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Paraplegia/paraparesis

MedGen UID:
869366
Concept ID:
C4023792
Disease or Syndrome
HPO: HP:0010551

Definition

Weakness of both lower extremities with sparing of the upper extremities. Paraplegia refers to a severe or complete loss of strength, whereas paraparesis refers to a relatively mild loss of strength. [from HPO]

Professional guidelines

PubMed

Wang J, Jin T, Chen B, Pan Y, Shao C
J Vasc Surg 2022 Oct;76(4):1099-1108.e3. Epub 2022 Apr 4 doi: 10.1016/j.jvs.2022.03.876. PMID: 35390485
Nuwer MR, Emerson RG, Galloway G, Legatt AD, Lopez J, Minahan R, Yamada T, Goodin DS, Armon C, Chaudhry V, Gronseth GS, Harden CL; American Association of Neuromuscular and Electrodiagnostic Medicine
J Clin Neurophysiol 2012 Feb;29(1):101-8. doi: 10.1097/WNP.0b013e31824a397e. PMID: 22353994
Nuwer MR, Emerson RG, Galloway G, Legatt AD, Lopez J, Minahan R, Yamada T, Goodin DS, Armon C, Chaudhry V, Gronseth GS, Harden CL; Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology; American Clinical Neurophysiology Society
Neurology 2012 Feb 21;78(8):585-9. doi: 10.1212/WNL.0b013e318247fa0e. PMID: 22351796

Recent clinical studies

Etiology

Coselli JS, Roselli EE, Preventza O, Malaisrie SC, Stewart A, Stelzer P, Takayama H, Chen EP, Estrera AL, Gleason TG, Fischbein MP, Girardi LN, Patel HJ, Bavaria JE, LeMaire SA
J Thorac Cardiovasc Surg 2024 May;167(5):1680-1692.e2. Epub 2022 Sep 6 doi: 10.1016/j.jtcvs.2022.08.029. PMID: 36253292
Sultan S, Concannon J, Veerasingam D, Tawfick W, McHugh P, Jordan F, Hynes N
Cochrane Database Syst Rev 2022 Apr 1;4(4):CD012926. doi: 10.1002/14651858.CD012926.pub2. PMID: 35363887Free PMC Article
Gelpi G, Romagnoni C, Epifani F, Contino M, Antona C
Medicina (Kaunas) 2021 Aug 30;57(9) doi: 10.3390/medicina57090909. PMID: 34577832Free PMC Article
Viscusi ER, Hugo V, Hoerauf K, Southwick FS
Reg Anesth Pain Med 2021 Feb;46(2):176-181. Epub 2020 Nov 3 doi: 10.1136/rapm-2020-101836. PMID: 33144409Free PMC Article
Thompson TP, Pearce J, Chang G, Madamba J
Spine (Phila Pa 1976) 2004 Aug 15;29(16):E353-6. doi: 10.1097/01.brs.0000134689.84162.e7. PMID: 15303045

Diagnosis

Rossi PJ, Desai ND, Malaisrie SC, Lyden SP, Nassiri N, Reece TB, Adams JD, Moanie SL, Shults CC; RelayPro-D Investigators
Ann Thorac Surg 2024 Feb;117(2):336-343. Epub 2023 Sep 27 doi: 10.1016/j.athoracsur.2023.08.035. PMID: 37769702
Khachatryan Z, Haunschild J, von Aspern K, Borger MA, Etz CD
Ann Thorac Surg 2022 May;113(5):1692-1702. Epub 2021 Jan 9 doi: 10.1016/j.athoracsur.2020.12.028. PMID: 33434541
Preventza O, Olive JK, Liao JL, Orozco-Sevilla V, Simpson K, Rodriguez MR, Price MD, Cheong BY, Chatterjee S, de la Cruz KI, Amarasekara HS, LeMaire SA, Coselli JS
J Thorac Cardiovasc Surg 2019 Nov;158(5):1273-1281. Epub 2019 Mar 9 doi: 10.1016/j.jtcvs.2018.11.145. PMID: 30955955
Thompson TP, Pearce J, Chang G, Madamba J
Spine (Phila Pa 1976) 2004 Aug 15;29(16):E353-6. doi: 10.1097/01.brs.0000134689.84162.e7. PMID: 15303045
Ungar-Sargon JY, Lovelace RE, Brust JC
J Neurol Sci 1980 Apr;46(1):1-12. doi: 10.1016/0022-510x(80)90039-8. PMID: 6154777

Therapy

Coselli JS, Roselli EE, Preventza O, Malaisrie SC, Stewart A, Stelzer P, Takayama H, Chen EP, Estrera AL, Gleason TG, Fischbein MP, Girardi LN, Patel HJ, Bavaria JE, LeMaire SA
J Thorac Cardiovasc Surg 2024 May;167(5):1680-1692.e2. Epub 2022 Sep 6 doi: 10.1016/j.jtcvs.2022.08.029. PMID: 36253292
Wang J, Jin T, Chen B, Pan Y, Shao C
J Vasc Surg 2022 Oct;76(4):1099-1108.e3. Epub 2022 Apr 4 doi: 10.1016/j.jvs.2022.03.876. PMID: 35390485
Sultan S, Concannon J, Veerasingam D, Tawfick W, McHugh P, Jordan F, Hynes N
Cochrane Database Syst Rev 2022 Apr 1;4(4):CD012926. doi: 10.1002/14651858.CD012926.pub2. PMID: 35363887Free PMC Article
Shimizu H, Yozu R
Gen Thorac Cardiovasc Surg 2011 Mar;59(3):155-63. Epub 2011 Mar 30 doi: 10.1007/s11748-010-0705-9. PMID: 21448790
Luebke T, Brunkwall J
J Cardiovasc Surg (Torino) 2010 Oct;51(5):613-32. PMID: 20924323

Prognosis

Wang J, Jin T, Chen B, Pan Y, Shao C
J Vasc Surg 2022 Oct;76(4):1099-1108.e3. Epub 2022 Apr 4 doi: 10.1016/j.jvs.2022.03.876. PMID: 35390485
Frankel WC, Green SY, Amarasekara HS, Zhang Q, Preventza O, LeMaire SA, Coselli JS
Ann Thorac Surg 2021 Sep;112(3):717-724. Epub 2020 Nov 18 doi: 10.1016/j.athoracsur.2020.09.032. PMID: 33217404
Tanaka A, Leonard SD, Sandhu HK, Afifi RO, Miller CC 3rd, Charlton-Ouw KM, Ray A, Hassan M, Safi HJ, Estrera AL
Ann Thorac Surg 2019 Sep;108(3):693-699. Epub 2019 Apr 19 doi: 10.1016/j.athoracsur.2019.03.058. PMID: 31009630
Coselli JS, LeMaire SA, Preventza O, de la Cruz KI, Cooley DA, Price MD, Stolz AP, Green SY, Arredondo CN, Rosengart TK
J Thorac Cardiovasc Surg 2016 May;151(5):1323-37. Epub 2016 Jan 14 doi: 10.1016/j.jtcvs.2015.12.050. PMID: 26898979
Luebke T, Brunkwall J
J Cardiovasc Surg (Torino) 2010 Oct;51(5):613-32. PMID: 20924323

Clinical prediction guides

Wang J, Jin T, Chen B, Pan Y, Shao C
J Vasc Surg 2022 Oct;76(4):1099-1108.e3. Epub 2022 Apr 4 doi: 10.1016/j.jvs.2022.03.876. PMID: 35390485
Frankel WC, Green SY, Amarasekara HS, Zhang Q, Preventza O, LeMaire SA, Coselli JS
Ann Thorac Surg 2021 Sep;112(3):717-724. Epub 2020 Nov 18 doi: 10.1016/j.athoracsur.2020.09.032. PMID: 33217404
Preventza O, Olive JK, Liao JL, Orozco-Sevilla V, Simpson K, Rodriguez MR, Price MD, Cheong BY, Chatterjee S, de la Cruz KI, Amarasekara HS, LeMaire SA, Coselli JS
J Thorac Cardiovasc Surg 2019 Nov;158(5):1273-1281. Epub 2019 Mar 9 doi: 10.1016/j.jtcvs.2018.11.145. PMID: 30955955
Coselli JS, LeMaire SA, Preventza O, de la Cruz KI, Cooley DA, Price MD, Stolz AP, Green SY, Arredondo CN, Rosengart TK
J Thorac Cardiovasc Surg 2016 May;151(5):1323-37. Epub 2016 Jan 14 doi: 10.1016/j.jtcvs.2015.12.050. PMID: 26898979
Luebke T, Brunkwall J
J Cardiovasc Surg (Torino) 2010 Oct;51(5):613-32. PMID: 20924323

Recent systematic reviews

Wang J, Jin T, Chen B, Pan Y, Shao C
J Vasc Surg 2022 Oct;76(4):1099-1108.e3. Epub 2022 Apr 4 doi: 10.1016/j.jvs.2022.03.876. PMID: 35390485
Sultan S, Concannon J, Veerasingam D, Tawfick W, McHugh P, Jordan F, Hynes N
Cochrane Database Syst Rev 2022 Apr 1;4(4):CD012926. doi: 10.1002/14651858.CD012926.pub2. PMID: 35363887Free PMC Article
Luebke T, Brunkwall J
J Cardiovasc Surg (Torino) 2010 Oct;51(5):613-32. PMID: 20924323

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