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Weakness due to upper motor neuron dysfunction

MedGen UID:
866899
Concept ID:
C4021255
Pathologic Function
Synonym: Paralysis due to lesions of the principle motor tracts
 
HPO: HP:0010549

Definition

Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Although the word paralysis is often used interchangeably to mean either complete or partial loss of muscle strength, it is preferable to use paralysis or plegia for complete or severe loss of muscle strength, and paresis for partial or slight loss. Paralysis due to lesions of the principle motor tracts is related to a lesion in the corticospinal, corticobulbar or brainstem descending (subcorticospinal) neurons. [from HPO]

Professional guidelines

PubMed

Oliveira R, Ramalho Rocha F, Teodoro T, Oliveira Santos M
J Clin Neurosci 2021 May;87:116-124. Epub 2021 Mar 20 doi: 10.1016/j.jocn.2021.02.024. PMID: 33863518
Goutman SA, Chen KS, Paez-Colasante X, Feldman EL
Handb Clin Neurol 2018;148:603-623. doi: 10.1016/B978-0-444-64076-5.00039-9. PMID: 29478603
Rocha JA, Reis C, Simões F, Fonseca J, Mendes Ribeiro J
J Neurol 2005 Dec;252(12):1435-47. doi: 10.1007/s00415-005-0007-9. PMID: 16362828

Recent clinical studies

Etiology

Oliveira R, Ramalho Rocha F, Teodoro T, Oliveira Santos M
J Clin Neurosci 2021 May;87:116-124. Epub 2021 Mar 20 doi: 10.1016/j.jocn.2021.02.024. PMID: 33863518
Pinto WBVR, Debona R, Nunes PP, Assis ACD, Lopes CG, Bortholin T, Dias RB, Naylor FGM, Chieia MAT, Souza PVS, Oliveira ASB
Rev Neurol (Paris) 2019 Apr;175(4):221-232. Epub 2019 Mar 4 doi: 10.1016/j.neurol.2018.04.016. PMID: 30846210
Oskarsson B, Gendron TF, Staff NP
Mayo Clin Proc 2018 Nov;93(11):1617-1628. Epub 2018 Jul 4 doi: 10.1016/j.mayocp.2018.04.007. PMID: 30401437
Khadilkar SV, Gupta N, Yadav RS
J Clin Neuromuscul Dis 2014 Dec;16(2):59-68. doi: 10.1097/CND.0000000000000059. PMID: 25415516
Sumner AJ
Neurosurgery 2009 Oct;65(4 Suppl):A150-2. doi: 10.1227/01.NEU.0000345355.59438.D1. PMID: 19927060

Diagnosis

Masrori P, Van Damme P
Eur J Neurol 2020 Oct;27(10):1918-1929. Epub 2020 Jul 7 doi: 10.1111/ene.14393. PMID: 32526057Free PMC Article
van den Bos MAJ, Geevasinga N, Higashihara M, Menon P, Vucic S
Int J Mol Sci 2019 Jun 10;20(11) doi: 10.3390/ijms20112818. PMID: 31185581Free PMC Article
Pinto WBVR, Debona R, Nunes PP, Assis ACD, Lopes CG, Bortholin T, Dias RB, Naylor FGM, Chieia MAT, Souza PVS, Oliveira ASB
Rev Neurol (Paris) 2019 Apr;175(4):221-232. Epub 2019 Mar 4 doi: 10.1016/j.neurol.2018.04.016. PMID: 30846210
Niedermeyer S, Murn M, Choi PJ
Chest 2019 Feb;155(2):401-408. Epub 2018 Jul 7 doi: 10.1016/j.chest.2018.06.035. PMID: 29990478
Hardiman O, Al-Chalabi A, Chio A, Corr EM, Logroscino G, Robberecht W, Shaw PJ, Simmons Z, van den Berg LH
Nat Rev Dis Primers 2017 Oct 5;3:17071. doi: 10.1038/nrdp.2017.71. PMID: 28980624

Therapy

Wen J, Li S, Zheng C, Wang F, Luo Y, Wu L, Cao J, Guo B, Yu P, Zhang G, Li S, Sun Y, Yang X, Zhang Z, Wang Y
Neuropharmacology 2021 Jan;182:108380. Epub 2020 Nov 2 doi: 10.1016/j.neuropharm.2020.108380. PMID: 33152451
Oskarsson B, Gendron TF, Staff NP
Mayo Clin Proc 2018 Nov;93(11):1617-1628. Epub 2018 Jul 4 doi: 10.1016/j.mayocp.2018.04.007. PMID: 30401437
Logan LR
Top Stroke Rehabil 2011 May-Jun;18(3):203-11. doi: 10.1310/tsr1803-203. PMID: 21642058
Rocha JA, Reis C, Simões F, Fonseca J, Mendes Ribeiro J
J Neurol 2005 Dec;252(12):1435-47. doi: 10.1007/s00415-005-0007-9. PMID: 16362828
Nobile-Orazio E
J Neuroimmunol 2001 Apr 2;115(1-2):4-18. doi: 10.1016/s0165-5728(01)00266-1. PMID: 11282149

Prognosis

Hu N, Zhang L, Yang X, Fu H, Cui L, Liu M
Neurol Sci 2023 Jun;44(6):1969-1978. Epub 2023 Mar 3 doi: 10.1007/s10072-023-06703-1. PMID: 36864244
Scaricamazza S, Salvatori I, Ferri A, Valle C
Cells 2021 Mar 2;10(3) doi: 10.3390/cells10030525. PMID: 33801336Free PMC Article
Zheng Q, Chu L, Tan L, Zhang H
Neurol Sci 2016 Dec;37(12):1905-1909. Epub 2016 Jul 29 doi: 10.1007/s10072-016-2686-7. PMID: 27473302
Finsterer J
J Neurol Sci 2010 Nov 15;298(1-2):1-10. Epub 2010 Sep 16 doi: 10.1016/j.jns.2010.08.025. PMID: 20846673
Sathasivam S
Orphanet J Rare Dis 2008 Apr 17;3:9. doi: 10.1186/1750-1172-3-9. PMID: 18416855Free PMC Article

Clinical prediction guides

Hu N, Zhang L, Yang X, Fu H, Cui L, Liu M
Neurol Sci 2023 Jun;44(6):1969-1978. Epub 2023 Mar 3 doi: 10.1007/s10072-023-06703-1. PMID: 36864244
Pinto WBVR, Debona R, Nunes PP, Assis ACD, Lopes CG, Bortholin T, Dias RB, Naylor FGM, Chieia MAT, Souza PVS, Oliveira ASB
Rev Neurol (Paris) 2019 Apr;175(4):221-232. Epub 2019 Mar 4 doi: 10.1016/j.neurol.2018.04.016. PMID: 30846210
Ward AB
Eur J Neurol 2012 Jan;19(1):21-7. Epub 2011 Jun 27 doi: 10.1111/j.1468-1331.2011.03448.x. PMID: 21707868
Ashby P, Mailis A, Hunter J
Can J Neurol Sci 1987 Aug;14(3 Suppl):497-500. doi: 10.1017/s0317167100037987. PMID: 3315151
Gourie-Devi M, Suresh TG, Shankar SK
Arch Neurol 1984 Apr;41(4):388-94. doi: 10.1001/archneur.1984.04050160050015. PMID: 6703940

Recent systematic reviews

Hu N, Zhang L, Yang X, Fu H, Cui L, Liu M
Neurol Sci 2023 Jun;44(6):1969-1978. Epub 2023 Mar 3 doi: 10.1007/s10072-023-06703-1. PMID: 36864244

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