GEO DataSets

(Submitter supplied) The emergence of new SARS-CoV-2 variants, capable of escaping the humoral immunity acquired by the available vaccines, together with waning immunity and vaccine hesitancy, challenges the efficacy of the vaccination strategy in fighting COVID-19. Improved therapeutic strategies are urgently needed to better intervene particularly in severe cases of the disease. They should aim at controlling the hyper-inflammatory state generated upon infection, reducing lung tissue pathology, and inhibiting viral replication. more...

Organism:

Homo sapiens; Mesocricetus auratus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL24490 GPL18573

56 Samples

Download data: TXT

(Submitter supplied) Atherosclerotic cardiovascular disease is the leading cause of mortality worldwide. Hypercholesterolemia is a risk factor of atherosclerosis. This study evaluated the effects of three doses of Totum-070 (3.5%, 4.25% and 5% of diet for 12 weeks; HFD-Totum-070 groups), a plant-based polyphenol-rich supplement, in hamsters with high-fat diet (HFD)-induced dyslipidemia (HFD group). Several functional tests were performed in vivo to characterize the effect of Totum-070 on lipoprotein metabolism. more...

Organism:

Mesocricetus auratus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24490

24 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mesocricetus auratus

Type:

Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:

GPL24490 GPL32100

27 Samples

Download data: COV

(Submitter supplied) Hibernation consist of alternating torpor/arousal phases, during which animals cope with repetitive hypothermia and ischemia-reperfusion. Due to limited transcriptomic and methylomic information for facultative hibernators, we here conducted RNA and whole genome bisulfite sequencing in liver of hibernating Syrian hamster (Mesocricetus auratus). Gene Ontology analysis was performed on 844 differentially expressed genes (DEGs) and confirmed the Liver, shift in metabolic fuel utilization, inhibition of RNA transcription and cell cycle regulation as found in seasonal hibernators. more...

Organism:

Mesocricetus auratus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24490

9 Samples

Download data: TXT

(Submitter supplied) Despite being largely confined to the airways, SARS-CoV-2 infection has been associated with sensory abnormalities that manifest in both acute and long-lasting phenotypes. To gain insight on the molecular basis of these sensory abnormalities, we used the golden hamster infection model to characterize the effects of SARS-CoV-2 versus Influenza A virus (IAV) infection on the sensory nervous system. SARS-CoV-2-infected hamsters demonstrated mechanical hypersensitivity during acute infection; intriguingly, this hypersensitivity was milder, but prolonged when compared to IAV-infected hamsters. more...

Organism:

Mesocricetus auratus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL24490 GPL28997

30 Samples

Download data: SF

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Purpose: Historically, the Syrian Hamster Embryo - cell transformation assay (SHE-CTA) has provided a method to predict the carcinogenicity of test chemicals. Note that the cells harvested for the SHE-CTA are from fetuses at gestation day 13.5 and not from embryos as historically recorded. This method has been criticized for insufficient mechanistic understanding and subjective assessment of colonies morphological transformation. more...

Organism:

Mesocricetus auratus; Homo sapiens

Type:

Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:

GPL18573 GPL24490

69 Samples

Download data: BEDGRAPH, TXT

(Submitter supplied) Purpose: To use reduced representation bisulfite sequencing and RNA-seq to identify demethylated promoters of genes that were derepressed following treatment with demethylating agent, 5-Aza-2'-deoxycytidine (5aCdR, CAS# 2353-33-5).

Organism:

Mesocricetus auratus; Homo sapiens

Type:

Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:

GPL24490 GPL18573

34 Samples

Download data: BEDGRAPH, TSV

(Submitter supplied) Purpose: To use reduced representaion bisulfite sequencing to measure differential genome methylation among: 1. cells treated with benzo[a]pyrene (B[a]P) versus vehicle alone (DMSO) using the Syrian Hamster Cell Transformation Assay method; 2. cells originating from normal (Nc) versus morphologically transformed (MTc) colonies; 3. cells in senescence (SEN) versus those that have bypassed senescence (SENbp).

Organism:

Mesocricetus auratus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL24490

24 Samples

Download data: TXT

(Submitter supplied) Purpose: To validate the reduced representation bisulfite sequencing (RRBS) methodology by comparing DNA methylation pattern in Syrian hamster fetal (SHF) primary cells to a SHF cell line (MT2) exposed to the DNA methyl transferase inhibitor,5aCdR. The MT2 cell line was originally derived from the expansion of a benzo[a]pyrene-induced morphologically transformed clone (Pickles et al 2016. Mutat.Res.Genet.Toxicol.Environ Mutagen. more...

Organism:

Mesocricetus auratus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL24490

11 Samples

Download data: TXT

(Submitter supplied) Here, we systemically profile transcriptional responses to SARS-CoV-2 and IAV in the Syrian golden hamster infection model at 3 and 31 days post-infection. In doing this, we are able to benchmark SARS-CoV-2-induced host-responses against those induced by IAV and highlight unique pathologies that occur in response to SARS-CoV-2 at the peak of infection and following viral clearance. Through profiling of neural (olfactory bulb, medial prefrontal cortex, thalamus, striatum, cerebellum, trigeminal ganglion) and peripheral organ (lung, heart, kidney) tissues, we are able to show that while both viruses are able to induce systemic IFN-I responses and immune activation during acute infection, SARS-CoV-2 induces a uniquely localized and persistent inflammatory phenotype in the olfactory bulb that persists out to 31 days post-infection.

Organism:

Mesocricetus auratus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL24490 GPL28997

194 Samples

Download data: SF

(Submitter supplied) We report the application of bulk RNA sequencing technology for high-throughput profiling of SARS-CoV-2 infection in the lung of Syrian golden hamsters (Mesocricetus auratus).

Organism:

Mesocricetus auratus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24490

15 Samples

Download data: TXT

(Submitter supplied) We describe the cellular response to SARS-CoV-2 infections in Syrian hamsters previously immunized with mRNA, Adenovirus, and life-attenuated virus vaccines.

Organism:

Mesocricetus auratus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL28997 GPL24490

114 Samples

Download data: GTF, H5, RDS, TXT, XLSX

(Submitter supplied) Assess the ability of disulfiram to inhibit NET formation and improve disease outcome in a Syrian hamster model of COVID-19. RNA sequencing was performed Golden Syrian hamster lung inoculated with SARS-CoV-2 in PBS or PBS only and treated with disulfiram or vehicle control sesame oil with dexamethasone.

Organism:

Mesocricetus auratus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24490

20 Samples

Download data: TXT

(Submitter supplied) Syrian golden hamsters were treated with TIP or control RNA and infected with SARS-CoV2, at 5 days post infection, RNA was extracted and RNAseq was performed, uninfected hamsters treated with TIP or Control RNA were used as controls.

Organism:

Mesocricetus auratus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24490

16 Samples

Download data: TXT, XLSX

(Submitter supplied) RNA sequencing was performed on Golden Syrian hamster fat tissue depots from hamsters inoculated with SARS-CoV-2 in PBS or PBS only

Organism:

Mesocricetus auratus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24490

22 Samples

Download data: TXT

(Submitter supplied) We tested if Brd2 inhibitor ABBV-744 could reduce SARS-CoV-2 infection in Syrian Hamsters. Three days post-infection, the lungs of hamsters were harvested and subjected to RNA-seq. Infected, but untreated, hamsters showed marked up-regulation of a number of genes including ISGs when compared to uninfected controls. In contrast, hamsters treated with ABBV-744 showed a down-regulation of ISG levels, confirming ABBV-744 activity. more...

Organism:

Mesocricetus auratus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24490

96 Samples

Download data: CSV

(Submitter supplied) PIWI-associated RNAs (piRNAs) support germline by suppressing retrotransposons and genes. In mice, piRNAs are essential for spermatogenesis but not oogenesis. To test how this applies to other mammals, we deleted Mov10l1 helicase in golden hamsters whose piRNA pathway configuration is closer to other mammals than that of mice. Mov10l1–/– male hamsters showed impaired establishment of spermatogonia accompanied by transcriptome dysregulation and surge of MYSERV retrotransposon expression. more...

Organism:

Mesocricetus auratus

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL24490

3 Samples

Download data: BW

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mesocricetus auratus

Type:

Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:

GPL24490 GPL29592 GPL28997

47 Samples

Download data: BW

(Submitter supplied) PIWI-associated RNAs (piRNAs) support germline by suppressing retrotransposons and genes. In mice, piRNAs are essential for spermatogenesis but not oogenesis. To test how this applies to other mammals, we deleted Mov10l1 helicase in golden hamsters whose piRNA pathway configuration is closer to other mammals than that of mice. Mov10l1–/– male hamsters showed impaired establishment of spermatogonia accompanied by transcriptome dysregulation and surge of MYSERV retrotransposon expression. more...

Organism:

Mesocricetus auratus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL24490 GPL29592

21 Samples

Download data: BW, TXT

(Submitter supplied) PIWI-associated RNAs (piRNAs) support germline by suppressing retrotransposons and genes. In mice, piRNAs are essential for spermatogenesis but not oogenesis. To test how this applies to other mammals, we deleted Mov10l1 helicase in golden hamsters whose piRNA pathway configuration is closer to other mammals than that of mice. Mov10l1–/– male hamsters showed impaired establishment of spermatogonia accompanied by transcriptome dysregulation and surge of MYSERV retrotransposon expression. more...

Organism:

Mesocricetus auratus

Type:

Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL24490 GPL28997

13 Samples

Download data: BW