GEO DataSets

(Submitter supplied) Plakortide F acid (PFA), a marine-derived polyketide endoperoxide, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus. In the present study, transcriptional profiling coupled with mutant and biochemical analyses were conducted using the model organism Saccharomyces cerevisiae, to investigate the mechanism of action of this compound. more...

Organism:

Saccharomyces cerevisiae; Saccharomyces cerevisiae S288C; Schizosaccharomyces pombe

Type:

Expression profiling by array

Platform:

GPL2529

6 Samples

Download data: CEL, CHP

(Submitter supplied) 6-Nonadecynoic acid (6-NDA), a plant-derived acetylenic acid, exhibits strong inhibitory activity against the human fungal pathogens Candida albicans, Aspergillus fumigatus, and Trichophyton mentagrophytes. In the present study, transcriptional profiling coupled with mutant and biochemical analyses were conducted using the model organism Saccharomyces cerevisiae to investigate the mechanism of action of this compound. more...

Organism:

Saccharomyces cerevisiae; Candida albicans; Schizosaccharomyces pombe

Type:

Expression profiling by array

Platforms:

GPL15195 GPL2529

14 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with the analysis of mutants were performed in an effort to elucidate its mechanism of action. Using Saccharomyces cerevisiae as a model organism, we show that sampangine produces a transcriptional response indicative of hypoxia, altering the expression of genes known to respond to low oxygen conditions. more...

Organism:

Saccharomyces cerevisiae; Candida albicans

Type:

Expression profiling by array

Platforms:

GPL6346 GPL90

9 Samples

Download data: CEL, TXT

(Submitter supplied) Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with the analysis of mutants were performed in an effort to elucidate its mechanism of action. Using Saccharomyces cerevisiae as a model organism, we show that sampangine produces a transcriptional response indicative of hypoxia, altering the expression of genes known to respond to low oxygen conditions. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL6346

3 Samples

Download data: TXT

(Submitter supplied) Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with the analysis of mutants were performed in an effort to elucidate its mechanism of action. Using Saccharomyces cerevisiae as a model organism, we show that sampangine produces a transcriptional response indicative of hypoxia, altering the expression of genes known to respond to low oxygen conditions. more...

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Dataset:

GDS3137

Platform:

GPL90

6 Samples

Download data: CEL

(Submitter supplied) The C. albicans Genome Oligo Set consisting of 70mer probes representing 6266 C. albicans genes was obtained from Qiagen (Valencia, CA), and printed on glass slides by Microarrays, Inc (Nashville, TN).

Organism:

Candida albicans

2 Series

3 Samples

Download data

Analysis of Saccharomyces cerevisiae cells treated with the antifungal compound sampangine. Sampangine exhibits strong inhibitory activity against opportunistic fungal pathogens such as Candida albicans. Using S. cerevisiae as a model, results provide insight into sampangine's mechanism of action.

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL90

Series:

GSE10073

6 Samples

Download data: CEL

(Submitter supplied) Growth assay in the presence of a toxic chemical (sr7575) that uses the barcoded collections of yeast gene deletions (haploid, diploid, DamP) to identify deletion strains that are hypersensitive to the drug.

Organism:

Saccharomyces cerevisiae S288C; Saccharomyces cerevisiae

Type:

Other

Platform:

GPL18088

4 Samples

Download data: GPR

(Submitter supplied) Eupolauridine and liriodenine are plant-derived aporphinoid alkaloids that exhibit potent inhibitory activity against the opportunistic fungal pathogens Candida albicans and Cryptococcus neoformans. However, the molecular mechanism of this antifungal activity is unknown. In this study, we show that eupolauridine 9591 (E9591), a synthetic analog of eupolauridine, and liriodenine methiodide (LMT), a methiodide salt of liriodenine, mediate their antifungal activities by disrupting mitochondrial iron-sulfur (Fe-S) cluster synthesis. more...

Organism:

Saccharomyces cerevisiae; Schizosaccharomyces pombe

Type:

Expression profiling by array

Platform:

GPL2529

30 Samples

Download data: CEL, CHP