GPL21020[Accession] - GEO DataSets

(Submitter supplied) We report the RNA-seq based analyses of the transcriptional changes in the Aedes aegypti transcriptome 4 days after blood feeding with 2 μM hsa-miR-150-5p antagomir or mock.

Organism:: Aedes aegypti

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21020
2 Samples

Download data: TXT

Series

Accession:: GSE167210

ID:: 200167210

PubMed Similar studies SRA Run Selector

Select item 2001621503.

Updated and validated global cis-regulatory element map which includes the M/m sex-determining region of Aedes aegypti

(Submitter supplied) Formaldehyde assisted isolation of regulatory element (FAIRE) enrichment was used to recover open chromatin from A. aegypti embryos. Next-generation sequencing of FAIRE DNA was performed. Computational detection and analysis of FAIRE-enriched DNA sequences followed.

Organism:: Aedes aegypti

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21020
3 Samples

Download data: NARROWPEAK

Series

Accession:: GSE162150

ID:: 200162150

SRA Run Selector

Select item 2001571684.

Argonaute-CLIP delineates versatile, functional RNAi networks in Aedes aegypti, a major vector of human viruses

(Submitter supplied) Argonaute (AGO) proteins bind small RNAs to silence complementary RNA transcripts and are central to RNA interference (RNAi). AGO-crosslinking immunoprecipitation (AGO-CLIP) has illuminated RNAi networks, but bioinformatic analysis is laborious and lack of experimental tools hinders its application outside of model organisms. RNAi is critical for regulation of gene expression and defense against viral infection in the Aedes aegypti mosquito, which transmits Zika, chikungunya, dengue, and yellow fever viruses to cause human disease. more...

Organism:: Aedes aegypti

Type:: Non-coding RNA profiling by high throughput sequencing; Other

Platforms:: GPL21020 GPL22761
97 Samples

Download data: TXT

Series

Accession:: GSE157168

ID:: 200157168

SRA Run Selector

Select item 2001332845.

Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes

(Submitter supplied) Mosquito-borne flaviviruses maintain life cycles in mammals and mosquitoes. RNA interference (RNAi) has been demonstrated as an anti-flavivirus mechanism in mosquitoes; however, whether and how flavivirus induces and antagonizes RNAi-mediated antiviral immunity in mammals remains unknown. Here we showed that NS2A of Dengue virus-2 (DENV2) act as a viral suppressor of RNAi (VSR). When NS2A-mediated RNAi suppression was disabled, the resulting mutant DENV2 induced Dicer-dependent production of abundant DENV2-derived siRNAs in differentiated mammalian cells. more...

Organism:: Aedes aegypti; Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL21020 GPL11154
6 Samples

Download data: TXT

Series

Accession:: GSE133284

ID:: 200133284

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001190366.

Human iron status mediates mosquito susceptibility to Dengue infection

(Submitter supplied) We report the RNA-seq based analyses of the transcriptional changes in the Aedes aegypti midguts transcriptome 24,48 hours after blood feeding with or without 250 um ferric ammonium citrate.

Organism:: Aedes aegypti

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21020
4 Samples

Download data: XLS

Series

Accession:: GSE119036

ID:: 200119036

PubMed Similar studies SRA Run Selector

Select item 2001255207.

Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids

(Submitter supplied) The re-emergence of Zika virus (ZIKV) in the Western Hemisphere has resulted in global public health crisis since 2015. ZIKV preferentially infects and targets human neural progenitor cells (hNPCs) and causes fetal microcephaly upon maternal infection. hNPCs not only play critical roles during fetal brain development, but also persist in adult brain throughout life. Yet the mechanism of innate antiviral immunity in hNPCs remains largely unknown. more...

Organism:: Aedes aegypti; Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL11154 GPL21020
5 Samples

Download data: TXT

Series

Accession:: GSE125520

ID:: 200125520

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000910348.

Mosquito hematophage-mediated GABAergic activation facilitates acquisition of mosquito-borne viruses

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Aedes aegypti

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21020
17 Samples

Download data: TXT

Series

Accession:: GSE91034

ID:: 200091034

Select item 2000910329.

Mosquito hematophage-mediated GABAergic activation facilitates acquisition of mosquito-borne viruses (dsRNA knocked-down)

(Submitter supplied) Two independent dsRNAs to knocked-down the AaGABAA-R1 gene in A. aegypti

Organism:: Aedes aegypti

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21020
3 Samples

Download data: TXT

Series

Accession:: GSE91032

ID:: 200091032

SRA Run Selector

Select item 20009102710.

Mosquito hematophage-mediated GABAergic activation facilitates acquisition of mosquito-borne viruses (infection)

(Submitter supplied) Gene regulation by infection flavivirus, alphavirus and orthobunyavirus in Aedes aegypti

Organism:: Aedes aegypti

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21020
14 Samples

Download data: TXT

Series

Accession:: GSE91027

ID:: 200091027

SRA Run Selector

Select item 20008069111.

The yellow fever virus capsid protein is a potent suppressor of RNA silencing that binds double stranded RNA.

(Submitter supplied) In this study, we describe a viral suppressor of RNA silencing encoded by the prototype flavivirus, yellow fever virus (YFV). We show that the YFV capsid protein inhibits RNA silencing in the mosquito Aedes aegypti by interfering with Dicer. These results suggest a molecular arms race between vector and pathogen underlies the continued existence of flaviviruses in nature.

Organism:: Aedes aegypti

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL21020
6 Samples

Download data: XLSX

Series

Accession:: GSE80691

ID:: 200080691

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007396712.

The midguts transcriptome of Aedes aegypti (Liverpool strain) females blood fed DENV2 NS1 versus those blood fed BSA

(Submitter supplied) We report the RNA-seq based analyses of the transcriptional changes in the Aedes aegypti midguts transcriptome 4,8,18 hours after blood feeding BSA or DENV2 NS1.

Organism:: Aedes aegypti

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21020
6 Samples

Download data: TXT

Series

Accession:: GSE73967

ID:: 200073967

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007907013.

The midguts transcriptome of Aedes aegypti (Liverpool strain) females knock down AaMesh and feed AaMesh antibody versus those knock down GFP and feed pre-immune.

(Submitter supplied) We reported the RNA-seq based analyses of the transcriptional changes in the Aedes aegypti midguts knock down 3, 6days, feed antibody 18h transcriptome.

Organism:: Aedes aegypti

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21020
6 Samples

Download data: TXT

Series

Accession:: GSE79070

ID:: 200079070

SRA Run Selector

Select item 20007478514.

Aedes aegypti Cry11Aa intoxication curve transcriptome

(Submitter supplied) Transcriptomic analysis of mosquito larvae exposed to LC50 of Cry11Aa toxin from Bti at different times was conducted to determine defense response pathways in order to better understand the toxin's mode of action and identify possible cellular targets to enhance toxin activity.