Similar studies for GEO DataSets (Select 200001648) - GEO DataSets

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Items: 13

Select item 2000016481.

Osmotic Loading of Human Intervertebral Disc Cells

(Submitter supplied) Human intervertebral disc tissue was obtained from patients (average age 51 yrs) undergoing surgery for lumbar interbody fusion (n=3) or lumbar disc herniation (n=1). Cells were isolated by sequential pronase-collagenase digestion [3]. Cells were passaged twice in monolayer and suspended at a density of 2 x 106 cells/ml in 1.2% alginate (low viscosity, Sigma Chemical, St Louis, MO) dissolved in 150 mM NaCl. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS738
Platform:: GPL96
11 Samples

Download data: CEL, EXP

Series

Accession:: GSE1648

ID:: 200001648

Select item 7382.

Intervertebral disc cells and osmotic loading

Gene expression profiles of intervertebral disc cells (IVD) exposed to iso-osmotic, hyper-osmotic and hypo-osmotic conditions. Under physiological conditions, IVD are subject to osmotic stress.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 4 individual, 3 protocol sets

Platform:: GPL96
Series:: GSE1648
11 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS738

ID:: 738

Select item 2000031663.

Influence of cyclical mechanical strain on global gene expression in human lamina cribrosa cells in vitro

(Submitter supplied) The mechanical effect of raised intraocular pressure is a recognised stimulus for optic neuropathy in primary open angle glaucoma (POAG). Characteristic extra-cellular matrix (ECM) remodelling accompanies axonal damage in the lamina cribrosa (LC) of the optic nerve head in POAG. Glial cells in the lamina cribrosa may play a role in this process but the precise cellular responses to mechanical forces in this region are unknown. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
2 Samples

Download data

Series

Accession:: GSE3166

ID:: 200003166

Select item 2000086024.

Early responsive genes in human amnion epithelial FL cells induced by N-methyl-N’-nitro-N-nitrosoguanidine

(Submitter supplied) The alkylating agent N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) induces cellular DNA damages and other comprehensive alterations that lead to chromosomal aberrations, mutations, tumor initiations, and cell death. However, the molecular mechanism of MNNG-induced cellular stress remains unclear.We have genome-wide analyzed early transcriptional responses of human FL amnion epithelial cells after exposure to three relatively low doses of MNNG (0.2, 1.0, and 10.0µM),and differential gene expression profiles were obtained 4 h after exposure using oligonucleotide microarrays followed by validation with quantitative real-time RT-PCR. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL96 GPL97
16 Samples

Download data: CEL, EXP

Series

Accession:: GSE8602

ID:: 200008602

Select item 2000030405.

Glucocorticoid Induced Changes in Gene Expression in Human Lens Epithelial Cells

(Submitter supplied) Prolonged use of glucocorticoids can lead to the formation of a cataract, however the mechanism is not known. We recently reported the presence of the functional glucocorticoid receptor in immortalized cultured mammalian lens epithelial cells (Gupta & Wagner, Invest Ophthalmol Vis Sci 2003), but the short term biological effect of glucocorticoid action in lens epithelial cells is not known. This study seeks to examine glucocorticoid induced changes in global gene expression in LECs. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1353
Platform:: GPL96
12 Samples

Download data

Series

Accession:: GSE3040

ID:: 200003040

Select item 13536.

Glucocorticoid effect on lens epithelial cells: time course

Analysis of cultured immortalized lens epithelial cells (LEC) 4 and 16 hours after treatment with 1 uM dexamethasone, a glucocorticoid steroid hormone. Long-term glucocorticoid use can induce cataract formation. Results identify glucocorticoid targets and short-term effects of glucocorticoid on LECs

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 2 time sets

Platform:: GPL96
Series:: GSE3040
12 Samples

Download data

DataSet

Accession:: GDS1353

ID:: 1353

Select item 2000068197.

Identification of genes that are linked with optineurin expression

(Submitter supplied) This study aimed to identify genes that are linked with optineurin expression using a combined siRNA-microarray approach Keywords: siRNA treatment study

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2892
Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE6819

ID:: 200006819

Select item 28928.

Optineurin depletion

Analysis of HeLa cells depleted for optineurin using RNAi knockdown. Mutations in the gene for optineurin are associated with open-angle glaucoma. Results provide insight into the function of optineurin and its role in the pathogenesis of open-angle glaucoma.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 protocol sets

Platform:: GPL570
Series:: GSE6819
6 Samples

Download data: CEL

DataSet

Accession:: GDS2892

ID:: 2892

Select item 2000078509.

Unique Gene Expression Profiles of Donor-Matched Human Retinal and Choroidal Vascular Endothelial Cells

(Submitter supplied) Consistent with clinical observations that posterior uveitis frequently involves the retinal vasculature and recent recognition of vascular heterogeneity, we hypothesized that retinal vascular endothelium was a cell population of unique molecular phenotype. Donor-matched cultures of primary retinal and choroidal endothelial cells from 6 human cadavers were incubated with either Toxoplasma gondii tachyzoites (10:1, parasite:cell) or Escherichia coli lipopolysaccharide (100 ng/mL); control cultures were simultaneously incubated with medium. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL201
46 Samples

Download data: CEL

Series

Accession:: GSE7850

ID:: 200007850

Select item 20000629810.

Comparison of gene expression profile of human trabecular meshwork cells induced by triamcinolone with dexamethasone

(Submitter supplied) PURPOSE. Triamcinolone acetonide (TA) and dexamethasone (DEX) are corticosteroids commonly used for ocular inflammation but both can cause ocular hypertension. We investigated the differential gene expression profile of human trabecular meshwork (TM) cells in response to treatment by TA compared to that by DEX. METHODS. Total RNA was extracted from cultured human TM cells treated with TA or DEX and used for microarray gene expression analysis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4564
9 Samples

Download data

Series

Accession:: GSE6298

ID:: 200006298

Select item 20000835011.

mRNA expression profile in peripheral blood cells of RA patients following treatment with an anti-TNFa mAb, infliximab

(Submitter supplied) Objectives: We monitored the mRNA expression profiles of peripheral blood cells during treatment with a tumor necrosis factor-a inhibitor, infliximab, in patients with rheumatoid arthritis (RA). Using a DNA microarray analysis, we demonstrated a unique set of genes, with distinct baseline and post-treatment changes in expression between responders and non-responders to infliximab treatment.Methods: Using a customized low-density cDNA microarray and a reliable data collection system, we monitored the mRNA expression profiles of whole blood cells from 18 RA patients before and after the infusion of infliximab for up to 22 weeks. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5460
72 Samples

Download data: TXT

Series

Accession:: GSE8350

ID:: 200008350

Select item 20000114412.

aging of cultured human myotubes

(Submitter supplied) Aging of skeletal muscle tissue is characterized by loss of metabolic and contractile competence. It is thought that this phenomenon is driven via extrinsic and intrinsic factors. In order to identify age-dependent changes intrinsic to the muscle cell, microarray transcriptional profiles and measurements of glucose metabolism were performed in primary cultured human myotubes at different time points over seven weeks. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS647
Platform:: GPL8300
7 Samples

Download data

Series

Accession:: GSE1144

ID:: 200001144

Select item 64713.

Aging of cultured myotubes and glucose metabolism

Examination of aging myotubes from a muscle biopsy incubated in glucose. Myotubes in 25 mM glucose at 2, 3, 4, 5, and 7 weeks, and in 10 mM glucose at 4 weeks examined in reference to 0 mM glucose control at 1 week.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 growth protocol, 6 time sets

Platform:: GPL8300
Series:: GSE1144
7 Samples

Download data

DataSet

Accession:: GDS647

ID:: 647

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Similar studies for GEO DataSets (Select 200001648) (13)
GEO DataSets
faa17g10.x1 Sugano SJD adult male Danio rerio cDNA clone IMAGE:5913019 3', mRNA ...
faa17g10.x1 Sugano SJD adult male Danio rerio cDNA clone IMAGE:5913019 3', mRNA sequence
gi|20464771|gnl|dbEST|12293265|gb|B 92.1|

Nucleotide
Homo sapiens bromodomain and PHD finger containing 1 (BRPF1), transcript variant...
Homo sapiens bromodomain and PHD finger containing 1 (BRPF1), transcript variant 2, mRNA
gi|1890335656|ref|NM_004634.3|

Nucleotide
Labrenzia sp. CP4, complete genome
Labrenzia sp. CP4, complete genome
gi|1002744569|gnl|PRJNA287684|CP4-c some|gb|CP011927.1|

Nucleotide
fcho2 FCH and mu domain containing endocytic adaptor 2 [Danio rerio]
fcho2 FCH and mu domain containing endocytic adaptor 2 [Danio rerio]
Gene ID:553949

Gene

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