U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 20

1.

Gene expression profiles of mouse liver tissue harboring deletion of RB and/or p53, untreated or post-hepatocarcinogen treatment

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Genome variation profiling by genome tiling array
Platforms:
GPL6246 GPL4092
32 Samples
Download data: CEL, TXT
Series
Accession:
GSE24347
ID:
200024347

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

Genomic profiles of mouse liver tissue harboring deletion of RB and/or p53, untreated or post-hepatocarcinogen treatment [CGH data]

(Submitter supplied) The retinoblastoma (RB) and p53 tumor suppressors are critical regulators of the cell cycle with profound impact on both normal cell biology and disease etiology. In the context of human cancers, compound inactivation of RB and p53 is a frequent occurrence; however, the cooperation of these tumor suppressors in driving tumorigenesis has proven to be intricate and dependent on both the tissue and type of cancer. more...
Organism:
Mus musculus
Type:
Genome variation profiling by genome tiling array
Platform:
GPL4092
7 Samples
Download data: TXT
Series
Accession:
GSE29847
ID:
200029847

PubMed Full text in PMC Similar studies Analyze with GEO2R

3.

Genomic profiles of mouse liver tissue harboring deletion of RB and/or p53, untreated or post-hepatocarcinogen treatment [expression data]

(Submitter supplied) The retinoblastoma (RB) and p53 tumor suppressors are critical regulators of the cell cycle with profound impact on both normal cell biology and disease etiology. In the context of human cancers, compound inactivation of RB and p53 is a frequent occurrence; however, the cooperation of these tumor suppressors in driving tumorigenesis has proven to be intricate and dependent on both the tissue and type of cancer. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
25 Samples
Download data: CEL
Series
Accession:
GSE29846
ID:
200029846

PubMed Full text in PMC Similar studies Analyze with GEO2R

4.

Transcriptome analysis to investigate the oncogenic TGF-β-Smad-Snail signaling pathway

(Submitter supplied) Our study shows that TGF-β signaling promotes tumorigenesis in the liver through upregulation of its target gene, Snail. We explored gene expression changes in tumors following TGF-β inhibition, and tumors ectopically expressing Snail with the TGF-β inhibition. RNA samples were harvested from tumors expressing Smad7 (S7HP tumors), firefly luciferase (LHP tumors), and Smad7 plus Snail (S7HP+Snail), respectively. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
9 Samples
Download data: TXT
Series
Accession:
GSE90024
ID:
200090024

PubMed Similar studies SRA Run Selector

5.

RB pathway deregulation promotes invasion and disease progression in a mouse model of MYC-overexpressing mammary tumorigenesis

(Submitter supplied) Breast cancer is a highly heterogeneous disease that is categorized into distinct tumor subtypes based on specific molecular attributes, which ultimately influence therapeutic options. Unlike ER+ and/or HER2+ cancers that are subject to specific targeted therapies, triple negative breast cancers (TNBCs) do not express these receptors, which leaves patients with limited treatment options. Thus, significant focus has been placed on identifying molecular attributes of basal-like disease that could be used to develop and/or direct novel treatment regimens. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
15 Samples
Download data: CEL
Series
Accession:
GSE40545
ID:
200040545

PubMed Full text in PMC Similar studies Analyze with GEO2R

6.

Hierarchical synergy of Pten, p53 and Rb pathways in high-grade astrocytoma induced in adult brain

(Submitter supplied) Mutations in the PTEN, TP53 and RB1 pathways are obligate events in the pathogenesis of human glioblastomas, the highest grade of astrocytoma. To investigate synergy between these tumor suppressors in mice, we induced various combinations of compound deletions conditionally in astrocytes and neural precursors in the mature brain. The resulting highly penetrant astrocytomas showed a spectrum of histopathological variation reminiscent of human tumors, and ranged from grade III to grade IV (glioblastoma). more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array; Genome variation profiling by genome tiling array
4 related Platforms
118 Samples
Download data: CEL, GPR, TXT
Series
Accession:
GSE22927
ID:
200022927

PubMed Full text in PMC Similar studies Analyze with GEO2R

7.

Spontaneous SCC induced by the somatic inactivation of Rb1 and Trp53 tumor suppressors in mouse stratified epithelia

(Submitter supplied) The squamous cell carcinomas represent the aggressive type of non melanoma skin cancer, the most frequent malignancy among human population. We have studied here the possible relationship between these two pathways in skin using epidermal-specific mutant mice. Loss of p53, but not pRb, produces spontaneous tumor development, indicating that, contrary to pRb, p53 is the predominant tumor suppressor acting in mouse epidermis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
8 Samples
Download data: CEL
Series
Accession:
GSE9144
ID:
200009144

PubMed Similar studies Analyze with GEO2R

8.

Gene expression of human hepatocellular carcinoma cells in response to acyclic retinoid

(Submitter supplied) To better understand the molecular basis of the anticancer effects of acyclic retinoid (ACR), a genome-wide screening was applied to identify novel targets of ACR in human hepatocellular carcinoma (HCC) cells JHH7. Gene expression profiles of JHH7 were measured at 0h, 1h and 4 hours after treatment with1 μM All-trans retinoic acid (AtRA) or 10 μM ACR. Hierarchical clustering with Ward’s method of 44,907 genes demonstrated diverse expression changes in HCC cells treated with ACR for 4h. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
5 Samples
Download data: CEL, CHP
Series
Accession:
GSE71856
ID:
200071856

PubMed Similar studies Analyze with GEO2R

9.

Identification of miRNAs correlated with Rb-depletion induced spherogenesis.

(Submitter supplied) We found that Rb inactivation induces sphere-forming activity under 3D culture condition in primary soft tissue sarcoma cells derived from p53 null mice. To elucidate molecular mechanism, we employed microRNA array as a discovery platform to identify miRNAs correlated with Rb-depeltion induced sphere-forming cells. To enrich sphere-forming cells and make the culture condition equivalent to that of parental cells (Primary cells), we replated sphere-forming cells on normal dishes (Rb shRNA Secondary cells), and obtained total RNA soon after replating.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL15169
7 Samples
Download data: TXT
Series
Accession:
GSE77222
ID:
200077222

PubMed Full text in PMC Similar studies

10.

RNA-seq of human foreskin fibroblast cells lacking RB, p130, and p107 treated with doxorubicin.

(Submitter supplied) We used human foreskin fibroblast cells with CRISPR-Cas9 mediated knockout of RB1 and p130 (RBL2) (sgP130, sgRB1+sg130), knocked down p107 using siRNA and measured gene expression changes after doxorubicin treatmnet (24 hr, 350 nM).
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
16 Samples
Download data: XLSX
Series
Accession:
GSE135842
ID:
200135842

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

11.

RNA-seq of human foreskin fibroblast cells lacking RB and/or p130 after doxorubicin treatment

(Submitter supplied) We used human foreskin fibroblast cells with CRISPR-Cas9 mediated knockout of RB1 and p130 (RBL2) (Control, sgRB1, sgP130, sgRB1+sg130) and measured gene expression changes after doxorubicin treatmnet (24 hr, 350 nM).
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
16 Samples
Download data: TXT
Series
Accession:
GSE128711
ID:
200128711

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

12.

RNA-seq (PolyA) of RNA from Tet-inducible SaOS2-p21 cells

(Submitter supplied) RNA was extracted from SaOS2 cells harboring a tet-inducible p21 expression vector. 3 replicates from untreated and 3 replicates from 24h doxycycline-treated cells.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: TXT
Series
Accession:
GSE128669
ID:
200128669

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

13.

Development of gene sets after deleting Rb or Rb and Pten in p53 null background primary prostate cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL11202 GPL10787
14 Samples
Download data: TXT
Series
Accession:
GSE68905
ID:
200068905

PubMed Similar studies Analyze with GEO2R

14.

Development of gene sets after deleting Rb and Pten in p53 null background primary prostate cells [Rb and Pten]

(Submitter supplied) Our findings suggested that cytokines were upregulated in p53 null primary prostate cells after deleting Rb and/or Pten. Rb and Pten deletion are important for prostate cancer progression.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
8 Samples
Download data: TXT
Series
Accession:
GSE68904
ID:
200068904

PubMed Similar studies Analyze with GEO2R

15.

Development of gene sets after deleting Rb in p53 null background primary prostate cells [Rb only]

(Submitter supplied) Our findings suggested that cytokines were upregulated in p53 null primary prostate cells after deleting Rb. Rb deletion is important for prostate cancer progression.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
6 Samples
Download data: TXT
Series
Accession:
GSE68903
ID:
200068903

PubMed Similar studies Analyze with GEO2R

16.

Differential gene expression profile of y79 retinoblastoma cells in response to Anti - HMGA2 siRNA treatment

(Submitter supplied) The differential gene expression study was conducted in the Anti - HMGA2 siRNA treated Retinoblastoma cell (Y79). The transient transfection in Y79 cells were performed using Anti-HMGA2 siRNA . The concentration and the time of incubation for the transfection was optimised to increase the silencing efficiency and reduce the off -target effects. After 48 hours of transfection the cells were collected and the whole genome cDNA microarray was performed to interpret the differential gene expression regulated by HMGA2 in Y79 cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13252
6 Samples
Download data: TXT
Series
Accession:
GSE31687
ID:
200031687

PubMed Full text in PMC Similar studies Analyze with GEO2R

17.

Genome wide maps of p53 binding in IMR90 cells

(Submitter supplied) Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F transcription factor potently upregulated during oncogene-induced senescence, a setting where it acts in response to p53 as a direct transcriptional target. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9052
4 Samples
Download data: BED, TXT
Series
Accession:
GSE42728
ID:
200042728

PubMed Full text in PMC Similar studies SRA Run Selector

18.

Expression data from either growing IMR90 human fibroblasts or senescent IMR90 cells with Ras expression and indicated hairpins

(Submitter supplied) Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F transcription factor potently upregulated during oncogene-induced senescence, a setting where it acts in response to p53 as a direct transcriptional target. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
10 Samples
Download data: CEL
Series
Accession:
GSE40349
ID:
200040349

PubMed Full text in PMC Similar studies Analyze with GEO2R

19.

Genome wide maps of E2F7 binding in IMR90 cells

(Submitter supplied) Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F transcription factor potently upregulated during oncogene-induced senescence, a setting where it acts in response to p53 as a direct transcriptional target. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9052
7 Samples
Download data: XLS
Series
Accession:
GSE40343
ID:
200040343

PubMed Full text in PMC Similar studies SRA Run Selector

20.

A Novel Tumor suppressor network in squamous malignancies

(Submitter supplied) The specific ablation of Rb1 gene in stratified epithelia (RbF/F;K14cre) promotes proliferation and altered differentiation but is insufficient to produce spontaneous tumors. The pRb relative, p107, compensates some of the functions of pRb in these tissues, however RbF/F;K14cre;p107-/- mice die postnatally. Acute pRb loss in stratified epithelia, using an inducible mouse model (RbF/F;K14creERTM), shows that p107 exerts specific tumor suppressor functions in its absence. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
14 Samples
Download data: CEL
Series
Accession:
GSE38257
ID:
200038257

PubMed Full text in PMC Similar studies Analyze with GEO2R

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Filters: Manage Filters

db=gds|term=|query=9|qty=3|blobid=MCID_6735e52e419a5e4c05815e21|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Important Links

Recent activity

Clear Turn Off Turn On

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
You are here: NCBI > Genes & Expression > Gene Expression Omnibus (GEO) Datasets
Support Center