Similar studies for GEO DataSets (Select 200018132) - GEO DataSets

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Items: 17

Select item 2000181321.

Dynamic O-GlcNAc cycling at promoters of C. elegans genes regulating Longevity, Stress, and Immunity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array; Genome binding/occupancy profiling by genome tiling array; Other

Platforms:: GPL5634 GPL200
72 Samples

Download data: BAR, BED, CEL, CHP

Series

Accession:: GSE18132

ID:: 200018132

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000403712.

Expression from C. elegans L1 animals

(Submitter supplied) Nutrient-driven O-GlcNAcylation of key components of the transcription machinery may epigenetically modulate gene expression in metazoans. Knockouts of the O-GlcNAc cycling enzymes in C. elegans are viable and fertile, allowing a global analysis of the impact of GlcNAcylation. Here we compare gene expression in wild type and O-GlcNAc mutants (ogt-1 and oga-1) in synchronized, fed L1 animals. Whole genome transcriptional profiling of the O-GlcNAc cycling mutants confirmed dramatic deregulation of genes in these key pathways. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL200
9 Samples

Download data: CEL, CHP

Series

Accession:: GSE40371

ID:: 200040371

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000186113.

O-GlcNAc Chromatin Marks from C. elegans L1 animals

(Submitter supplied) Nutrient-driven O-GlcNAcylation of key components of the transcription machinery may epigenetically modulate gene expression in metazoans. Knockouts of the O-GlcNAc cycling enzymes in C. elegans are viable and fertile, allowing a global analysis of the impact of GlcNAcylation. Whole genome ChIP profiling of the O-GlcNAc cycling mutants identified over 800 genes associated with GlcNAcylated chromatin. more...

Organism:: Caenorhabditis elegans

Type:: Genome binding/occupancy profiling by genome tiling array; Other

Platform:: GPL5634
45 Samples

Download data: BAR, BED, CEL

Series

Accession:: GSE18611

ID:: 200018611

PubMed Full text in PMC Similar studies

Select item 2000181314.

Expression from C. elegans L4 animals

(Submitter supplied) Nutrient-driven O-GlcNAcylation of key components of the transcription machinery may epigenetically modulate gene expression in metazoans. Knockouts of the O-GlcNAc cycling enzymes in C. elegans are viable and fertile, allowing a global analysis of the impact of GlcNAcylation. Whole genome transcriptional profiling of the O-GlcNAc cycling mutants confirmed dramatic deregulation of genes in these key pathways. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL200
9 Samples

Download data: CEL, CHP

Series

Accession:: GSE18131

ID:: 200018131

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000181305.

Expression from C. elegans L1 animals

(Submitter supplied) Nutrient-driven O-GlcNAcylation of key components of the transcription machinery may epigenetically modulate gene expression in metazoans. Knockouts of the O-GlcNAc cycling enzymes in C. elegans are viable and fertile, allowing a global analysis of the impact of GlcNAcylation. Whole genome transcriptional profiling of the O-GlcNAc cycling mutants confirmed dramatic deregulation of genes in these key pathways. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL200
9 Samples

Download data: CEL, CHP

Series

Accession:: GSE18130

ID:: 200018130

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000748466.

Drosophila Oga deletion perturbs O-GlcNAcylation of chromatin factors

(Submitter supplied) Drosophila development is a complex and dynamic process regulated, in part, by members of the Polycomb (Pc), Trithorax (Trx) and Compass chromatin modifier complexes. O-GlcNAc Transferase (OGT/SXC) is essential for Pc repression suggesting that the O-GlcNAcylation of proteins plays a key role in regulating development. OGT transfers N-acetyl-D-glucosamine (GlcNAc) onto hydroxyl groups of serine or threonine residues of key transcriptional regulators using the nutrient-derived UDP-GlcNAc as a substrate, which is dynamically removed by O-GlcNAcase (OGA). more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by genome tiling array

Platform:: GPL6629
9 Samples

Download data: CEL, TXT

Series

Accession:: GSE74846

ID:: 200074846

PubMed Full text in PMC Similar studies

Select item 2000651977.

O-GlcNAcase is an epigenetic regulator of nutrient-responsive Drosophila Oogenesis

(Submitter supplied) Nutrient-responsive oogenesis in Drosophila is a complex and dynamic process regulated, in part, by members of the Pc and Trx complexes. The recent finding that O-GlcNAc Transferase (ogt/sxc) is essential for Pc repression raises the question of whether this nutrient-sensing pathway plays a role in regulating oogenesis. OGT transfers O-GlcNAc to key transcriptional regulators in response to graded levels of the nutrient-derived precursor UDP-GlcNAc; O-GlcNAcase (OGA) catalyzes the removal of O-GlcNAc. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL1322
9 Samples

Download data: CEL, CHP

Series

Accession:: GSE65197

ID:: 200065197

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000537328.

Conserved nutrient sensor O-GlcNAc transferase is integral to the C. elegans pathogen-specific immune response

(Submitter supplied) Discriminating pathogenic bacteria from energy-harvesting commensals is key to host immunity. Using mutants defective in the enzymes of O-linked N-acetylglucosamine (O-GlcNAc) cycling, we examined the role of this nutrient-sensing pathway in the Caenorhabidits elegans innate immune response. Using whole genome transcriptional profiling, O-GlcNAc cycling mutants exhibited deregulation of unique stress- and immune-responsive genes as well as genes shared with the p38 MAPK/PMK-1 pathway. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL200
36 Samples

Download data: CEL

Series

Accession:: GSE53732

ID:: 200053732

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Select item 2001696499.

Nutrient sensing mediated by O-GlcNAcylation regulates gene expression through epigenetic mechanisms during embryonic neurogenesis

(Submitter supplied) We show that pharmacological upregulation of O-GlcNAc levels during hESCs-neuronal differentiation leads to upregulation of key neurogenic TF gene which in turn is associated with increased H3K4me3 levels, reduction in H3K27me3 levels and increase in Pol IISer5 phosphorylation. Our results demonstrate O-GlcNAc mediated sensitivity of chromatin to nutrient status, and indicate how metabolic dysregulations could affect stem cell fate decisions through epigenetic gene regulatory mechanisms

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
16 Samples

Download data: TXT

Series

Accession:: GSE169649

ID:: 200169649

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20008615410.

O-GlcNAc Aminidase is an RNA Pol II Elongation Factor Coupled to Pausing Factors SPT5 and TIF1b

(Submitter supplied) ChIP-seq shows that OGA and O-GlcNAc are found at promoters/TSS concomitantly with the known elongation factors SPT5 and TIF1b as well as RNA pol II. There are gene body overlaps of various combinations of factors as well.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
7 Samples

Download data: BEDGRAPH, NARROWPEAK

Series

Accession:: GSE86154

ID:: 200086154

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005272111.

Effects of O-GlcNAc modification on gene expression using O-GlcNAcase deleted Mouse Embryonic Fibroblast cells.

(Submitter supplied) Single O-GlcNAc modification orchestrate by O-GlcNAc Transferase (OGT) and O-GlcNAcase (OGA alias MGEA5) enzymes, affects signal transduction and gene expression by chromatin modulation. We developed Oga deleted MEF (mouse embryonic fibroblast) cells to investigate effects of O-GlcNAc modification in mice. RNA isolated from Mouse Embryonic Fibroblast cells generated from Oga Knock out (KO) Heterozygous (Het) and wild type (WT) cells and subjected to microarray analysis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
9 Samples

Download data: CEL, CHP

Series

Accession:: GSE52721

ID:: 200052721

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005766412.

Gene Expression Profiling Reveals Molecular Patterns Underlying the Lifespan-Extending Effect of Tyrosol in Caenorhabditis elegans

(Submitter supplied) We have previously reported that tyrosol (TYR), one of the main phenols in extra virgin olive oil (EVOO), promotes lifespan extension in the nematode Caenorhabditis elegans, also inducing a stronger resistance to thermal and oxidative stress in this animal model. Although the influence of several longevity-related genes in these effects has been reported by our group, we decided to perform a whole genome DNA-microarray approach in order to identify other genes and molecular pathways further involved in TYR effects on C. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL200
6 Samples

Download data: CEL

Series

Accession:: GSE57664

ID:: 200057664

Select item 20007242613.

daf-16/FoxO isoform-specific deletion mutants

(Submitter supplied) FoxO transcription factors promote longevity across taxa. How they do so is poorly understood. In the nematode Caenorhabditis elegans, the A- and F-isoforms of the FoxO transcription factor DAF-16 extend life span in the context of reduced DAF-2 insulin-like growth factor receptor (IGFR) signaling. To elucidate the mechanistic basis for DAF-16/FoxO-dependent life span extension, we performed an integrative analysis of isoform-specific daf-16/FoxO mutants. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13657
21 Samples

Download data: TXT

Series

Accession:: GSE72426

ID:: 200072426

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011098414.

Role of mitochondrial unfolded protein response transcription fatcor ATFS-1 in lifespan of long-lived mitochondrial mutants

(Submitter supplied) In this work, we examined the effect of the transcription factor ATFS-1 in the long lifespan of the nuo-6 mitochondrial mutant. We also examined the effect of the hypoxia transcription factor hif-1. We sequenced both atfs-1 deletion mutants and atfs-1 gain-of-function point mutants in which the mitochondrial localization sequence of ATFS-1 is disrupted. Note that sequencing batch 2 was previously uploaded as part of GSE93724.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19757
43 Samples

Download data: TXT

Series

Accession:: GSE110984

ID:: 200110984

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20000176215.

C. elegans daf2 mutant adults

(Submitter supplied) Analysis of gene expression in long-lived daf-2 mutants for the insulin/IGF-1 receptor. daf-2(e1370) and daf-2(m577) alleles each examined as single and as double mutations with the daf-16(df50) allele. DAF-2 regulates DAF-16, a transcription factor. Results provide insight into longevity. Keywords: other

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Dataset:: GDS770
Platform:: GPL200
20 Samples

Download data

Series

Accession:: GSE1762

ID:: 200001762

Select item 77016.

Long-lived daf-2 insulin/IGF-1 receptor mutant expression profiling

Analysis of gene expression in long-lived daf-2 mutants for the insulin/IGF-1 receptor. daf-2(e1370) and daf-2(m577) alleles each examined as single and as double mutations with the daf-16(df50) allele. DAF-2 regulates DAF-16, a transcription factor. Results provide insight into longevity.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:: GPL200
Series:: GSE1762
20 Samples

Download data

DataSet

Accession:: GDS770

ID:: 770

Select item 20011999317.

Comparison of gene expression in the long-lived hsb-1 mutant and hsf-1 overexpression C. elegans strains

(Submitter supplied) Purpose: We used RNA-Seq to compare the gene expression profiles in two long-lived C. elegans strains: (1) animals with a loss-of-function mutation in the hsb-1 gene, and (2) animals overexpressing hsf-1 under its endogenous promoter. Previous studies indicated that life span extension in both these strains is hsf-1-dependent. Methods: mRNA-Seq profiles for three biological replicates each of day 1 adult wild-type (N2 strain), hsb-1 mutant and hsf-1 overexpression strains were generated using 50 bp single-end sequencing on an Illumina HiSeq 2500 platform. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18245
9 Samples

Download data: TXT

Series

Accession:: GSE119993

ID:: 200119993

PubMed Full text in PMC Similar studies SRA Run Selector

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