GPL33261[RGSE] - GEO DataSets

Select item 2002646571.

SIV infection and ARV treatment reshape the transcriptional and epigenetic profile of naïve and memory T cells in vivo (RNA-Seq)

(Submitter supplied) Here we use RNAseq and ATACseq to study the transcriptomics and epigenetic landscape of longitudinally sampled naïve and memory CD4+ and CD8+ T cells in two species of non-human primates prior to SIV infection, during chronic SIV infection, and after administration of ARVs. We find that SIV infection leads to significant alteration to the transcriptomic profile of all T cell subsets that are only partially reversed by administration of ARVs. more...

Organism:: Macaca nemestrina; Macaca mulatta

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL27943 GPL33261
116 Samples

Download data: TXT

Series

Accession:: GSE264657

ID:: 200264657

PubMed Similar studies

Select item 2002646562.

SIV infection and ARV treatment reshape the transcriptional and epigenetic profile of naïve and memory T cells in vivo (ATAC-Seq)

Organism:: Macaca mulatta; Macaca nemestrina

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL33261 GPL27943
120 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE264656

ID:: 200264656

PubMed Similar studies

Select item 2002286883.

Pro-inflammatory feedback loops define immune responses to pathogenic lentivirus infection

(Submitter supplied) HIV causes chronic inflammation and AIDS in humans, though the rate of disease progression varies between individuals. Similarly, simian lentiviruses vary in their pathogenicity based on characteristics of both the host (simian species) and virus strain. Here, we profile immune responses in pig-tailed macaques infected with variants of SIV that differ in virulence to understand the immune mechanisms underlying lentiviral pathogenicity. more...

Organism:: Macaca nemestrina

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33261
37 Samples

Download data: RDS

Series

Accession:: GSE228688

ID:: 200228688

PubMed Full text in PMC Similar studies

Select item 2002275334.

Spatial transcriptomics on Zika virus infected fetal brains of nonhuman primates

(Submitter supplied) Investigation of spatial transcriptomic responses of nonhuman primate fetal brains during development

Organism:: Macaca nemestrina

Type:: Other; Expression profiling by high throughput sequencing

Platform:: GPL33261
141 Samples

Download data: CSV, DCC, PKC

Series

Accession:: GSE227533

ID:: 200227533

PubMed Full text in PMC Similar studies

Select item 2002369315.

Total RNA profiles of brain tissue in simian immunodeficiency virus (SIV) infection and SIV-related central nervous system pathology

(Submitter supplied) Antiretroviral treatment regimens can effectively control HIV replication and some aspects of disease progression. However, molecular events in end-organ diseases such as central nervous system (CNS) disease are not yet fully understood, and routine eradication of latent reservoirs is not yet in reach. Regulatory RNAs have emerged as important participants in HIV disease pathogenesis. Using brain tissue from the simian immunodeficiency virus (SIV) model of HIV disease, we profiled messenger RNAs (mRNAs) and circular RNAs (circRNAs), seeking to identify possible networks of RNA interaction in SIV infection and neuroinflammation.

Organism:: Macaca nemestrina

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33261
38 Samples

Download data: XLSX

Series

Accession:: GSE236931

ID:: 200236931

PubMed Similar studies

Select item 2002366566.

Small RNA profiles of brain tissue and brain tissue-derived extracellular vesicles in simian immunodeficiency virus (SIV) infection and SIV-related central nervous system pathology

(Submitter supplied) Antiretroviral treatment regimens can effectively control HIV replication and some aspects of disease progression. However, molecular events in end-organ diseases such as central nervous system (CNS) disease are not yet fully understood, and routine eradication of latent reservoirs is not yet in reach. Brain tissue-derived extracellular vesicles (bdEVs) act locally in the source tissue and may indicate molecular mechanisms in HIV CNS pathology. more...