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Links from GEO DataSets

Items: 20

1.

microRNA-expression profile in a series of Nodal marginal zone lymphoma patients [miRNA expression]

(Submitter supplied) Nodal marginal zone lymphoma (NMZL) is a small B cell neoplasm whose molecular pathogenesis is still essentially unknown and whose differentiation from other small B cell lymphomas is hampered by the lack of specific markers. We have analyzed gene expression, miRNA profile and copy number data from 15 NMZLs. For comparison, 16 follicular lymphomas, 9 extranodal marginal zone lymphomas, 8 reactive lymph nodes and B cell subtypes were included. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL9081
46 Samples
Download data: TXT
Series
Accession:
GSE32232
ID:
200032232
2.

Molecular characterization of Nodal marginal zone lymphoma [CGH]

(Submitter supplied) Nodal marginal zone lymphoma (NMZL) is a small B cell neoplasm whose molecular pathogenesis is still essentially unknown and whose differentiation from other small B cell lymphomas is hampered by the lack of specific markers. We have analyzed gene expression, miRNA profile and copy number data from 15 NMZL cases. For comparison, 16 follicular lymphomas, 9 extranodal marginal zone lymphomas, 8 reactive lymph nodes and B-cell subtypes were included. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL8841
14 Samples
Download data: TXT
Series
Accession:
GSE32436
ID:
200032436
3.

Molecular characterization of Nodal marginal zone lymphoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array; Genome variation profiling by array
Platforms:
GPL9081 GPL8841 GPL6848
108 Samples
Download data: GPR, TXT
Series
Accession:
GSE32233
ID:
200032233
4.

Molecular characterization of Nodal marginal zone lymphoma [Gene Expression]

(Submitter supplied) Nodal marginal zone lymphoma (NMZL) is a small B cell neoplasm whose molecular pathogenesis is still essentially unknown and whose differentiation from other small B cell lymphomas is hampered by the lack of specific markers. We have analyzed gene expression, miRNA profile and copy number data from 15 NMZL cases. For comparison, 16 follicular lymphomas, 9 extranodal marginal zone lymphomas, 8 reactive lymph nodes and B-cell subtypes were included. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6848
48 Samples
Download data: GPR
Series
Accession:
GSE32231
ID:
200032231
5.

Cytoscan HD arrays data for Nodal marginal zone lymphoma (NMZL)

(Submitter supplied) Nodal marginal zone lymphoma (NMZL) is one of the few B-cell tumors still remaining orphan of cancer gene lesions. By combining whole exome sequencing (WES), deep sequencing of tumor-related genes, high resolution SNP array and RNAseq, here we aim at characterizing the coding genome of NMZL and at disclosing the pathways that are molecularly deregulated in this lymphoma. The study was based on 35 NMZL (tumor representation >70%) with a diagnosis confirmed by: i) pathological revision of lymph node histology; and ii) lack of clinico-radiological evidence of extranodal or splenic disease either at diagnosis or during follow-up. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array
Platform:
GPL16131
58 Samples
Download data: CEL, CYCHP, TXT
Series
Accession:
GSE68078
ID:
200068078
6.

Characterizing the genetic background of nodal marginal zone lymphoma

(Submitter supplied) Nodal marginal zone lymphoma (NMZL) is a rare small B cell lymphoma lacking disease-defining phenotype and precise diagnostic markers. To better understand the mutational landscape of NMZL, particularly in comparison to other small nodal B cell lymphomas, we performed whole exome sequencing, targeted high throughput sequencing and array comparative genomic hybridization on a retrospective series. Our study identified for the first time recurrent, diagnostically useful and potentially therapeutically relevant BRAF mutations in NMZL. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL10150
22 Samples
Download data: TXT
Series
Accession:
GSE109487
ID:
200109487
7.

Gene expression profile of duodenal follicular lymphoma

(Submitter supplied) To clarify the molecular pathogenesis of DFL pathogenesis using GEP. DFL shares characteristics of both NFL and MALT lymphoma.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14550
55 Samples
Download data: TXT
Series
Accession:
GSE48047
ID:
200048047
8.

Gene expression profiling of pulmonary MALT lymphoma

(Submitter supplied) Molecular pathways activated in MALT lymphoma are not well defined. In this study, we perform gene expression profiling on 35 pulmonary MALT lymphoma using fresh frozen biopsy samples Keywords: Cell type analysis and disease state analysis
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
35 Samples
Download data: CEL
Series
Accession:
GSE13314
ID:
200013314
9.

Dissecting the grey zone between follicular lymphoma and nodal marginal zone lymphoma using morphological and genetic features

(Submitter supplied) Nodal marginal zone lymphoma is a poorly defined entity in the WHO classification, largely based on criteria by exclusion and the diagnosis often remains subjective. Follicular Lymphoma lacking t(14;18), have similar characteristics which results in a major potential diagnostic overlap which this study aims to dissect. Four subgroups of lymphoma samples (n=56) were analyzed with high-resolution arrayCGH; Nodal marginal zone lymphoma, t(14;18)-negative Follicular Lymphoma, localized t(14:18)-positive Follicular Lymphoma and disseminated t(14;18)-positive Follicular Lymphoma. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL10197
56 Samples
Download data: TXT
Series
Accession:
GSE40641
ID:
200040641
10.

The different epidemiologic subtypes of Burkitt Lymphoma share a largely homogenous micro RNA profile distinct from diffuse large B-cell lymphoma.

(Submitter supplied) Sporadic Burkitt lymphoma (sBL) can be delineated from diffuse large B-cell lymphoma (DLBCL) by a very homogeneous mRNA expression signature. However, it remained unclear whether all three BL variants – sBL, endemic BL (eBL) and immunodeficiency-associated BL (HIV-BL) – represent a uniform biological entity despite their differences in geographical occurrence, association with immunodeficiency and/or incidence of EBV infection. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL10554
150 Samples
Download data: GPR
Series
Accession:
GSE22420
ID:
200022420
11.

Overlap Between Pediatric Nodal Marginal Zone Lymphoma (PNMZL) and Pediatric-Type Follicular Lymphoma (PTFL) : Morphological and Molecular Analysis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Cavia porcellus; Ignicoccus hospitalis; Homo sapiens; Mus musculus; Capra hircus
Type:
Genome variation profiling by genome tiling array
7 related Platforms
56 Samples
Download data: CEL, CYCHP, OSCHP
Series
Accession:
GSE154834
ID:
200154834
12.

Overlap Between Pediatric Nodal Marginal Zone Lymphoma (PNMZL) and Pediatric-Type Follicular Lymphoma (PTFL) : Morphological and Molecular Analysis (OncoScan)

(Submitter supplied) Pediatric nodal marginal zone lymphoma (PNMZL) is an unusual and poorly understood primary B-cell nodal neoplasms. Patients are predominantly young males presenting with localized disease. The tumor shows overlapping morphological features with pediatric-type follicular lympgoma. The alterations involved in the pathogenesis of PNMZL are not known.
Organism:
Ignicoccus hospitalis; Homo sapiens; Cavia porcellus; Capra hircus; Mus musculus
Type:
Genome variation profiling by genome tiling array
6 related Platforms
53 Samples
Download data: CEL, OSCHP
Series
Accession:
GSE154831
ID:
200154831
13.

Overlap Between Pediatric Nodal Marginal Zone Lymphoma (PNMZL) and Pediatric-Type Follicular Lymphoma (PTFL) : Morphological and Molecular Analysis (CytoScan)

(Submitter supplied) Pediatric nodal marginal zone lymphoma (PNMZL) is an unusual and poorly understood primary B-cell nodal neoplasms. Patients are predominantly young males presenting with localized disease. The tumor shows overlapping morphological features with pediatric-type follicular lympgoma. The alterations involved in the pathogenesis of PNMZL are not known.
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL16131
3 Samples
Download data: CEL, CYCHP
Series
Accession:
GSE154830
ID:
200154830
14.

Expression data from Bone-Marrow Mesenchymal Stromal Cells (BM-MSC) from Follicular Lymphoma patient (FL) or Healthy Donor (HD).

(Submitter supplied) Human bone marrow mesenchymal stromal cells (BM-MSC) could be committed toward a functional lymphoid-like stroma by a combination of TNFalpha (TNF) and Lymphotoxin alpha1/beta2 (LT) (Amé-Thomas et al Blood 2007). Bone marrow and lymph node stromal cells support FL malignant cell recruitment and growth in particular after comittment to a lymphoid-like differentiation in vitro. In addition, more than 70% of FL patients exhibit a bone marrow involvment at diagnosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
28 Samples
Download data: CEL
Series
Accession:
GSE35331
ID:
200035331
15.

Gene expression Profiling in Follicular Lymphomas

(Submitter supplied) Follicular lymphoma (FL) is an indolent, but incurable subtype of non-Hodgkin lymphoma. These tumor harbor t (14;18) translocation in at least 90% of patients. Recently, activating EZH2 mutations have been Follicular lymphoma (FL) is an indolent, but incurable subtype of non-Hodgkin lymphoma. These tumor harbor t (14;18) translocation in at least 90% of patients. Recently, activating EZH2 mutations have been found in a significant number of patients with FL. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
69 Samples
Download data: CEL
Series
Accession:
GSE55267
ID:
200055267
16.

microRNA profiling of follicular lymphoma cells

(Submitter supplied) The hallmark of follicular lymphoma (FL) is the t(14;18) chromosomal translocation. However, constitutive expression of anti-apoptotic Bcl-2 alone is insufficient for lymphomagenesis and subsequent molecular hits are required. We explored the role of microRNA (miRNA or miR) in the biology of FL by generating miRNA profiles of enriched sorted grade 1 and 2 FL tumor cells derived from 18 patients compared with enriched germinal center B-cells derived from seven follicular hyperplasia (FH). more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL11487
25 Samples
Download data: TXT
Series
Accession:
GSE28090
ID:
200028090
17.

Genome-wide analysis of t(14;18)-negative/BCL2 expression-negative FL

(Submitter supplied) A subset of FL in adults are negative for t(14;18) translocation and BCL2 expression The tumor shows low grade cytology and lack both BCL2 expression and t(14;18) translocation. The genetic alterations involved in the pathogenesis of FL without t(14;18)-negative translocation and BCL2 expression are not well known.
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platforms:
GPL21558 GPL18602
53 Samples
Download data: CEL, OSCHP, XLSX
Series
Accession:
GSE80103
ID:
200080103
18.

Array comparative genomic hybridization of canine follicular lymphoma (cFL) and canine marginal zone lymphoma (cMZL)

(Submitter supplied) The aim of this work was to identify the copy number aberrations (CNAs) by high-resolution array comparative genomic hybridization (aCGH) on 7 dogs with newly diagnosed FL and 5 dogs with newly diagnosed MZL.
Organism:
Canis lupus familiaris
Type:
Genome variation profiling by array
Platform:
GPL24897
12 Samples
Download data: TXT
Series
Accession:
GSE131618
ID:
200131618
19.

An integrated genomic and expression analysis of 7q deletion in splenic marginal zone lymphoma (Affymetrix HG-U133plus2 gene expression microarray)

(Submitter supplied) Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoproliferative disorder characterised by 7q32 deletion, but the target genes of this deletion remain unknown. In order to elucidate the genetic target of this deletion, we performed an integrative analysis of the genetic, epigenetic, transcriptomic and miRNomic data. High resolution array comparative genomic hybridization of 56 cases of SMZL delineated a minimally deleted region (2.8Mb) at 7q32, but showed no evidence of any cryptic homozygous deletion or recurrent breakpoint in this region. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
24 Samples
Download data: CEL
Series
Accession:
GSE35426
ID:
200035426
20.

An integrated genomic and expression analysis of 7q deletion in SMZL (Oligo aCGH)

(Submitter supplied) Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoproliferative disorder characterised by 7q32 deletion, but the target genes of this deletion remain unknown. In order to elucidate the genetic target of this deletion, we performed an integrative analysis of the genetic, epigenetic, transcriptomic and miRNomic data. High resolution array comparative genomic hybridization of 56 cases of SMZL delineated a minimally deleted region (2.8Mb) at 7q32, but showed no evidence of any cryptic homozygous deletion or recurrent breakpoint in this region. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL10383
21 Samples
Download data: TXT
Series
Accession:
GSE35425
ID:
200035425
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