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Links from GEO DataSets

Items: 20

1.

Array-based gene expression in neuroblastic tumors

(Submitter supplied) Title: Array-based gene expression, CGH and tissue data define a 12q24 gain in neuroblastic tumors with prognostic implication. Background: Neuroblastoma has successfully served as a model system for the identification of neuroectoderm-derived oncogenes. However, in spite of various efforts, only a few clinically useful prognostic markers have been found. Here, we present a framework, which integrates DNA, RNA and tissue data to identify and prioritize genetic events that represent clinically relevant new therapeutic targets and prognostic biomarkers for neuroblastoma. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
3 Samples
Download data: CEL
Series
Accession:
GSE18139
ID:
200018139
2.

Array-based gene expression, CGH and tissue data define a 12q24 gain in neuroblastic tumors with prognostic implication

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by genome tiling array
Platforms:
GPL570 GPL9202
5 Samples
Download data: CEL, TXT
Series
Accession:
GSE18144
ID:
200018144
3.

aCGH of neuroblastic tumors

(Submitter supplied) Title: Array-based gene expression, CGH and tissue data define a 12q24 gain in neuroblastic tumors with prognostic implication. Background: Neuroblastoma has successfully served as a model system for the identification of neuroectoderm-derived oncogenes. However, in spite of various efforts, only a few clinically useful prognostic markers have been found. Here, we present a framework, which integrates DNA, RNA and tissue data to identify and prioritize genetic events that represent clinically relevant new therapeutic targets and prognostic biomarkers for neuroblastoma. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL9202
2 Samples
Download data: TXT
Series
Accession:
GSE18143
ID:
200018143
4.

Identification of candidate neuroblastoma genes by combining genomic and expression microarrays

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by SNP array; SNP genotyping by SNP array
Platforms:
GPL2004 GPL570
53 Samples
Download data: CEL
Series
Accession:
GSE13141
ID:
200013141
5.

Identification of candidate neuroblastoma genes by combining genomic and expression microarrays: SNP data

(Submitter supplied) Gene expression analysis was performed on 30 Neuroblastomas to identify genes whose transcription is significantly altered by recurrent chromosomal alterations. Genomic copy number losses and gains had been delineated in the tumours using FISH and SNP arrays. We have identified genes significantly altered by 7 recurrent alterations: 1p, 3p, 4p, 10q and 11q loss, 2p and 17q gain, and genes co-amplified and over-expressed as a result of MYCN amplification. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array
Platform:
GPL2004
23 Samples
Download data: CEL
Series
Accession:
GSE13137
ID:
200013137
6.

Identification of candidate neuroblastoma genes by combining genomic and expression microarrays: expression data

(Submitter supplied) Gene expression analysis was performed on 30 Neuroblastomas to identify genes whose transcription is significantly altered by recurrent chromosomal alterations. Genomic copy number losses and gains had been delineated in the tumours using FISH and SNP arrays. We have identified genes significantly altered by 7 recurrent alterations: 1p, 3p, 4p, 10q and 11q loss, 2p and 17q gain, and genes co-amplified and over-expressed as a result of MYCN amplification. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
30 Samples
Download data: CEL
Series
Accession:
GSE13136
ID:
200013136
7.

FOXP1 inhibits cell growth and attenuates tumorigenicity of neuroblastoma

(Submitter supplied) Single-color gene expression profiles from 3 neuroblastoma cell lines were generated using 44K oligonucleotide microarrays. To gain insights into the molecular processes occurring upon FOXP1 re-expression, we performed series of time-resolved gene expression measurements in FOXP1 and GFP transgenic neuroblastoma cell lines.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16876
24 Samples
Download data: TXT
Series
Accession:
GSE62419
ID:
200062419
8.

Chromosome 17/17q gain and unaltered profiles in high resolution array-CGH are prognostically informative in neuroblastoma

(Submitter supplied) Oligonucleotide aCGH profiles from 37 neuroblastoma tumor samples were generated using 44K or 105K microarrays.
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platforms:
GPL4093 GPL2873 GPL2879
37 Samples
Download data: TXT
Series
Accession:
GSE56109
ID:
200056109
9.

Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome variation profiling by array; Expression profiling by array
6 related Platforms
881 Samples
Download data: TXT
Series
Accession:
GSE45480
ID:
200045480
10.

miRNA Expression Profiling in Ovarian Cell Lines compared to pooled commercial RNA samples

(Submitter supplied) We investigated whether levels of serum microRNAs (miRNAs) could discriminate women with high-grade serous ovarian epithelial cancer (SEOC) from age matched healthy volunteers. miRNA expression profiling was performed on 4 SEOC cell lines and normal human ovarian surface epithelial cells (HOSE). miR-182, miR-200a, b and c were highly overexpressed in the SEOC cell lines. miR-103, miR-92a and miR-638 displayed relatively invariant expression and with RNU48, were assessed, as putative serum miRNA normalizers. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL15257
5 Samples
Download data: GAL, SPOT
Series
Accession:
GSE35951
ID:
200035951
11.

High-resolution, genome-wide analysis of human metastatic neuroblastoma samples by array-Comparative Genomic Hybridization (aCGH)

(Submitter supplied) Neuroblastoma (NB) is an aggressive tumor that affects both infants and children. The disease outcome is greatly influenced by age of patient, stage, chromosome copy number aberrations (CNAs) and gene expression abnormalities. We analyzed, by microarray technology, genome and transcriptome of 3 groups of tumors of patients with metastatic disease: G1, stage 4S and MYCN single copy; G2, stage 4 younger than 18 months of age, MYCN single copy with no disease progression and G3, stage 4, older than 19 months, with unfavorable outcome. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
4 related Platforms
133 Samples
Download data: TXT
Series
Accession:
GSE25771
ID:
200025771
12.

Integrated analysis of genome-wide copy number and matched expression data reveals novel genes in esophageal adenocarcinoma

(Submitter supplied) The incidence of esophageal and junctional adenocarcinoma has increased 6-fold in the west in the last 30 years and 5 year survival remains <14%. We aimed to characterize genome-wide aberrations in esophageal adenocarcinoma to further understand disease pathogenesis and ultimately identify groups with differential survivals with implications for clinical management. Oligo-array-based high-resolution analysis of copy number changes in 89 fresh frozen esophageal adenocarcinoma resection sections with long-term clinical follow-up data was performed. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platform:
GPL8856
9 Samples
Download data: TXT
Series
Accession:
GSE25201
ID:
200025201
13.

Array CGH characterization of esophago-gastric adenocarcinoma

(Submitter supplied) The incidence of esophageal and junctional adenocarcinoma has increased 6-fold in the west in the last 30 years and 5 year survival remains <14%. We aimed to characterize genome-wide aberrations in esophageal adenocarcinoma to further understand disease pathogenesis and ultimately identify groups with differential survivals with implications for clinical management. Oligo-array-based high-resolution analysis of copy number changes in 89 fresh frozen esophageal adenocarcinoma resection sections with long-term clinical follow-up data was performed. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL10001
56 Samples
Download data: GPR
Series
Accession:
GSE20154
ID:
200020154
14.

Array-based comparative genomic hybridization analysis of primary neuroblastoma

(Submitter supplied) We conducted microarray-based comparative genomic hybridization (array-CGH) with a DNA chip carrying 2,464 BAC clones to examine genomic aberrations of 236 neuroblastomas (112 sporadic and 124 mass screening-detected). In paralell, gene-expression profiling was also performed by using in-house cDNA microarrays. Keywords: Comparative genomic hybridization
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL4242
236 Samples
Download data
Series
Accession:
GSE5784
ID:
200005784
15.

Array-CGH screening of medulloblastoma

(Submitter supplied) DNA copy-number profiling of 80 primary medulloblastomas of different histologies Keywords: Genetic modification
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL5685
80 Samples
Download data: GPR
Series
Accession:
GSE8634
ID:
200008634
16.

Detection of novel amplification units in prostate cancer

(Submitter supplied) Genome-wide screening for regions of genetic gains and losses on nine prostate cancer cell lines (PC3, DU145, LNCaP, CWR22, and derived sublines) was carried out using comparative genomic hybridization on a 35 K longmer oligonucleotide microarray (arrayCGH). Compared to conventional chromosomal CGH more deletions and small regions of gains, particularly in pericentromeric regions and regions next to the telomers, were detected. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL5046
11 Samples
Download data: TXT
Series
Accession:
GSE7376
ID:
200007376
17.

Human ependymomas.

(Submitter supplied) Whole-genome screening of DNA-copy number changes by array-based or matrix comparative genomic hybridization (matrix-CGH). Keywords: Repeat sample.
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL2920
68 Samples
Download data
Series
Accession:
GSE3435
ID:
200003435
18.

DKFZ Homo sapiens 6k-array, version 3/4, upgrade

(Submitter supplied) Whole-genome BAC-array. Isolated BAC-DNA was amplified by two-step DOP-PCR. PCR products were dissolved in 3xSSC, 1.5M betaine and spotted as triplicates on epoxysilane-coated slides.
Organism:
Homo sapiens
1 Series
68 Samples
Download data
Platform
Accession:
GPL2920
ID:
100002920
19.

Integrative Genomics Reveals Mechanisms of Copy Number Alterations Responsible for Transcriptional Deregulation in Colorectal Cancer

(Submitter supplied) To evaluate the mechanisms and consequences of chromosomal aberrations in colorectal cancer (CRC), we used a combination of spectral karyotyping, array comparative genomic hybridization (aCGH), and array-based global gene expression profiling on 31 primary carcinomas and 15 established cell lines. Importantly, aCGH showed that the genomic profiles of primary tumors are recapitulated in the cell lines. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6848 GPL6480
50 Samples
Download data: TXT
Series
Accession:
GSE126053
ID:
200126053
20.

Integrated bioinformatic and wet-lab approach to identify potential oncogenic networks in neuroblastoma

(Submitter supplied) mRNA profiles of thousands of human tumors are available, but methods to deduce oncogenic signaling networks from these data lag behind. It is especially challenging to identify main-regulatory routes, and to generalize conclusions obtained from experimental models. We designed the bioinformatic platform R2 in parallel with a wet-lab approach of neuroblastoma. Here we demonstrate how R2 facilitates an integrated analysis of our neuroblastoma data. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
88 Samples
Download data: CEL
Series
Accession:
GSE16476
ID:
200016476
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