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Abnormality of multiple cell lineages in the bone marrow

MedGen UID:
868624
•Concept ID:
C4023024
•
Anatomical Abnormality
HPO: HP:0012145

Recent clinical studies

Etiology

Aging and Bone Metabolism.
Pignolo RJ
Compr Physiol 2023 Jan 30;13(1):4355-4386. doi: 10.1002/cphy.c220012. PMID: 36715278
Multifaceted characterization of the signatures and efficacy of mesenchymal stem/stromal cells in acquired aplastic anemia.
Huo J, Zhang L, Ren X, Li C, Li X, Dong P, Zheng X, Huang J, Shao Y, Ge M, Zhang J, Wang M, Nie N, Jin P, Zheng Y
Stem Cell Res Ther 2020 Feb 13;11(1):59. doi: 10.1186/s13287-020-1577-2. PMID: 32054519Free PMC Article
The role of NELL-1, a growth factor associated with craniosynostosis, in promoting bone regeneration.
Zhang X, Zara J, Siu RK, Ting K, Soo C
J Dent Res 2010 Sep;89(9):865-78. Epub 2010 Jul 20 doi: 10.1177/0022034510376401. PMID: 20647499Free PMC Article
The lower risk MDS patient at risk of rapid progression.
Mittelman M, Oster HS, Hoffman M, Neumann D
Leuk Res 2010 Dec;34(12):1551-5. Epub 2010 Jun 22 doi: 10.1016/j.leukres.2010.05.023. PMID: 20573398
Congenital cytopenias and bone marrow failure syndromes.
Rivers A, Slayton WB
Semin Perinatol 2009 Feb;33(1):20-8. doi: 10.1053/j.semperi.2008.10.009. PMID: 19167578

Diagnosis

Twenty-Five Years of Gene Therapy for ADA-SCID: From Bubble Babies to an Approved Drug.
Ferrua F, Aiuti A
Hum Gene Ther 2017 Nov;28(11):972-981. doi: 10.1089/hum.2017.175. PMID: 28847159
Diamond-Blackfan anemia and nutritional deficiency-induced anemia in children.
Gelbart D
JAAPA 2014 Apr;27(4):36-44. doi: 10.1097/01.JAA.0000442702.95598.fc. PMID: 24662257
The lower risk MDS patient at risk of rapid progression.
Mittelman M, Oster HS, Hoffman M, Neumann D
Leuk Res 2010 Dec;34(12):1551-5. Epub 2010 Jun 22 doi: 10.1016/j.leukres.2010.05.023. PMID: 20573398
Congenital cytopenias and bone marrow failure syndromes.
Rivers A, Slayton WB
Semin Perinatol 2009 Feb;33(1):20-8. doi: 10.1053/j.semperi.2008.10.009. PMID: 19167578
Fates of human B-cell precursors.
LeBien TW
Blood 2000 Jul 1;96(1):9-23. PMID: 10891425

Therapy

Prostate cancer, chronic myelogenous leukemia and multiple myeloma in a single patient: a case report and review of the literature.
Allahyari A, Maharati A, Jafari-Nozad AM, Zangooie A
J Med Case Rep 2023 Feb 5;17(1):35. doi: 10.1186/s13256-023-03753-z. PMID: 36739400Free PMC Article
Mesenchymal stem cells in multiple myeloma: a therapeutical tool or target?
Xu S, De Veirman K, De Becker A, Vanderkerken K, Van Riet I
Leukemia 2018 Jul;32(7):1500-1514. Epub 2018 Feb 22 doi: 10.1038/s41375-018-0061-9. PMID: 29535427Free PMC Article
Twenty-Five Years of Gene Therapy for ADA-SCID: From Bubble Babies to an Approved Drug.
Ferrua F, Aiuti A
Hum Gene Ther 2017 Nov;28(11):972-981. doi: 10.1089/hum.2017.175. PMID: 28847159
The lower risk MDS patient at risk of rapid progression.
Mittelman M, Oster HS, Hoffman M, Neumann D
Leuk Res 2010 Dec;34(12):1551-5. Epub 2010 Jun 22 doi: 10.1016/j.leukres.2010.05.023. PMID: 20573398
Characterization of in vitro expanded bone marrow-derived mesenchymal stem cells from patients with multiple sclerosis.
Mallam E, Kemp K, Wilkins A, Rice C, Scolding N
Mult Scler 2010 Aug;16(8):909-18. Epub 2010 Jun 11 doi: 10.1177/1352458510371959. PMID: 20542920

Prognosis

Establishing a human bone marrow single cell reference atlas to study ageing and diseases.
Lee NYS, Li M, Ang KS, Chen J
Front Immunol 2023;14:1127879. Epub 2023 Mar 15 doi: 10.3389/fimmu.2023.1127879. PMID: 37006302Free PMC Article
Twenty-Five Years of Gene Therapy for ADA-SCID: From Bubble Babies to an Approved Drug.
Ferrua F, Aiuti A
Hum Gene Ther 2017 Nov;28(11):972-981. doi: 10.1089/hum.2017.175. PMID: 28847159
Fibroblast abnormalities in the pathogenesis of systemic sclerosis.
Usategui A, del Rey MJ, Pablos JL
Expert Rev Clin Immunol 2011 Jul;7(4):491-8. doi: 10.1586/eci.11.39. PMID: 21790292
The lower risk MDS patient at risk of rapid progression.
Mittelman M, Oster HS, Hoffman M, Neumann D
Leuk Res 2010 Dec;34(12):1551-5. Epub 2010 Jun 22 doi: 10.1016/j.leukres.2010.05.023. PMID: 20573398
Haematological aspects of HIV infection.
Evans RH, Scadden DT
Baillieres Best Pract Res Clin Haematol 2000 Jun;13(2):215-30. doi: 10.1053/beha.1999.0069. PMID: 10942622

Clinical prediction guides

Establishing a human bone marrow single cell reference atlas to study ageing and diseases.
Lee NYS, Li M, Ang KS, Chen J
Front Immunol 2023;14:1127879. Epub 2023 Mar 15 doi: 10.3389/fimmu.2023.1127879. PMID: 37006302Free PMC Article
Abnormal Peyer patch development and B-cell gut homing drive IgA deficiency in Kabuki syndrome.
Pilarowski GO, Cazares T, Zhang L, Benjamin JS, Liu K, Jagannathan S, Mousa N, Kasten J, Barski A, Lindsley AW, Bjornsson HT
J Allergy Clin Immunol 2020 Mar;145(3):982-992. Epub 2019 Dec 6 doi: 10.1016/j.jaci.2019.11.034. PMID: 31816409
Twenty-Five Years of Gene Therapy for ADA-SCID: From Bubble Babies to an Approved Drug.
Ferrua F, Aiuti A
Hum Gene Ther 2017 Nov;28(11):972-981. doi: 10.1089/hum.2017.175. PMID: 28847159
The role of NELL-1, a growth factor associated with craniosynostosis, in promoting bone regeneration.
Zhang X, Zara J, Siu RK, Ting K, Soo C
J Dent Res 2010 Sep;89(9):865-78. Epub 2010 Jul 20 doi: 10.1177/0022034510376401. PMID: 20647499Free PMC Article
The lower risk MDS patient at risk of rapid progression.
Mittelman M, Oster HS, Hoffman M, Neumann D
Leuk Res 2010 Dec;34(12):1551-5. Epub 2010 Jun 22 doi: 10.1016/j.leukres.2010.05.023. PMID: 20573398

Recent systematic reviews

Mosaicism in Fanconi anemia: concise review and evaluation of published cases with focus on clinical course of blood count normalization.
Nicoletti E, Rao G, Bueren JA, Río P, Navarro S, Surrallés J, Choi G, Schwartz JD
Ann Hematol 2020 May;99(5):913-924. Epub 2020 Feb 17 doi: 10.1007/s00277-020-03954-2. PMID: 32065290Free PMC Article
Bone Health in Patients With Hematopoietic Disorders of Bone Marrow Origin: Systematic Review and Meta- Analysis.
Steer K, Stavnichuk M, Morris M, Komarova SV
J Bone Miner Res 2017 Apr;32(4):731-742. Epub 2016 Nov 30 doi: 10.1002/jbmr.3026. PMID: 27787922

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