GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL20710 GPL23092 GPL24247

24 Samples

Download data: CEL, MTX, TSV

(Submitter supplied) Hematopoietic stem cells (HSCs) are formed in the Aorta-Gonad-Mesobephros (AGM) region of mouse midgestation embryos. This process is tightly regulated in time and space by surrounding cells inculding mesenchymal cells located underneath the dorsal aorta. We combined laser microdissection and microarrays to isolate the dorsal and ventral aortic tissues at three developmental stages and to explore their gene expression profiling.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23092

8 Samples

Download data: CEL

(Submitter supplied) Hematopoietic stem cells (HSCs) are formed in the Aorta-Gonad-Mesobephros (AGM) region of mouse midgestation embryos. This process is tightly regulated in time and space by surrounding cells inculding mesenchymal cells located underneath the dorsal aorta. We combined laser microdissection and microarrays to isolate the dorsal and ventral aortic tissues at three developmental stages and to explore their gene expression profiling.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23092

2 Samples

Download data: CEL

(Submitter supplied) Hematopoietic stem cells (HSCs) are formed in the Aorta-Gonad-Mesobephros (AGM) region of mouse midgestation embryos. This process is tightly regulated in time and space by surrounding cells inculding mesenchymal cells located underneath the dorsal aorta. We combined laser microdissection and microarrays to isolate the dorsal and ventral aortic tissues at three developmental stages and to explore their gene expression profiling.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23092

6 Samples

Download data: CEL

(Submitter supplied) Cancer and cardiovascular disease (CVD) share common risk factors such as dyslipidemia, obesity and inflammation. However, the role of pro-atherogenic environment and its associated low-grade inflammation in tumor progression remains underexplored. Here we show that two-week feeding of wildtype C57BL/6J mice with a high fat high cholesterol atherogenic diet (HFHCD) increases the pool of circulating Ly6C hi monocytes available for initial melanoma development, under the control of IL-1. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23092

8 Samples

Download data: CEL

(Submitter supplied) ChREBP was stably overexpressed in the liver of C57BL/6J mice through the use of the sleeping beauty transposon system. ChREBP overexpression resulted in HCC tumor development in 12 months. We used microarray analysis to detail the global program of gene expression in ChREBP overexpressing tumors compared to non-tumoral adjacent tissue or compared with normal liver samples from C57BL/6J mice. WE then identified distinct classes of up and down regulated genes.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23092

16 Samples

Download data: CEL

(Submitter supplied) Tumor derived factors can promote the differentiation of hematopoietic precursors into suppressive myeloid derived suppressor cells however, the molecular pathways that regulate this differentiation are not fully disclosed. In this study we identified a pathway by which tumor derived factors induce the expression of CCL3 and CCL4 from early HSPCs that autocrinally bind to CCR1 and CCR5 mediate the differentiation of BM cells into suppressive and protumoral cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23092

9 Samples

Download data: CEL

(Submitter supplied) The mammalian retina contains an endogenous circadian clock system, located in various cell types. This system enables timing of a broad range of essential retinal functions to anticipate daily changes in environmental lighting conditions. Furthermore, the circadian clocks appear to promote retinal health. A leading cause of blindness in developed countries is diabetic retinopathy. While it is clear that diabetes affects the master clock and its circadian output in the SCN, the effect of diabetic retinopathy on the retinal clock system is unknown. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23092

12 Samples

Download data: CEL

(Submitter supplied) Hepcidin is demonstrated to be the key iron regulatory hormone, produced by the liver. Here we show an unexpected role of hepcidin as a master initiator of the local and systemic inflammatory response. We demonstrated that Hepcidin is a key new essential component of the immune system and may be a promising target in many inflammatory diseases.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23092

12 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL23092 GPL22598 GPL20710

50 Samples

Download data: CEL

(Submitter supplied) Disturbance of heterologous cell communication is associated with a structural reorganization of the vascular niche, a process called capillarization, which is already initiated in early stages of liver tumor development. In this study, the molecular characterization of endothelial cell (EC) subpopulations from healthy livers and yes-associated protein (Yap)-induced liver tumors revealed a dynamic crosstalk between liver sinusoidal endothelial cells (LSECs) and capillary endothelial cells (CECs). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23092

10 Samples

Download data: CEL

(Submitter supplied) Disturbance of heterologous cell communication is associated with a structural reorganization of the vascular niche, a process called capillarization, which is already initiated in early stages of liver tumor development. In this study, the molecular characterization of endothelial cell (EC) subpopulations from healthy livers and yes-associated protein (Yap)-induced liver tumors revealed a dynamic crosstalk between liver sinusoidal endothelial cells (LSECs) and capillary endothelial cells (CECs). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23092

8 Samples

Download data: CEL

(Submitter supplied) The intestinal epithelium is continuously renewed by a pool of intestinal stem cells expressing Lgr5. We show that deletion of the key autophagy gene Atg7 affects the survival of Lgr5+ intestinal stem cells. Mechanistically, this involves defective DNA repair, oxidative stress, and altered interactions with the microbiota. This study highlights the importance of autophagy in maintaining the integrity of intestinal stem cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23092

14 Samples

Download data: CEL

(Submitter supplied) To define the genes and pathways which are influenced by Foxp1 in the striatum at embryonic stage (E)18.5 we performed a microarray expression study comparing gene expression in striatal tissue from WT and Nestin-Cre (Foxp1-/-) animals.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23092

12 Samples

Download data: CEL

(Submitter supplied) Pianp (also known as Leda-1) is a type I transmembrane protein with preferential expression in the mammalian central nervous system. We used microarrays to analyze the programme of gene expression in murine brain regions amygdala, cortex, hippocampus and hypothalamus of Pianp deficient mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23092

39 Samples

Download data: CEL

(Submitter supplied) This Platform is identical to GPL16570 but a custom CDF environment was used to extract data [Brainarray Version 21, mogene20st]. The CDF file can be downloaded using the supplementary file link at the bottom of this record; the CDF and other files can be downloaded at: http://brainarray.mbni.med.umich.edu/Brainarray/Database/CustomCDF/21.0.0/entrezg.asp Protocol: See manufacturer's website (www.affymetrix.com).

Organism:

Mus musculus

15 Series

1 Related Platform

156 Samples

Download data: CDF

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html Jan 30, 2013: annotation table updated with netaffx build 33 Protocol: See manufacturer's web site

Organism:

Mus musculus

1094 Series

7 Related Platforms

11078 Samples

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