GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL200

20 Samples

Download data: CEL

(Submitter supplied) Utilizing M. musculus as a model of mitochondrial dysfunction provides insight into cellular adaptations which occur as a consequence of genetic alterations causative of human disease. We characterized genome-wide expression profiles of liver-conditional knockout mice for Pdss2 compared with loxP controls. Our goal was to detect concordant changes among clusters of genes that comprise defined metabolic pathways utilizing gene set enrichment analysis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3454

Platform:

GPL1261

6 Samples

Download data: CEL

(Submitter supplied) Utilizing C. elegans as a model of mitochondrial dysfunction provides insight into cellular adaptations which occur as a consequence of genetic alterations causative of human disease. We characterized genome-wide expression profiles of hypomorphic C. ele Our goal was to detect concordant changes among clusters of genes that comprise defined metabolic pathways utilizing gene set enrichment analysis. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Dataset:

GDS3453

Platform:

GPL200

10 Samples

Download data: CEL

(Submitter supplied) Utilizing C. elegans as a model of mitochondrial dysfunction provides insight into cellular adaptations which occur as a consequence of genetic alterations causative of human disease. We characterized genome-wide expression profiles of hypomorhpic C. elegans mutants in nuclear-encoded subunits of respiratory chain complexes I, II and III. Our goal was to detect concordant changes among clusters of genes that comprise defined metabolic pathways utilizing gene set enrichment analysis. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Dataset:

GDS3452

Platform:

GPL200

10 Samples

Download data: CEL

Analysis of hepatocytes from Pdss2 liver-specific knockouts. The mutant livers are depleted for Coenzyme Q (CoQ), a critical component of the mitochondrial respiratory chain. Results from this mammalian model of primary mitochondrial dysfunction are compared to nematode models (GDS3452 and GDS3453).

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE10904

6 Samples

Download data: CEL

Analysis of 8 different electron transport chain (ETC) subunit mutants (3 missense and 5 RNAi-induced) in complexes I, II, and III. Results from this validation set provide insight into the contributions of individual complexes or subunits to primary mitochondrial dysfunction.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 4 genotype/variation, 4 protocol sets

Platform:

GPL200

Series:

GSE9897

10 Samples

Download data: CEL

Analysis of gas-1(fc21) electron transport chain complex I mutants. The gas-1(fc21) mutation affects the 49 kD subunit of complex I, decreasing the rate of complex I-dependent oxidative phosphorylation. Results provide insight into molecular mechanisms underlying primary mitochondrial disease .

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL200

Series:

GSE9896

10 Samples

Download data: CEL

(Submitter supplied) To discern whether the same transcriptional signature of mitochondrial dysfunction previously reported in B6.Alb/cre,Pdss2loxP/loxP liver-conditional knockout mice (Peng, Falk et al. PLoS Genetics, 2008 [PMID 18437205]) was present regardless of Pdss2 mutation type, as well as to assess whether pharmacologic therapies modulate expression of particular pathways, genome-wide transcriptional profiling was performed in liver from B6.Pdss2(kd/kd) missense mutant mice on standard chow or supplemented long-term with either probucol or CoQ10.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

20 Samples

Download data: TXT

(Submitter supplied) isp-1;sod double mutants have decreased lifespan, increased resistance to oxidative stress and slow physiologic rates. We performed RNA sequencing to compare gene expression between isp-1 mutants and isp-1;sod-3 and isp-1;sod-5 double mutants

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19757

12 Samples

Download data: TXT

(Submitter supplied) In this work, we examined the effect of the transcription factor ATFS-1 in the long lifespan of the nuo-6 mitochondrial mutant. We also examined the effect of the hypoxia transcription factor hif-1. We sequenced both atfs-1 deletion mutants and atfs-1 gain-of-function point mutants in which the mitochondrial localization sequence of ATFS-1 is disrupted. Note that sequencing batch 2 was previously uploaded as part of GSE93724.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19757

43 Samples

Download data: TXT

(Submitter supplied) We have shown that worms that possess mutations in two electron transport chain subunits live longer due to mtROS signalling. Wild type worms can also live longer by treatment with the pro-oxidant paraquat. Paraquat treatment is not additive to the mutations in the ETC subunits. We aimed to determine the underlying changes in gene expression that were common to both paraquat treatment and the two mutations. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Datasets:

GDS5193 GDS5194 GDS5195

Platform:

GPL200

22 Samples

Download data: CEL

Analysis of nuo-6;ced-4 double mutants. ced-4 mutation in the intrinsic apoptosis signaling pathway suppresses the longevity of electron transport chain mutant nuo-6. Results provide insight into molecular mechanisms underlying lifespan expansion.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:

GPL200

Series:

GSE54024

13 Samples

Download data: CEL

Analysis of isp-1;ced-4 double mutants. ced-4 mutation in the intrinsic apoptosis signaling pathway suppresses the longevity of electron transport chain mutant isp-1. Results provide insight into molecular mechanisms underlying lifespan expansion.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:

GPL200

Series:

GSE54024

13 Samples

Download data: CEL

Analysis of wildtype worms treated with the pro-oxidant paraquat and electron transport chain mutants isp-1 and nuo-6. Results provide insight into common molecular mechanisms underlying the increased longevity in all three conditions.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 genotype/variation, 3 protocol sets

Platform:

GPL200

Series:

GSE54024

13 Samples

Download data: CEL

(Submitter supplied) Microarray expression profiling has become a valuable tool in the evaluation of the genetic consequences of metabolic disease. Although 3’-biased gene expression microarray platforms were the first generation to have widespread availability, newer platforms are gradually emerging that have more up-to-date content and/or higher cost efficiency. Deciphering the relative strengths and weaknesses of these various platforms for metabolic pathway level analyses can be daunting. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3616 GDS3618 GDS3619

4 related Platforms

18 Samples

Download data: CEL, TXT

Analysis of livers from B6.Alb/cre,Pdss2(loxP/loxP) animals following treatment with probucol, an antioxidant/antihyperlipidemic agent. Results used to evaluate the performance of Illumina Mouse WG-6 in comparison to Affymetrix 430 2.0, and Affymetrix Gene 1.0 ST.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 2 gender, 4 individual sets

Platform:

GPL9526

Series:

GSE18677

6 Samples

Download data

Analysis of livers from B6.Alb/cre,Pdss2(loxP/loxP) animals following treatment with probucol, an antioxidant/antihyperlipidemic agent. Results used to evaluate the performance of Affymetrix Gene 1.0 ST in comparison to Affymetrix 430 2.0, and Illumina Mouse WG-6.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 2 gender sets

Platform:

GPL9525

Series:

GSE18677

4 Samples

Download data: CEL

Analysis of livers from B6.Alb/cre,Pdss2(loxP/loxP) animals following treatment with probucol, an antioxidant/antihyperlipidemic agent. Results used to evaluate the performance of Affymetrix 430 2.0 in comparison to Affymetrix Gene 1.0 ST, and Illumina Mouse WG-6.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 2 gender sets

Platform:

GPL9523

Series:

GSE18677

4 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL19757

19 Samples

Download data: BW, TSV

(Submitter supplied) Intestine-specific transcriptome of wild-type. gas-1(fc21) and gas-1(fc21); cest-2.2 OE Caenorhaditis elegans in order to gain insight into how cest-2.2 overexpression ameliorates Complex I deficiency

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19757

15 Samples

Download data: FA, TSV, TXT, XLSX