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Items: 4

1.

Small-molecule-induced epigenetic rejuvenation overcomes myelinogenic barriers and stimulates myelin repair

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
4 related Platforms
21 Samples
Download data: BW, TXT, WIG
Series
Accession:
GSE232956
ID:
200232956

PubMed Similar studies

2.

Small-molecule-induced epigenetic rejuvenation overcomes myelinogenic barriers and stimulates myelin repair [Cut&Run]

(Submitter supplied) Failure of oligodendrocytes to remyelinate underlies diseases such as multiple sclerosis (MS). We found that epigenetic silencing prevents oligodendrocytes from producing myelin sheaths in demyelinating MS lesions. Here, we developed a transgenic reporter system to identify a small-molecule epigenetic modulator that stimulates oligodendrocyte maturation and myelin ensheathment in vitro. This compound promoted remyelination in animal models of MS and myelination of regenerated axons and increased myelin sheath lengths in human iPSC-derived organoids. more...
Organism:
Rattus norvegicus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL25029
8 Samples
Download data: BW, WIG
Series
Accession:
GSE232953
ID:
200232953

PubMed Similar studies

3.

NextSeq 550 (Rattus norvegicus)

Organism:
Rattus norvegicus
54 Series
1067 Samples
Download data
Platform
Accession:
GPL25029
ID:
100025029

4.

DMSO_H3K27AC

Organism:
Rattus norvegicus
Source name:
brain
Platform:
GPL25029
Series:
GSE232953 GSE232956
Download data: WIG
Sample
Accession:
GSM7398487
ID:
307398487

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db=gds|term=GSM7398487[Accession]|query=4|qty=3|blobid=MCID_673b6ee561a458799d451125|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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