GEO DataSets

Analysis of microvascular endothelial cells (HMEC) stimulated with tumor necrosis factor (TNF)-alpha for 5 hours. TNF is a potent inflammatory stimulus. Results provide insight into the relevance of the diversity of endothelial cell subtypes for the response to inflammatory stimuli.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL96

Series:

GSE2638

6 Samples

Download data: CEL, EXP

(Submitter supplied) HUVEC were left untreated or stimulated for 5h with 2 ng/ml TNF. Comparsion of the gene profiles revealed TNF-mediated gene expression changes in HUVEC. Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1542

Platform:

GPL96

8 Samples

Download data: CEL, EXP

(Submitter supplied) HMEC cultures were left untreated or stimulated for 5h with 2 ng/ml TNF. Comparison of the gene expression profiles revealed the TNF-mediated gene expression changes. Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1543

Platform:

GPL96

6 Samples

Download data: CEL, EXP

Analysis of macrovascular umbilical vein endothelial cells (HUVEC) stimulated with tumor necrosis factor (TNF)-alpha for 5 hours. TNF is a potent inflammatory stimulus. Results provide insight into the relevance of the diversity of endothelial cell subtypes for the response to inflammatory stimuli.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL96

Series:

GSE2639

8 Samples

Download data: CEL, EXP

(Submitter supplied) Genes regulated by inflammatory cytokines in five primary endothelial cell types Keywords: ordered

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS498 GDS499 GDS501 GDS502

Platform:

GPL371

15 Samples

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Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary colon endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

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Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary dermal endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

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Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary aortic endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

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Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary lung endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

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(Submitter supplied) Comparison of gd T cell clones with ab T cell clones that responded to the same antigen. Clones were identically stimulated with ConA/IL-2 and analyzed with two separate microarrays. Keywords: other

Organism:

Bos taurus

Type:

Expression profiling by array

Platforms:

GPL2113 GPL2112

4 Samples

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(Submitter supplied) Objectives: We monitored the mRNA expression profiles of peripheral blood cells during treatment with a tumor necrosis factor-a inhibitor, infliximab, in patients with rheumatoid arthritis (RA). Using a DNA microarray analysis, we demonstrated a unique set of genes, with distinct baseline and post-treatment changes in expression between responders and non-responders to infliximab treatment.Methods: Using a customized low-density cDNA microarray and a reliable data collection system, we monitored the mRNA expression profiles of whole blood cells from 18 RA patients before and after the infusion of infliximab for up to 22 weeks. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5460

72 Samples

Download data: TXT

(Submitter supplied) Introduction. Factors contributing to kidney transplant fibrosis remain incompletely understood—particularly in the absence of acute complications. Methods. Baseline and one-year surveillance biopsies from 15 uncomplicated living donor kidney transplants were subjected to microarray and quantitative RT-PCR (qRT-PCR) analyses in order to examine changes in gene expression patterns over time. Biopsy pairs were purposefully selected from allografts with no history of acute complications and were divided into those that were histologically normal (n = 7) and those that had developed subclinical interstitial fibrosis (n = 8) at 1 year. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

30 Samples

Download data: CEL, CHP

(Submitter supplied) Lymph node vs. tonsil Keywords: repeat sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1618

Platform:

GPL96

20 Samples

Download data: CEL, EXP

Analysis of lymph node (sinuses) and tonsil (no sinuses), highly similar secondary lymphoid organs. Metastatic tumor cells are preferentially arrested in the lymph node sinuses. Results identify signature genes that are prime candidates for mediating adhesion of tumor cells to sinusoidal cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL96

Series:

GSE2665

20 Samples

Download data: CEL, EXP

(Submitter supplied) Activation of the vascular endothelium with cytokines such as TNF is widely used to study the role of the vasculature in proinflammatory disease. To gain insight into mechanisms of prolonged vascular endothelial activation we compared changes in gene expression induced by continuous activation in stable tmTNFalpha expressing cells with changes due to acute TNFalpha challenge in vitro. Affymetrix Genechip® analysis was performed on RNA from control, acute and continuous TNFalpha-activated endothelial cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2773

Platform:

GPL1261

12 Samples

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Analysis of endothelial cells acutely activated by treatment with soluble tumor necrosis factor (TNF) or chronically activated by expression of an uncleavable form of the transmembrane TNF precursor. Results provide insight into the mechanisms mediating the effect of chronic endothelial activation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 agent sets

Platform:

GPL1261

Series:

GSE4518

12 Samples

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(Submitter supplied) Messenger RNA of C trachomatis infected monocytes of the three healthy donors was compared with the corresponding mock-infected samples. For mock infection, SPG buffer was used instead of the C trachomatis suspension, all other procedures were performed identically. Cells were resuspended in solution D and total RNA was extracted by application of phenol:chloroform 5:1 (pH 4.5, Ambion, Austin, TX) followed by precipitation in isopropanol at -80°C for 1 hr and incubation with RQ1 DNase (Promega, Madison, WI) at 37 °C for 1 hr. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL127

6 Samples

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(Submitter supplied) Response to allergen was studied in bronchial epithelial cell line H292. Cells were cultured and subsequently exposed to House dust mite or vessel (saline) Microarray data was analysed using bioinformatics and biostastics. We find a strong response to allergen in epithelial cells Keywords: cellular response to allergen

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3003

Platform:

GPL570

6 Samples

Download data: CEL, EXP

Analysis of H292 bronchial epithelial cells exposed to house dust mite (HDM) extract. More than just a physical barrier, epithelium can produce mediators in response to pathogens and allergens. Results provide insight into the nature of the response of bronchial epithelial cells to HDM allergen.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL570

Series:

GSE9151

6 Samples

Download data: CEL, EXP

(Submitter supplied) Gene expression in human umbilical vein endothelial cells (HUVEC) was investigated by microarray analysis after 4 h infection with S. aureus isolated from healthy nasal carriers (n=5) and from blood (n=5) of septic patients. All bacterial isolates were spa-typed and characterized with a DNA microarray to determine the presence of virulence genes. Keywords: infection studies, pathogen, S. aureus

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4030

Platform:

GPL570

12 Samples

Download data: CEL