GSE138438[Accession] - GEO DataSets

Select item 2001384381.

Copy-number profiling by SNP array of 4 acute myeloid leukemia (AML) cell lines

(Submitter supplied) DNMT inhibitors (DNMTi) are finally approved for AML/MDS, also based on their activity in patients with high-risk cytogenetics (often monosomal karyotype) such as -5/del(5q) or -7/del(7q), often - but not always - harboring TP53-mutations. Several studies provided evidence for aberrant hypermethylation/silencing on monoallelic gene loci, including tumor suppressor genes. We hypothesized that transcriptional repression on monosomal gene loci may be preferentially reversed by DNMTi. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platforms:: GPL18637 GPL6801
4 Samples

Download data: CEL, CNCHP, CYCHP

Series

Accession:: GSE138438

ID:: 200138438

PubMed Similar studies

Select item 1000186372.

[CytoScan750K_Array] Affymetrix CytoScan 750K Array

(Submitter supplied) #CytoScan750K_Array.cn.na32.3.annot.csv #%create_date=2012-11-27 GMT-08:00 16:16:00 #%chip_type=CytoScan750K_Array #%genome-species=Homo sapiens #%genome-version=hg19 #%genome-version-ucsc=hg19 #%genome-version-ncbi=37 #%genome-version-create_date=2009-02-00 #%dbSNP_date=2010-09-23 #%dbSNP_version=132 #%dgv-date=2010-10-00 #%dgv-version=10 #%hapmap-date=2008-01-08 #%hapmap-version=23 #%netaffx-annotation-date=2012-11-05 #%netaffx-annotation-netaffx-build=32.3 #CytoScan750K_Array.na32.3.annot.csv #%create_date=2012-11-27 GMT-08:00 16:17:00 #%chip_type=CytoScan750K_Array #%genome-species=Homo sapiens #%genome-version=hg19 #%genome-version-ucsc=hg19 #%genome-version-ncbi=37 #%genome-version-create_date=2009-02-00 #%dbSNP_date=2010-09-23 #%dbSNP_version=132 #%dgv-date=2010-10-00 #%dgv-version=10 #%hapmap-date=2008-01-08 #%hapmap-version=23 #%netaffx-annotation-date=2012-11-05 #%netaffx-annotation-netaffx-build=32.3 Protocol: see manufacturer's web site

Organism:: Homo sapiens

43 Series
1486 Samples

Download data: CSV

Platform

Accession:: GPL18637

ID:: 100018637

Select item 1000068013.

[GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 (ucsc=hg18; ncbi=NCBI36) August 01, 2012: annotation table updated with netaffx build 32 (ucsc=hg19; ncbi=GRCh37) Protocol: see manufacturer's web site The new Affymetrix® Genome-Wide Human SNP Array 6.0 features 1.8 million genetic markers, including more than 906,600 single nucleotide polymorphisms (SNPs) and more than 946,000 probes for the detection of copy number variation. more...