GEO DataSets

(Submitter supplied) The goal of these studies is to identify genes that are regulated by glucocorticoids in human peripheral blood mononuclear cells in vitro.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4685

8 Samples

Download data: CEL

(Submitter supplied) Cutaneous T-cell lymphoma (CTCL) is defined by infiltration of activated and malignant T cells in the skin. The clinical manifestations and prognosis in CTCL are highly variable. In this study, we hypothesized that gene expression analysis in lesional skin biopsies can improve understanding of the disease and its management. Based on 63 skin samples, we performed consensus clustering, revealing 3 patient clusters. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4685

63 Samples

Download data: CEL

(Submitter supplied) Molecular responses to MEK inhibition in cancer cells are complex and dynamic. We performed a time-series experiment to measure global RNA expression changes following treatment with the MEK inihibor U0126

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4685

96 Samples

Download data: CEL

(Submitter supplied) Comparison of ATG gene family members in MPN pattients with normal controls

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4685

66 Samples

Download data: CEL

(Submitter supplied) The HMT3522 progression series of breast cells has been used to discover the roles of tissue architecture, microenvironment and signaling molecules in nonmalignant and malignant breast cell growth and behaviors, including the potential of various factors to cause phenotypic reversion of malignant cells to nonmalignant states. Despite many efforts to delineate key signaling pathways governing the malignant as well as the phenotypic reversion behaviors of T4 cells, much remains to be elucidated about the regulatory mechanisms underlying these cell states at the systems level. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL4685 GPL3921

15 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4685

116 Samples

Download data: CEL

(Submitter supplied) We used expression profiling, SNP arrays, and mutational profiling to investigate a well-characterized cohort of MPN patients. MPN patients with homozygous JAK2V617F mutations were characterized by a distinctive transcriptional profile. Notably, a transcriptional signature consistent with activated JAK2 signaling is seen in all MPN patients regardless of clinical phenotype or mutational status. In addition, the activated JAK2 signature was present in patients with somatic CALR mutations. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4685

12 Samples

Download data: CEL

(Submitter supplied) We used expression profiling, SNP arrays, and mutational profiling to investigate a well-characterized cohort of MPN patients. MPN patients with homozygous JAK2V617F mutations were characterized by a distinctive transcriptional profile. Notably, a transcriptional signature consistent with activated JAK2 signaling is seen in all MPN patients regardless of clinical phenotype or mutational status. In addition, the activated JAK2 signature was present in patients with somatic CALR mutations. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4685

104 Samples

Download data: CEL

(Submitter supplied) We have reported more than a dozen microenvironmental factors whose signaling must be integrated in order to effect an organized, functional tissue morphology. In order to identify underlying commonalities in gene transcription associated with the phenotype, we compared the gene expression of organized and disorganized epithelial cells of the HMT-3522 breast cancer progression series: the non-malignant S1 cells that form polarized spheres (‘acini’), the malignant T4-2 cells that form large tumor-like clusters, and the ‘phenotypically reverted’ T4-2 cells that polarize as a result of correction of the microenvironmental signaling.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL3921 GPL4685

24 Samples

Download data: CEL

(Submitter supplied) Gene expression data from BE(2)-C cells treated in triplicate with either vehicle (DMSO), 5 μM all-trans retinoic acid (ATRA), 1 mM valproic acid (VPA), or 5 μM ATRA + 1 mM VPA for 6, 24, or 72 hours. Genome-wide expression profiling was performed using Affymetrix U133A microarrays. While cytotoxic chemotherapy remains the hallmark of cancer treatment, intensive regimens fall short in many malignancies, including high-risk neuroblastoma. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4685

35 Samples

Download data: CEL

(Submitter supplied) To elucidate potential mechanisms by which Rab25 contributes to tumor aggressiveness, we determined the transcription profile induced by expression of Rab25.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4685

24 Samples

Download data: CEL

(Submitter supplied) Tremendous progress has been made in identifying individual transcription factors that regulate hematopoietic differentiation, but many aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct purified populations of human hematopoietic cells and used probabilistic models of gene expression patterns and sequence-based analysis of motifs in gene promoters to decipher the general organization of their regulatory circuitry. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4685

211 Samples

Download data: CEL, TXT, XLSX

(Submitter supplied) PDEF(Prostate Derived Ets factor) is a member of Ets transcription factor with specific expression in Prostate. We identified target genes for PDEF in prostate cancer cell line PC-3 using Affymetrix Genechip Microarray technology. Keywords: target gene identification for transcription factor

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4685

4 Samples

Download data: CEL

(Submitter supplied) Cutaneous T cell lymphoma (CTCL) is defined by infiltration of activated and malignant T cells in skin. The clinical manifestations and prognosis in CTCL are highly variable. In this study, we hypothesized that gene expression analysis in lesional skin biopsies can improve understanding of the disease and its management. Based on 63 skin samples, we performed consensus clustering, revealing three patient clusters. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4685

63 Samples

Download data: CEL

(Submitter supplied) To investigate the biological basis between aging and sporadic breast cancer incidence and prognosis, RNA samples from matched ER+ invasive breast cancers diagnosed in either young (≤45) or old (≥70) women were analyzed by expression microarrays Keywords: biomarker identification

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4685

47 Samples

Download data: CEL

(Submitter supplied) Signaling pathways that converge on two different transcription factor complexes, NFκB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. In this study, biomarkers co-ordinately up-regulated by NFKB and AP-1 with prognositic significance are identified in a largely TAM-treated set of ER+ node negative breast cancers. The prognostic value with respect to age is also investigated. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4685

54 Samples

Download data: CEL

(Submitter supplied) An increasing number of cancer-associated mutations have been identified. Unfortunately, little therapy today exploits these tumor-specific genetic lesions. Often, the resulting oncoproteins have been intractable to easy manipulation with current small molecule screening approaches. To overcome this impasse, we developed an expression-based approach to small molecule library screening. We applied this platform to the discovery of modulators of the activity of EWS/FLI, the Ewing sarcoma associated oncoprotein. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2733

Platform:

GPL4685

68 Samples

Download data: CEL