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Items: 3

1.

The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells

(Submitter supplied) Pax5 is a critical regulator of B cell commitment. Here we identified direct Pax5 target genes by streptavidin-mediated ChIP-chip analysis of pro-B cells expressing in vivo biotinylated Pax5. By binding to promoters and enhancers, Pax5 directly regulates the expression of multiple transcription factor, cell surface receptor and signal transducer genes. One of the newly identified enhancers was shown by transgenic analysis to confer Pax5-dependent B-cell-specific activity to the Nedd9 gene controlling B cell trafficking. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by genome tiling array
Platforms:
GPL13366 GPL13123
29 Samples
Download data: PAIR
Series
Accession:
GSE28373
ID:
200028373
2.

IGH analysis in pro-B cells with H3K4me3, H3K4me2, H3K9ac, H3K27me3, Pax5 and CTCF

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by genome tiling array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL9185 GPL13123
16 Samples
Download data: BED, PAIR
Series
Accession:
GSE27215
ID:
200027215
3.

IGH analysis in pro-B cells with H3K4me3, H3K4me2, H3K9ac, H3K27me3, Pax5 and CTCF [ChIP-chip]

(Submitter supplied) VH-DJH recombination of the immunoglobulin heavy-chain (Igh) locus is temporally and spatially controlled during early B-cell development, and yet no regulatory elements other than the VH gene promoters have been identified throughout the entire 2.5-Mb VH gene cluster. Here we discovered novel regulatory sequences that are interspersed in the distal VH gene region. These conserved repeat elements were characterized by the presence of Pax5-dependent active chromatin, the binding of Pax5, E2A, CTCF and Rad21 as well as by Pax5-dependent antisense transcription in pro-B cells. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL13123
12 Samples
Download data: PAIR
Series
Accession:
GSE27074
ID:
200027074
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