GEO DataSets

(Submitter supplied) The liver is one of most important organs in our bodies. It performs many essential functions including metabolism, synthesis, secretion, detoxification, and storage. Hepatocytes are the principal cell type in the liver and are involved in multiple liver-specific functions. There have been several efforts to develop in vitro culture systems capable of maintaining hepatocyte-specific phenotype over long time periods. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

24 Samples

Download data: CEL

(Submitter supplied) The primary aim of this study was to evaluate the changes in hepatocyte gene expression under short-term hypoxic conditions in wild type and HIF-1a null cultures. To this end, hypoxia treated cultures were subjected to incubation with 1% O2/5% CO2/94% N2 at 37° C for eight hours prior to RNA isolation. Duplicate normoxic controls were established from separate animals wherein cultures were untreated and treated with Adbgal. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1648

Platform:

GPL81

10 Samples

Download data: CEL

Analysis of hypoxia-inducible factor-1alpha (HIF-1alpha) null mutant hepatocytes subjected to hypoxic conditions for 8 hours. The HIF-1alpha transcription factor is a key regulator of oxygen homeostasis. Results provide insight into hepatocyte gene expression changes induced by short-term hypoxia.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 stress sets

Platform:

GPL81

Series:

GSE1321

10 Samples

Download data: CEL

(Submitter supplied) To identify the CAR-, PXR- and PPARα-specific genome-wide expression changes, hepatocyte cultures from six individual donors were treated with the prototypical ligands for CAR (CITCO), PXR (rifampicin) and PPARα (WY14,643) as well as DMSO (vehicle control). Afterwards, the mRNA expression in these samples was determined utilizing Affymetrix® microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

24 Samples

Download data: CEL

(Submitter supplied) To invesigate the physiology roles of mir-122 in liver, we performed expression profiling of mir-122 knockout mice and the control B6/129 mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

7 Samples

Download data: CEL, CHP

(Submitter supplied) There are many toxic chemicals to contaminate the world and cause harm to human and other organisms. How to quickly discriminate these compounds and characterize their potential molecular mechanism and toxicity is essential. High through put transcriptomics profiles such as microarray have been proven useful to identify biomarkers for different classification and toxicity prediction purposes. Here we aim to investigate how to use microarray to predict chemical contaminants and their possible mechanisms. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL4135

531 Samples

Download data: TXT

(Submitter supplied) The use of a systems biology approach to analyze common and specific mechanisms of liver toxicity induced by munitions compounds TNT, 2,6-DNT, 2,4-DNT, 4A-DNT, and 2A-DNT The munitions compound 2,4,6-trinitrotoluene (TNT), its environmental degradation products 2-amino-4,6-dinitrotoluene (2A-DNT) and 4-amino-2,6-dinitrotoulene (4A-DNT), and two other munitions, 2,4-dinitrotoluene (2,4-DNT) and 2,4-dinitrotoluene (2,6-DNT) contaminate contaminate land, water and retired ammunitions plants. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL4135

199 Samples

Download data: TXT

(Submitter supplied) Genotypic differences greatly influence susceptibility and resistance to disease. Understanding genotype-phenotype relationships requires that phenotypes be viewed as manifestations of network properties, rather than simply as the result of individual genomic variations. Genome sequencing efforts have identified numerous germline mutations associated with cancer predisposition and large numbers of somatic genomic alterations. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15648

449 Samples

Download data: CEL

(Submitter supplied) Based on sensorial analysis over 2 years, 12 apple varieties and 4 hybrides with contrasted fruit texture were selected for transcriptionnal analyses over 4 months of cold storage (harvest, 1 month, 2 and 4 months).

Organism:

Malus domestica

Type:

Expression profiling by array

Platform:

GPL16374

192 Samples

Download data: PAIR, TXT

(Submitter supplied) Based on sensorial analysis, 8 apple genotypes with contrasted fruit texture for mealiness were selected among a progeny. Apple samples were collected at 60 days after flowering (60DAF), 110 days after flowering (110DAF), harvest (Rec), and after 1 or 2 months of cold storage (1M and 2M respectively).

Organism:

Malus domestica

Type:

Expression profiling by array

Platform:

GPL16374

152 Samples

Download data: PAIR

(Submitter supplied) Based on sensorial analysis over 4 years, 6 apple genotypes with contrasted fruit texture (mealy or not) were selected among a progeny. Apple samples were collected at 100 days after flowering (100 DAF), harvest (H), after 2 and 4 months of cold storage (60DAH and 120DAH respectively).

Organism:

Malus domestica

Type:

Expression profiling by array

Platform:

GPL16374

60 Samples

Download data: PAIR