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Items: 1 to 20 of 25

1.

Increased IL-6 expression in microglia prior to detection of virus in the brain of rhesus macaques with acute SIVmac239 infection

(Submitter supplied) Knowledge on immune activation in the brain during acute HIV infection is crucial for the prevention and treatment of HIV associated neurological disorders (HAND), which is prevalent in people living with HIV (PLWH), even in those treated with antiretroviral therapy. In this study, we determined regional brain (basal ganglia, thalamus, and frontal cortex) immune and virological profiles 7 and 14 days after infection (dpi) with SIVmac239 in rhesus macaques. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
21 Samples
Download data: TXT
Series
Accession:
GSE182427
ID:
200182427
2.

Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIVmac239 in rhesus macaques

(Submitter supplied) The accessory viral protein R (Vpr) is encoded by all primate lentiviruses. Vpr counteracts DNA repair pathways, modulates viral immune sensing, and induces cell-cycle arrest in cell culture. However, its impact in vivo is controversial. Here, we show that deletion of vpr is associated with delayed viral replication kinetics, rapid innate immune activation, development and maintenance of strong B cell responses, and generation of higher avidity p27 Gag antibodies in rhesus macaques. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
46 Samples
Download data: TXT
Series
Accession:
GSE229310
ID:
200229310
3.

Intradermal but not intramuscular MVA immunizations protect against intravaginal tier2 SHIV challenges in macaques

(Submitter supplied) Route of immunization can markedly influence the quality of immune response. Here, we show that intradermal (ID) but not intramuscular (IM) modified vaccinia Ankara (MVA) vaccinations provide protection from acquisition of intravaginal tier2 SHIV challenges in female macaques. Both routes of vaccination induced comparable levels of serum IgG with neutralizing and non-neutralizing activities. The protection in MVA-ID group correlated positively with serum neutralizing and antibody-dependent phagocytic activities, and envelope-specific vaginal IgA; while the limited protection in MVA-IM group correlated only with serum neutralizing activity. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
97 Samples
Download data: TXT
Series
Accession:
GSE219118
ID:
200219118
4.

Profiling non-human primate exosomal RNA to understand the legacy of early life stress

(Submitter supplied) Validation of the etection of the RNA content in plasma exosomes of rhesus macaques.
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
13 Samples
Download data: CSV
Series
Accession:
GSE223984
ID:
200223984
5.

RNA-Seq of rhesus macaque macrophages generated by TET2-mutant hematopoiesis

(Submitter supplied) Gene expression profile of purified peripheral CD14+CD163+ macrophages was analyzed via RNA-Seq in the presence or absence of inflammatory stress to assess the impact of TET2 disruption on gene expression in macaque hematopoiesis.
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
12 Samples
Download data: TXT
Series
Accession:
GSE148085
ID:
200148085
6.

RNA-Seq of TET2 uniallelic mutated and wild type CFU colonies from rhesus macaque HSPCs

(Submitter supplied) Gene expression profile of individual CFU-GM colonies identified as uniallelic TET2 mutant versus TET2 wild type was analyzed via RNA-Seq to verify the impact of TET2 editing on gene expression in the rhesus macaque clonal hematopoiesis model.
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
6 Samples
Download data: TXT
Series
Accession:
GSE148132
ID:
200148132
7.

Pharmacological modulation of the Wnt/β-catenin pathway inhibits the proliferation of long-lived latently-infected memory CD4+ T-cells in ART-suppressed SIV-infected macaques

(Submitter supplied) The major obstacle to human immunodeficiency type 1 (HIV-1) eradication is a reservoir of latently-infected cells that persists despite long-term antiretroviral therapy (ART) and is maintained through cellular proliferation. Long-lived memory CD4+ T-cells with high self-renewal capacity such as central memory T-cells (CM) and T memory stem cells (SCM) are major contributors to the viral reservoir in HIV-infected individuals on ART. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
47 Samples
Download data: TXT
Series
Accession:
GSE127330
ID:
200127330
8.

Interleukin-10 contributes to reservoir establishment and persistence in antiretroviral therapy-treated, SIV-infected macaques

(Submitter supplied) Interleukin (IL)-10 is an immunosuppressive cytokine that signals through STAT3 to regulate T follicular helper cell (TFH) differentiation and germinal center formation. In SIV-infected macaques, levels of IL-10 in plasma and lymph node (LN) are induced by infection and not normalized with ART. During chronic infection, plasma IL-10 and transcriptomic signatures of IL-10 signaling were significantly correlated with the cell-associated SIV-DNA content within LN CD4+ memory subsets, including TFH, and predicted the frequency of CD4+ TFH and their cell- associated SIV-DNA content during ART, respectively. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL23804 GPL20313
59 Samples
Download data: TXT
Series
Accession:
GSE196182
ID:
200196182
9.

Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection

(Submitter supplied) HIV associated immune activation (IA) is associated with increased morbidity in people living with HIV (PLWH) on antiretroviral therapy, and remains a barrier for strategies aimed at reducing the HIV reservoir. The underlying mechanisms of IA have not been definitively elucidated, however, persistent production of Type I IFNs and expression of ISGs is considered to be one of the primary factors. Plasmacytoid DCs (pDCs) are a major producer of Type I IFN during viral infections, and are highly immunomodulatory in acute HIV and SIV infection, however their role in chronic HIV/SIV infection has not been firmly established. more...
Organism:
Macaca mulatta; Cercocebus atys
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL23804 GPL23805
56 Samples
Download data: TXT
Series
Accession:
GSE178225
ID:
200178225
10.

Profiling non-human primate germline RNA to understand the legacy of early life stress

(Submitter supplied) Validation of the methodology for extracting and demonstrating the quality of the ability to profile RNA in sperm of rhesus macaques.
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
7 Samples
Download data: CSV, TXT
Series
Accession:
GSE168978
ID:
200168978
11.

Combination Anti-PD-1 and Anti-retroviral Therapy Provides Therapeutic Benefit Against SIV

(Submitter supplied) Therapeutic strategies that enhance anti-viral immunity and reduce the viral reservoir are critical to achieving durable remission of HIV. The co-inhibitory receptor programmed death-1 (PD-1) regulates CD8+ T cell dysfunction during chronic HIV and SIV infections 1-4. In addition, PD-1+ CD4+ T cells constitute a significant fraction of the HIV/SIV viral reservoir5-7. We previously demonstrated that in vivo blockade of PD-1 during chronic SIV infection improves the function of anti-viral CD8+ T cells and B cells 4,8. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
60 Samples
Download data: TXT
Series
Accession:
GSE111435
ID:
200111435
12.

IL-21 and IFNalpha therapy rescues terminally-differentiated NK cells and limit SIV reservoir in ART-treated macaques

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL20313 GPL23804
61 Samples
Download data
Series
Accession:
GSE163443
ID:
200163443
13.

IL-21 and IFNalpha therapy rescues terminally-differentiated NK cells and limit SIV reservoir in ART-treated macaques [cohort2]

(Submitter supplied) Unlike HIV infection, which progresses to AIDS absent suppressive anti-retroviral therapy (ART), nonpathogenic infections in natural hosts, such African green monkeys (AGMs), are characterized by a lack of gut microbial translocation and robust secondary lymphoid Natural Killer (NK) cell responses resulting in absence of chronic inflammation and limited SIV dissemination in lymph nodes (LN) B-cell-follicles, respectively. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
26 Samples
Download data: TXT
Series
Accession:
GSE163441
ID:
200163441
14.

IL-21 and IFNalpha therapy rescues terminally-differentiated NK cells and limit SIV reservoir in ART-treated macaques [cohort1]

(Submitter supplied) Unlike HIV infection, which progresses to AIDS absent suppressive anti-retroviral therapy (ART), nonpathogenic infections in natural hosts, such African green monkeys (AGMs), are characterized by a lack of gut microbial translocation and robust secondary lymphoid Natural Killer (NK) cell responses resulting in absence of chronic inflammation and limited SIV dissemination in lymph nodes (LN) B-cell-follicles, respectively. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
11 Samples
Download data: TXT
Series
Accession:
GSE163440
ID:
200163440
15.

Fetal lung maturation induced by chorioamnionitis and its interaction with antenatal corticosteroids in rhesus macaque fetuses

(Submitter supplied) Purpose: Our goal was to evaluate the pathways through which chorioamnionitis induces fetal lung maturation and how it interacts with a low-dose treatment with antenatal corticosteroids to further enhance fetal lung maturation. Methods: We treated pregnant rhesus macaque at 132 days (80% gestation) with intre-amniotic bacterla lipopolissacharide to model chorioamnionitis or a low-dose antenatal corticosteroids treatment with betamethasone-acetate (Beta-Ac 0.125mg/kg) or both treatments. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
16 Samples
Download data: CSV
Series
Accession:
GSE148645
ID:
200148645
16.

Chromatin Accessibility and Transcription Dynamics During In Vitro Astrocyte Differentiation of Huntington’s Disease Monkey Pluripotent Stem Cells.

(Submitter supplied) Huntington’s Disease (HD) is a fatal, neurodegenerative disorder caused by a CAG repeat expansion, resulting in a mutant huntingtin protein. While it is now clear that astrocytes are affected by HD and significantly contribute to neuronal dysfunction and pathogenesis, the alterations in the transcriptional and epigenetic profiles in HD astrocytes have yet to be characterized. Here, we examined global transcription and chromatin accessibility dynamics during in vitro astrocyte differentiation in a transgenic non-human primate model of HD. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19129 GPL23804
40 Samples
Download data: BW
Series
Accession:
GSE130570
ID:
200130570
17.

Delineation and modulation of the natural killer cell transcriptome in rhesus macaques during ZIKV and SIV infections

(Submitter supplied) Natural killer (NK) cells are crucial regulators of antiviral and anti-tumor immune responses. Although in humans some NK cell transcriptional programs are relatively well established, NK cell transcriptional networks in non-human primates (NHP) remain poorly delineated. Here we performed RNA-Seq experiments using purified NK cells from experimentally naïve rhesus macaques, providing the first transcriptional characterization of pure NK cells in a NHP species. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
6 Samples
Download data: TXT
Series
Accession:
GSE148290
ID:
200148290
18.

Nef-mediated downmodulation of CD3 dampens immune activation and is critical for maintenance of high virus loads in SIV-infected macaques

(Submitter supplied) The inability of Nef to downmodulate the T cell receptor CD3 distinguishes HIV-1 from most other primate lentiviruses and may contribute to its high virulence. However, the role of this Nef function in viral immune evasion and pathogenicity remained speculative. Here, we selectively disrupted this Nef activity in SIVmac239 and analyzed the consequences for the virological, immunological and clinical outcome of infection in rhesus macaques. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
40 Samples
Download data: TXT
Series
Accession:
GSE141626
ID:
200141626
19.

TNF-signaling modulates neutrophil-mediated immunity at the feto-maternal interface during LPS-induced intrauterine inflammation

(Submitter supplied) We demonstrate that anti-TNF antibody (Adalimumab) inhibited ~80% of highly LPS-induced genes that sub-serve inflammatory signaling and innate immunity in chorio-decidua neutrophils.
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
23 Samples
Download data: TXT
Series
Accession:
GSE145918
ID:
200145918
20.

Systemic HIV/SIV latency reversal via activation of the non-canonical NF-B signaling pathway in vivo

(Submitter supplied) Resting CD4+ T cells that are both persistent and latently infected with HIV represent the most important challenge to HIV eradication. Estimates indicate the need for >70 years of continuous, fully suppressive, antiretroviral therapy (ART) to eliminate the HIV reservoir. Alternatively, induction of HIV from its latent state could accelerate the decline of the reservoir, thereby shortening the time to eradication. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23804
24 Samples
Download data: TXT
Series
Accession:
GSE141546
ID:
200141546
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