GEO DataSets

(Submitter supplied) Array analysis of My-bi and Ly-bi HSC identifies candidate molecules for myeloid-bias. Collectively the data show that HSC in adults are largely epigenetically fixed in differentiation and self-renewal behavior. A direct examination of the epigenetic mechanisms that imprint HSC is difficult. However, an indirect way of assessing the effects of epigenetic imprinting is to look for the expressed gene programs of different types of HSC. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1073

4 Samples

Download data: CEL, TXT

(Submitter supplied) Monocytes and macrophages express an extensive repertoire of G Protein-Coupled Receptors (GPCRs) that regulate inflammation and immunity. In this study we performed a systematic microarray analysis of GPCR expression in primary mouse tissues to identify family members that are either enriched in macrophages compared to a panel of other cell types, or are regulated by an inflammatory stimulus, the bacterial product lipopolysaccharide (LPS). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1073

16 Samples

Download data: CEL

(Submitter supplied) Genome-wide gene expression profiling has been extensively used to generate biological hypotheses based on differential expression. Recently, many studies have used microarrays to measure gene expression levels across genetic mapping populations. These gene expression phenotypes have been used for genome-wide association analyses, an analysis referred to as expression QTL (eQTL) mapping. Here, eQTL analysis was performed in fat issue from 28 inbred strains of mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1073

28 Samples

Download data: CEL

(Submitter supplied) The discovery of quantitative trait loci (QTL) in model organisms has relied heavily on the ability to perform controlled breeding to generate genotypic and phenotypic diversity. Recently, we and others have demonstrated the use of a set of diverse inbred mice as a QTL mapping population. The use of this population has many advantages, including increased phenotypic diversity, a higher recombination frequency and the ability to collect genotype data in community databases. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1073

58 Samples

Download data: CEL

(Submitter supplied) One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into DD (CT18), tissues from 5 (skeletal muscle) or 10 (liver or SCN) wildtype mice were collected every 4 hours for 48 hours, for a total of 12 timepoints. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1073

38 Samples

Download data: CEL

(Submitter supplied) One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into DD (CT18), the left leg muscle from 5 wildtype mice, and the right leg muscle from the same wildtype mice were collected every 4 hours for 48 hours, for a total of 12 timepoints. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1073

38 Samples

Download data: CEL

(Submitter supplied) One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into DD (CT18), tissues from 5 (skeletal muscle) or 10 (liver or SCN) wildtype mice were collected every 4 hours for 48 hours, for a total of 12 timepoints. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1073

76 Samples

Download data: CEL

(Submitter supplied) To elucidate transcriptional differences between naïve, tolerant and memory CD8+ T cells, genome-wide gene expression profiling was performed. The indicated cell populations were purified from immunized or naïve Rag-/- TCR mice by cell sorting and RNA was extracted labeled and hybridized to an Affymetrix custom mouse array GNF1M GeneChip. RNA from sorted samples was prepared, split into two aliquots prior to making labeled cDNA, so that two arrays were used for each cell population.Alterations in transcript levels were determined through pair wise comparisons of naïve cells to either memory or tolerant CD8+ T cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2327

Platform:

GPL1073

6 Samples

Download data: CEL

Analysis of tolerant, naïve, and memory CD8+ T cells purified from TCRxGag transgenics. T cell tolerance to self-proteins prevents autoimmunity but impedes the response to tumor-associated antigens. Results provide insight into the feasibility of rescuing tolerant cells for tumor immunotherapy.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 cell type sets

Platform:

GPL1073

Series:

GSE3800

6 Samples

Download data: CEL

(Submitter supplied) The tissue-specific pattern of mRNA expression can indicate important clues about gene function. High-density oligonucleotide arrays offer the opportunity to examine patterns of gene expression on a genome scale. Toward this end, we have designed custom arrays that interrogate the expression of the vast majority of protein-encoding human and mouse genes and have used them to profile a panel of 79 human and 61 mouse tissues. more...

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS592 GDS596

Platforms:

GPL96 GPL1073 GPL1074

438 Samples

Download data: CEL

Gene atlas of mouse protein-encoding transcriptome. Gene expression profiles from 61 physiologically normal tissues. Samples generated from adult (10-12 week old) C57BL/6 mice (4 male, 3 female) by dissection.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 61 tissue sets

Platform:

GPL1073

Series:

GSE1133

122 Samples

Download data: CEL

(Submitter supplied) GNF1M We identified a non-redundant set of target sequences for the mouse using the following sources: RefSeq (12,029 sequences), Celera (29,331 sequences), and RIKEN (46,299 sequences). First, all sequences were RepeatMasked to remove repetitive elements. Next, sequence identity between individual sequences was established using pairwise BLAT or BLAST and sim4. The results from single-linkage clustering were further triaged to produce a final target set of 36,182 targets with the highest degree of confidence of computational prediction (biasing toward sequences containing Interpro domains and away from non-coding RNAs). more...

Organism:

Mus musculus

2 DataSets

9 Series

310 Samples

Download data: CDF, CIF, GIN, PROBE, PSI, SIF, TAB