GEO DataSets

(Submitter supplied) The microarray analysis of gene expression difference between cattle,buffalo and goat,provide us a profiling as a new platform to discover the difference between their compatibility

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL10987

9 Samples

Download data: TXT

(Submitter supplied) To investigate microRNAs (miRNAs) involving in the regulation of the schistosome development and survival, we compared miRNA expression profiles of adult Schistosoma japonicum derived from yellow cattle and water buffalo using high-throughput sequencing with Illumina Hiseq Xten.

Organism:

Schistosoma japonicum

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL25984

8 Samples

Download data: TXT

(Submitter supplied) The microarray analysis of gene expression difference between cattle and buffalo, provide us a profiling as a new platform to discover the difference between their compatibility with schistosoma japonicum.

Organism:

Bubalus bubalis; Bos taurus

Type:

Expression profiling by array

Platform:

GPL11648

12 Samples

Download data: TXT

(Submitter supplied) Although numerous researches on schistosomiasis japonica have been performed using laboratory animal models, the comparison of gene expression profiles of S. japonicum from the different laboratory animals and natural hosts is still a gap. We systematically compared the gene expression profiles of schistosomes from different laboratory animals and water buffaloes. The findings of this study provide the basis for schistosomiasis research in different mammalian hosts at transcriptional level and valuable resource for the screening of anti-schistosomal intervention targets.

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL18617

24 Samples

Download data: PAIR

(Submitter supplied) In this study, we isolated and identified the small RNAs associated with the S. japonicum Argonaute protein, SjAgo1, by HITS-CLIP combined with bioinformatic analysis. These data reveal a genome-wide miRNA-mRNA interaction map in S. japonicum in vivo, which will help us understand the complex gene regulation network in this pathogen and thereby facilitate to develop novel approaches against Schistosomiasis.

Organism:

Schistosoma japonicum

Type:

Other

Platform:

GPL11650

1 Sample

Download data: FA, TXT

(Submitter supplied) We report on the small RNA profiles of Schistosoma japonicum (S. japonicum) miRNAs using small RNA deep sequencing in the key stages of male-female pairing, gametogenesis, and egg production.

Organism:

Schistosoma japonicum

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL20772

8 Samples

Download data: TXT

(Submitter supplied) More than 40 species of mammal have been reported to be infected naturally with Schistosoma japonicum (Chinese mainland strain) in China. The reed vole, Microtus fortis, is the only known mammalian host in which the schistosomes are unable to mature and cause significant pathogenic changes. Gene expression profiling of the 10 day old schistosomula was performed.

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL9759

4 Samples

Download data: TXT

(Submitter supplied) Background: Schistosoma japonicum is a pathogen of the phylum Platyhelminths that causes zoonotic schistosomiasis endemic in China and Southeast Asian countries. Control of the disease has been hampered by the lack of efficient measures. The development of tools for diagnosis of acute and chronic infection, and novel antiparasite reagents all relies on the understanding of the biological mechanism of the parasite. more...

Organism:

Schistosoma japonicum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18816

2 Samples

Download data: XLS

(Submitter supplied) Schistosomiasis japonica remains a significant public health problem in China and Southeast Asian countries. The most typical and serious outcome of the chronic oriental schistosomiasis is the progressive granuloma and fibrosis in the host liver, which has been a major medical challenge. However, the molecular mechanisms that underlie the hepatic pathogenesis induced by schistosomal egg deposition have not yet been well-defined. more...

Organism:

Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL10192

4 Samples

Download data: PAIR

(Submitter supplied) We utilised a 22,575 feature custom oligonucleotide DNA microarray designed from public domain databases of schistosome expressed sequence tags to explore differential gene expression between the Philippine (SJP) and Chinese (SJC) strains of S. japonicum, and between male and female S. japonicum. We found that 593, 664 and 426 probes were differentially expressed between the two geographical strains when we compared mix sexed adults, male worms and female worms. more...

Organism:

Schistosoma mansoni; Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL3821

12 Samples

Download data

(Submitter supplied) In the complex lifecycle of schistosomes, four developmental stages are closely associated with their definitive hosts: cercaria (infective stage), schistosomula and adult worm (parasitic stages), egg (pathogenic- and pathophoresis-stage). We have examined the gene expression profiles of Schistosoma japonicum in the four developmental stages. Genes with different expression patterns were identified and the information obtained will help indentify new anti-schistosomal intervention targets in the future.

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL18617

23 Samples

Download data: PAIR

(Submitter supplied) miRNA profiling of S. japonicum infected mouse plasma comparing control untreated mouse plasma. Schistosomiasis, caused by dioecious flatworms in the genus Schistosoma, is torturing people predominantly in the developing countries. Knowledge on schistosome-host interaction and its parasitism may result in the development of novel strategies for schistosomiasis control. MicroRNAs (miRNAs) are involved in a wide range of biological processes including development, cell proliferation, metabolism ,signal transduction, et al. more...

Organism:

Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1; Cytomegalovirus; JC polyomavirus; Betapolyomavirus macacae; Rattus norvegicus; Human alphaherpesvirus 2; Lymphocryptovirus; Merkel cell polyomavirus; Homo sapiens; Rhadinovirus; Murid gammaherpesvirus 4; Betapolyomavirus hominis

Type:

Non-coding RNA profiling by array

Platform:

GPL16016

4 Samples

Download data: GAL, GPR, TXT, XLS

(Submitter supplied) We report the design, fabrication, and validation of a microarray covering the majority of the Schistosoma japonicum and Schistosoma mansoni transcriptomes. The oligonucleotide microarray contains 12,166 S. mansoni and 7055 S. japonicum target sequences. A confidence threshold of 0.001 (P value) was used in all analyses. The cross hybridization potential of the microarray was representative of 10,362 probes detected in both channels, while 12,052 probes hybridised to S. more...

Organism:

Schistosoma mansoni; Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL3821

4 Samples

Download data

(Submitter supplied) More than 40 kinds of mammals in China are known to be naturally infected with Schistosoma japonicum (S. japonicum); Microtus fortis (M. fortis), a species of vole, is the only mammal in which the schistosomes cannot mature or cause significant pathogenic changes. In the current study, we compared the differences in pathology by Hematoxylin-eosin staining and in changes in the T cell subsets with flow cytometry as well as gene expression using genome oligonucleotide microarrays in the lung and liver, before challenge and 10 days post-infection with schistosomes in a S. more...

Organism:

Rattus norvegicus; Mus musculus; Microtus fortis

Type:

Expression profiling by array

Platforms:

GPL10389 GPL10390

6 Samples

Download data: TXT

(Submitter supplied) More than 40 kinds of mammals in China are known to be naturally infected with Schistosoma japonicum (S. japonicum); Microtus fortis (M. fortis), a species of vole, is the only mammal in which the schistosomes cannot mature or cause significant pathogenic changes. In the current study, we compared the differences in pathology by Hematoxylin-eosin staining and in changes in the T cell subsets with flow cytometry as well as gene expression using genome oligonucleotide microarrays in the lung and liver, before challenge and 10 days post-infection with schistosomes in a S. more...

Organism:

Microtus fortis; Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL10390

4 Samples

Download data: TXT

(Submitter supplied) More than 40 kinds of mammals in China are known to be naturally infected with Schistosoma japonicum (S. japonicum); Microtus fortis (M. fortis), a species of vole, is the only mammal in which the schistosomes cannot mature or cause significant pathogenic changes. In the current study, we compared the differences in pathology by Hematoxylin-eosin staining and in changes in the T cell subsets with flow cytometry as well as gene expression using genome oligonucleotide microarrays in the lung and liver, before challenge and 10 days post-infection with schistosomes in a S. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10389

2 Samples

Download data: TXT

(Submitter supplied) The life cycle of schistosomes is complex, being characterised by a series of distinct parasitic and free-living phases involving an invertebrate snail host, water and a mammalian host. A custom designed oligonucleotide microarray was utilized to profile developmental gene expression in the Asian blood fluke, Schistosoma japonicum during these parasitic and free-living transitions. Total RNAs were isolated from lung schistosomula, juvenile females and males (paired but little or no egg production), adult males and females (paired with full scale egg production), eggs, miracidia, sporocysts and cercariae. more...

Organism:

Schistosoma mansoni; Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL7160

45 Samples

Download data: TXT

(Submitter supplied) The schistosomulum is the main target of vaccine- induced protective immunity; however, most studies have utilized schistosomula produced by mechanical transformation of infective larvae followed by in vitro culture rather than larvae isolated directly from the lungs of infected mammals. Using transmission electron microscopy, we demonstrated that there was little difference in the ultrastructure of Schistosoma japonicum schistosomula obtained by the two methods. more...

Organism:

Schistosoma japonicum; Schistosoma mansoni

Type:

Expression profiling by array

Platform:

GPL3821

5 Samples

Download data

(Submitter supplied) Migrating schistosomula are an important stage of the schistosome lifecycle and represent a key target for elimination of infection by natural and vaccine induced host immune responses. To gain a better understanding of how these parasites initiate a primary host immune response we have characterised the host lung response to migrating Schistosoma japonicum schistosomula using a combination of histochemistry, microarrays and quantitative cytokine analysis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

6 Samples

Download data: TXT

(Submitter supplied) Schistosoma japonicum is one of the remarkable platyhelminths that are endemic in the South Asian countries. The parasite is dioecious and can parasitize inside host blood stream for many years. Rapid reproduction by producing large number of eggs and count-react or active manipulating host anti-parasite responses are the strategies that benefit the long term parasitization of the parasite. Currently, Praziquantel is the only commercial drug that is effective against the worms but not the eggs of parasite in the host and no vaccine available to prevent human or animal schistosomiasis. more...

Organism:

Schistosoma japonicum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11650

2 Samples

Download data