GPL15018[RGSE] - GEO DataSets

(Submitter supplied) The majority of breast tumours express oestrogen receptor (ER) and receive endocrine therapy (ET) as standard care. Despite its efficacy, ~40% of women relapse with endocrine therapy-resistant (ETR) disease. A global transcription analysis and subsequent integrative approaches of ETR cells showed a deregulated node between miR-23b-3p and the amino acids transporter SLC6A14. Mechanistic analysis supports a model in which such deregulation impairs amino acids metabolism in the ETR cells with subsequent activation of autophagy and enhanced aspartate and glutamate import mediated by the SLC1A2 transporter. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15018
9 Samples

Download data: TXT

Series

Accession:: GSE120930

ID:: 200120930

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001342273.

The effect of H1N1 vaccination on serum miRNA expression in children: a tale of caution for microRNA microarray studies

(Submitter supplied) To describe vaccine associated changes in the expression of microRNAs 21 days after vaccination in children receiving one of two pandemic influenza (H1N1) vaccines.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15018
48 Samples

Download data: TXT

Series

Accession:: GSE134227

ID:: 200134227

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001219014.

miRNA expression data through TNF-alpha-signaling in human umblical vein endothelial cells (HUVECs)

(Submitter supplied) Lysine 9 di-methylation and lysine 27 tri-methylation of histone H3 (H3K9me2 and H3K27me3) are mostly linked to gene repression. However, functions of repressive histone methylation dynamics during inflammatory responses remain poorly understood. Here, we show that lysine demethylase 7A (KDM7A) and 6A (UTX) are rapidly transported to nuclear factor kappa-B (NF-κB) related elements in human endothelial cells in response to tumor necrosis factor (TNF)-α. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15018
4 Samples

Download data: TXT

Series

Accession:: GSE121901

ID:: 200121901

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001215225.

TNF-alpha-stimulated human umblical vein endothelial cells (HUVECs)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array; Expression profiling by high throughput sequencing; Non-coding RNA profiling by array

5 related Platforms
95 Samples

Download data: BED, BIGWIG, BW, CEL, TXT

Series

Accession:: GSE121522

ID:: 200121522

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001102176.

miRNA expression signatures in chronic hepatitis B (CHB) treated with nucleos(t)ide analogues (NA)

(Submitter supplied) Hepatitis B virus (HBV) infection is one of the major causes of hepatocellular carcinoma (HCC). Nucleos(t)ide analogue (NA) therapy is effective to reduce the HCC incidence, while it doesn’t completely prevent HCC. In this study, we explored the involvement of microRNA (miRNA) in the post-NA treatment HCC development. Chronic hepatitis B (CHB) patients who received NA treatment (n = 18) were divided into 2 groups: those who didn’t develop HCC during the follow-up period (non-HCC group) and those who developed HCC after treatment (HCC group). more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15018
42 Samples

Download data: TXT

Series

Accession:: GSE110217

ID:: 200110217

Select item 2001083077.

Dysregulated mRNA and miRNA expression networks in Helicobacter pylori infected gastric epithelial cell line, AGS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL13252 GPL15018
8 Samples

Download data: TXT

Series

Accession:: GSE108307

ID:: 200108307

Analyze with GEO2R

Select item 2001083068.

Dysregulated mRNA and miRNA expression networks in Helicobacter pylori infected gastric epithelial cell line, AGS (miRNA)

(Submitter supplied) We performed genome-wide mRNA and miRNA expression analysis in gastric epithelial cell line AGS infected with Helicobacter pylori at 100 Multiplicity of Infection (MOI), comparing the expression profile of infected cells with uninfected cells. Differentially expressed mRNAs and miRNAs were identified, which showed a 1.5 fold change in expression in infected cells compared to uninfected cells. We performed in silico analysis of miRNA-mRNA target interactions among the inversely correlated differentially expressed miRNAs and mRNAs, and performed functional enrichment analysis of the target genes, to identify important cellular pathways that reflect the patho-biology of H. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15018
4 Samples

Download data: TXT

Series

Accession:: GSE108306

ID:: 200108306

Analyze with GEO2R

Select item 2001023149.

Differential Expression of MicroRNAs in Leprosy Skin Lesions

(Submitter supplied) In this study, a comprehensive assessment of human miRNA was performed on leprosy skin lesions using DNA chip microarrays, which included the entire spectrum of the disease along with its reactional states. Sixty-eight samples from leprotic lesions (10TT, 10BT, 10BB, 10BL, 4LL, 14R1, and 10R2) and nine skin biopsies from healthy individuals were used as controls (CC) (ages ranged from 06 to 83 years, 48 were male and 29 female). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15018
77 Samples

Download data: TXT

Series

Accession:: GSE102314

ID:: 200102314

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010108510.

Ionizing radiation induced changes of miRNA expression in A549 lung cancer cells

(Submitter supplied) We have employed microarray expression profiling as a discovery platform to identify microRNAs induced by radiation. Human A549 lung cancer cells were irradiated (2Gy/day for consistent 3days) and miRNA signature was identified that distinguished between control and radiation treated samples.Irradiated and un-irradiated A549 cells were harvested after 48 hr of treatment and microarray analysis was performed. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15018
2 Samples

Download data: TXT

Series

Accession:: GSE101085

ID:: 200101085

Analyze with GEO2R

Select item 20006847511.

Characterizing the global changes in miRNA expression in human atrial appendages with persistent atrial fibrillation.

(Submitter supplied) Atrial fibrillation (AF), the most common cardiac rhythm disorder, is a major cause of cardiovascular morbidity and mortality. AF is characterized by the rapid and irregular activation of the atrium with diverse abnormalities, including electrical, structural, metabolic, neurohormonal, or molecular alterations.3 Although the pathophysiology of AF is complex, it has traditionally been treated with antiarrhythmic drugs that control the rhythm by altering cardiac electrical properties, principally by modulating ion channel function. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15018
21 Samples

Download data: TXT

Series

Accession:: GSE68475

ID:: 200068475

Select item 20007334812.

Comparison of gene expression profiles between myxoid and round cell component in myxoid liposarcoma

(Submitter supplied) Round cell component is a resk factor associated with metastasis and poor prognosis in myxoid liposarcoma. To identify microRNAs which play a role in the malignancy of round cell component, we performed microRNA microarray analysis and compared the miRNA expression profilings between myxoid and round cell component.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15018
16 Samples

Download data: TXT

Series

Accession:: GSE73348

ID:: 200073348

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006912813.

Identification of microRNA profile specific to Cancer Stem-Like Cells directly isolated from Human Larynx Cancer Specimens

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platforms:: GPL15018 GPL20228
24 Samples

Download data: TXT

Series

Accession:: GSE69128

ID:: 200069128

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006912614.

Identification of microRNA profile specific to Cancer Stem-Like Cells directly isolated from Human Larynx Cancer Specimens (Agilent-031181)

(Submitter supplied) Our results showed that certain miRNAs in CD133high cells could be used as cancer stem cell markers. Based on these results, we propose that this panel of miRNAs might carry crucial roles in LCa initiation, progression, metastasis, chemoresistance and recurrence through regulating stem cell properties of tumor cells.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15018
8 Samples

Download data: TXT

Series

Accession:: GSE69126

ID:: 200069126

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008213015.

microRNA expression signatures for colon cancer initiating cell in CRC

(Submitter supplied) In CCICs, G9a expression significantly increases K-RAS protein expression but has no effect on mRNA level. This raises the question of whether microRNA (miRNA) is involved in regulation. A heat map of a miRNA array in G9a versus shG9a transfectants ranked the Let-7 family first, with only Let-7b consistently up-regulated in G9a-knockdown CCICs and down-regulated in G9a-overexpressed non-CCICs

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15018
4 Samples

Download data: TXT

Series

Accession:: GSE82130

ID:: 200082130

Analyze with GEO2R

Select item 20008426016.

miRNAs as Common Regulators of the Transforming Growth Factor (TGF)-β Pathway in the Preeclamptic Placenta and Cadmium-treated Trophoblasts: Links between the Environment, the Epigenome and Preeclampsia

(Submitter supplied) Preeclampsia (PE) is a pregnancy disorder characterized by high blood pressure and proteinuria that can cause adverse health effects in both mother and fetus. There is no current cure for PE other than delivery of the fetus. While the etiology is unknown, poor placentation of the placenta due to aberrant signaling of growth and angiogenic factors has been postulated as causal factors of PE. In addition, environmental contaminants, such as the metal cadmium (Cd), have been linked to placental toxicity and increased risk of developing PE. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15018
38 Samples

Download data: TXT

Series

Accession:: GSE84260

ID:: 200084260

Analyze with GEO2R

Select item 20006948917.

Inhibition of Histone Deacetylase induces miR-320-mediated Androgen Receptor Suppression in Prostate Cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platforms:: GPL18046 GPL15018
6 Samples

Download data: TXT

Series

Accession:: GSE69489

ID:: 200069489

Select item 20006948818.

Development of miRNA expression signatures for induction of histone deacetylase inhibitor (part 2)

(Submitter supplied) To clarify the relationship between histone acetylation and miRNA expression, we performed miRNA arrays to detect histone deacetylase inhibitor (OBP-801) induced miRNA regulating AR expression in 22Rv1.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15018
2 Samples

Download data: TXT

Series

Accession:: GSE69488

ID:: 200069488

Select item 20008114119.

A Novel role for GSK3B as a modulator of Drosha Microprocessor activity and microRNA biogenesis

(Submitter supplied) Regulation of microRNA (miR) biogenesis is complex and stringently controlled. Here we identify the kinase GSK3B as an important modulator of global miR biogenesis at microprocessor level. Repression of GSK3B activity reduces Drosha activity towards pri-miRs, leading to accumulation of unprocessed pri-miRs and reduction of pre-miRs and mature miRs without altering levels or cellular localisationof miR biogenesisproteins. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15018
6 Samples

Download data: TXT

Series

Accession:: GSE81141

ID:: 200081141

Analyze with GEO2R

Select item 20007219920.

Downregulation of microRNA-132 is associated with liver metastasis of colorectal cancer by targeting Anoctamin 1.

(Submitter supplied) In this study, we conducted a microarray-based analysis to identify differentially expressed miRNAs in CRC by comparing miRNA profiles among primary CRC tissues from patients with liver metastases, primary tissues without liver metastases, and liver metastatic lesions. microRNAs (miRNAs) have been shown to have a potential for cancer diagnosis lately. The main objective of this study is to identify a novel biomarker serum miRNA from the patients with colorectal cancer (CRC). more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15018
36 Samples

Download data: TXT

Series

Accession:: GSE72199

ID:: 200072199

PubMed Full text in PMC Similar studies Analyze with GEO2R

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