. Epub 2022 Nov 15 doi: 10.1080/00224499.2022.2134978. PMID: 36378887
Topiramate-associated sexual dysfunction: A systematic review.
Chen LW, Chen MY, Chen KY, Lin HS, Chien CC, Yin HL
Epilepsy Behav 2017 Aug;73:10-17. Epub 2017 Jun 9 doi: 10.1016/j.yebeh.2017.05.014. PMID: 28605628
Let's talk about sex.
Goodwach R
Aust Fam Physician 2017 Jan/Feb;46(1):14-18. PMID: 28189125
A double-blind, randomized, pilot dose-finding study of maca root (L. meyenii) for the management of SSRI-induced sexual dysfunction.
Dording CM, Fisher L, Papakostas G, Farabaugh A, Sonawalla S, Fava M, Mischoulon D
CNS Neurosci Ther 2008 Fall;14(3):182-91. doi: 10.1111/j.1755-5949.2008.00052.x. PMID: 18801111Free PMC Article

Recent systematic reviews

Effectiveness of physical therapy interventions in women with dyspareunia: a systematic review and meta-analysis.
Fernández-Pérez P, Leirós-Rodríguez R, Marqués-Sánchez MP, Martínez-Fernández MC, de Carvalho FO, Maciel LYS
BMC Womens Health 2023 Jul 24;23(1):387. doi: 10.1186/s12905-023-02532-8. PMID: 37482613Free PMC Article
Vaginismus, Dyspareunia and Abuse History: A Systematic Review and Meta-analysis.
Tetik S, Yalçınkaya Alkar Ö
J Sex Med 2021 Sep;18(9):1555-1570. Epub 2021 Aug 6 doi: 10.1016/j.jsxm.2021.07.004. PMID: 34366265
European Association of Urology Guidelines on Sexual and Reproductive Health-2021 Update: Male Sexual Dysfunction.
Salonia A, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, Cocci A, Corona G, Dimitropoulos K, Gül M, Hatzichristodoulou G, Jones TH, Kadioglu A, Martínez Salamanca JI, Milenkovic U, Modgil V, Russo GI, Serefoglu EC, Tharakan T, Verze P, Minhas S; EAU Working Group on Male Sexual and Reproductive Health
Eur Urol 2021 Sep;80(3):333-357. Epub 2021 Jun 26 doi: 10.1016/j.eururo.2021.06.007. PMID: 34183196
INFERTILITY AND SEXUAL DYSFUNCTIONS: A SYSTEMATIC LITERATURE REVIEW.
Starc A, Trampuš M, Pavan Jukić D, Rotim C, Jukić T, Polona Mivšek A
Acta Clin Croat 2019 Sep;58(3):508-515. doi: 10.20471/acc.2019.58.03.15. PMID: 31969764Free PMC Article
Erectile Dysfunction: AUA Guideline.
Burnett AL, Nehra A, Breau RH, Culkin DJ, Faraday MM, Hakim LS, Heidelbaugh J, Khera M, McVary KT, Miner MM, Nelson CJ, Sadeghi-Nejad H, Seftel AD, Shindel AW
J Urol 2018 Sep;200(3):633-641. Epub 2018 May 7 doi: 10.1016/j.juro.2018.05.004. PMID: 29746858

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