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Links from GEO DataSets

Items: 16

1.

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part C

(Submitter supplied) Thyroid hormone (TH) controls the remodeling of the pancreas and the liver. TH-induces dedifferentiation of the exocrine pancreas to a progenitor state (Proc. Nat. Acad Sci. 105, 8962-8967 (2008)) and it remodels the endocrine pancreas (Dev. Biol. 328, 384-391 (2009)). The redifferentiated frog pancreas resembles closely the pancreas of other typical vertebrates. Two pancreas arrays were carried out. more...
Organism:
Xenopus laevis
Type:
Expression profiling by array
Platform:
GPL3936
9 Samples
Download data: TXT
Series
Accession:
GSE16018
ID:
200016018
2.

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Xenopus laevis
Type:
Expression profiling by array
Platforms:
GPL8463 GPL2901 GPL3936
34 Samples
Download data: TXT
Series
Accession:
GSE16075
ID:
200016075
3.

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part A

(Submitter supplied) Thyroid hormone (TH) controls the remodeling of the pancreas and the liver. TH-induces dedifferentiation of the exocrine pancreas to a progenitor state (Proc. Nat. Acad Sci. 105, 8962-8967 (2008)) and it remodels the endocrine pancreas (Dev. Biol. 328, 384-391 (2009)). The redifferentiated frog pancreas resembles closely the pancreas of other typical vertebrates. Two pancreas arrays were carried out. more...
Organism:
Xenopus laevis
Type:
Expression profiling by array
Platform:
GPL8463
16 Samples
Download data: TXT
Series
Accession:
GSE16074
ID:
200016074
4.

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part B

(Submitter supplied) Thyroid hormone (TH) controls the remodeling of the pancreas and the liver. TH-induces dedifferentiation of the exocrine pancreas to a progenitor state (Proc. Nat. Acad Sci. 105, 8962-8967 (2008)) and it remodels the endocrine pancreas (Dev. Biol. 328, 384-391 (2009)). The redifferentiated frog pancreas resembles closely the pancreas of other typical vertebrates. Two pancreas arrays were carried out. more...
Organism:
Xenopus laevis
Type:
Expression profiling by array
Platform:
GPL2901
9 Samples
Download data: TXT
Series
Accession:
GSE16017
ID:
200016017
5.

Thyroid hormone induced resorption of tail in Xenopus laevis tadpole

(Submitter supplied) Premetamorphic Xenopus laevis tadpole tail respond to thyroid hormone by resorption. The goal of this experiment is to identify the genes involved in the TH-induced resorption tadpole tail and compare it to TH-induced proliferation and differentiation program in tadpole limb and brain. Xenopus tadpoles (NF54) were treated with 100 nM T3 in 0.1 x MMR for another 24h and 48h or without T3 for 48h (control group). more...
Organism:
Xenopus laevis; unidentified
Type:
Expression profiling by array
Dataset:
GDS1719
Platform:
GPL2901
12 Samples
Download data: TIFF
Series
Accession:
GSE3405
ID:
200003405
6.

Thyroid hormone induced changes in Xenopus laevis tadpole limb bud

(Submitter supplied) Premetamorphic Xenopus laevis tadpoles limb bud cells respond to thyroid hormone by proliferation and subsequent differentiation. The goal of this experiment is to identify the genes involved in the TH-induced proliferation pathway in developing tadpole limb bud and compare it to TH-induced proliferation and differentiation program in tadpole brain. Xenopus tadpoles (NF54) were treated with 1 mM methimazole in 0.1 X MMR solution for 1 week to block the endogenous TH production and reduce the TH present in the system of the tadpole. more...
Organism:
Xenopus laevis; unidentified
Type:
Expression profiling by array
Dataset:
GDS1718
Platform:
GPL2901
12 Samples
Download data: TIFF
Series
Accession:
GSE3404
ID:
200003404
7.

Thyroid hormone induced changes in Xenopus laevis tadpole brain

(Submitter supplied) Premetamorphic Xenopus laevis tadpoles brain ventricle cells respond to thyroid hormone by proliferation and subsequent differentiation. The goal of this experiment is to identify the genes involved in the TH-induced proliferation pathway in tadpole brain and compare it to TH-induced proliferation and differentiation program in tadpole limb. Xenopus tadpoles (NF54) were treated with 1 mM methimazole in 0.1 X MMR solution for 1 week to block the endogenous TH production and reduce the TH present in the system of the tadpole. more...
Organism:
unidentified; Xenopus laevis
Type:
Expression profiling by array
Dataset:
GDS1717
Platform:
GPL2901
9 Samples
Download data: TIFF
Series
Accession:
GSE3402
ID:
200003402
8.
Full record GDS1719

Thyroid hormone triiodothyronine effect on tadpole tail: time course

Analysis of tails of NF stage 54 (NF54) premetamorphic tadpoles treated with thyroid hormone (TH) triiodothyronine (T3) up to 48 hours. NF61 tadpoles were in 0.1xMMR till they reached NF62. Premetamorphic tails are resorbed in response to TH. Results identify genes involved in TH-induced resorption.
Organism:
Xenopus laevis; unidentified
Type:
Expression profiling by array, log ratio, 2 agent, 2 development stage, 3 time sets
Platform:
GPL2901
Series:
GSE3405
12 Samples
Download data: TIFF
DataSet
Accession:
GDS1719
ID:
1719
9.
Full record GDS1718

Thyroid hormone triiodothyronine effect on tadpole limb bud: time course

Analysis of limb buds of NF stage 54 (NF54) premetamorphic tadpoles treated with thyroid hormone (TH) triiodothyronine (T3) for 14, 24 or 48 hours. Premetamorphic limb buds proliferate and differentiate in response to TH. Results identify genes involved in the TH-induced proliferation pathway.
Organism:
Xenopus laevis; unidentified
Type:
Expression profiling by array, log ratio, 2 agent, 3 time sets
Platform:
GPL2901
Series:
GSE3404
12 Samples
Download data: TIFF
DataSet
Accession:
GDS1718
ID:
1718
10.
Full record GDS1717

Thyroid hormone triiodothyronine effect on tadpole brain: time course

Analysis of brains of NF stage 54 (NF54) premetamorphic tadpoles treated with thyroid hormone (TH) triiodothyronine (T3) for 24 or 48 hours. Premetamorphic brain ventricle cells proliferate and differentiate in response to TH. Results identify genes involved in the TH-induced proliferation pathway.
Organism:
Xenopus laevis; unidentified
Type:
Expression profiling by array, log ratio, 2 agent, 2 time sets
Platform:
GPL2901
Series:
GSE3402
9 Samples
Download data: TIFF
DataSet
Accession:
GDS1717
ID:
1717
11.

DNA methylation dynamics underlie metamorphic gene regulation programs in Xenopus tadpole brain [ChIP-seq]

(Submitter supplied) Association of thyroid hormone receptors (TRs) in chromatin across the genome of neural cells in the preoptic area/hypothalamus/thalamus of metamorphic climax stage Xenopus tropicalis tadpoles, analyzed by chromatin-immunoprecipitation sequencing (ChIP-seq).
Organism:
Xenopus tropicalis
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21874
2 Samples
Download data: TXT
Series
Accession:
GSE214697
ID:
200214697
12.

DNA methylation dynamics underlie metamorphic gene regulation programs in Xenopus tadpole brain [RNA-seq]

(Submitter supplied) Changes in gene expression in the preoptic area/hypothalamus/thalamus of Xenopus tropicalis tadpoles were analyzed using RNAseq at four stages of metamorphosis.
Organism:
Xenopus tropicalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21874
12 Samples
Download data: FA, MATRIX, TXT
Series
Accession:
GSE140120
ID:
200140120
13.

DNA methylation dynamics underlie metamorphic gene regulation programs in Xenopus tadpole brain

(Submitter supplied) Changes in DNA methylation in the preoptic area/hypothalamus/thalamus of Xenopus tropicalis tadpoles were analyzed using Methylated DNA Capture sequencing (MethlCap-seq) at four stages of metamorphosis.
Organism:
Xenopus tropicalis
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL21874
15 Samples
Download data: BED
Series
Accession:
GSE139267
ID:
200139267
14.

Temporal and Spatial Transcriptomic Dynamics across Brain Development in Xenopus laevis tadpoles

(Submitter supplied) We conducted differential gene expression analyses of the developing X. laevis tadpole midbrain between stages 44 and 61, and across brain regions at stage 46. We found that genes pertaining to positive regulation of neural progenitor cell proliferation as well as known progenitor cell markers were upregulated in the midbrain prior to metamorphic climax; concurrently, expression of cell cycle timing regulators decreased across this period. more...
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17682
30 Samples
Download data: TXT
Series
Accession:
GSE183193
ID:
200183193
15.

Profiling limb muscle degeneration by inducible dominant negative thyroid hormone receptor transgene over-expression

(Submitter supplied) Premetamorphic Xenopus laevis tadpoles limbs develop in response to thyroid hormone by proliferation and subsequent differentiation. We have previously reported that inhibiting the thyroid hormone action using a dominant negative receptor in limbs of developing tadpoles inhibits its growth and the tadpole limb has almost no muscle. The goal of this experiment is to study the role of thyroid hormone in the maintenance of limb muscle using transgenic tadpoles carrying a doxycyline inducible dominant negative thyroid receptor transgene expressed exclusively in the muscle using a muscle specific promoter and identify the genes involved in the degenerative process . more...
Organism:
Xenopus laevis
Type:
Expression profiling by array
Dataset:
GDS2120
Platform:
GPL3936
12 Samples
Download data: TXT
Series
Accession:
GSE5249
ID:
200005249
16.
Full record GDS2120

Dominant negative thyroid hormone receptor overexpression effect on hind limb muscle development

Analysis of hind limbs of premetamorphic (NF55) and postmetamorphic (NF66) transgenics 2 or 6 weeks following transcriptional induction of a dominant negative thyroid hormone (TH) receptor transgene. Results provide insight into the role of TH in the maintenance of limb muscle during development.
Organism:
Xenopus laevis
Type:
Expression profiling by array, log10 ratio, 2 development stage, 2 genotype/variation, 2 time sets
Platform:
GPL3936
Series:
GSE5249
12 Samples
Download data: TXT
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